7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase Inhibitors (Unknown)
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- New search for: Curtin, Michael L.
- New search for: Albert, Daniel H.
- New search for: Glaser, Keith B.
- New search for: Pease, Lori J.
- New search for: Soni, Niru B.
- New search for: Bouska, Jennifer J.
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In:
Journal of Medicinal Chemistry
;
51
, 13
;
3777-3787
;
2008
- Article (Journal) / Electronic Resource
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Title:7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase Inhibitors
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Additional title:Pyrimidines as Inhibitors
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Contributors:Frey, Robin R. ( author ) / Curtin, Michael L. ( author ) / Albert, Daniel H. ( author ) / Glaser, Keith B. ( author ) / Pease, Lori J. ( author ) / Soni, Niru B. ( author ) / Bouska, Jennifer J. ( author ) / Reuter, David ( author ) / Stewart, Kent D. ( author ) / Marcotte, Patrick ( author )
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Published in:Journal of Medicinal Chemistry ; 51, 13 ; 3777-3787
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Publisher:
- New search for: American Chemical Society
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Publication date:2008-07-10
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 51, Issue 13
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 3661
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Recent Developments in Fragment-Based Drug DiscoveryCongreve, Miles / Chessari, Gianni / Tisi, Dominic / Woodhead, Andrew J. et al. | 2008
- 3681
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Hydrochalarones: A Novel Endohedral Metallofullerene Platform for Enhancing Magnetic Resonance Imaging ContrastMacFarland, Darren K. / Walker, Kenneth L. / Lenk, Robert P. / Wilson, Stephen R. / Kumar, Krishan / Kepley, Christopher L. / Garbow, Joel R. et al. | 2008
- 3684
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Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal DisordersShi, Zhi-Cai / Devasagayaraj, Arokiasamy / Gu, Kunjian / Jin, Haihong / Marinelli, Brett / Samala, Lakshman / Scott, Sheldon / Stouch, Terry / Tunoori, Ashok / Wang, Ying et al. | 2008
- 3688
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Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)Liu, Longbin / Siegmund, Aaron / Xi, Ning / Kaplan-Lefko, Paula / Rex, Karen / Chen, April / Lin, Jasmine / Moriguchi, Jodi / Berry, Loren / Huang, Liyue et al. | 2008
- 3692
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Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel AntagonistShipe, William D. / Barrow, James C. / Yang, Zhi-Qiang / Lindsley, Craig W. / Yang, F. Vivien / Schlegel, Kelly-Ann S. / Shu, Youheng / Rittle, Kenneth E. / Bock, Mark G. / Hartman, George D. et al. | 2008
- 3696
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A Tissue-Selective Nonsteroidal Progesterone Receptor Modulator: 7,9-Difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinolinePedram, Bijan / Oeveren, Arjan van / Mais, Dale E. / Marschke, Keith B. / Verbost, Pieter M. / Groen, Marinus B. / Zhi, Lin et al. | 2008
- 3700
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Synthesis and Biological Evaluation of Substituted [18F]Imidazo[1,2-a]pyridines and [18F]Pyrazolo[1,5-a]pyrimidines for the Study of the Peripheral Benzodiazepine Receptor Using Positron Emission TomographyFookes, Christopher J. R. / Pham, Tien Q. / Mattner, Filomena / Greguric, Ivan / Loc’h, Christian / Liu, Xiang / Berghofer, Paula / Shepherd, Rachael / Gregoire, Marie-Claude / Katsifis, Andrew et al. | 2008
- 3713
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Enhanced Concentration-Dependent Cytotoxic Effect of the Dinuclear Copper(II) Complex of l-Carnitine [Cu2(l-carnitine)2Cl2(H2O)2]Cl2, Compared to l-Carnitine or Copper Chloride Dihydrate, in Human Leukemic Cell LinesThomadaki, Hellinida / Karaliota, Alexandra / Litos, Charalambos / Scorilas, Andreas et al. | 2008
- 3713
-
Enhanced Concentration-Dependent Cytotoxic Effect of the Dinuclear Cooper(II) Complex of L-Carnitine [Cu~2(L-carnitine)~2Cl~2(H~2O)~2]Cl~2, Compared to L-Carnitine or Copper Chloride Dihydrate, in Human Leukemic Cell LinesThomadaki, H. / Karaliota, A. / Litos, C. / Scorilas, A. et al. | 2008
- 3720
-
Toward Prediction of Alkane/Water Partition CoefficientsToulmin, Anita / Wood, J. Matthew / Kenny, Peter W. et al. | 2008
- 3731
-
Potent Non-Nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase ComplexSun, Aiming / Yoon, Jeong-Joong / Yin, Yan / Prussia, Andrew / Yang, Yutao / Min, Jaeki / Plemper, Richard K. / Snyder, James P. et al. | 2008
- 3742
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The Micelle-Associated 3D Structures of Boc-Y(SO3)-Nle-G-W-Nle-D-2-phenylethylester (JMV-180) and CCK-8(s) Share Conformational Elements of a Calculated CCK1 Receptor-Bound ModelKumar, Mohanraja / Reeve, Joseph R. / Hu, Weidong / Miller, Laurence J. / Keire, David A. et al. | 2008
- 3755
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Characterization of the Drug Binding Specificity of Rat Liver Fatty Acid Binding ProteinChuang, Sara / Velkov, Tony / Horne, James / Porter, Christopher J. H. / Scanlon, Martin J. et al. | 2008
- 3765
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Theoretical Studies on the Structure and Symmetry of the Transmembrane Region of Glutamatergic GluR5 ReceptorKaczor, Agnieszka A. / Kijkowska-Murak, Urszula A. / Matosiuk, Dariusz et al. | 2008
- 3777
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7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase InhibitorsFrey, Robin R. / Curtin, Michael L. / Albert, Daniel H. / Glaser, Keith B. / Pease, Lori J. / Soni, Niru B. / Bouska, Jennifer J. / Reuter, David / Stewart, Kent D. / Marcotte, Patrick et al. | 2008
- 3788
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Selective Influence on Contextual Memory: Physiochemical Properties Associated with Selectivity of Benzodiazepine Ligands at GABA~A Receptors Containing the alpha 5 SubunitHarris, D. / Clayton, T. / Cook, J. / Sahbaie, P. / Halliwell, R.F. / Furtmuller, R. / Huck, S. / Sieghart, W. / DeLorey, T.M. et al. | 2008
- 3788
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Selective Influence on Contextual Memory: Physiochemical Properties Associated with Selectivity of Benzodiazepine Ligands at GABAA Receptors Containing the α5 SubunitHarris, Danni / Clayton, Terry / Cook, James / Sahbaie, Peyman / Halliwell, Robert F. / Furtmüller, Roman / Huck, Sigismund / Sieghart, Werner / DeLorey, Timothy M. et al. | 2008
- 3804
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Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A ReductaseSarver, Ronald W. / Bills, Elizabeth / Bolton, Gary / Bratton, Larry D. / Caspers, Nicole L. / Dunbar, James B. / Harris, Melissa S. / Hutchings, Richard H. / Kennedy, Robert M. / Larsen, Scott D. et al. | 2008
- 3814
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Design, Synthesis, and Biological Evaluation of Novel 3-Aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as Vascular Endothelial Growth Factor Receptor (VEGF-R) InhibitorsPeifer, Christian / Selig, Roland / Kinkel, Katrin / Ott, Dimitri / Totzke, Frank / Schächtele, Christoph / Heidenreich, Regina / Röcken, Martin / Schollmeyer, Dieter / Laufer, Stefan et al. | 2008
- 3825
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Novel γ-Aminobutyric Acid ρ1 Receptor Antagonists; Synthesis, Pharmacological Activity and Structure−Activity RelationshipsKumar, Rohan J. / Chebib, Mary / Hibbs, David E. / Kim, Hye-Lim / Johnston, Graham A. R. / Salam, Noeris K. / Hanrahan, Jane R. et al. | 2008
- 3825
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Novel gamma -Aminobutyric Acid rho ~1 Receptor Antagonists; Synthesis, Pharmacological Activity and Structure-Activity RelationshipsKumar, R.J. / Chebib, M. / Hibbs, D.E. / Kim, H.-L. / Johnston, G.A.R. / Salam, N.K. / Hanrahan, J.R. et al. | 2008
- 3841
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1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, New Imidazoles with Potent Activity against Candida albicans and Dermatophytes. Synthesis, Structure−Activity Relationship, and Molecular Modeling StudiesLa Regina, Giuseppe / D’Auria, Felicia Diodata / Tafi, Andrea / Piscitelli, Francesco / Olla, Stefania / Caporuscio, Fabiana / Nencioni, Lucia / Cirilli, Roberto / La Torre, Francesco / De Melo, Nadja Rodrigues et al. | 2008
- 3856
-
Sodium Late Current Blockers in Ischemia Reperfusion: Is the Bullet Magic?Le Grand, Bruno / Pignier, Christophe / Létienne, Robert / Cuisiat, Florence / Rolland, Françoise / Mas, Agnes / Vacher, Bernard et al. | 2008
- 3867
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Improvement of meta-tetra(Hydroxyphenyl)chlorin-Like Photosensitizer Selectivity with Folate-Based Targeted Delivery. Synthesis and in Vivo Delivery StudiesGravier, Julien / Schneider, Raphaël / Frochot, Céline / Bastogne, Thierry / Schmitt, Frédéric / Didelon, Jacques / Guillemin, François / Barberi-Heyob, Muriel et al. | 2008
- 3878
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Ensemble-Based Virtual Screening Reveals Potential Novel Antiviral Compounds for Avian Influenza NeuraminidaseCheng, Lily S. / Amaro, Rommie E. / Xu, Dong / Li, Wilfred W. / Arzberger, Peter W. / McCammon, J. Andrew et al. | 2008
- 3895
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Design, Synthesis, and Evaluation of Novel Mutual Prodrugs (Hybrid Drugs) of All-trans-Retinoic Acid and Histone Deacetylase Inhibitors with Enhanced Anticancer Activities in Breast and Prostate Cancer Cells in VitroGediya, Lalji K. / Khandelwal, Aakanksha / Patel, Jyoti / Belosay, Aashvini / Sabnis, Gauri / Mehta, Jhalak / Purushottamachar, Puranik / Njar, Vincent C. O. et al. | 2008
- 3905
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Synthesis and Pharmacological Characterization of Chiral Pyrrolidinylfuran Derivatives: The Discovery of New Functionally Selective Muscarinic AgonistsScapecchi, Serena / Nesi, Marta / Matucci, Rosanna / Bellucci, Cristina / Buccioni, Michela / Dei, Silvia / Guandalini, Luca / Manetti, Dina / Martini, Elisabetta / Marucci, Gabriella et al. | 2008
- 3913
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Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether AnaloguesBergeron, Raymond J. / Wiegand, Jan / McManis, James S. / Bharti, Neelam / Singh, Shailendra et al. | 2008
- 3924
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Synthesis, Biological Activity, and Structure−Activity Relationships for Potent Cytotoxic Rhodium(III) Polypyridyl ComplexesHarlos, Melanie / Ott, Ingo / Gust, Ronald / Alborzinia, Hamed / Wölfl, Stefan / Kromm, Anna / Sheldrick, William S. et al. | 2008
- 3934
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Structure−Activity Relationships of 7-Deaza-6-benzylthioinosine Analogues as Ligands of Toxoplasma gondii Adenosine KinaseKim, Young Ah / Sharon, Ashoke / Chu, Chung K. / Rais, Reem H. / Al Safarjalani, Omar N. / Naguib, Fardos N. M. / el Kouni, Mahmoud H. et al. | 2008
- 3946
-
2-Aminobenzophenones as a Novel Class of Bradykinin B1 Receptor AntagonistsSu, Dai-Shi / Lim, John L. / Tinney, Elizabeth / Wan, Bang-Lin / Murphy, Kathy L. / Reiss, Duane R. / Harrell, C. Meacham / O’Malley, Stacy S. / Ransom, Rick W. / Chang, Raymond S. L. et al. | 2008
- 3953
-
Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Modelxref rid="afn6"->Julian, Lisa D. et al. | 2008
- 3953
-
Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo ModelJulian, Lisa D. / Wang, Zhulun / Bostick, Tracy / Caille, Seb / Choi, Rebekah / DeGraffenreid, Michael / Di, Yongmei / He, Xiao / Hungate, Randall W. / Jaen, Juan C. et al. | 2008
- 3953
-
Discovery of Novel, Potent Benzamide Inhibitors 11 beta -Hydroxysteroid Dehydrogenase Type 1 (11 beta -HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo ModelJulian, L.D. / Wang, Z. / Bostick, T. / Caille, S. / Choi, R. / DeGraffenreid, M. / Di, Y. / He, X. / Hungate, R.W. / Jaen, J.C. et al. | 2008
- 3961
-
Hydrolytic Reactivity Trends among Potential Prodrugs of the O2-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial ActivityValdez, Carlos A. / Saavedra, Joseph E. / Showalter, Brett M. / Davies, Keith M. / Wilde, Thomas C. / Citro, Michael L. / Barchi, Joseph J. / Deschamps, Jeffrey R. / Parrish, Damon / El-Gayar, Stefan et al. | 2008
- 3971
-
Design of Novel Cyclic Altered Peptide Ligands of Myelin Basic Protein MBP83−99 That Modulate Immune Responses in SJL/J MiceKatsara, Maria / Deraos, George / Tselios, Theodore / Matsoukas, John / Apostolopoulos, Vasso et al. | 2008
- 3979
-
Brassinosteroids: Synthesis and Activity of Some Fluoro AnaloguesSlavikova, Barbora / Kohout, Ladislav / Budesinsky, Milos / Swaczynova, Jana / Kasal, Alexander et al. | 2008
- 3985
-
Trithiocarbonates as a Novel Class of HDAC Inhibitors: SAR Studies, Isoenzyme Selectivity, and Pharmacological ProfilesDehmel, Florian / Weinbrenner, Steffen / Julius, Heiko / Ciossek, Thomas / Maier, Thomas / Stengel, Thomas / Fettis, Kamal / Burkhardt, Carmen / Wieland, Heike / Beckers, Thomas et al. | 2008
- 4002
-
Discovery of a Novel Series of Biphenyl Benzoic Acid Derivatives as Highly Potent and Selective Human β3 Adrenergic Receptor Agonists with Good Oral Bioavailability. Part IIImanishi, Masashi / Itou, Shinji / Washizuka, Kenichi / Hamashima, Hitoshi / Nakajima, Yutaka / Araki, Takanobu / Tomishima, Yasuyo / Sakurai, Minoru / Matsui, Shigeo / Imamura, Emiko et al. | 2008
- 4002
-
Discovery of a Novel Series of Biphenyl Benzoic Acid Derivatives as Highly Potent and Selective Human beta 3 Adrenergic Receptor Agonists with Good Oral Bioavailability. Part IIImanishi, M. / Itou, S. / Washizuka, K. / Hamashima, H. / Nakajima, Y. / Araki, T. / Tomishima, Y. / Sakurai, M. / Matsui, S. / Imamura, E. et al. | 2008
- 4021
-
A Novel Class of Cycloalkano[b]pyridines as Potent and Orally Active Opioid Receptor-like 1 Antagonists with Minimal Binding Affinity to the hERG K+ ChannelYoshizumi, Takashi / Takahashi, Hirobumi / Miyazoe, Hiroshi / Sugimoto, Yuichi / Tsujita, Tomohiro / Kato, Tetsuya / Ito, Hirokatsu / Kawamoto, Hiroshi / Hirayama, Mioko / Ichikawa, Daisuke et al. | 2008
- 4030
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Design and in Vitro Characterization of Highly sst2-Selective Somatostatin Antagonists Suitable for RadiotargetingCescato, Renzo / Erchegyi, Judith / Waser, Beatrice / Piccand, Véronique / Maecke, Helmut R. / Rivier, Jean E. / Reubi, Jean Claude et al. | 2008
- 4038
-
Structure−Activity Relationships of the Cycloalkanol Ethylamine Scaffold: Discovery of Selective Norepinephrine Reuptake InhibitorsMahaney, Paige E. / Gavrin, Lori K. / Trybulski, Eugene J. / Stack, Gary P. / Vu, An T. / Cohn, Stephen T. / Ye, Fei / Belardi, Justin K. / Santilli, Arthur A. / Sabatucci, Joseph P. et al. | 2008
- 4050
-
Interaction of Methimazole with I2: X-ray Crystal Structure of the Charge Transfer Complex Methimazole−I2. Implications for the Mechanism of Action of Methimazole-Based Antithyroid DrugsIsaia, Francesco / Aragoni, M. Carla / Arca, Massimiliano / Demartin, Francesco / Devillanova, Francesco A. / Floris, Giovanni / Garau, Alessandra / Hursthouse, Michael B. / Lippolis, Vito / Medda, Rosaria et al. | 2008
- 4054
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Efficient Synthesis and Neuroprotective Effect of Substituted 1,3-Diphenyl-2-propen-1-onesJung, Jae-Chul / Jang, Soyong / Lee, Yongnam / Min, Dongguk / Lim, Eunyoung / Jung, Heyin / Oh, Miyeon / Oh, Seikwan / Jung, Mankil et al. | 2008