Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief (Unknown)
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In:
Journal of Medicinal Chemistry
;
62
, 1
;
276-287
;
2019
- Article (Journal) / Electronic Resource
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Title:Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief
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Additional title:J. Med. Chem.
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Contributors:Gado, Francesca ( author ) / Di Cesare Mannelli, Lorenzo ( author ) / Lucarini, Elena ( author ) / Bertini, Simone ( author ) / Cappelli, Elena ( author ) / Digiacomo, Maria ( author ) / Stevenson, Lesley A. ( author ) / Macchia, Marco ( author ) / Tuccinardi, Tiziano ( author ) / Ghelardini, Carla ( author )
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Published in:Journal of Medicinal Chemistry ; 62, 1 ; 276-287
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Publisher:
- New search for: American Chemical Society
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Publication date:2019-01-10
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 62, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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Allosteric Modulators of Drug Targets| 2019
- 3
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Positive and Negative Allosteric Modulators of N‑Methyl‑d‑aspartate (NMDA) Receptors: Structure–Activity Relationships and Mechanisms of ActionBurnell, Erica S. / Irvine, Mark / Fang, Guangyu / Sapkota, Kiran / Jane, David E. / Monaghan, Daniel T. et al. | 2019
- 24
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Small Molecule Allosteric Modulators of G‑Protein-Coupled Receptors: Drug–Target InteractionsLu, Shaoyong / Zhang, Jian et al. | 2019
- 46
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Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type GlutaminaseZimmermann, Sarah C. / Duvall, Bridget / Tsukamoto, Takashi et al. | 2019
- 60
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Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug DesignFerraro, Mariarosaria / D’Annessa, Ilda / Moroni, Elisabetta / Morra, Giulia / Paladino, Antonella / Rinaldi, Silvia / Compostella, Federica / Colombo, Giorgio et al. | 2019
- 88
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Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging ConceptsWold, Eric A. / Chen, Jianping / Cunningham, Kathryn A. / Zhou, Jia et al. | 2019
- 128
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Novel Strategies To Activate the Dopamine D1 Receptor: Recent Advances in Orthosteric Agonism and Positive Allosteric ModulationHall, Adrian / Provins, Laurent / Valade, Anne et al. | 2019
- 141
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A Surprising Recipe for Designing Biased LigandsTopiol, Sid et al. | 2019
- 144
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Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β‑Arrestin 2 Recruitment) Within the Melanocortin ReceptorsLensing, Cody J. / Freeman, Katie T. / Schnell, Sathya M. / Speth, Robert C. / Zarth, Adam T. / Haskell-Luevano, Carrie et al. | 2019
- 159
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Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in MiceLi, Yuanheng / Sun, Lilan / Yang, Taoyi / Jiao, Wenxuan / Tang, Jingshu / Huang, Xiaomin / Huang, Zongze / Meng, Ying / Luo, Laichun / Wang, Xintong et al. | 2019
- 174
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A Thieno[2,3‑d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 ReceptorFyfe, Tim J. / Zarzycka, Barbara / Lim, Herman D. / Kellam, Barrie / Mistry, Shailesh N. / Katrich, Vsevolod / Scammells, Peter J. / Lane, J. Robert / Capuano, Ben et al. | 2019
- 207
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Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X‑ray StructuresChristopher, John A. / Orgován, Zoltán / Congreve, Miles / Doré, Andrew S. / Errey, James C. / Marshall, Fiona H. / Mason, Jonathan S. / Okrasa, Krzysztof / Rucktooa, Prakash / Serrano-Vega, Maria J. et al. | 2019
- 223
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Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological CharacterizationDoornbos, Maarten L. J. / Wang, Xuesong / Vermond, Sophie C. / Peeters, Luc / Pérez-Benito, Laura / Trabanco, Andrés A. / Lavreysen, Hilde / Cid, José María / Heitman, Laura H. / Tresadern, Gary et al. | 2019
- 234
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Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural InformationSzabó, György / Túrós, György I. / Kolok, Sándor / Vastag, Mónika / Sánta, Zsuzsanna / Dékány, Miklós / Lévay, György I. / Greiner, István / Natsumi, Minami / Tatsuya, Watanabe et al. | 2019
- 247
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Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase InhibitorsBagal, Sharan K. / Omoto, Kiyoyuki / Blakemore, David C. / Bungay, Peter J. / Bilsland, James G. / Clarke, Philip J. / Corbett, Matthew S. / Cronin, Ciaran N. / Cui, J. Jean / Dias, Rebecca et al. | 2019
- 266
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Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4Li, Cong / Deng, Xiaobing / Zhang, Weilin / Xie, Xiaowen / Conrad, Marcus / Liu, Ying / Angeli, José Pedro Friedmann / Lai, Luhua et al. | 2019
- 276
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Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain ReliefGado, Francesca / Di Cesare Mannelli, Lorenzo / Lucarini, Elena / Bertini, Simone / Cappelli, Elena / Digiacomo, Maria / Stevenson, Lesley A. / Macchia, Marco / Tuccinardi, Tiziano / Ghelardini, Carla et al. | 2019
- 288
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Design, Synthesis, and Characterization of 4‑Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5‑HT2C ReceptorWild, Christopher T. / Miszkiel, Joanna M. / Wold, Eric A. / Soto, Claudia A. / Ding, Chunyong / Hartley, Rachel M. / White, Mark A. / Anastasio, Noelle C. / Cunningham, Kathryn A. / Zhou, Jia et al. | 2019
- 306
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Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like MoleculeTautermann, Christofer S. / Binder, Florian / Büttner, Frank H. / Eickmeier, Christian / Fiegen, Dennis / Gross, Ulrike / Grundl, Marc A. / Heilker, Ralf / Hobson, Scott / Hoerer, Stefan et al. | 2019
- 317
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Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ‑Aminobutyric Acid Type A (GABAA) Receptor ModulatorsStadler, Marco / Monticelli, Serena / Seidel, Thomas / Luger, Denise / Salzer, Isabella / Boehm, Stefan / Holzer, Wolfgang / Schwarzer, Christoph / Urban, Ernst / Khom, Sophia et al. | 2019
- 342
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Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6‑((1H‑Pyrazolo[4,3‑b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)Bollinger, Sean R. / Engers, Darren W. / Panarese, Joseph D. / West, Mary / Engers, Julie L. / Loch, Matthew T. / Rodriguez, Alice L. / Blobaum, Anna L. / Jones, Carrie K. / Thompson Gray, Analisa et al. | 2019
- 359
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Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome ActivityGiżyńska, Małgorzata / Witkowska, Julia / Karpowicz, Przemysław / Rostankowski, Rafał / Chocron, Estrella S. / Pickering, Andrew M. / Osmulski, Pawel / Gaczynska, Maria / Jankowska, Elżbieta et al. | 2019
- 371
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Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N‑((trans)‑4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1H)‑yl)ethyl)cyclohexyl)‑1H‑indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D2 ReceptorKopinathan, Anitha / Draper-Joyce, Christopher / Szabo, Monika / Christopoulos, Arthur / Scammells, Peter J. / Lane, J. Robert / Capuano, Ben et al. | 2019
- 378
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Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5‑a]pyrimidine-5-carboxamide and Thieno[3,2‑b]pyridine-5-carboxamide CoresChildress, Elizabeth S. / Wieting, Joshua M. / Felts, Andrew S. / Breiner, Megan M. / Long, Madeline F. / Luscombe, Vincent B. / Rodriguez, Alice L. / Cho, Hyekyung P. / Blobaum, Anna L. / Niswender, Colleen M. et al. | 2019