Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease (Unknown)
- New search for: Baggio, Carlo
- New search for: Velazquez, Jalene V.
- New search for: Fragai, Marco
- Further information on Fragai, Marco:
- https://orcid.org/0000-0002-8440-1690
- New search for: Nordgren, Tara M.
- New search for: Pellecchia, Maurizio
- Further information on Pellecchia, Maurizio:
- https://orcid.org/0000-0001-5179-470X
- New search for: Baggio, Carlo
- New search for: Velazquez, Jalene V.
- New search for: Fragai, Marco
- Further information on Fragai, Marco:
- https://orcid.org/0000-0002-8440-1690
- New search for: Nordgren, Tara M.
- New search for: Pellecchia, Maurizio
- Further information on Pellecchia, Maurizio:
- https://orcid.org/0000-0001-5179-470X
In:
Journal of Medicinal Chemistry
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63
, 21
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12911-12920
;
2020
- Article (Journal) / Electronic Resource
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Title:Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease
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Additional title:J. Med. Chem.
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Contributors:Baggio, Carlo ( author ) / Velazquez, Jalene V. ( author ) / Fragai, Marco ( author ) / Nordgren, Tara M. ( author ) / Pellecchia, Maurizio ( author )
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Published in:Journal of Medicinal Chemistry ; 63, 21 ; 12911-12920
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Publisher:
- New search for: American Chemical Society
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Publication date:2020-11-12
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 63, Issue 21
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 12129
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Epigenetics 2.0: Special Issue on EpigeneticsCall for PapersConway, Stuart J. / Arimondo, Paola / Arrowsmith, Cheryl / Jin, Jian / Luo, Cheng / Meanwell, Nicholas / Young, Wendy / Georg, Gunda / Wang, Shaomeng et al. | 2020
- 12131
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Synthetic Access to Cannabidiol and Analogs as Active Pharmaceutical IngredientsPirrung, Michael C. et al. | 2020
- 12137
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The Essential Medicinal Chemistry of Cannabidiol (CBD)Nelson, Kathryn M. / Bisson, Jonathan / Singh, Gurpreet / Graham, James G. / Chen, Shao-Nong / Friesen, J. Brent / Dahlin, Jayme L. / Niemitz, Matthias / Walters, Michael A. / Pauli, Guido F. et al. | 2020
- 12156
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Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug OptimizationMiller, Randy R. / Madeira, Maria / Wood, Harold B. / Geissler, Wayne M. / Raab, Conrad E. / Martin, Iain J. et al. | 2020
- 12171
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Teixobactin: A Paving Stone toward a New Class of Antibiotics?Gunjal, Vidya B. / Thakare, Ritesh / Chopra, Sidharth / Reddy, D. Srinivasa et al. | 2020
- 12196
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Adenosine A2A Receptor Antagonists for Cancer ImmunotherapyYu, Fazhi / Zhu, Chenyu / Xie, Qiong / Wang, Yonghui et al. | 2020
- 12213
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Progress toward a Glycoprotein VI Modulator for the Treatment of ThrombosisFoster, Holly / Wilson, Clare / Philippou, Helen / Foster, Richard et al. | 2020
- 12243
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Enhancing Chemogenomics with Predictive PharmacologyJames, Tim / Sardar, Adam / Anighoro, Andrew et al. | 2020
- 12256
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Inhibitors of SARS-CoV‑2 Entry: Current and Future OpportunitiesXiu, Siyu / Dick, Alexej / Ju, Han / Mirzaie, Sako / Abdi, Fatemeh / Cocklin, Simon / Zhan, Peng / Liu, Xinyong et al. | 2020
- 12275
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Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of DrugsFelicetti, Tommaso / Cecchetti, Violetta / Manfroni, Giuseppe et al. | 2020
- 12290
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Amide Bond Bioisosteres: Strategies, Synthesis, and SuccessesKumari, Shikha / Carmona, Angelica V. / Tiwari, Amit K. / Trippier, Paul C. et al. | 2020
- 12359
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COVID-19: Drug Targets and Potential TreatmentsGil, Carmen / Ginex, Tiziana / Maestro, Inés / Nozal, Vanesa / Barrado-Gil, Lucía / Cuesta-Geijo, Miguel Ángel / Urquiza, Jesús / Ramírez, David / Alonso, Covadonga / Campillo, Nuria E. et al. | 2020
- 12387
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Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand DevelopmentNguyen, Thuy / Marusich, Julie / Li, Jun-Xu / Zhang, Yanan et al. | 2020
- 12403
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Small-Molecule Fms-like Tyrosine Kinase 3 Inhibitors: An Attractive and Efficient Method for the Treatment of Acute Myeloid LeukemiaZhong, Yue / Qiu, Run-Ze / Sun, Shan-Liang / Zhao, Chao / Fan, Tian-Yuan / Chen, Min / Li, Nian-Guang / Shi, Zhi-Hao et al. | 2020
- 12429
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Recent Progress in the Discovery of Antifungal Agents Targeting the Cell WallLiu, Wei / Yuan, Lin / Wang, Shengzheng et al. | 2020
- 12460
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Thirty Years of HDAC Inhibitors: 2020 Insight and HindsightHo, Terence C. S. / Chan, Alex H. Y. / Ganesan, A. et al. | 2020
- 12485
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From Seeds of Apium graveolens Linn. to a Cerebral Ischemia Medicine: The Long Journey of 3‑n‑ButylphthalideMarco-Contelles, José / Zhang, Yihua et al. | 2020
- 12511
-
Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β‑LactamasesDurand-Réville, Thomas F. / Comita-Prevoir, Janelle / Zhang, Jing / Wu, Xiaoyun / May-Dracka, Tricia L. / Romero, Jan Antoinette C. / Wu, Frank / Chen, April / Shapiro, Adam B. / Carter, Nicole M. et al. | 2020
- 12526
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Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune DiseasesMa, Bin / Bohnert, Tonika / Otipoby, Kevin L. / Tien, Eric / Arefayene, Million / Bai, Judy / Bajrami, Bekim / Bame, Eris / Chan, Timothy R. / Humora, Michael et al. | 2020
- 12542
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Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4Fairhurst, Robin A. / Knoepfel, Thomas / Buschmann, Nicole / Leblanc, Catherine / Mah, Robert / Todorov, Milen / Nimsgern, Pierre / Ripoche, Sebastien / Niklaus, Michel / Warin, Nicolas et al. | 2020
- 12574
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Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral PharmacokineticsHillisch, Alexander / Gericke, Kersten M. / Allerheiligen, Swen / Roehrig, Susanne / Schaefer, Martina / Tersteegen, Adrian / Schulz, Simone / Lienau, Philip / Gnoth, Mark / Puetter, Vera et al. | 2020
- 12595
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Stapled and Xenopus Glucagon-Like Peptide 1 (GLP-1)-Based Dual GLP-1/Gastrin Receptor Agonists with Improved Metabolic Benefits in Rodent Models of Obesity and DiabetesChen, Xinyu / Fu, Junjie / Zhou, Feng / Yang, Qimeng / Wang, Jialing / Feng, Hui / Jiang, Wen / Jin, Luofan / Tang, Xuelin / Jiang, Neng et al. | 2020
- 12614
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Sila-IbuprofenKleemiss, Florian / Justies, Aileen / Duvinage, Daniel / Watermann, Patrick / Ehrke, Eric / Sugimoto, Kunihisa / Fugel, Malte / Malaspina, Lorraine A. / Dittmer, Anneke / Kleemiss, Torsten et al. | 2020
- 12623
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Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial In Vitro and In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureusRehberg, Nidja / Sommer, Gereon A. / Drießen, Daniel / Kruppa, Marco / Adeniyi, Emmanuel T. / Chen, Shang / Wang, Lin / Wolf, Karina / Tasch, Boris O. A. / Ioerger, Thomas R. et al. | 2020
- 12642
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Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate CancerHe, Yali / Hwang, Dong-Jin / Ponnusamy, Suriyan / Thiyagarajan, Thirumagal / Mohler, Michael L. / Narayanan, Ramesh / Miller, Duane D. et al. | 2020
- 12666
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Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β‑Cell ApoptosisKokotou, Maroula G. / Kokotos, Alexandros C. / Gkikas, Dimitrios / Mountanea, Olga G. / Mantzourani, Christiana / Almutairi, Abdulaziz / Lei, Xiaoyong / Ramanadham, Sasanka / Politis, Panagiotis K. / Kokotos, George et al. | 2020
- 12682
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Backbone Cyclization Turns a Venom Peptide into a Stable and Equipotent Ligand at Both Muscle and Neuronal Nicotinic ReceptorsGiribaldi, Julien / Haufe, Yves / Evans, Edward R. J. / Amar, Muriel / Durner, Anna / Schmidt, Casey / Faucherre, Adèle / Moha Ou Maati, Hamid / Enjalbal, Christine / Molgó, Jordi et al. | 2020
- 12693
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One-Step, Rapid, 18F–19F Isotopic Exchange Radiolabeling of Difluoro-dioxaborinins: Substituent Effect on Stability and In Vivo ApplicationsAn, Feifei / Nurili, Fuad / Sayman, Haluk / Ozer, Zahide / Cakiroglu, Huseyin / Aras, Omer / Ting, Richard et al. | 2020
- 12707
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Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant GlioblastomaLi, Bo / Li, Yongliang / Tomkiewicz-Raulet, Céline / Dao, Pascal / Lietha, Daniel / Yen-Pon, Expédite / Du, Zhiyun / Coumoul, Xavier / Garbay, Christiane / Etheve-Quelquejeu, Mélanie et al. | 2020
- 12725
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Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19Hoffman, Robert L. / Kania, Robert S. / Brothers, Mary A. / Davies, Jay F. / Ferre, Rose A. / Gajiwala, Ketan S. / He, Mingying / Hogan, Robert J. / Kozminski, Kirk / Li, Lilian Y. et al. | 2020
- 12748
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Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic SteatohepatitisLi, Junyou / Liu, Mengqi / Li, Yazhou / Sun, Dan-dan / Shu, Zhihao / Tan, Qian / Guo, Shimeng / Xie, Rongrong / Gao, Lixin / Ru, Hongbo et al. | 2020
- 12773
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Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances PotencyPeschel, Alicia / Cardoso, Fernanda C. / Walker, Andrew A. / Durek, Thomas / Stone, M. Rhia L. / Braga Emidio, Nayara / Dawson, Philip E. / Muttenthaler, Markus / King, Glenn F. et al. | 2020
- 12786
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Proposed Allosteric Inhibitors Bind to the ATP Site of CK2αBrear, Paul / Ball, Darby / Stott, Katherine / D’Arcy, Sheena / Hyvönen, Marko et al. | 2020
- 12799
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Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B BromodomainLloyd, Jonathan T. / McLaughlin, Kyle / Lubula, Mulu Y. / Gay, Jamie C. / Dest, Andrea / Gao, Cong / Phillips, Margaret / Tonelli, Marco / Cornilescu, Gabriel / Marunde, Matthew R. et al. | 2020
- 12814
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Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer AgentsWander, Dennis P. A. / van der Zanden, Sabina Y. / van der Marel, Gijsbert A. / Overkleeft, Herman S. / Neefjes, Jacques / Codée, Jeroen D. C. et al. | 2020
- 12830
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Discovery of Novel Substituted N‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus InhibitorsXu, Jimin / Berastegui-Cabrera, Judith / Ye, Na / Carretero-Ledesma, Marta / Pachón-Díaz, Jerónimo / Chen, Haiying / Pachón-Ibáñez, Maria Eugenia / Sánchez-Céspedes, Javier / Zhou, Jia et al. | 2020
- 12853
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A Peptidyl Inhibitor that Blocks Calcineurin–NFAT Interaction and Prevents Acute Lung InjuryDougherty, Patrick G. / Karpurapu, Manjula / Koley, Amritendu / Lukowski, Jessica K. / Qian, Ziqing / Srinivas Nirujogi, Teja / Rusu, Luiza / Chung, Sangwoon / Hummon, Amanda B. / Li, Hao W. et al. | 2020
- 12873
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Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over βOrtega, Jose Antonio / Arencibia, Jose M. / Minniti, Elirosa / Byl, Jo Ann W. / Franco-Ulloa, Sebastian / Borgogno, Marco / Genna, Vito / Summa, Maria / Bertozzi, Sine Mandrup / Bertorelli, Rosalia et al. | 2020
- 12887
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[1,2,4]Triazolo[1,5‑a]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided ExplorationTresadern, Gary / Velter, Ingrid / Trabanco, Andrés A. / Van den Keybus, Frans / Macdonald, Gregor J. / Somers, Marijke V. F. / Vanhoof, Greet / Leonard, Philip M. / Lamers, Marieke B. A. C. / Van Roosbroeck, Yves E. M. et al. | 2020
- 12911
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Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary DiseaseBaggio, Carlo / Velazquez, Jalene V. / Fragai, Marco / Nordgren, Tara M. / Pellecchia, Maurizio et al. | 2020
- 12921
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Host Defense Peptide-Mimicking Amphiphilic β‑Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective ActivityEtayash, Hashem / Qian, Yuxin / Pletzer, Daniel / Zhang, Qiang / Xie, Jiayang / Cui, Ruxin / Dai, Chengzhi / Ma, Pengcheng / Qi, Fan / Liu, Runhui et al. | 2020
- 12929
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Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship StudiesGonzalez, Simon / Dumitrascuta, Maria / Eiselt, Emilie / Louis, Stevany / Kunze, Linda / Blasiol, Annalisa / Vivancos, Mélanie / Previti, Santo / Dewolf, Elke / Martin, Charlotte et al. | 2020
- 12942
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5‑Phenyl-1,3,4-oxadiazol-2(3H)‑ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening HitMahy, William / Willis, Nicky J. / Zhao, Yuguang / Woodward, Hannah L. / Svensson, Fredrik / Sipthorp, James / Vecchia, Luca / Ruza, Reinis R. / Hillier, James / Kjær, Svend et al. | 2020
- 12957
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Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical PropertiesSoth, Michael J. / Le, Kang / Di Francesco, Maria Emilia / Hamilton, Matthew M. / Liu, Gang / Burke, Jason P. / Carroll, Chris L. / Kovacs, Jeffrey J. / Bardenhagen, Jennifer P. / Bristow, Christopher A. et al. | 2020
- 12978
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Identification, Structure–Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer EfficacyWang, Jinhui / Jin, Weiyang / Zhou, Xiaoxin / Li, Jiaqi / Xu, Chengdong / Ma, Zhongjun / Wang, Jianan / Qin, Lele / Zhou, Biao / Ding, Wanjing et al. | 2020
- 12992
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Property-Driven Design and Development of Lipids for Efficient Delivery of siRNARajappan, Kumar / Tanis, Steven P. / Mukthavaram, Rajesh / Roberts, Scott / Nguyen, Michelle / Tachikawa, Kiyoshi / Sagi, Amit / Sablad, Marciano / Limphong, Pattraranee / Leu, Angel et al. | 2020
- 13013
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Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse ModelHoratscheck, André / Andrijevic, Ana / Nchinda, Aloysius T. / Le Manach, Claire / Paquet, Tanya / Khonde, Lutete Peguy / Dam, Jean / Pawar, Kailash / Taylor, Dale / Lawrence, Nina et al. | 2020
- 13031
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Novel Copper-Containing Cytotoxic Agents Based on 2‑ThioxoimidazolonesKrasnovskaya, Olga O. / Guk, Dmitry A. / Naumov, Alexey E. / Nikitina, Vita N. / Semkina, Alevtina S. / Vlasova, Kseniya Yu. / Pokrovsky, Vadim / Ryabaya, Oksana O. / Karshieva, Saida S. / Skvortsov, Dmitry A. et al. | 2020
- 13064
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Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X‑Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide BackboneAndring, Jacob T. / Fouch, Mallorie / Akocak, Suleyman / Angeli, Andrea / Supuran, Claudiu T. / Ilies, Marc A. / McKenna, Robert et al. | 2020
- 13076
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N‑Trifluoromethyl Amines and Azoles: An Underexplored Functional Group in the Medicinal Chemist’s ToolboxSchiesser, Stefan / Chepliaka, Hanna / Kollback, Johanna / Quennesson, Thibaut / Czechtizky, Werngard / Cox, Rhona J. et al. | 2020
- 13090
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Discovery of a G Protein-Biased Radioligand for the Histamine H2 Receptor with Reversible Binding PropertiesTropmann, Katharina / Höring, Carina / Plank, Nicole / Pockes, Steffen et al. | 2020
- 13103
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Structure–Activity Relationships of Noncovalent Immunoproteasome β5i-Selective DipeptidesZhan, Wenhu / Singh, Pradeep K. / Ban, Yi / Qing, Xiaoping / Ah Kioon, Marie Dominique / Fan, Hao / Zhao, Quanju / Wang, Rong / Sukenick, George / Salmon, Jane et al. | 2020
- 13124
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A Novel N‑Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological ActivitiesPeiretti, Franck / Montanari, Roberta / Capelli, Davide / Bonardo, Bernadette / Colson, Cécilia / Amri, Ez-Zoubir / Grimaldi, Marina / Balaguer, Patrick / Ito, Keiichi / Roeder, Robert G. et al. | 2020
- 13140
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Evaluation of the Pharmacophoric Role of the O–O Bond in Synthetic Antileishmanial Compounds: Comparison between 1,2-Dioxanes and TetrahydropyransOrtalli, Margherita / Varani, Stefania / Cimato, Giorgia / Veronesi, Ruben / Quintavalla, Arianna / Lombardo, Marco / Monari, Magda / Trombini, Claudio et al. | 2020
- 13159
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Acylated 1H‑1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of ActionKorff, Marvin / Imberg, Lukas / Will, Jonas M. / Bückreiß, Nico / Kalinina, Svetlana A. / Wenzel, Benjamin M. / Kastner, Gregor A. / Daniliuc, Constantin G. / Barth, Maximilian / Ovsepyan, Ruzanna A. et al. | 2020
- 13187
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Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein–Protein InteractionsShi, Yan / Sang, Peng / Lu, Junhao / Higbee, Pirada / Chen, Lihong / Yang, Leixiang / Odom, Timothy / Daughdrill, Gary / Chen, Jiandong / Cai, Jianfeng et al. | 2020