Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol Metabolism (Unknown)
- New search for: Ortar, Giorgio
- New search for: Bisogno, Tiziana
- New search for: Ligresti, Alessia
- New search for: Morera, Enrico
- New search for: Nalli, Marianna
- New search for: Di Marzo, Vincenzo
- New search for: Ortar, Giorgio
- New search for: Bisogno, Tiziana
- New search for: Ligresti, Alessia
- New search for: Morera, Enrico
- New search for: Nalli, Marianna
- New search for: Di Marzo, Vincenzo
In:
Journal of Medicinal Chemistry
;
51
, 21
;
6970-6979
;
2008
- Article (Journal) / Electronic Resource
-
Title:Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol Metabolism
-
Additional title:Tetrahydrolipstatin Analogues
-
Contributors:Ortar, Giorgio ( author ) / Bisogno, Tiziana ( author ) / Ligresti, Alessia ( author ) / Morera, Enrico ( author ) / Nalli, Marianna ( author ) / Di Marzo, Vincenzo ( author )
-
Published in:Journal of Medicinal Chemistry ; 51, 21 ; 6970-6979
-
Publisher:
- New search for: American Chemical Society
-
Publication date:2008-11-13
-
ISSN:
-
Coden:
-
DOI:
-
Type of media:Article (Journal)
-
Type of material:Electronic Resource
-
Language:Unknown
-
Source:
Table of contents – Volume 51, Issue 21
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 6621
-
Small Molecule Modulators of Toll-like ReceptorsCzarniecki, Michael et al. | 2008
- 6627
-
Structure-Based Virtual Screening and Biological Evaluation of Mycobacterium tuberculosis Adenosine 5′-Phosphosulfate Reductase InhibitorsCosconati, Sandro / Hong, Jiyoung A. / Novellino, Ettore / Carroll, Kate S. / Goodsell, David S. / Olson, Arthur J. et al. | 2008
- 6631
-
Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular DiseasesSehon, Clark A. / Wang, Gren Z. / Viet, Andrew Q. / Goodman, Krista B. / Dowdell, Sarah E. / Elkins, Patricia A. / Semus, Simon F. / Evans, Christopher / Jolivette, Larry J. / Kirkpatrick, Robert B. et al. | 2008
- 6635
-
Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid−Glutamic Acid−Alanine−Aspartic Acid Box Polypeptide 3Maga, Giovanni / Falchi, Federico / Garbelli, Anna / Belfiore, Amalia / Witvrouw, Myriam / Manetti, Fabrizio / Botta, Maurizio et al. | 2008
- 6639
-
Efficient Solid-Phase Synthesis of FK228 Analogues as Potent Antitumoral AgentsDi Maro, Salvatore / Pong, Rey-Chen / Hsieh, Jer-Tsong / Ahn, Jung-Mo et al. | 2008
- 6642
-
Discovery of Substituted 4-(Pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as Potent and Highly Selective Rho Kinase (ROCK-II) InhibitorsFeng, Yangbo / Yin, Yan / Weiser, Amiee / Griffin, Evelyn / Cameron, Michael D. / Lin, Li / Ruiz, Claudia / Schürer, Stephan C. / Inoue, Toshihiro / Rao, P. Vasanth et al. | 2008
- 6646
-
Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway AntagonistsTremblay, Martin R. / Nevalainen, Marta / Nair, Somarajan J. / Porter, James R. / Castro, Alfredo C. / Behnke, Mark L. / Yu, Lin-Chen / Hagel, Margit / White, Kerry / Faia, Kerrie et al. | 2008
- 6650
-
Improved Synthesis of 6-epi-Dictyostatin and Antitumor Efficacy in Mice Bearing MDA-MB231 Human Breast Cancer XenograftsEiseman, Julie L. / Bai, Lihua / Jung, Won-Hyuk / Moura-Letts, Gustavo / Day, Billy W. / Curran, Dennis P. et al. | 2008
- 6654
-
Hit Identification and Binding Mode Predictions by Rigorous Free Energy SimulationsMichel, Julien / Essex, Jonathan W. et al. | 2008
- 6665
-
Design, Synthesis, and Structure−Affinity Relationships of Novel Series of Sialosides as CD22-Specific InhibitorsAbdu-Allah, Hajjaj H. M. / Tamanaka, Taichi / Yu, Jie / Zhuoyuan, Lu / Sadagopan, Magesh / Adachi, Takahiro / Tsubata, Takeshi / Kelm, Soerge / Ishida, Hideharu / Kiso, Makoto et al. | 2008
- 6682
-
Molecular Probes for Imaging Myelinated White Matter in CNSWu, Chunying / Wei, Jinjun / Tian, Donghua / Feng, Yue / Miller, Robert H. / Wang, Yanming et al. | 2008
- 6689
-
Synthesis, In Vitro, and In Silico Evaluation of Organometallic Technetium and Rhenium Thymidine Complexes with Retained Substrate Activity toward Human Thymidine Kinase Type 1Desbouis, Dominique / Struthers, Harriet / Spiwok, Vojtech / Küster, Tatiana / Schibli, Roger et al. | 2008
- 6699
-
Structure−Activity Relationship Studies of Phenanthridine-Based Bcl-XL InhibitorsBernardo, Paul H. / Wan, Kah-Fei / Sivaraman, Thirunavukkarasu / Xu, Jin / Moore, Felicity K. / Hung, Alvin W. / Mok, Henry Y. K. / Yu, Victor C. / Chai, Christina L. L. et al. | 2008
- 6711
-
Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of SalinosporamidesManam, Rama Rao / McArthur, Katherine A. / Chao, Ta-Hsiang / Weiss, Jeffrey / Ali, Janid A. / Palombella, Vito J. / Groll, Michael / Lloyd, G. Kenneth / Palladino, Michael A. / Neuteboom, Saskia T. C. et al. | 2008
- 6725
-
Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17 beta -Hydroxysteroid Dehydrogenase Type 1 (17 beta -HSD1)Bey, E. / Marchais-Oberwinkler, S. / Werth, R. / Negri, M. / Al-Soud, Y.A. / Kruchten, P. / Oster, A. / Frotscher, M. / Birk, B. / Hartmann, R.W. et al. | 2008
- 6725
-
Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)Bey, Emmanuel / Marchais-Oberwinkler, Sandrine / Werth, Ruth / Negri, Matthias / Al-Soud, Yaseen A. / Kruchten, Patricia / Oster, Alexander / Frotscher, Martin / Birk, Barbara / Hartmann, Rolf W. et al. | 2008
- 6740
-
Quantitative Structure−Activity Relationship and Complex Network Approach to Monoamine Oxidase A and B InhibitorsSantana, Lourdes / González-Díaz, Humberto / Quezada, Elías / Uriarte, Eugenio / Yáñez, Matilde / Viña, Dolores / Orallo, Francisco et al. | 2008
- 6752
-
Studies on Enzyme-Cleavable Dialkoxymethyl-cycloSaligenyl-2′,3′-dideoxy-2′,3′-didehydrothymidine MonophosphatesGisch, Nicolas / Balzarini, Jan / Meier, Chris et al. | 2008
- 6761
-
Design and Synthesis of a Novel Series of Pyranonaphthoquinones as Topoisomerase II Catalytic InhibitorsJiménez-Alonso, Sandra / Orellana, Haydee Chávez / Estévez-Braun, Ana / Ravelo, Angel G. / Pérez-Sacau, Elisa / Machín, Felix et al. | 2008
- 6773
-
Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene CompoundsCasini, Angela / Gabbiani, Chiara / Sorrentino, Francesca / Rigobello, Maria Pia / Bindoli, Alberto / Geldbach, Tilmann J. / Marrone, Alessandro / Re, Nazzareno / Hartinger, Christian G. / Dyson, Paul J. et al. | 2008
- 6782
-
Solution Structure of the Supramolecular Adduct between a Liver Cytosolic Bile Acid Binding Protein and a Bile Acid-Based Gadolinium(III)-Chelate, a Potential Hepatospecific Magnetic Resonance Imaging Contrast AgentTomaselli, Simona / Zanzoni, Serena / Ragona, Laura / Gianolio, Eliana / Aime, Silvio / Assfalg, Michael / Molinari, Henriette et al. | 2008
- 6793
-
Magnetically Aligned Bicelles To Study the Orientation of Lipophilic Ligands in Membrane BilayersGuo, Jianxin / Yang, De-Ping / Chari, Ravi / Tian, Xiaoyu / Pavlopoulos, Spiro / Lu, Dai / Makriyannis, Alexandros et al. | 2008
- 6800
-
Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a γδ-T Lymphocytes-Mediated Activation MechanismSimoni, Daniele / Gebbia, Nicola / Invidiata, Francesco Paolo / Eleopra, Marco / Marchetti, Paolo / Rondanin, Riccardo / Baruchello, Riccardo / Provera, Stefano / Marchioro, Carla / Tolomeo, Manlio et al. | 2008
- 6800
-
Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a gamma delta -T Lymphocytes-Mediated Activation MechanismSimoni, D. / Gebbia, N. / Invidiata, F.P. / Eleopra, M. / Marchetti, P. / Rondanin, R. / Baruchello, R. / Provera, S. / Marchioro, C. / Tolomeo, M. et al. | 2008
- 6808
-
Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT2A Receptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis and Receptor Modeling InvestigationRunyon, Scott P. / Mosier, Philip D. / Roth, Bryan L. / Glennon, Richard A. / Westkaemper, Richard B. et al. | 2008
- 6829
-
Novel D3 Selective Dopaminergics Incorporating Enyne Units as Nonaromatic Catechol Bioisosteres: Synthesis, Bioactivity, and Mutagenesis StudiesDörfler, Miriam / Tschammer, Nuska / Hamperl, Katharina / Hübner, Harald / Gmeiner, Peter et al. | 2008
- 6839
-
Structure-Based Approach to the Development of Potent and Selective Inhibitors of Dihydrofolate Reductase from CryptosporidiumBolstad, David B. / Bolstad, Erin S. D. / Frey, Kathleen M. / Wright, Dennis L. / Anderson, Amy C. et al. | 2008
- 6853
-
Tricyclic [1,2,4]Triazine 1,4-Dioxides As Hypoxia Selective CytotoxinsHay, Michael P. / Hicks, Kevin O. / Pchalek, Karin / Lee, Ho H. / Blaser, Adrian / Pruijn, Frederik B. / Anderson, Robert F. / Shinde, Sujata S. / Wilson, William R. / Denny, William A. et al. | 2008
- 6866
-
Prevention of Drug-Induced Memory Impairment by ImmunopharmacotherapyTreweek, Jennifer B. / Sun, Chengzao / Mayorov, Alexander V. / Qi, Longwu / Levy, Coree L. / Roberts, Amanda J. / Dickerson, Tobin J. / Janda, Kim D. et al. | 2008
- 6876
-
2-Phenyl-imidazo[1,2-a]pyridine Compounds Containing Hydrophilic Groups as Potent and Selective Ligands for Peripheral Benzodiazepine Receptors: Synthesis, Binding Affinity and Electrophysiological StudiesDenora, Nunzio / Laquintana, Valentino / Pisu, Maria Giuseppina / Dore, Riccardo / Murru, Luca / Latrofa, Andrea / Trapani, Giuseppe / Sanna, Enrico et al. | 2008
- 6889
-
Synthesis and Evaluation of Structurally Constrained Quinazolinone Derivatives as Potent and Selective Histamine H3 Receptor Inverse AgonistsNagase, Tsuyoshi / Mizutani, Takashi / Sekino, Etsuko / Ishikawa, Shiho / Ito, Sayaka / Mitobe, Yuko / Miyamoto, Yasuhisa / Yoshimoto, Ryo / Tanaka, Takeshi / Ishihara, Akane et al. | 2008
- 6902
-
Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 ProteinsPark, Cheol-Min / Bruncko, Milan / Adickes, Jessica / Bauch, Joy / Ding, Hong / Kunzer, Aaron / Marsh, Kennan C. / Nimmer, Paul / Shoemaker, Alexander R. / Song, Xiaohong et al. | 2008
- 6916
-
Antibody Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN-38) for Targeted Cancer ChemotherapyMoon, Sung-Ju / Govindan, Serengulam V. / Cardillo, Thomas M. / D’Souza, Christopher A. / Hansen, Hans J. / Goldenberg, David M. et al. | 2008
- 6927
-
Synthesis and Antiprotozoal Activity of Cationic 2-PhenylbenzofuransBakunov, Stanislav A. / Bakunova, Svetlana M. / Wenzler, Tanja / Barszcz, Todd / Werbovetz, Karl A. / Brun, Reto / Tidwell, Richard R. et al. | 2008
- 6945
-
Spirocyclic Benzopyran-Based Derivatives as New Anti-ischemic Activators of Mitochondrial ATP-Sensitive Potassium ChannelBreschi, Maria C. / Calderone, Vincenzo / Digiacomo, Maria / Manganaro, Mariaelisa / Martelli, Alma / Minutolo, Filippo / Rapposelli, Simona / Testai, Lara / Tonelli, Federica / Balsamo, Aldo et al. | 2008
- 6955
-
Linking Bisphosphonates to the Free Amino Groups in Fluoroquinolones: Preparation of Osteotropic Prodrugs for the Prevention of OsteomyelitisHoughton, Tom J. / Tanaka, Kelly S. E. / Kang, Ting / Dietrich, Evelyne / Lafontaine, Yanick / Delorme, Daniel / Ferreira, Sandra S. / Viens, Frederic / Arhin, Francis F. / Sarmiento, Ingrid et al. | 2008
- 6970
-
Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol MetabolismOrtar, Giorgio / Bisogno, Tiziana / Ligresti, Alessia / Morera, Enrico / Nalli, Marianna / Di Marzo, Vincenzo et al. | 2008
- 6980
-
Advances toward New Antidepressants with Dual Serotonin Transporter and 5-HT1A Receptor Affinity within a Class of 3-Aminochroman Derivatives. Part 2Hatzenbuhler, Nicole T. / Baudy, Reinhardt / Evrard, Deborah A. / Failli, Amedeo / Harrison, Boyd L. / Lenicek, Steven / Mewshaw, Richard E. / Saab, Annmarie / Shah, Uresh / Sze, Jean et al. | 2008
- 7005
-
Potential Nicotinic Acetylcholine Receptor Ligands from 2,4-Methanoproline DerivativesPatel, Anup B. / Malpass, John R. et al. | 2008
- 7010
-
Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological IndicationsLi, Jie Jack / Iula, Donna M. / Nguyen, Maria N. / Hu, Lain-Yen / Dettling, Danielle / Johnson, Theodore R. / Du, Daniel Y. / Shanmugasundaram, Veerabahu / Van Camp, Jennifer A. / Wang, Zhi et al. | 2008
- 7015
-
Virtual Screening to Successfully Identify Novel Janus Kinase 3 Inhibitors: A Sequential Focused Screening ApproachChen, Xin / Wilson, Lawrence J. / Malaviya, Ravi / Argentieri, Rochelle L. / Yang, Shyh-Ming et al. | 2008
- 7020
-
Book Review of Molecular Design. Concepts and ApplicationsFiler, Crist N. et al. | 2008
- 7020
-
Molecular Design. Concepts and ApplicationsFiler, C.N. et al. | 2008