Studies of vitamin D (calciferol) and its analogs. 39. Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogs of 1.alpha.,25-dihydroxyvitamin D3 (English)
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- New search for: Figadere, Bruno
- New search for: Norman, Anthony W.
- New search for: Henry, Helen L.
- New search for: Koeffler, H. Phillip
- New search for: Zhou, Jian Yuan
- New search for: Okamura, William H.
- New search for: Figadere, Bruno
- New search for: Norman, Anthony W.
- New search for: Henry, Helen L.
- New search for: Koeffler, H. Phillip
- New search for: Zhou, Jian Yuan
- New search for: Okamura, William H.
In:
Journal of Medicinal Chemistry
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34
, 8
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2452-2463
;
1991
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Studies of vitamin D (calciferol) and its analogs. 39. Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogs of 1.alpha.,25-dihydroxyvitamin D3
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Additional title:J. Med. Chem.
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Contributors:Figadere, Bruno ( author ) / Norman, Anthony W. ( author ) / Henry, Helen L. ( author ) / Koeffler, H. Phillip ( author ) / Zhou, Jian Yuan ( author ) / Okamura, William H. ( author )
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Published in:Journal of Medicinal Chemistry ; 34, 8 ; 2452-2463
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Publisher:
- New search for: American Chemical Society
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Publication date:1991-08-01
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 34, Issue 8
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 2305
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HIV protease: a novel chemotherapeutic target for AIDSHuff, Joel R. et al. | 1991
- 2314
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Cholinergic activity of acetylenic imidazoles and related compoundsMoon, Malcolm W. / Chidester, Connie G. / Heier, Richard F. / Morris, Jeanette K. / Collins, R. James / Russell, Roland R. / Francis, Jonathan W. / Sage, G. Patrick / Sethy, Vimala H. et al. | 1991
- 2328
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Sulfonylbenzoyl-nitrostyrenes: Potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinaseTraxler, Peter M. / Wacker, Oskar / Bach, Ha L. / Geissler, Johanna F. / Kump, Wilhelm / Meyer, Thomas / Regenass, Urs / Roesel, Johannes L. / Lydon, Nicholas et al. | 1991
- 2338
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Comparative molecular field analysis of some clodronic acid estersBjorkroth, J. P. / Pakkanen, T. A. / Lindroos, J. / Pohjala, E. / Hanhijarvi, H. / Lauren, L. / Hannuniemi, R. / Juhakoski, A. / Kippo, K. / Kleimola, T. et al. | 1991
- 2344
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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activityThaisrivongs, Suvit / Tomasselli, Alfredo G. / Moon, Joseph B. / Hui, John / McQuade, Thomas J. / Turner, Steve R. / Strohbach, Joseph W. / Howe, W. Jeffrey / Tarpley, W. Gary / Heinrikson, Robert L. et al. | 1991
- 2356
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2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteriaDickens, Jon P. / Ellames, George J. / Hare, Nigel J. / Lawson, Kevin R. / McKay, William R. / Metters, Anthony P. / Myers, Peter L. / Pope, Anthony M. S. / Upton, Roger M. et al. | 1991
- 2361
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Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosidesSecrist, John A. / Tiwari, Kamal N. / Riordan, James M. / Montgomery, John A. et al. | 1991
- 2366
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Modeling study of the structure of the macromolecular antitumor antibiotic neocarzinostatin. Origin of the stabilization of the chromophoreIshiguro, Masaji / Imajo, Seiichi / Hirama, Masahiro et al. | 1991
- 2373
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Synthesis and antitumor evaluations of symmetrically and unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones and 1,4-bis[(aminoalkyl)amino]-5,8-dihydroxyanthracene-9,10-dionesKrapcho, A. Paul / Getahun, Zelleka / Avery, Kenneth L. / Vargas, Kevin J. / Hacker, Miles P. / Spinelli, Silvano / Pezzoni, Gabriella / Manzotti, Carla et al. | 1991
- 2380
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Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogs of acyclovir and ganciclovirBoryski, Jerzy / Golankiewicz, Bozenna / De Clercq, Erik et al. | 1991
- 2383
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5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replicationWigerinck, P. / Pannecouque, C. / Snoeck, R. / Claes, P. / De Clercq, E. / Herdewijn, P. et al. | 1991
- 2389
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Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranesGoodnow, R. A. / Bukownik, R. / Nakanishi, K. / Usherwood, P. N. R. / Eldefrawi, A. T. / Anis, N. A. / Eldefrawi, M. E. et al. | 1991
- 2395
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Novel gonadotropin-releasing hormone antagonists: peptides incorporating modified N.omega.-cyanoguanidino moietiesTheobald, Paula / Porter, John / Rivier, Catherine / Corrigan, Anne / Perrin, Marilyn / Vale, Wylie / Rivier, Jean / Hook, William / Siraganian, Reuben et al. | 1991
- 2402
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Synthesis and biological activity of angiotensin II analog containing a Val-His replacement, Val.psi.[CH(CONH2)HN]HisMohan, Raju / Chou, Yuo Ling / Bihovsky, Ron / Lumma, William C. / Erhardt, Paul W. / Shaw, Kenneth J. et al. | 1991
- 2410
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Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist propertiesBovy, P. R. / Collins, J. T. / Olins, G. M. / McMahon, E. G. / Hutton, W. C. et al. | 1991
- 2414
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Synthesis and DNA-binding properties of polyamine analogsEdwards, Michael L. / Snyder, Ronald D. / Stemerick, David M. et al. | 1991
- 2420
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Synthesis of structural analogs of lyngbyatoxin A and their evaluation as activators of protein kinase CKozikowski, Alan P. / Shum, Patrick W. / Basu, Alakananda / Lazo, John S. et al. | 1991
- 2430
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Pseudopeptide analogs of substance P and leucine enkephalinamide containing the .psi.(methyleneoxy) modification: synthesis and biological activityRoubini, Eli / Laufer, Ralph / Gilon, Chaim / Selinger, Zvi / Roques, Bernard P. / Chorev, Michael et al. | 1991
- 2438
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Electrophilic .gamma.-lactone .kappa.-opioid receptor probes. Analogs of 2'-hydroxy-2-(tetrahydrofurfuryl)-5,9-dimethyl-6,7-benzomorphan diastereomersKlein, Peter / Nelson, Wendel L. et al. | 1991
- 2444
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Preparation and anticonvulsant activity of a series of functionalized .alpha.-heteroatom-substituted amino acidsKohn, Harold / Sawhney, Kailash N. / LeGall, Philippe / Robertson, David W. / Leander, J. David et al. | 1991
- 2452
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Studies of vitamin D (calciferol) and its analogs. 39. Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogs of 1.alpha.,25-dihydroxyvitamin D3Figadere, Bruno / Norman, Anthony W. / Henry, Helen L. / Koeffler, H. Phillip / Zhou, Jian Yuan / Okamura, William H. et al. | 1991
- 2464
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Aldosterone antagonists. 4. Synthesis and activities of steroidal 6,6-ethylene-15,16-methylene 17-spirolactonesNickisch, Klaus / Beier, Sybille / Bittler, Dieter / Elger, Walter / Laurent, Henry / Losert, Wolfgang / Nishino, Yukishige / Schillinger, Ekkehard / Wiechert, Rudolf et al. | 1991
- 2468
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Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17.alpha.-esters containing a functional groupUeno, Hiroaki / Maruyama, Akira / Miyake, Motoyoshi / Nakao, Etsuko / Nakao, Kenichiro / Umezu, Kohei / Nitta, Issei et al. | 1991
- 2474
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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 8. Side chain ether analogs of lovastatinLee, Ta Jyh / Holtz, W. J. / Smith, R. L. / Alberts, A. W. / Gilfillan, J. L. et al. | 1991
- 2477
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Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonistsMalleron, Jean Luc / Comte, Marie Therese / Gueremy, Claude / Peyronel, Jean Francis / Truchon, Alain / Blanchard, Jean Charles / Doble, Adam / Piot, Odile / Zundel, Jean Luc et al. | 1991
- 2484
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A new class of analog of the bifunctional radiosensitizer .alpha.-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridinesSuto, Mark J. / Stier, Michael A. / Werbel, Leslie M. / Arundel-Suto, Carla M. / Leopold, Wilbur R. / Elliott, William E. / Sebolt-Leopold, Judith S. et al. | 1991
- 2489
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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivativesDuggan, Mark E. / Alberts, Alfred W. / Bostedor, Rick / Chao, Yu Sheng / Germershausen, John I. / Gilfillan, James L. / Halczenko, Wasyl / Hartman, George D. / Hunt, Vincent et al. | 1991
- 2496
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Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitorsNumazawa, Mitsuteru / Mutsumi, Ayako / Hoshi, Kumiko / Oshibe, Mariko / Ishikawa, Etsushi / Kigawa, Hiroki et al. | 1991
- 2504
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Syntheses of tolrestat analogs containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivativesWrobel, Jay / Millen, Jane / Sredy, Janet / Dietrich, Arlene / Gorham, Beverly J. / Malamas, Michael / Kelly, Joseph M. / Bauman, John G. / Harrison, Maria C. et al. | 1991
- 2521
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Active conformation of 1,4-dihydropyridine calcium entry blockers. Effect of size of 2-aryl substituent on rotameric equilibria and receptor bindingRovnyak, George / Andersen, Niels / Gougoutas, Jack / Hedberg, Anders / Kimball, S. David / Malley, Mary / Moreland, Suzanne / Porubcan, Michael / Pudzianowski, Andrew et al. | 1991
- 2525
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Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensivesCarini, David J. / Duncia, John V. / Aldrich, Paul E. / Chiu, Andrew T. / Johnson, Alexander L. / Pierce, Michael E. / Price, William A. / Santella, Joseph B. / Wells, Gregory J. et al. | 1991
- 2547
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GABA-uptake inhibitors: construction of a general pharmacophore model and successful prediction of a new representativeN'Goka, Victor / Schlewer, Gilbert / Linget, Jean Michel / Chambon, Jean Pierre / Wermuth, Camille Georges et al. | 1991
- 2557
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3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studiesBerthelot, Pascal / Vaccher, Claude / Flouquet, Nathalie / Debaert, Michel / Luyckx, Michel / Brunet, Claude et al. | 1991
- 2561
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Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptorDeNinno, Michael P. / Schoenleber, Robert / Perner, Richard J. / Lijewski, Linda / Asin, Karen E. / Britton, Donald R. / MacKenzie, Robert / Kebabian, John W. et al. | 1991
- 2570
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Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosinesFrancis, John E. / Webb, Randy L. / Ghai, Geetha R. / Hutchison, Alan J. / Moskal, Michael A. / DeJesus, Reynalda / Yokoyama, Rina / Rovinski, Stephen L. / Contardo, Nicolina et al. | 1991
- 2579
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Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerizationCushman, Mark / Nagarathnam, Dhanapalan / Gopal, D. / Chakraborti, Asit K. / Lin, Chii M. / Hamel, Ernest et al. | 1991
- 2588
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Relaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides and their analogs in guinea pig trachealisArch, Jonathan R. S. / Buckle, Derek R. / Carey, Claire / Parr-Dobrzanski, Hilary / Faller, Andrew / Foster, Keith A. / Houge-Frydrych, Catherine S. V. / Pinto, Ivan L. / Smith, David G. / Taylor, Stephen G. et al. | 1991
- 2595
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Solid-state and solution conformation of 3'-amino-3'-deoxythymidine, precursor to a noncompetitive inhibitor of HIV-1 reverse transcriptaseKovacs, Terez / Parkanyi, Laszlo / Pelczer, Istvan / Cervantes-Lee, Francisco / Pannell, Keith H. / Torrence, Paul F. et al. | 1991
- 2600
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Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogs of 5'-deoxy-5'-(methylthio)adenosineSufrin, Janice R. / Spiess, Arthur J. / Kramer, Debora L. / Libby, Paul R. / Miller, John T. / Bernacki, Ralph J. / Lee, Younha / Borchardt, Ronald T. / Porter, Carl W. et al. | 1991
- 2607
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Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogs and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochlorideLin, Tai Shun / Luo, Mei Zhen / Liu, Mao Chin / Clarke-Katzenburg, Regina H. / Cheng, Yung Chi / Prusoff, William H. / Mancini, William R. / Birnbaum, George I. / Gabe, Eric J. / Giziewicz, Jerzy et al. | 1991
- 2615
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Synthesis, stereochemistry, and biological activity of the 1-(1-phenyl-2-methylcyclohexyl)piperidines and the 1-(1-phenyl-4-methylcyclohexyl)piperidines. Absolute configuration of the potent trans-(-)-1-(1-phenyl-2-methylcyclohexyl)piperidineIorio, Maria A. / Tomassini, Lamberto / Mattson, Mariena V. / George, Clifford / Jacobson, Arthur E. et al. | 1991
- 2624
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(1S)-1-(Aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent .kappa. opioid analgesicsVecchietti, Vittorio / Clarke, Geoffrey D. / Colle, Roberto / Giardina, Giuseppe / Petrone, Giuseppe / Sbacchi, Massimo et al. | 1991
- 2633
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Analogs of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced .alpha.1-adrenergic affinityRaghupathi, Revathi K. / Rydelek-Fitzgerald, Laura / Teitler, Milt / Glennon, Richard A. et al. | 1991
- 2638
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Acyclic analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transportEfange, S. M. N. / Michelson, R. H. / Dutta, A. K. / Parsons, S. M. et al. | 1991
- 2643
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Synthesis of 2-deoxy-2-[(2,2-difluoro-3-hydroxytetradecanoyl)amino]-3-O-[(R)-3-(tetradecanoyloxy)tetradecanoyl]-D-glucopyranose 4-phosphateShiozaki, Masao / Kobayashi, Yoshiyuki / Arai, Masami / Watanabe, Takashi / Hiraoka, Tetsuo / Nishijima, Masahiro / Kuge, Sayuri / Otsuka, Toshiaki / Akamatsu, Yuzuru et al. | 1991
- 2647
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3-(5-Alkyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acids as orally active inhibitors of IL-1 generationTanaka, Masayuki / Chiba, Kenichi / Okita, Makoto / Kaneko, Toshihiko / Tagami, Katsuya / Hibi, Shigeki / Okamoto, Yasushi / Shirota, Hiroshi / Goto, Masaki et al. | 1991
- 2649
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Probing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptidesKyle, Donald J. / Martin, Jennifer A. / Burch, Ronald M. / Carter, John P. / Lu, Songfeng / Meeker, Sonya / Prosser, Judith C. / Sullivan, James P. / Togo, James et al. | 1991
- 2654
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Determination of the relative binding free energies of peptide inhibitors to the HIV-1 proteaseFerguson, David M. / Radmer, Randall J. / Kollman, Peter A. et al. | 1991
- 2660
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Book Reviews| 1991
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Masthead| 1991