Amino-Substituted 3‑Aryl- and 3‑Heteroarylquinolines as Potential Antileishmanial Agents (English)
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In:
Journal of Medicinal Chemistry
;
64
, 16
;
12152-12162
;
2021
- Article (Journal) / Electronic Resource
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Title:Amino-Substituted 3‑Aryl- and 3‑Heteroarylquinolines as Potential Antileishmanial Agents
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Additional title:J. Med. Chem.
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Contributors:Hammill, Jared T. ( author ) / Sviripa, Vitaliy M. ( author ) / Kril, Liliia M. ( author ) / Ortiz, Diana ( author ) / Fargo, Corinne M. ( author ) / Kim, Ho Shin ( author ) / Chen, Yizhe ( author ) / Rector, Jonah ( author ) / Rice, Amy L. ( author ) / Domagalska, Malgorzata A. ( author )
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Published in:Journal of Medicinal Chemistry ; 64, 16 ; 12152-12162
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Publisher:
- New search for: American Chemical Society
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Publication date:2021-08-26
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Licence:
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Source:
Table of contents – Volume 64, Issue 16
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 11747
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Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical DevelopmentSaha, Debasmita / Ryan, Katie Rose / Lakkaniga, Naga Rajiv / Acharya, Baku / Garcia, Noemi Garcia / Smith, Erica Lane / Frett, Brendan et al. | 2021
- 11774
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Polycomb Repressive Complex 2 Modulation through the Development of EZH2–EED Interaction Inhibitors and EED BindersTomassi, Stefano / Romanelli, Annalisa / Zwergel, Clemens / Valente, Sergio / Mai, Antonello et al. | 2021
- 11798
-
Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug DiscoveryLi, Yang / Yang, Gaoxia / Yang, Chengcan / Tang, Pan / Chen, Juncheng / Zhang, Jifa / Liu, Jie / Ouyang, Liang et al. | 2021
- 11816
-
EP2 Antagonists (2011–2021): A Decade’s Journey from Discovery to TherapeuticsSluter, Madison N. / Hou, Ruida / Li, Lexiao / Yasmen, Nelufar / Yu, Ying / Liu, Jiawang / Jiang, Jianxiong et al. | 2021
- 11837
-
A New Era in ER+ Breast Cancer: Best-in-Class Oral Selective Estrogen Receptor Degrader (SERD) Designed as an Endocrine Backbone TreatmentShao, Pengcheng et al. | 2021
- 11841
-
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast CancerLiang, Jun / Zbieg, Jason R. / Blake, Robert A. / Chang, Jae H. / Daly, Stephen / DiPasquale, Antonio G. / Friedman, Lori S. / Gelzleichter, Thomas / Gill, Matthew / Giltnane, Jennifer M. et al. | 2021
- 11857
-
Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C InhibitorChen, Xing / Yan, Yaoyao / Zhang, Zhaoyan / Zhang, Faming / Liu, Mingming / Du, Leran / Zhang, Haixia / Shen, Xiaobao / Zhao, Dahai / Shi, Jing Bo et al. | 2021
- 11886
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Discovery of the Selective Protein Kinase C‑θ Kinase Inhibitor, CC-90005Papa, Patrick / Whitefield, Brandon / Mortensen, Deborah S. / Cashion, Dan / Huang, Dehua / Torres, Eduardo / Parnes, Jason / Sapienza, John / Hansen, Joshua / Correa, Matthew et al. | 2021
- 11904
-
Discovery of 5‑{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 BiologyHeinrich, Timo / Sala-Hojman, Ada / Ferretti, Roberta / Petersson, Carl / Minguzzi, Stefano / Gondela, Andrzej / Ramaswamy, Shivapriya / Bartosik, Anna / Czauderna, Frank / Crowley, Lindsey et al. | 2021
- 11934
-
Identification of Thieno[3,2‑d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3Cho, Hanna / Shin, Injae / Yoon, Hojong / Jeon, Eunhye / Lee, Jiwon / Kim, Younghoon / Ryu, SeongShick / Song, Chiman / Kwon, Nam Hoon / Moon, Youngji et al. | 2021
- 11958
-
Development of Novel Glucocorticoids for Use in Antibody–Drug Conjugates for the Treatment of Inflammatory DiseasesHan, Amy / Olsen, Olav / D’Souza, Christopher / Shan, Jing / Zhao, Feng / Yanolatos, Jean / Hovhannisyan, Zaruhi / Haxhinasto, Sokol / Delfino, Frank / Olson, William et al. | 2021
- 11972
-
Discovery of Quinoxaline-Based P1–P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus VariantsNageswara Rao, Desaboini / Zephyr, Jacqueto / Henes, Mina / Chan, Elise T. / Matthew, Ashley N. / Hedger, Adam K. / Conway, Hasahn L. / Saeed, Mohsan / Newton, Alicia / Petropoulos, Christos J. et al. | 2021
- 11990
-
Design, Synthesis, and Evaluation of 11C‑Labeled 3‑Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in BrainHattori, Yasushi / Yamasaki, Tomoteru / Ohashi, Tomohiro / Miyanohana, Yuhei / Kusumoto, Tomokazu / Maeda, Ryouta / Miyamoto, Maki / Debori, Yasuyuki / Hata, Akito / Zhang, Yiding et al. | 2021
- 12003
-
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological ProteinsLiu, Longbin / Johnson, Peter D. / Prime, Michael E. / Khetarpal, Vinod / Lee, Matthew R. / Brown, Christopher J. / Chen, Xuemei / Clark-Frew, Daniel / Coe, Samuel / Conlon, Mike et al. | 2021
- 12022
-
Discovery, Synthesis, and Evaluation of Highly Selective Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) Inhibitor for the Potential Treatment of Metastatic Triple-Negative Breast CancerLi, Yang / Yang, Gaoxia / Zhang, Jifa / Tang, Pan / Yang, Chengcan / Wang, Guan / Chen, Juncheng / Liu, Jie / Zhang, Lan / Ouyang, Liang et al. | 2021
- 12049
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Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6‑Aryl-2-benzoyl-pyridines as Potential Anticancer AgentsChen, Hao / Deng, Shanshan / Albadari, Najah / Yun, Mi-Kyung / Zhang, Sicheng / Li, Yong / Ma, Dejian / Parke, Deanna N. / Yang, Lei / Seagroves, Tiffany N. et al. | 2021
- 12075
-
Discovery of High-Affinity Inhibitors of the BPTF BromodomainLu, Tian / Lu, Haibo / Duan, Zhe / Wang, Jun / Han, Jie / Xiao, Senhao / Chen, HuanHuan / Jiang, Hao / Chen, Yu / Yang, Feng et al. | 2021
- 12089
-
Discovery of Novel Apigenin–Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase‑1 (PARP-1) Inhibitors for the Treatment of CancerLong, Huan / Hu, Xiaolong / Wang, Baolin / Wang, Quan / Wang, Rong / Liu, Shumeng / Xiong, Fei / Jiang, Zhenzhou / Zhang, Xiao-Qi / Ye, Wen-Cai et al. | 2021
- 12109
-
Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β‑Catenin/B-Cell Lymphoma 9 Protein–Protein InteractionWang, Zhen / Zhang, Min / Quereda, Victor / Frydman, Sylvia M. / Ming, Qianqian / Luca, Vincent C. / Duckett, Derek R. / Ji, Haitao et al. | 2021
- 12132
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Structure–Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating LigandsFronik, Philipp / Poetsch, Isabella / Kastner, Alexander / Mendrina, Theresa / Hager, Sonja / Hohenwallner, Katharina / Schueffl, Hemma / Herndler-Brandstetter, Dietmar / Koellensperger, Gunda / Rampler, Evelyn et al. | 2021
- 12152
-
Amino-Substituted 3‑Aryl- and 3‑Heteroarylquinolines as Potential Antileishmanial AgentsHammill, Jared T. / Sviripa, Vitaliy M. / Kril, Liliia M. / Ortiz, Diana / Fargo, Corinne M. / Kim, Ho Shin / Chen, Yizhe / Rector, Jonah / Rice, Amy L. / Domagalska, Malgorzata A. et al. | 2021
- 12163
-
Discovery of N‑((3S,4S)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1H‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous ToxicityChe, Jinxin / Dai, Xiaoyang / Gao, Jian / Sheng, Haichao / Zhan, Wenhu / Lu, Yang / Li, Dan / Gao, Zizheng / Jin, Zegao / Chen, Binhui et al. | 2021
- 12181
-
Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5H88Y Mutant MiceYun, Ying / Zhang, Chenlu / Guo, Shimeng / Liang, Xiaoying / Lan, Yuan / Wang, Min / Zhuo, Ning / Yin, Jianpeng / Liu, Huanan / Gu, Min et al. | 2021
- 12200
-
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I‑BET282E, Suitable for Clinical ProgressionJones, Katherine L. / Beaumont, Dominic M. / Bernard, Sharon G. / Bit, Rino A. / Campbell, Simon P. / Chung, Chun-wa / Cutler, Leanne / Demont, Emmanuel H. / Dennis, Kate / Gordon, Laurie et al. | 2021
- 12228
-
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H)Koike, Tatsuki / Yoshikawa, Masato / Ando, Haruhi Kamisaki / Farnaby, William / Nishi, Toshiya / Watanabe, Etsurou / Yano, Jason / Miyamoto, Maki / Kondo, Shigeru / Ishii, Tsuyoshi et al. | 2021
- 12245
-
Polyethylenimine–Bisphosphonate–Cyclodextrin Ternary Conjugates: Supramolecular Systems for the Delivery of Antineoplastic DrugsPlesselova, Simona / Garcia-Cerezo, Pablo / Blanco, Victor / Reche-Perez, Francisco J. / Hernandez-Mateo, Fernando / Santoyo-Gonzalez, Francisco / Giron-Gonzalez, María Dolores / Salto-Gonzalez, Rafael et al. | 2021
- 12261
-
Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo ActivityFacchini, Fabio A. / Minotti, Alberto / Luraghi, Andrea / Romerio, Alessio / Gotri, Nicole / Matamoros-Recio, Alejandra / Iannucci, Andrea / Palmer, Charys / Wang, Guanbo / Ingram, Rebecca et al. | 2021
- 12273
-
Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting ChimerasChen, He / Liu, Jing / Kaniskan, H. Ümit / Wei, Wenyi / Jin, Jian et al. | 2021
- 12286
-
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2Heightman, Tom D. / Berdini, Valerio / Bevan, Luke / Buck, Ildiko M. / Carr, Maria G. / Courtin, Aurélie / Coyle, Joseph E. / Day, James E. H. / East, Charlotte / Fazal, Lynsey et al. | 2021
- 12304
-
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γBellenie, Benjamin R / Hall, Edward / Bruce, Ian / Spendiff, Matthew / Culshaw, Andrew / McDonald, Sarah / Ambarkhane, Ameet / Chinn, Colin / Thomas, Matthew / Rosner, Elisabeth et al. | 2021
- 12322
-
Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo StudiesJung, Sascha / Fuchs, Natalie / Johe, Patrick / Wagner, Annika / Diehl, Erika / Yuliani, Tri / Zimmer, Collin / Barthels, Fabian / Zimmermann, Robert A. / Klein, Philipp et al. | 2021
- 12359
-
Optimization of Artificial Siderophores as 68Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial InfectionsPeukert, Carsten / Langer, Laura N. B. / Wegener, Sophie M. / Tutov, Anna / Bankstahl, Jens P. / Karge, Bianka / Bengel, Frank M. / Ross, Tobias L. / Brönstrup, Mark et al. | 2021
- 12379
-
Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine ReceptorsWang, Xintong / Xiao, Haoran / Wang, Jing / Huang, Zongze / Peng, Geng / Xie, Wenjun / Bian, Xiling / Liu, Huijie / Shi, Cheng / Yang, Taoyi et al. | 2021
- 12397
-
Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure–Activity Relationship StudiesRahman, Md Toufiqur / Decker, Ann M. / Laudermilk, Lucas / Maitra, Rangan / Ma, Weiya / Ben Hamida, Sami / Darcq, Emmanuel / Kieffer, Brigitte L. / Jin, Chunyang et al. | 2021
- 12414
-
Discovery of an M‑Substituted N‑Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ‑Opioid Receptor Agonist with an Improved Central Nervous System Safety ProfileHe, Qian / Wei, Yuanyuan / Liu, Xiao / Ye, Rongrong / Kong, Linghui / Li, Zixiang / Jiang, Shuang / Yu, Linqian / Chai, Jingrui / Xie, Qiong et al. | 2021