Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production (Unknown)
- New search for: Isidro-Llobet, Albert
- Further information on Isidro-Llobet, Albert:
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https://orcid.org/0000-0001-9108-5916
- New search for: Kenworthy, Martin N.
- New search for: Mukherjee, Subha
- New search for: Kopach, Michael E.
- New search for: Wegner, Katarzyna
- New search for: Gallou, Fabrice
- New search for: Smith, Austin G.
- New search for: Roschangar, Frank
- New search for: Isidro-Llobet, Albert
- Further information on Isidro-Llobet, Albert:
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https://orcid.org/0000-0001-9108-5916
- New search for: Kenworthy, Martin N.
- New search for: Mukherjee, Subha
- New search for: Kopach, Michael E.
- New search for: Wegner, Katarzyna
- New search for: Gallou, Fabrice
- New search for: Smith, Austin G.
- New search for: Roschangar, Frank
In:
The Journal of Organic Chemistry
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84
, 8
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4615-4628
;
2019
- Article (Journal) / Electronic Resource
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Title:Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production
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Additional title:J. Org. Chem.
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Contributors:Isidro-Llobet, Albert ( author ) / Kenworthy, Martin N. ( author ) / Mukherjee, Subha ( author ) / Kopach, Michael E. ( author ) / Wegner, Katarzyna ( author ) / Gallou, Fabrice ( author ) / Smith, Austin G. ( author ) / Roschangar, Frank ( author )
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Published in:The Journal of Organic Chemistry ; 84, 8 ; 4615-4628
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Publisher:
- New search for: American Chemical Society
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Publication date:2019-04-19
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 84, Issue 8
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4577
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Excellence in Industrial Organic Synthesis 2019: The Past, Present, and FutureRagan, John A. / Dreher, Spencer D. et al. | 2019
- 4580
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Greening Organic Chemistry with Process ChemistryRossen, Kai et al. | 2019
- 4583
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Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical IndustryCaille, Seb / Cui, Sheng / Faul, Margaret M. / Mennen, Steven M. / Tedrow, Jason S. / Walker, Shawn D. et al. | 2019
- 4604
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Tackling Challenges in Industrially Relevant Homogeneous Catalysis: The Catalysis Research Laboratory (CaRLa), an Industrial–Academic PartnershipSchaub, Thomas / Hashmi, A. Stephen K. / Paciello, Rocco A. et al. | 2019
- 4615
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Sustainability Challenges in Peptide Synthesis and Purification: From R&D to ProductionIsidro-Llobet, Albert / Kenworthy, Martin N. / Mukherjee, Subha / Kopach, Michael E. / Wegner, Katarzyna / Gallou, Fabrice / Smith, Austin G. / Roschangar, Frank et al. | 2019
- 4629
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Stereoretentive Etherification of an α‑Aryl-β-amino Alcohol Using a Selective Aziridinium Ring Opening for the Synthesis of AZD7594McMillan, Angus E. / Steven, Alan / Ashworth, Ian W. / Mullen, Alexander K. / Chan, Lai C. / Galan Espinosa, Maria Rita / Pilling, Michael J. / Raw, Steven A. / Jones, Martin F. et al. | 2019
- 4639
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Optical Chirality Sensing with a Stereodynamic Aluminum Biphenolate ProbeDe los Santos, Zeus A. / Joyce, Leo A. / Sherer, Edward C. / Welch, Christopher J. / Wolf, Christian et al. | 2019
- 4646
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Synthesis of 2′-Methyl-6-methoxyguanosine from the Parent Ribonucleoside GuanosineYuan, Changxia / Chen, Ke / Eastgate, Martin et al. | 2019
- 4653
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Effects of Multiple Catalyst Deactivation Pathways and Continuous Ligand Recycling on the Kinetics of Pd-Catalyzed C–N Coupling ReactionsStrotman, Neil A. / Soumeillant, Maxime C. / Zhu, Keming / Markwalter, Chester E. / Wei, Carolyn S. / Hsiao, Yi / Eastgate, Martin D. et al. | 2019
- 4661
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C–H Arylation in the Formation of a Complex Pyrrolopyridine, the Commercial Synthesis of the Potent JAK2 Inhibitor, BMS-911543Fox, Richard J. / Cuniere, Nicolas L. / Bakrania, Lopa / Wei, Carolyn / Strotman, Neil A. / Hay, Michael / Fanfair, Dayne / Regens, Christopher / Beutner, Gregory L. / Lawler, Michael et al. | 2019
- 4670
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Surprising Reactivity in NiXantphos/Palladium-Catalyzed α‑Arylation of Substituted Cyclopropyl NitrilesWright, Brandon A. / Ardolino, Michael J. et al. | 2019
- 4680
-
Convergent Synthesis of the NS5B Inhibitor GSK8175 Enabled by Transition Metal CatalysisArrington, Kenneth / Barcan, Gregg A. / Calandra, Nicholas A. / Erickson, Greg A. / Li, Ling / Liu, Li / Nilson, Mark G. / Strambeanu, Iulia I. / VanGelder, Kelsey F. / Woodard, John L. et al. | 2019
- 4695
-
A Predictive Tool for Electrophilic Aromatic Substitutions Using Machine LearningTomberg, Anna / Johansson, Magnus J. / Norrby, Per-Ola et al. | 2019
- 4704
-
Utilizing Native Directing Groups: Synthesis of a Selective IKur Inhibitor, BMS-919373, via a Regioselective C–H ArylationWisniewski, Steven R. / Stevens, Jason M. / Yu, Miao / Fraunhoffer, Kenneth J. / Romero, Evan O. / Savage, Scott A. et al. | 2019
- 4715
-
Mechanistic and Synthetic Implications of the Diol-Ritter Reaction: Unexpected Yet Reversible Pathways in the Regioselective Synthesis of Vicinal-AminoalcoholsOndari, Mark E. / Klosin, Jerzy / Froese, Robert D. J. / Kruper, William R. / MacDonald, Jason / Arriola, Dan J. / Bell, Bruce M. / Briggs, John R. / Kruper, William J. et al. | 2019
- 4723
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Synthesis of ABBV-168, a 2′-Bromouridine for the Treatment of Hepatitis CVoight, Eric A. / Brown, Brian S. / Greszler, Stephen N. / Halvorsen, Geoff T. / Zhao, Gang / Kruger, Albert W. / Hartung, John / Lukin, Kirill A. / Martinez, Steven R. / Moschetta, Eric G. et al. | 2019
- 4735
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Process Design and Optimization in the Pharmaceutical Industry: A Suzuki–Miyaura Procedure for the Synthesis of SavolitinibAdlington, Neil K. / Agnew, Lauren R. / Campbell, Andrew D. / Cox, Robert J. / Dobson, Andrew / Barrat, Cristina Fernandez / Gall, Malcolm A. Y. / Hicks, William / Howell, Gareth P. / Jawor-Baczynska, Anna et al. | 2019
- 4748
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Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR MonitoringAbdiaj, Irini / Horn, Clemens R. / Alcazar, Jesus et al. | 2019
- 4754
-
Understanding the Alkylation of a Phenol by 1‑(3-Chloropropyl)pyrrolidine: Evidence for the Intermediacy of an Azetidinium IonAshworth, Ian W. / Chan, Lai C. / Cox, Brian G. / McFarlane, Ian M. / Phillips, Andrew R. et al. | 2019
- 4763
-
Development of a Commercial Process To Prepare AMG 232 Using a Green Ozonolysis–Pinnick Tandem TransformationCochran, Brian M. / Corbett, Michael T. / Correll, Tiffany L. / Fang, Yuan-Qing / Flick, Tawnya G. / Jones, Siân C. / Silva Elipe, Maria V. / Smith, Austin G. / Tucker, John L. / Vounatsos, Filisaty et al. | 2019
- 4780
-
Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase InhibitorZhong, Yong-Li / Cleator, Ed / Liu, Zhijian / Yin, Jianguo / Morris, William J. / Alam, Mahbub / Bishop, Brian / Dumas, Aaron M. / Edwards, John / Goodyear, Adrian et al. | 2019
- 4796
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Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C–H Arylation toward DihydrobenzothienooxepinesZhang, Haiming / Li, Beryl X. / Wong, Brian / Stumpf, Andreas / Sowell, C. Gregory / Gosselin, Francis et al. | 2019
- 4803
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Cyclic Peptide Design Guided by Residual Dipolar Couplings, J‑Couplings, and Intramolecular Hydrogen Bond AnalysisFarley, Kathleen A. / Che, Ye / Navarro-Vázquez, Armando / Limberakis, Chris / Anderson, Dennis / Yan, Jiangli / Shapiro, Michael / Shanmugasundaram, Veerabahu / Gil, Roberto R. et al. | 2019
- 4814
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Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL‑2 Selective InhibitorKu, Yi-Yin / Chan, Vincent S. / Christesen, Alan / Grieme, Timothy / Mulhern, Mathew / Pu, Yu-Ming / Wendt, Michael D. et al. | 2019
- 4830
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An Alternative Focus for Route Design for the Synthesis of Antibody–Drug Conjugate PayloadsTiberghien, Arnaud C. / Howard, Philip W. / Goundry, William R. F. / McCormick, Marc / Parker, Jeremy S. et al. | 2019
- 4837
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Synthesis of (R)‑Boc-2-methylproline via a Memory of Chirality Cyclization. Application to the Synthesis of Veliparib, a Poly(ADP-ribose) Polymerase InhibitorKolaczkowski, Lawrence / Barkalow, Jufang / Barnes, David M. / Haight, Anthony / Pritts, Wayne / Schellinger, Adam et al. | 2019
- 4846
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Deprotection of N‑Boc Groups under Continuous-Flow High-Temperature ConditionsLi, Bryan / Li, Ruizhi / Dorff, Peter / McWilliams, J. Christopher / Guinn, Robert M. / Guinness, Steven M. / Han, Lu / Wang, Ke / Yu, Shu et al. | 2019
- 4856
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Chemoenzymatic Synthesis of a Chiral Ozanimod Key Intermediate Starting from Naphthalene as Cheap Petrochemical FeedstockUthoff, Florian / Löwe, Jana / Harms, Christina / Donsbach, Kai / Gröger, Harald et al. | 2019
- 4867
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Enzymatic Synthesis of Aliphatic Nitriles at a Substrate Loading of up to 1.4 kg/L: A Biocatalytic Record Achieved with a Heme ProteinHinzmann, Alessa / Glinski, Sylvia / Worm, Marion / Gröger, Harald et al. | 2019
- 4873
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Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase InhibitorBarnes, David M. / Shekhar, Shashank / Dunn, Travis B. / Barkalow, Jufang H. / Chan, Vincent S. / Franczyk, Thaddeus S. / Haight, Anthony R. / Hengeveld, John E. / Kolaczkowski, Lawrence / Kotecki, Brian J. et al. | 2019
- 4893
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Synthesis of a 6‑CF3‑Substituted 2‑Amino-dihydro-1,3-thiazine β‑Secretase Inhibitor by N,N‑Diethylaminosulfur Trifluoride-Mediated Chemoselective CyclizationOguma, Takuya / Anan, Kosuke / Suzuki, Shinji / Hisakawa, Shinya / Takada, Akihiro / Ogawa, Masayoshi / Kusakabe, Ken-ichi et al. | 2019
- 4898
-
Synthesis of a Polycyclic Halichondrin C1–C14 Fragment via Intermolecular Oxy-Michael/Trans-KetalizationKim, Dae-Shik / Fang, Francis G. / Choi, Hyeong-wook / Fang, Hui et al. | 2019
- 4904
-
2,2,2-Trifluoroethoxy Aromatic Heterocycles: Hydrolytically Stable Alternatives to Heteroaryl ChloridesFisher, Ethan L. / am Ende, Christopher W. / Humphrey, John M. et al. | 2019
- 4910
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Preparation of 2′-Deoxy-2′-spirocyclopropylcytidine via an Alternative Cyclopropanation ReactionLemaire, Sébastien / Diène, Coura / Gavryushin, Andrei / Du Jourdin, Xavier Mollat / Paolini, Léa / Jusseau, Xavier / Knochel, Paul / Farina, Vittorio et al. | 2019
- 4915
-
Enantioselective Synthesis of 4‑Methyl-3,4-dihydroisocoumarin via Asymmetric Hydroformylation of Styrene DerivativesQu, Bo / Tan, Renchang / Herling, Madison R. / Haddad, Nizar / Grinberg, Nelu / Kozlowski, Marisa C. / Zhang, Xumu / Senanayake, Chris H. et al. | 2019
- 4921
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Synthesis of Pyridopyrazine-1,6-dione γ‑Secretase Modulators via Selective 4‑Methylimidazole N 1‑Buchwald ArylationXie, Longfei / am Ende, Christopher W. / Pettersson, Martin / Rankic, Danica A. / Sach, Neal W. / Sakya, Subbas / Humphrey, John M. et al. | 2019
- 4926
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Application of a Preformed Pd-BIDIME Precatalyst to Suzuki–Miyaura Cross-Coupling Reaction in FlowSieber, Joshua D. / Buono, Frederic / Brusoe, Andrew / Desrosiers, Jean-Nicolas / Haddad, Nizar / Lorenz, Jon C. / Xu, Yibo / Wu, Hao / Zhang, Li / Han, Zhengxu Steve et al. | 2019
- 4932
-
Ring-Closing Metathesis on Commercial Scale: Synthesis of HCV Protease Inhibitor SimeprevirHorváth, András / Depré, Dominique / Vermeulen, Wim A. A. / Wuyts, Stijn L. / Harutyunyan, Syuzanna R. / Binot, Grégori / Cuypers, Jef / Couck, Wouter / Den Heuvel, Dirk Van et al. | 2019
- 4940
-
Ir-Catalyzed C–H Amidation and Borylation of AnthraquinonesCamelio, Andrew M. / Wright, Robert J. / Knight, Nicole T. / Jazdzewski, Brian A. et al. | 2019
- 4948
-
Investigation of a Weak Temperature–Rate Relationship in the Carbamoylation of a Barbituric Acid Pharmaceutical IntermediateO’Brien, Alexander G. / Liu, Yangmu Chloe / Hughes, Mark J. / Lim, John Jin / Hodnett, Neil S. / Falco, Nicholas et al. | 2019