Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox (Unknown)
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In:
Journal of Medicinal Chemistry
;
60
, 21
;
9067-9089
;
2017
- Article (Journal) / Electronic Resource
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Title:Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox
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Additional title:J. Med. Chem.
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Contributors:Hermant, Paul ( author ) / Bosc, Damien ( author ) / Piveteau, Catherine ( author ) / Gealageas, Ronan ( author ) / Lam, BaoVy ( author ) / Ronco, Cyril ( author ) / Roignant, Matthieu ( author ) / Tolojanahary, Hasina ( author ) / Jean, Ludovic ( author ) / Renard, Pierre-Yves ( author )
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Published in:Journal of Medicinal Chemistry ; 60, 21 ; 9067-9089
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Publisher:
- New search for: American Chemical Society
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Publication date:2017-11-09
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 60, Issue 21
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 8681
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Halogen Bonding in Nucleic Acid ComplexesKolář, Michal H. / Tabarrini, Oriana et al. | 2017
- 8691
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Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)Ma, Yong / Fu, Yue / Khojasteh, S. Cyrus / Dalvie, Deepak / Zhang, Donglu et al. | 2017
- 8706
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Filling Blank Spots on the Map: Identification of Ligand Binding Modes and Interacting Water Molecules for Brd4-BD1 by WaterLOGSY TitrationsPöppler, Ann-Christin et al. | 2017
- 8708
-
Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug DesignGeist, Leonhard / Mayer, Moriz / Cockcroft, Xiao-Ling / Wolkerstorfer, Bernhard / Kessler, Dirk / Engelhardt, Harald / McConnell, Darryl B. / Konrat, Robert et al. | 2017
- 8716
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Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 AgonistsPalmer, Daniel / Gonçalves, Juliana P. L. / V. Hansen, Louise / Wu, Boqian / Hald, Helle / Schoffelen, Sanne / Diness, Frederik / Le Quement, Sebastian T. / Nielsen, Thomas E. / Meldal, Morten et al. | 2017
- 8731
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Structural Basis of Inhibition of ERα-Coactivator Interaction by High-Affinity N‑Terminus Isoaspartic Acid Tethered Helical PeptidesXie, Mingsheng / Zhao, Hui / Liu, Qisong / Zhu, Yujia / Yin, Feng / Liang, Yujie / Jiang, Yanhong / Wang, Dongyuan / Hu, Kuan / Qin, Xuan et al. | 2017
- 8741
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Design, Syntheses, and in Vitro Evaluation of New Fluorine-18 Radiolabeled Tau-Labeling Molecular ProbesRejc, Luka / Šmid, Lojze / Kepe, Vladimir / Podlipnik, Črtomir / Golobič, Amalija / Bresjanac, Mara / Barrio, Jorge R. / Petrič, Andrej / Košmrlj, Janez et al. | 2017
- 8758
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9‑Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P‑Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance ProteinStefan, Katja / Schmitt, Sven Marcel / Wiese, Michael et al. | 2017
- 8781
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Identification of the Privileged Position in the Imidazo[1,2‑a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) InhibitorsKaźmierczak, Aleksandra / Kusy, Damian / Niinivehmas, Sanna P. / Gmach, Joanna / Joachimiak, Łukasz / Pentikäinen, Olli T. / Gendaszewska-Darmach, Edyta / Błażewska, Katarzyna M. et al. | 2017
- 8801
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Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KITKaitsiotou, Helena / Keul, Marina / Hardick, Julia / Mühlenberg, Thomas / Ketzer, Julia / Ehrt, Christiane / Krüll, Jasmin / Medda, Federico / Koch, Oliver / Giordanetto, Fabrizio et al. | 2017
- 8816
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Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad β Residue DistributionCheloha, Ross W. / Chen, Bingming / Kumar, Niyanta N. / Watanabe, Tomoyuki / Thorne, Robert G. / Li, Lingjun / Gardella, Thomas J. / Gellman, Samuel H. et al. | 2017
- 8834
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Structure–Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)Jørgensen, Lars / Al-Khawaja, Anas / Kickinger, Stefanie / Vogensen, Stine B. / Skovgaard-Petersen, Jonas / Rosenthal, Emil / Borkar, Nrupa / Löffler, Rebekka / Madsen, Karsten K. / Bräuner-Osborne, Hans et al. | 2017
- 8847
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Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic NephropathyHuang, Zhangjian / Mou, Yi / Xu, Xiaojun / Zhao, Di / Lai, Yisheng / Xu, Yuwen / Chen, Cen / Li, Ping / Peng, Sixun / Tian, Jide et al. | 2017
- 8858
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Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s DiseaseFiorito, Jole / Vendome, Jeremie / Saeed, Faisal / Staniszewski, Agnieszka / Zhang, Hong / Yan, Shijun / Deng, Shi-Xian / Arancio, Ottavio / Landry, Donald W. et al. | 2017
- 8876
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Noncovalent Protein Arginine Deiminase (PAD) Inhibitors Are Efficacious in Animal Models of Multiple SclerosisTejeda, Elizabeth J. Curiel / Bello, Angelica M. / Wasilewski, Ewa / Koebel, Adam / Dunn, Shannon / Kotra, Lakshmi P. et al. | 2017
- 8888
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Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell ProliferationWang, Chen / Jiang, Hao / Jin, Jia / Xie, Yiqian / Chen, Zhifeng / Zhang, Hao / Lian, Fulin / Liu, Yu-Chih / Zhang, Chenhua / Ding, Hong et al. | 2017
- 8906
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Small-Molecule Inhibitors of the CD40–CD40L Costimulatory Protein–Protein InteractionChen, Jinshui / Song, Yun / Bojadzic, Damir / Tamayo-Garcia, Alejandro / Landin, Ana Marie / Blomberg, Bonnie B. / Buchwald, Peter et al. | 2017
- 8923
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A Smart Europium–Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light ExcitationsLi, Hongguang / Xie, Chen / Lan, Rongfeng / Zha, Shuai / Chan, Chi-Fai / Wong, Wing-Yan / Ho, Ka-Lok / Chan, Brandon Dow / Luo, Yuxia / Zhang, Jing-Xiang et al. | 2017
- 8933
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Methodology for Monobactam Diversification: Syntheses and Studies of 4‑Thiomethyl Substituted β‑Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumanniiCarosso, Serena / Liu, Rui / Miller, Patricia A. / Hecker, Scott J. / Glinka, Tomasz / Miller, Marvin J. et al. | 2017
- 8945
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Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)Williamson, Douglas S. / Smith, Garrick P. / Acheson-Dossang, Pamela / Bedford, Simon T. / Chell, Victoria / Chen, I-Jen / Daechsel, Justus C. A. / Daniels, Zoe / David, Laurent / Dokurno, Pawel et al. | 2017
- 8963
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Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ‑5 Desaturase (D5D) InhibitorsFujimoto, Jun / Okamoto, Rei / Noguchi, Naoyoshi / Hara, Ryoma / Masada, Shinichi / Kawamoto, Tetsuji / Nagase, Hiroki / Tamura, Yumiko Okano / Imanishi, Mitsuaki / Takagahara, Shuichi et al. | 2017
- 8982
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Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein–Protein InteractionsKrüger, Dennis M. / Glas, Adrian / Bier, David / Pospiech, Nicole / Wallraven, Kerstin / Dietrich, Laura / Ottmann, Christian / Koch, Oliver / Hennig, Sven / Grossmann, Tom N. et al. | 2017
- 8989
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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic ScreenRiggs, Jennifer R. / Nagy, Mark / Elsner, Jan / Erdman, Paul / Cashion, Dan / Robinson, Dale / Harris, Roy / Huang, Dehua / Tehrani, Lida / Deyanat-Yazdi, Gordafaried et al. | 2017
- 9003
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Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX)Fragai, Marco / Comito, Giuseppina / Di Cesare Mannelli, Lorenzo / Gualdani, Roberta / Calderone, Vito / Louka, Alexandra / Richichi, Barbara / Francesconi, Oscar / Angeli, Andrea / Nocentini, Alessio et al. | 2017
- 9012
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Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) OrthologsArtigas, Gerard / Monteiro, João T. / Hinou, Hiroshi / Nishimura, Shin-Ichiro / Lepenies, Bernd / Garcia-Martin, Fayna et al. | 2017
- 9022
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Molecular Hybridization of Potent and Selective γ‑Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3‑Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) AnalogsKrall, Jacob / Jensen, Claus Hatt / Bavo, Francesco / Falk-Petersen, Christina Birkedahl / Haugaard, Anne Stæhr / Vogensen, Stine Byskov / Tian, Yongsong / Nittegaard-Nielsen, Mia / Sigurdardóttir, Sara Björk / Kehler, Jan et al. | 2017
- 9040
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Hit-to-Lead Optimization and Discovery of 5‑((5-([1,1′-Biphenyl]-4-yl)-6-chloro‑1H‑benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein KinaseLan, Ping / Romero, F. Anthony / Wodka, Dariusz / Kassick, Andrew J. / Dang, Qun / Gibson, Tony / Cashion, Daniel / Zhou, Gaochao / Chen, Yuli / Zhang, Xiaoping et al. | 2017
- 9053
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Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C‑Terminal InhibitorsShao, Li-Dong / Su, Jia / Ye, Baixin / Liu, Jiang-Xin / Zuo, Zhi-Li / Li, Yan / Wang, Yue-Ying / Xia, Chengfeng / Zhao, Qin-Shi et al. | 2017
- 9067
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Controlling Plasma Stability of Hydroxamic Acids: A MedChem ToolboxHermant, Paul / Bosc, Damien / Piveteau, Catherine / Gealageas, Ronan / Lam, BaoVy / Ronco, Cyril / Roignant, Matthieu / Tolojanahary, Hasina / Jean, Ludovic / Renard, Pierre-Yves et al. | 2017
- 9090
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Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and UbiquitinHarding, Rachel J. / Ferreira de Freitas, Renato / Collins, Patrick / Franzoni, Ivan / Ravichandran, Mani / Ouyang, Hui / Juarez-Ornelas, Kevin A. / Lautens, Mark / Schapira, Matthieu / von Delft, Frank et al. | 2017