A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung (Unknown)
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In:
Molecular Pharmaceutics
;
15
, 5
;
1766-1777
;
2018
- Article (Journal) / Electronic Resource
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Title:A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung
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Additional title:Mol. Pharmaceutics
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Contributors:Forkuo, Gloria S. ( author ) / Nieman, Amanda N. ( author ) / Kodali, Revathi ( author ) / Zahn, Nicolas M. ( author ) / Li, Guanguan ( author ) / Rashid Roni, M. S. ( author ) / Stephen, Michael Rajesh ( author ) / Harris, Ted W. ( author ) / Jahan, Rajwana ( author ) / Guthrie, Margaret L. ( author )
-
Published in:Molecular Pharmaceutics ; 15, 5 ; 1766-1777
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Publisher:
- New search for: American Chemical Society
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Publication date:2018-05-07
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ISSN:
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Coden:
-
DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Keywords:
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Source:
Table of contents – Volume 15, Issue 5
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1735
-
Grapefruit Flavonoid Naringenin Regulates the Expression of LXRα in THP‑1 Macrophages by Modulating AMP-Activated Protein KinaseSaenz, Javier / Santa-María, Consuelo / Reyes-Quiroz, María Edith / Geniz, Isabel / Jiménez, Juan / Sobrino, Francisco / Alba, Gonzalo et al. | 2018
- 1746
-
Oral Administration and Detection of a Near-Infrared Molecular Imaging Agent in an Orthotopic Mouse Model for Breast Cancer ScreeningBhatnagar, Sumit / Verma, Kirti Dhingra / Hu, Yongjun / Khera, Eshita / Priluck, Aaron / Smith, David E. / Thurber, Greg M. et al. | 2018
- 1755
-
Fasudil and DETA NONOate, Loaded in a Peptide-Modified Liposomal Carrier, Slow PAH Progression upon Pulmonary DeliveryRashid, Jahidur / Nahar, Kamrun / Raut, Snehal / Keshavarz, Ali / Ahsan, Fakhrul et al. | 2018
- 1766
-
A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the LungForkuo, Gloria S. / Nieman, Amanda N. / Kodali, Revathi / Zahn, Nicolas M. / Li, Guanguan / Rashid Roni, M. S. / Stephen, Michael Rajesh / Harris, Ted W. / Jahan, Rajwana / Guthrie, Margaret L. et al. | 2018
- 1778
-
Improvement in Therapeutic Efficacy and Reduction in Cellular Toxicity: Introduction of a Novel Anti-PSMA-Conjugated Hybrid Antiandrogen NanoparticleThangavel, Chellappagounder / Perepelyuk, Maryna / Boopathi, Ettickan / Liu, Yi / Polischak, Steven / Deshpande, Deepak A. / Rafiq, Khadija / Dicker, Adam P. / Knudsen, Karen E. / Shoyele, Sunday A. et al. | 2018
- 1791
-
Iron Oxide Nanoparticles-Based Vaccine Delivery for Cancer TreatmentZhao, Yi / Zhao, Xiaotian / Cheng, Yuan / Guo, Xiaoshuang / Yuan, Weien et al. | 2018
- 1800
-
Double-Edged Effect of Hydroxychloroquine on Human Umbilical Cord-Derived Mesenchymal Stem Cells Treating Lupus Nephritis in MRL/lpr MiceMai, Shaoshan / Zou, Lin / Tian, Xiaoyan / Liao, Xiao / Luan, Yizhao / Han, Xing / Wei, Yuling / Wu, Yue / Kuang, Shengnan / Yang, Yang et al. | 2018
- 1814
-
DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow InvolvementMai, Junhua / Li, Xin / Zhang, Guodong / Huang, Yi / Xu, Rong / Shen, Qi / Lokesh, Ganesh L. / Thiviyanathan, Varatharasa / Chen, Lingxiao / Liu, Haoran et al. | 2018
- 1826
-
Multiple Linear Regression Modeling To Predict the Stability of Polymer–Drug Solid Dispersions: Comparison of the Effects of Polymers and Manufacturing Methods on Solid Dispersion StabilityFridgeirsdottir, Gudrun A. / Harris, Robert J. / Dryden, Ian L. / Fischer, Peter M. / Roberts, Clive J. et al. | 2018
- 1842
-
Prostate-Specific Membrane Antigen Targeted Therapy of Prostate Cancer Using a DUPA–Paclitaxel ConjugateLv, Qingzhi / Yang, Jincheng / Zhang, Ruoshi / Yang, Zimeng / Yang, Zhengtao / Wang, Yongjun / Xu, Youjun / He, Zhonggui et al. | 2018
- 1853
-
Reversal of Ovarian Cancer Multidrug Resistance by a Combination of LAH4-L1-siMDR1 Nanocomplexes with ChemotherapeuticsGuo, Nana / Gao, Chen / Liu, Jing / Li, Jun / Liu, Nan / Hao, Yanli / Chen, Lei / Zhang, Xiaoning et al. | 2018
- 1862
-
Physical Stability and Dissolution Behavior of Ketoconazole–Organic Acid Coamorphous SystemsFung, Michelle / Be̅rziņš, Ka̅rlis / Suryanarayanan, Raj et al. | 2018
- 1870
-
Manufacturing Amorphous Solid Dispersions with a Tailored Amount of Crystallized API for Biopharmaceutical TestingTheil, Frank / Milsmann, Johanna / Anantharaman, Sankaran / van Lishaut, Holger et al. | 2018
- 1878
-
Bioinspired Star-Shaped Poly(l‑lysine) Polypeptides: Efficient Polymeric Nanocarriers for the Delivery of DNA to Mesenchymal Stem CellsWalsh, David P. / Murphy, Robert D. / Panarella, Angela / Raftery, Rosanne M. / Cavanagh, Brenton / Simpson, Jeremy C. / O’Brien, Fergal J. / Heise, Andreas / Cryan, Sally-Ann et al. | 2018
- 1892
-
Exosomes from Irradiated Nonsmall Cell Lung Cancer Cells Reduced Sensitivity of Recipient Cells to Anaplastic Lymphoma Kinase InhibitorsWu, Hao / Zeng, Chao / Ye, Yiwang / Liu, Jixian / Mu, Zhimin / Xie, Yuancai / Chen, Baokun / Nong, Qiaohong / Wu, Da et al. | 2018
- 1901
-
Solid-State Characterization and Relative Formation Enthalpies To Evaluate Stability of Cocrystals of an Antidiabetic DrugDuggirala, Naga Kiran / Frericks Schmidt, Heather L. / Lei, Zhaohui / Zaworotko, Michael J. / Krzyzaniak, Joseph F. / Arora, Kapildev K. et al. | 2018
- 1909
-
Assembling the Puzzle of Apixaban Solid FormsBarbas, Rafael / Puigjaner, Cristina / Prohens, Rafel et al. | 2018
- 1917
-
Molecular Understanding and Implication of Structural Integrity in the Deformation Behavior of Binary Drug–Drug Eutectic SystemsYadav, Jay Prakash A. / Bansal, Arvind K. / Jain, Sanyog et al. | 2018
- 1928
-
Can Storage Time Improve the Physical Stability of Amorphous Pharmaceuticals with Tautomerization Ability Exposed to Compression? The Case of a Chloramphenicol DrugKnapik-Kowalczuk, Justyna / Wojnarowska, Zaneta / Chmiel, Krzysztof / Rams-Baron, Marzena / Tajber, Lidia / Paluch, Marian et al. | 2018
- 1941
-
One-Pot Synthesis of a Bismuth Selenide Hexagon Nanodish Complex for Multimodal Imaging-Guided Combined Antitumor PhototherapySong, Yilin / Wang, Jinping / Liu, Li / Sun, Qi / You, Qing / Cheng, Yu / Wang, Yidan / Wang, Siyu / Tan, Fengping / Li, Nan et al. | 2018
- 1954
-
A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle CellsNakagawa, Akito / Ferrari, Michele / Schleifer, Grigorij / Cooper, Marissa K. / Liu, Chen / Yu, Binglan / Berra, Lorenzo / Klings, Elizabeth S. / Safo, Ronni S. / Chen, Qiukan et al. | 2018
- 1964
-
Crystallization Kinetics of an Amorphous Pharmaceutical Compound Using Fluorescence-Lifetime-Imaging MicroscopyRautaniemi, Kaisa / Vuorimaa-Laukkanen, Elina / Strachan, Clare J. / Laaksonen, Timo et al. | 2018
- 1972
-
A Novel AS1411 Aptamer-Based Three-Way Junction Pocket DNA Nanostructure Loaded with Doxorubicin for Targeting Cancer Cells in Vitro and in VivoTaghdisi, Seyed Mohammad / Danesh, Noor Mohammad / Ramezani, Mohammad / Yazdian-Robati, Rezvan / Abnous, Khalil et al. | 2018
- 1979
-
Improved Predictions of Drug–Drug Interactions Mediated by Time-Dependent Inhibition of CYP3AYadav, Jaydeep / Korzekwa, Ken / Nagar, Swati et al. | 2018
- 1996
-
CysLTR1 Blockage Ameliorates Liver Injury Caused by Aluminum-Overload via PI3K/AKT/mTOR-Mediated Autophagy Activation in Vivo and in VitroHu, Congli / Yang, Junqing / He, Qin / Luo, Ying / Chen, Zhihao / Yang, Lu / Yi, Honggang / Li, Huan / Xia, Hui / Ran, Dongzhi et al. | 2018
- 2007
-
Efficient Targeting Drug Delivery System for Lewis Lung Carcinoma, Leading to Histomorphological Abnormalities Restoration, Physiological and Psychological Statuses Improvement, and Metastasis InhibitionYang, Ye / Cai, Hanxu / Yuan, Xiuyan / Xu, Huihui / Hu, Yingying / Rui, Xue / Wu, Jingjing / Chen, Jing / Li, Jing / Gao, Xiangdong et al. | 2018
- 2017
-
Combined Effects of Supersaturation Rates and Doses on the Kinetic-Solubility Profiles of Amorphous Solid Dispersions Based on Water-Insoluble Poly(2-hydroxyethyl methacrylate) HydrogelsSchver, Giovanna C. R. M. / Lee, Ping I. et al. | 2018
- 2027
-
The Curious Case of the OZ439 Mesylate Salt: An Amphiphilic Antimalarial Drug with Diverse Solution and Solid State StructuresClulow, Andrew J. / Salim, Malinda / Hawley, Adrian / Gilbert, Elliot P. / Boyd, Ben J. et al. | 2018
- 2036
-
Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and l‑ArginineUeda, Hiroshi / Wu, Wenqi / Löbmann, Korbinian / Grohganz, Holger / Müllertz, Anette / Rades, Thomas et al. | 2018
- 2045
-
Qualitative and Quantitative Characterization of Composition Heterogeneity on the Surface of Spray Dried Amorphous Solid Dispersion Particles by an Advanced Surface Analysis Platform with High Surface Sensitivity and Superior Spatial ResolutionBhujbal, Sonal V. / Zemlyanov, Dmitry Y. / Cavallaro, Alex / Mangal, Sharad / Taylor, Lynne S. / Zhou, Qi Tony et al. | 2018
- 2054
-
Toward a Ferrous Iron-Cleavable Linker for Antibody–Drug ConjugatesSpangler, Benjamin / Kline, Toni / Hanson, Jeffrey / Li, Xiaofan / Zhou, Sihong / Wells, James A. / Sato, Aaron K. / Renslo, Adam R. et al. | 2018
- 2060
-
In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular AdministrationTanaka, Hiroki / Nakatani, Taichi / Furihata, Tomomi / Tange, Kota / Nakai, Yuta / Yoshioka, Hiroki / Harashima, Hideyoshi / Akita, Hidetaka et al. | 2018