Synthesis of Imatinib by C–N Coupling Reaction of Primary Amide and Bromo-Substituted Pyrimidine Amine (Unknown)
- New search for: Wang, Cuiling
- Further information on Wang, Cuiling:
- https://orcid.org/0000-0001-7806-1928
- New search for: Bai, Xiao
- New search for: Wang, Rui
- New search for: Zheng, Xudong
- New search for: Ma, Xiumei
- New search for: Chen, Huan
- New search for: Ai, Yun
- New search for: Bai, Yajun
- New search for: Liu, Yifeng
- New search for: Wang, Cuiling
- Further information on Wang, Cuiling:
- https://orcid.org/0000-0001-7806-1928
- New search for: Bai, Xiao
- New search for: Wang, Rui
- New search for: Zheng, Xudong
- New search for: Ma, Xiumei
- New search for: Chen, Huan
- New search for: Ai, Yun
- New search for: Bai, Yajun
- New search for: Liu, Yifeng
In:
Organic Process Research & Development
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23
, 9
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1918-1925
;
2019
- Article (Journal) / Electronic Resource
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Title:Synthesis of Imatinib by C–N Coupling Reaction of Primary Amide and Bromo-Substituted Pyrimidine Amine
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Additional title:Org. Process Res. Dev.
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Contributors:Wang, Cuiling ( author ) / Bai, Xiao ( author ) / Wang, Rui ( author ) / Zheng, Xudong ( author ) / Ma, Xiumei ( author ) / Chen, Huan ( author ) / Ai, Yun ( author ) / Bai, Yajun ( author ) / Liu, Yifeng ( author )
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Published in:Organic Process Research & Development ; 23, 9 ; 1918-1925
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Publisher:
- New search for: American Chemical Society
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Publication date:2019-09-20
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Keywords:
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Source:
Table of contents – Volume 23, Issue 9
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1773
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Some Items of Interest to Process R&D Chemists and EngineersRichardson, Paul / Steven, Alan / Kargbo, Robert / Nawrat, Christopher C. / Zlota, Andrei A. / Matcha, Kiran / Knight, John et al. | 2019
- 1784
-
Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent AdvancesTome, Tim / Žigart, Nina / Časar, Zdenko / Obreza, Aleš et al. | 2019
- 1803
-
Development and Scale-up of Continuous Electrocatalytic Hydrogenation of Functionalized Nitro Arenes, Nitriles, and Unsaturated AldehydesEgbert, Jonathan D. / Thomsen, Edwin C. / O’Neill-Slawecki, Stacy A. / Mans, Douglas M. / Leitch, David C. / Edwards, Lee J. / Wade, Charles E. / Weber, Robert S. et al. | 2019
- 1813
-
A Tailor-Made Self-Sufficient Whole-Cell Biocatalyst Enables Scalable Enantioselective Synthesis of (R)‑3-Quinuclidinol in a High Space-Time YieldChen, Qian / Xie, Baogang / Zhou, Liping / Sun, Lili / Li, Shanshan / Chen, Yuhan / Shi, Shan / Li, Yang / Yu, Mingan / Li, Wei et al. | 2019
- 1822
-
Development of an Enzymatic Process for the Synthesis of (S)‑2-Chloro-1-(2,4-dichlorophenyl) EthanolWei, Teng-Yun / Tang, Jia-Wei / Ni, Guo-Wei / Wang, Hong-Yi / Yi, Dong / Zhang, Fu-Li / Chen, Shao-Xin et al. | 2019
- 1829
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Improved Synthesis of the Nav1.7 Inhibitor GDC-0276 via a Highly Regioselective SNAr ReactionStumpf, Andreas / Cheng, Zhigang Ken / Beaudry, Danial / Angelaud, Remy / Gosselin, Francis et al. | 2019
- 1841
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Asymmetric Transfer Hydrogenation in Thermomorphic Microemulsions Based on Ionic LiquidsHejazifar, Mahtab / Pálvölgyi, Ádám Márk / Bitai, Jacqueline / Lanaridi, Olga / Bica-Schröder, Katharina et al. | 2019
- 1852
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Biocatalyst Immobilization by Anchor Peptides on an Additively Manufacturable MaterialBüscher, Niclas / Sayoga, Giovanni V. / Rübsam, Kristin / Jakob, Felix / Schwaneberg, Ulrich / Kara, Selin / Liese, Andreas et al. | 2019
- 1860
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Investigating the Underappreciated Hydrolytic Instability of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Related Unsaturated Nitrogenous BasesHyde, Alan M. / Calabria, Ralph / Arvary, Rebecca / Wang, Xiao / Klapars, Artis et al. | 2019
- 1872
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Process Development and Scale Up of a Selective JAK3 Covalent Inhibitor PF-06651600Tao, Yong / McWilliams, J. Christopher / Wiglesworth, Kristin E. / Girard, Kevin P. / Makowski, Teresa M. / Sach, Neal W. / Mustakis, Jason G. / Mehta, Ruchi / Trujillo, John I. / Chen, Xiaofeng et al. | 2019
- 1881
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Efficient and Practical Synthesis of 3′,4′,5′-Trifluoro-[1,1′-biphenyl]-2-amine: A Key Intermediate of FluxapyroxadLi, Zhenhua / Zhang, Xuchao / Qin, Jinjing / Tan, Zhiyong / Han, Meizhen / Jin, Guoqiang et al. | 2019
- 1887
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Economical Process for Preparation of the 19-nor A Ring of Paricalcitol from (−)-Shikimic AcidZhou, Shengfeng / Zhu, Runyu / Hu, Jingwen / Zhang, Lixiong / Lu, Qian / Yu, Xinhong et al. | 2019
- 1892
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An Integrated Continuous Flow Micro-Total Ultrafast Process System (μ-TUFPS) for the Synthesis of Celecoxib and Other Cyclooxygenase InhibitorsSthalam, Vinay Kumar / Singh, Ajay K. / Pabbaraja, Srihari et al. | 2019
- 1900
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Versatile Methods to Dispense Submilligram Quantities of Solids Using Chemical-Coated Beads for High-Throughput ExperimentationMartin, M. Cynthia / Goshu, Gashaw M. / Hartnell, Jeffery R. / Morris, Collin D. / Wang, Ying / Tu, Noah P. et al. | 2019
- 1908
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Development of a Robust Synthesis of Dactolisib on a Commercial Manufacturing ScaleBaenziger, Markus / Pachinger, Werner / Stauffer, Frédéric / Zaugg, Werner et al. | 2019
- 1918
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Synthesis of Imatinib by C–N Coupling Reaction of Primary Amide and Bromo-Substituted Pyrimidine AmineWang, Cuiling / Bai, Xiao / Wang, Rui / Zheng, Xudong / Ma, Xiumei / Chen, Huan / Ai, Yun / Bai, Yajun / Liu, Yifeng et al. | 2019
- 1926
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Using Spinchem Rotating Bed Reactor Technology for Immobilized Enzymatic Reactions: A Case StudyPithani, Subhash / Karlsson, Staffan / Emtenäs, Hans / Öberg, Christopher T. et al. | 2019
- 1932
-
Large Scale Synthesis of an Ampakine-type Active Pharmaceutical Ingredient Based on a Telescoped Regioselective Double Amidation ReactionHardouin, Christophe / Pin, Frédéric / Giffard, Jean-François / Hervouet, Yvon / Hublet, Julie / Janvier, Solenn / Penloup, Christine / Picard, Julien / Pinault, Nathalie / Schiavi, Bruno et al. | 2019
- 1948
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Isothermal by Design: An Accelerated Approach to the Prediction of the Crystallizability of Slowly Nucleating SystemsKaskiewicz, Peter L. / Xu, Guangyi / Lai, Xiaojun / Warren, Nicholas J. / Roberts, Kevin J. / Morton, Colin / Dowding, Peter / George, Neil et al. | 2019
- 1960
-
Incorporating Solvent-Dependent Kinetics To Design a Multistage, Continuous, Combined Cooling/Antisolvent Crystallization ProcessSchall, Jennifer M. / Capellades, Gerard / Mandur, Jasdeep S. / Braatz, Richard D. / Myerson, Allan S. et al. | 2019
- 1970
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Enantiospecific Synthesis of (3R,4R)‑1-Benzyl-4-fluoropyrrolidin-3-amine Utilizing a Burgess-Type TransformationWidlicka, Daniel W. / Gontcharov, Alexander / Mehta, Ruchi / Pedro, Dylan J. / North, Robert et al. | 2019
- 1979
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Process Research and Impurity Control Strategy for Obeticholic Acid, a Farnesoid X Receptor AgonistFeng, Wei-Dong / Zhuo, Song-Ming / Zhang, Fu-Li et al. | 2019
- 1990
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Development of a Scalable Synthesis for an Inhaled pan-JAK InhibitorGontcharov, Alexander / Magano, Javier / Samp, Lacey / Houck, Tim L. / Rose, Peter R. / Rane, Anil / Coe, Jotham W. / Kortum, Steven W. / Chung, SeungWon / Jones, Peter et al. | 2019
- 2001
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Effect of Oiling-Out during Crystallization on Purification of an Intermediate CompoundTanaka, Kota / Takiyama, Hiroshi et al. | 2019
- 2009
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Quantitative Link between Secondary Nucleation and Mixing Hydrodynamics in Batch Cooling Crystallization: A New Approach in Process DevelopmentYousuf, Mustafa / Frawley, Patrick J. et al. | 2019
- 2020
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Model-Based Scale-Up Predictions: From Micro- to Millireactors Using Inline Fourier Transform Infrared SpectroscopyFath, Verena / Szmais, Stefanie / Lau, Philipp / Kockmann, Norbert / Röder, Thorsten et al. | 2019
- 2031
-
Resolution Control in a Continuous Preferential Crystallization ProcessDunn, Andrew S. / Svoboda, Vaclav / Sefcik, Jan / ter Horst, Joop H. et al. | 2019
- 2042
-
Efficient Chemoenzymatic Synthesis of Optically Active Pregabalin from Racemic IsobutylsuccinonitrileZhang, Qin / Wu, Zhe-Ming / Liu, Shuang / Tang, Xiao-Ling / Zheng, Ren-Chao / Zheng, Yu-Guo et al. | 2019
- 2050
-
Follow the Silyl Cation: Insights into the Vorbrüggen ReactionBeutner, Gregory L. / Bultman, Michael S. / Cohen, Benjamin M. / Fan, Junying / Marshall, Jonathan / Sfouggatakis, Chris et al. | 2019
- 2057
-
Process-Related Impurities of PazopanibTerentjeva, Svetlana / Muceniece, Dzintra / Lu̅sis, Viesturs et al. | 2019
- 2069
-
Large-Scale Preparation of N‑Butanoyl‑l‑glutathione (C4-GSH)Bartoccini, Francesca / Mari, Michele / Retini, Michele / Fraternale, Alessandra / Piersanti, Giovanni et al. | 2019
- 2074
-
Purification of Artemisinin from the Product Solution of a Semisynthetic Reaction within a Single Crystallization StepHorosanskaia, Elena / Triemer, Susann / Seidel-Morgenstern, Andreas / Lorenz, Heike et al. | 2019
- 2080
-
A Quantitative Assay of Sodium TriacetoxyborohydrideZacuto, Michael J. / Perona, Joseph / Dunn, Robert et al. | 2019
- 2088
-
A Practical and Robust Multistep Continuous Process for Manufacturing 5‑Bromo‑N‑(tert-butyl)pyridine-3-sulfonamideYu, Miao / Strotman, Neil A. / Savage, Scott A. / Leung, Simon / Ramirez, Antonio et al. | 2019
- 2096
-
Scalability of a Time- and Cost-Effective Procedure for the Synthesis of Picryl BromideKlapötke, Thomas M. / Dosch, Dominik E. et al. | 2019
- 2099
-
Generation of Hydrogen Cyanide from the Reaction of Oxyma (Ethyl Cyano(hydroxyimino)acetate) and DIC (Diisopropylcarbodiimide)McFarland, Adam D. / Buser, Jonas Y. / Embry, Matthew C. / Held, Charles B. / Kolis, Stanley P. et al. | 2019
- 2106
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Correction to “Regulatory Highlights”Teasdale, Andrew / Popkin, Matthew et al. | 2019