(2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase (English)
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In:
Bioorganic and Medicinal Chemistry Letters
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3
, 8
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1571-1576
;
1993
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ISSN:
- Article (Journal) / Electronic Resource
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Title:(2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase
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Contributors:Kim, Choung Un ( author ) / Misco, Peter F. ( author ) / Luh, Bing Y. ( author ) / Terry, Brian ( author ) / Bisacchi, Gregory ( author ) / Mansuri, Muzammil M. ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 3, 8 ; 1571-1576
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Publisher:
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Publication date:1993-04-22
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Size:6 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 3, Issue 8
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1457
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Contributors to this issue| 1993
- 1461
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Graphical abstracts| 1993
- 1477
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Dopamine autoreceptor agonists: computational studies, synthesis and biological investigationsGmeiner, Peter / Sommer, Josef / Mierau, Joachim / Höfner, Georg et al. | 1993
- 1485
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The design and synthesis of novel hydroxyproline inhibitors of HIV-1 proteinaseHolmes, Duncan S. / Bethell, Richard C. / Hann, Michael M. / Kitchin, John / Starkey, Ian D. / Storer, Richard et al. | 1993
- 1493
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Cyclic ether acetal platelet activating factor (PAF) receptor antagonists I: 3-pyridyl derivativesWhittaker, Mark / Thompson, Timothy M. / Spavold, Zoë M. / Price, Michael / Miller, Andrew / Galloway, W.Alan / Fraser, Fiona / Floyd, Christopher D. / Drummond, Alan H. / Davidson, Alan H. et al. | 1993
- 1499
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Cyclic ether acetal platelet activating factor (PAF) receptor antagonists II: imidazo[4,5-c]pyridyl derivativesWood, L.Michael / Whittaker, Mark / Timmis, David J. / Thompson, Timothy M. / Saroglou, Lydia / Miller, Andrew / Davidson, Alan H. / Christodoulou, Mark S. / Cackett, Karen S. / Bowles, Stephen A. et al. | 1993
- 1505
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Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphateMills, Stephen J / Safrany, Stephen T / Wilcox, Robert A / Nahorski, Stefan R / Potter, Barry VL et al. | 1993
- 1511
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2-NAP: a selective, hydrophilic, non-peptide CCKA - receptor antagonist derived from the cholecystokinin C-terminal dipeptide.McDonald, Iain M. / Bodkin, Michael J. / Broughton, Howard B. / Dunstone, David J. / Kalindjian, S.Barret / Low, Caroline M.R. et al. | 1993
- 1517
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A new structural analogue antagonist of peptido-leukotrienes. The discovery of bay x7195Abram, T.S. / Böshagen, H. / Butler, J.E. / Cuthbert, N.J. / Francis, H.P. / Gardiner, P.J. / Hartwig, W. / Kluender, H.C. / Norman, P. / Meier, H. et al. | 1993
- 1523
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A highly efficient synthesis of RWJ 47639: a novel orally active angiotensin II receptor antagonist.Hsi, Jeffrey D. / Murray, William V. / Gill, Alan et al. | 1993
- 1527
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On the function of the 2′-hydroxyl group in the peptidyl tRNA terminus during elongation in ribosomal peptide biosynthesisGoldberg, Stanley I. / Liu, Xing-Ping et al. | 1993
- 1531
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Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C4′ aryl positionJaynes, Burton H. / Cooper, Christopher B. / Hecker, Scott J. / Blair, Kyle T. / Elliott, Nancy C. / Lilley, Susan C. / Minich, Martha L. / Schicho, Douglas L. / Werner, Kim M. et al. | 1993
- 1531
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Synthesis and in vitro antibacterial activity of hygromycin A analogs modified at the C4-aryl positionJaynes, B.H. et al. | 1993
- 1537
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Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c.McCombie, Stuart W / Bishop, Robert W / Carr, Donna / Dobek, Emily / Kirkup, Michael P / Kirschmeier, Paul / Lin, Sue-Ing / Petrin, Joanne / Rosinski, Karen / Shankar, Bandarpalle B et al. | 1993
- 1537
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Indolocarbazoles--I. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252cMcCombie, S.W. et al. | 1993
- 1543
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Antiviral optically pure dioxolane purine nucleoside analoguesSiddiqui, M.A. et al. | 1993
- 1543
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Antiviral optically pure dioxolane purine nucleosides analoguesSiddiqui, M.Arshad / Brown, William L. / Nguyen-Ba, Nghe / Dixit, Dilip M. / Mansour, Tarek S. / Hooker, Elizabeth / Viner, K.Claire / Cameron, Janet M. et al. | 1993
- 1547
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Synthesis of phosphodiester and triester derivatives of AZT with tethered N-methyl piperazine and N,N,N′ trimethylethylenediamine.Desseaux, Carole / Huynh-Dinh, Tam et al. | 1993
- 1551
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Synthesis and anti-inflammatory activity of some 3-heterocyclyl-1,2-benzisothiazolesSawhney, S.N. et al. | 1993
- 1551
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Synthesis and antiflammatory activity of some 3-heterocycle-1,2-benzisothiazolesSawhney, Shanti N. / Sharma, Pawan K. et al. | 1993
- 1555
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Derivatives of quinuclidine as 5-HT3 receptor antagonists: influence of an additional carbonyl group on the recognition of chirality by the receptor.Langlois, M. / Soulier, J.L. / Allainmat, M. / Shen, S. / Gallais, C. et al. | 1993
- 1559
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4,5,6,7-Tetrahdryo-8-oxo-cycloheptimidazoles: a new class of potent non-peptide angiiotensin II receptor antagonistsYanagisawa, Takashi / Ueyama, Naoto / Kawai, Tomoyuki / Sonegawa, Motoharu / Baba, Hiromi / Mochizuki, Seiichiro / Kozakai, Kazukiro / Tomiyama, Tsuyoshi et al. | 1993
- 1559
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4,5,6,7-Tetrahydro-8-oxo-cycloheptimidazoles: a new class of potent non-peptide angiotensin II receptor antagonistsYanagisawa, T. et al. | 1993
- 1565
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Synthesis and DNA cleaving properties of hybrid molecules containing propargylic sulfones and minor groove binding lexitropsinsXie, Guojian / Morgan, A.Richard / Lown, J.William et al. | 1993
- 1571
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(2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinaseKim, Choung Un / Misco, Peter F. / Luh, Bing Y. / Terry, Brian / Bisacchi, Gregory / Mansuri, Muzammil M. et al. | 1993
- 1577
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Stereochemistry of the KDO8P synthase. An efficient synthesis of the 3-fluoro analogues of KDO8PKohen, Amnon / Berkovich, Ronit / Belakhov, Valery / Baasov, Timor et al. | 1993
- 1583
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Insight into the catalytic mechanism of KDO8P synthase. Synthesis and evaluation of the isosteric phosphonate mimic of the putative cyclic intermediateSheffer-Dee-Noor, Shani / Belakhov, Valery / Baasov, Timor et al. | 1993
- 1589
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Structure activity studies on pseudo-symmetrical HIV-1 protease inhibitorsBabine, Robert E. / Zhang, Nan / Schow, Steven R. / Jirousek, Michael R. / Johnson, Bernard D. / Kerwar, Suresh S. / Desai, Parimal R. / Byrn, Randal A. / Hastings, Richard C. / Wick, Michael M. et al. | 1993
- 1595
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Synthesis and biological evaluation of a series of HIV-1 protease inhibitorsTrova, Michael P. / Babine, Robert E. / Byrn, Randal A. / Casscles, Wellington T. Jr. / Hastings, Richard C. / Hsu, Grace C. / Jirousek, Michael R. / Johnson, Bernard D. / Kerwar, Suresh S. / Schow, Steven R. et al. | 1993
- 1601
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Synthesis and fluorescence properties of a substrate for a continuous fluorimetric assay of protein tyrosine phosphatasesGarcía-Echeverría, Carlos / Rich, Daniel H. et al. | 1993
- 1605
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A diazine heterocycle replaces a six-membered hydrogen-bonded array in the active site of scytalone dehydrataseHodge, C.Nicholas / Pierce, John et al. | 1993
- 1609
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A concise enantioselective synthesis of trans-olefin dipeptide isosteresBeresis, R. et al. | 1993
- 1609
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A concise enantioselective synthesis of rans-olefin dipeptide isosteresBeresis, Richard / Panek, James S. et al. | 1993
- 1615
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A combined chemical-enzymatic synthesis of a new phosphoramidate analogue of phosphoenolpyruvateSheffer-Dee-Noor, Shani / Baasov, Timor et al. | 1993
- 1619
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Synthesis and biological activity of 3′,4′,5′-trihydroxy etoposideSaulnier, Mark G. / LeBoulluec, Karen L. / McGee, Danny P.C. / Long, Byron H. / Crosswell, Alfred R. / Vyas, Dolatrai M. et al. | 1993
- 1625
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Hypoglycaemic activity of an analogue of human growth hormone [6-13] incorporating a d-ala-pro dipeptide unitThompson, Philip E. / Lim, Noel / Wijaya, Effendi / Ng, Frank M. / Hearn, Milton T.W. et al. | 1993
- 1629
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Synthesis of a biologically active chlorinated analog of (E,E)-8,10- dodecadienol (codlemone)Tellier, Frédérique / Hammoud, Abdelhay / Ratovelomanana, Victoria / Linstrumelle, Gérard / Descoins, Charles et al. | 1993
- 1633
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Synthesis of N-Acetylhemiaminal metabolites of opc-21268, vasopressin V1 receptor antagonistOtsubo, Kenji / Morita, Seiji / Uchida, Minoru et al. | 1992
- 1637
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Hydride transfer versus electron transfer in the baker's yeast reduction of α-haloacetophenonesAleixo, Luis M. / de Carvalho, Márcia / Moran, Paulo José Samenho / Rodrigues, J.Augusto R. et al. | 1993
- 1637
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Hydride transfer versus electron transfer in the baker's yeast reduction of a-haloacetophenonesAleixo, L.M. et al. | 1993
- 1643
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Investigation of the conformation, solubility, structure and selectivity of alkaline proteases in anhydrous alcohols.Chen, Shui-Tein / Chen, Shiah-Yun / Tu, Chen-Chen / Wang, Kung-Tsung et al. | 1993
- 1649
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Excitatory amino acid receptor atagonists: synthesis and pharmacology of 3-(carboxymethoxy)isoxazoles derived from AMPAMadsen, U. / Andresen, L. / Poulsen, G.A. / Rasmussen, T.B. / Ebert, B. / Krogsgaard-Larsen, P. / Brehm, L. et al. | 1993
- 1649
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Excitatory amino acid receptor antagonists: synthesis and pharmacology of 3-(carboxymethoxy)isoxazoles derived from AMPAMadsen, U. et al. | 1993
- 1655
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The effect of aryl fluorines in a lipase resolution.Dasaradhi, Lakkaraju / O'Hagan, David et al. | 1993
- 1659
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Structure-activity relationships of 6-substituted benzopyran-4-carbothioamide potassium channel openersIshizawa, Takenori / Koga, Hiroshi / Ohta, Masateru / Sato, Haruhiko / Makino, Toshihiko / Kuromaru, Kiyonori / Taka, Naoki / Takahashi, Tadakatsu / Sato, Tsutomu / Nabata, Hiroyuki et al. | 1993
- 1663
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Synthesis and cardiotonic activity of 2,9-dihydro-6-(5-methyl-3-oxo-2,3,4,5-tetrahydropyridazin-6-yl)pyrazolo[4,3-b][1,4]benzoxazineCombs, Donald W. et al. | 1993
- 1667
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Conformation of the CYP2D6 model substrate sparteine under physiological conditionsSchneider, Frank / Fischer, Peter / Ebner, Thomas / Meese, Claus O. et al. | 1993
- 1671
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Transfecting activity of photoirradiated φx 174 DNA in the presence of hydroperoxynaphthalimidesMatsugo, Seiichi / Kodaira, Ken-ichi / Saito, Isao et al. | 1993
- 1675
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Fibrinogen receptor antagonists containing a gamma-lactam Gly-Asp isostereKottirsch, Georg / Tapparelli, Carlo / Zerwes, Hans-Günther et al. | 1993
- 1681
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Synthesis of a potential photoaffinity labelling reagent for HIV-1 reverse transcriptaseTanaka, Hiromichi / Baba, Masanori / Yamamoto, Tomomi / Mori, Shuichi / Walker, Richard T. / De Clercq, Erik / Miyasaka, Tadashi et al. | 1993
- 1687
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Role of sulfonamide moiety in non-prostanoid txa2 receptor antagonist kt2-962 : modifications of this moiety and the resulting activitiesYokota, Masayuki / Imamaki, Kenji / Uchibori, Satoko / Kondo, Masahiro / Kosakai, Kazuhiro / Tomiyama, Tsuyoshi et al. | 1993
- 1693
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Angiotensin II receptor antagonists containing a phenylpyridine element.Mantlo, Nathan.B. / Chang, Raymond S.L. / Siegl, Peter.K.S. et al. | 1993
- 1697
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Targeting radiosensitizers to DNA by minor groove binding: nitroarenes based on netropsin and distamycinParrick, John / Porssa, Manuchehr / Davies, Lisa K. / Dennis, Madeleine F. / Patel, Kantilal B. / Stratford, Michael R.L. / Wardman, Peter et al. | 1993
- 1703
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Quinuclidine based NK-1 antagonists 2: determination of the absolute stereochemical requirementsSwain, C.J. / Seward, E.M. / Sabin, V. / Owen, S. / Baker, R. / Cascieri, M.A. / Sadowski, S. / Strader, C. / Ball, R.G. et al. | 1993
- 1703
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Quinuclidine based NK-1 antagonists--II. Determination of the absolute stereochemical requirementsSwain, C.J. et al. | 1993
- 1707
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Synthesis and antimalarial evaluation of 2,3,5-trioxabicyclo(2.2.3)nonane a model for the putative pharmacophore artemisininCasteel, D.A. et al. | 1993
- 1707
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Synthesis and antimalarial evaluation of 2,3,5-trioxabicyclo[2.2.3]nonane, a model for the putative pharmacophore of artemisininCasteel, Dee Ann / Peri, S.Prasad / Gerena, Lucia et al. | 1993
- 1711
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Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibitionWentland, Mark P. / Lesher, George Y. / Reuman, Michael / Pilling, Garry M. / Saindane, Manohar T. / Perni, Robert B. / Eissenstat, Michael A. / Weaver, John D. III / Singh, Baldev / Rake, James et al. | 1993
- 1717
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Synthesis and biological activity of sulfoximine-modified myristic acid analoguesMcDonald, Ian A. / Nyce, Philip L. / Ku, George S. / Bowlin, Terry L. et al. | 1993
- 1723
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A novel class of 1,3-oxathiolane nucleoside analogues having potent anti-HIV activityBelleau, Bernard / Brasili, Livio / Chan, Laval / DiMarco, Marika P. / Zacharie, Boulos / Nguyen-Ba, Nghe / Jenkinson, Helen J. / Coates, Jonathan A.V. / Cameron, Janet M. et al. | 1993
- 1729
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Oxazole, thiazole, and imidazole derivatives of 2,6-di-tert-butylphenol as dual 5-lipoxygenase and cyclooxygenase inhibitorsUnangst, Paul C. / Connor, David T. / Cetenko, Wiaczeslaw A. / Sorenson, Roderick J. / Sircar, Jagadish C. / Wright, Clifford D. / Schrier, Denis J. / Dyer, Richard D. et al. | 1993
- 1735
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Synthesis and evaluation of 3-carboxymethyl steroids as inhibitors of human prostatic steroid 5α-reductaseHolt, Dennis A. / Oh, Hye-Ja / Rozamus, Leonard W. / Yen, Hwa-Kwo / Brandt, Martin / Levy, Mark A. / Brian W., Metcalf et al. | 1993
- 1735
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Synthesis and evaluation of 3-carboxymethyl steroids as inhibitors of human prostatic steroid 5a-reductaseHolt, D.A. et al. | 1993
- 1739
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Design and synthesis of cosalane, a novel anti-HIV agentGolebiewski, W.Marek / Bader, John P. / Cushman, Mark et al. | 1993
- 1743
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The selective inhibition of phosphodiesterase IV by benzopyran derivatives of rolipramPinto, I.L. / Buckle, D.R. / Readshaw, S.A. / Smith, D.G. et al. | 1993
- 1747
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A new galactosyl transferase inhibitorSchmidt, Richard R. / Frische, Klaus et al. | 1993
- 1751
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Design of DNA-cleaving molecules which incorporate a simplified metal-complexing moiety of bleomycin and lexitropsin carriersHuang, Liren / Morgan, A.Richard / Lown, J.William et al. | 1993
- 1757
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Semisynthesis of Linear Fragments Corresponding to the Eastern Portion of Azalide AntibioticsWaddell, Sherman T. / Blizzard, Timothy A. et al. | 1993
- 1761
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Novel water soluble phosphate prodrugs of Taxol(R) possessing in vivo antitumor activityUeda, Y. et al. | 1993
- 1761
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Novel water soluble phosphate prodrugs of taxol® possessing in vivo antitumor activityUeda, Yasutsugu / Mikkilineni, Amarendra B. / Knipe, Jay O. / Rose, William C. / Casazza, Anna Maria / Vyas, Dolatrai M. et al. | 1993
- 1767
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Identification of simpler analogs of neurotensin(9–13) which retain antinociceptive activityCain, Gary A. / Christos, Thomas E. / Johnson, Alexander L. / Pottorf, Richard S. / Tam, S.William / Schmidt, William K. et al. | 1993
- 1773
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Additions and Corrections| 1993
- iii
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Announcements| 1993
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Instructions to Contributors| 1993