Synthesis and TNF expression inhibitory properties of new thalidomide analogues derived via Heck cross coupling (English)
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In:
Bioorganic and Medicinal Chemistry Letters
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17
, 21
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5819-5824
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2007
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Synthesis and TNF expression inhibitory properties of new thalidomide analogues derived via Heck cross coupling
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Contributors:Stewart, Scott G. ( author ) / Spagnolo, Daniel ( author ) / Polomska, Marta E. ( author ) / Sin, Melvin ( author ) / Karimi, Mahdad ( author ) / Abraham, Lawrence J. ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 17, 21 ; 5819-5824
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Publisher:
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Publication date:2007-08-21
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Size:6 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 17, Issue 21
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 5725
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Graphical contents list| 2007
- 5740
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Discovery of potent T-type calcium channel blockerSeo, Han Na / Choi, Ja Youn / Choe, Yun Jeong / Kim, Yoonjee / Rhim, Hyewhon / Lee, So Ha / Kim, Jungahn / Joo, Dong Jun / Lee, Jae Yeol et al. | 2007
- 5744
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Studies on the interactions between some flavonols and cyclodextrinsBergonzi, Maria Camilla / Bilia, Anna Rita / Bari, Lorenzo Di / Mazzi, Giovanni / Vincieri, Franco Francesco et al. | 2007
- 5749
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Two new phenylpiperazines with atypical antipsychotic potentialTomić, Mirko / Ignjatović, Djurdjica / Tovilović, Gordana / Andrić, Deana / Roglić, Goran / Kostić-Rajačić, Sladjana et al. | 2007
- 5754
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Synthesis and identification of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs with dissociated antiprogesterone activitiesJin, Chunyang / Manikumar, G. / Kepler, John A. / Edgar Cook, C. / Allan, George F. / Kiddoe, Margaret / Bhattacharjee, Sheela / Linton, Olivia / Lundeen, Scott G. / Sui, Zhihua et al. | 2007
- 5754
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Synthesis and identification of novel 11b-aryl-4prime,5prime-dihydrospiro[estra-4,9-diene-17b,4prime-oxazole] analogs with dissociated antiprogesterone activitiesJin, C. / Manikumar, G. / Kepler, J. A. / Edgar Cook, C. / Allan, G. F. / Kiddoe, M. / Bhattacharjee, S. / Linton, O. / Lundeen, S. G. / Sui, Z. et al. | 2007
- 5758
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Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensorHernout, Olivier / Berthoin, Karine / Delattre, Isabelle / Tulkens, Paul M. / Carryn, Stéphane / Marchand-Brynaert, Jacqueline et al. | 2007
- 5763
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Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA–topoisomerase I complexVan, Hue Thi My / Le, Quynh Manh / Lee, Kwang Youl / Lee, Eung-Seok / Kwon, Youngjoo / Kim, Tae Sung / Le, Thanh Nguyen / Lee, Suh-Hee / Cho, Won-Jea et al. | 2007
- 5768
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Design and synthesis of opioidmimetics containing 2′,6′-dimethyl-l-tyrosine and a pyrazinone-ring platformShiotani, Kimitaka / Li, Tingyou / Miyazaki, Anna / Tsuda, Yuko / Yokoi, Toshio / Ambo, Akihiro / Sasaki, Yusuke / Bryant, Sharon D. / Lazarus, Lawrence H. / Okada, Yoshio et al. | 2007
- 5768
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Design and synthesis of opioidmimetics containing 2prime,6prime-dimethyl-l-tyrosine and a pyrazinone-ring platformShiotani, K. / Li, T. / Miyazaki, A. / Tsuda, Y. / Yokoi, T. / Ambo, A. / Sasaki, Y. / Bryant, S. D. / Lazarus, L. H. / Okada, Y. et al. | 2007
- 5772
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Design and synthesis of novel antibacterial peptide-resin conjugatesCho, Won-Mi / Joshi, Bishnu Prasad / Cho, Hyeongjin / Lee, Keun-Hyeung et al. | 2007
- 5777
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Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylasesWen, Xiaoan / Xia, Jun / Cheng, Keguang / Zhang, Liying / Zhang, Pu / Liu, Jun / Zhang, Luyong / Ni, Peizhou / Sun, Hongbin et al. | 2007
- 5783
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N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher diseaseHuang, Wenwei / Zheng, Wei / Urban, Daniel J. / Inglese, James / Sidransky, Ellen / Austin, Christopher P. / Thomas, Craig J. et al. | 2007
- 5790
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Amino-caprolactam derivatives as γ-secretase inhibitorsParker, Michael F. / Bronson, Joanne J. / Barten, Donna M. / Corsa, Jason A. / Du, Wengsheng / Felsenstein, Kevin M. / Guss, Valerie L. / Izzarelli, Darcy / Loo, Alice / McElhone, Kate E. et al. | 2007
- 5790
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Amino-caprolactam derivatives as g-secretase inhibitorsParker, M. F. / Bronson, J. J. / Barten, D. M. / Corsa, J. A. / Du, W. / Felsenstein, K. M. / Guss, V. L. / Izzarelli, D. / Loo, A. / McElhone, K. E. et al. | 2007
- 5796
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Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan®Molinari, Albert J. / Trybulski, Eugene J. / Bagli, Jehan / Croce, Susan / Considine, John / Qi, Jian / Ali, Kadum / DeMaio, William / Lihotz, Lynne / Cochran, David et al. | 2007
- 5801
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d-Phenylglycinol-derived non-covalent factor Xa inhibitors: Effect of non-peptidic S4 linkage elements on affinity and anticoagulant activityKlimkowski, Valentine J. / Watson, Brian M. / Wiley, Michael R. / Liebeschuetz, John / Franciskovich, Jeffry B. / Marimuthu, Jothirajah / Bastian, Jolie A. / Sall, Daniel J. / Smallwood, Jeffrey K. / Chirgadze, Nikolay Y. et al. | 2007
- 5806
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4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IVKaelin, David E. / Smenton, Abigail L. / Eiermann, George J. / He, Huaibing / Leiting, Barbara / Lyons, Kathryn A. / Patel, Reshma A. / Patel, Sangita B. / Petrov, Alexsandr / Scapin, Giovanna et al. | 2007
- 5812
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The design and preliminary structure–activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymesCao, Jianguo / Fine, Richard / Gritzen, Colleen / Hood, John / Kang, Xinshan / Klebansky, Boris / Lohse, Dan / Mak, Chi Ching / McPherson, Andrew / Noronha, Glenn et al. | 2007
- 5819
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Synthesis and TNF expression inhibitory properties of new thalidomide analogues derived via Heck cross couplingStewart, Scott G. / Spagnolo, Daniel / Polomska, Marta E. / Sin, Melvin / Karimi, Mahdad / Abraham, Lawrence J. et al. | 2007
- 5825
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Structure–activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonistsGore, Vijay K. / Ma, Vu V. / Tamir, Rami / Gavva, Narender R. / Treanor, James J.S. / Norman, Mark H. et al. | 2007
- 5831
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Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitorsMoore, Keith P. / Zhu, Hong / Rajapakse, Hemaka A. / McGaughey, Georgia B. / Colussi, Dennis / Price, Eric A. / Sankaranarayanan, Sethu / Simon, Adam J. / Pudvah, Nicole T. / Hochman, Jerome H. et al. | 2007
- 5836
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Quantitative structure–activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivativesNarasimhan, Balasubramanian / Judge, Vikramjeet / Narang, Rakesh / Ohlan, Ruchita / Ohlan, Sucheta et al. | 2007
- 5846
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Effect of indole ethyl isothiocyanates on proliferation, apoptosis, and MAPK signaling in neuroblastoma cell linesSingh, Rakesh K. / Lange, Thilo S. / Kim, Kyukwang / Zou, Yongping / Lieb, Casey / Sholler, Giselle L. / Brard, Laurent et al. | 2007
- 5853
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Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetesChen, Ping / Caldwell, Charles G. / Mathvink, Robert J. / Leiting, Barbara / Marsilio, Frank / Patel, Reshma A. / Wu, Joseph K. / He, Huaibing / Lyons, Kathryn A. / Thornberry, Nancy A. et al. | 2007
- 5858
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A novel class of potent NF-kB signaling inhibitorsLeban, J. / Baierl, M. / Mies, J. / Trentinaglia, V. / Rath, S. / Kronthaler, K. / Wolf, K. / Gotschlich, A. / Seifert, M. H. et al. | 2007
- 5858
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A novel class of potent NF-κB signaling inhibitorsLeban, Johann / Baierl, Marcel / Mies, Jan / Trentinaglia, Viola / Rath, Sandra / Kronthaler, Kerstin / Wolf, Kristina / Gotschlich, Astrid / Seifert, Markus H.J. et al. | 2007
- 5863
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Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: Identification of new scaffolds for potent EGFR tyrosine kinase inhibitorsKitano, Yasunori / Suzuki, Tsuyoshi / Kawahara, Eiji / Yamazaki, Takahisa et al. | 2007
- 5868
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Taxodistines A and B, abietane-type diterpenes from Taxodium distichumHirasawa, Yusuke / Izawa, Emi / Matsuno, Yosuke / Kawahara, Nobuo / Goda, Yukihiro / Morita, Hiroshi et al. | 2007
- 5872
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Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptorsToyooka, Naoki / Kobayashi, Soushi / Zhou, Dejun / Tsuneki, Hiroshi / Wada, Tsutomu / Sakai, Hideki / Nemoto, Hideo / Sasaoka, Toshiyasu / Garraffo, H. Martin / Spande, Thomas F. et al. | 2007
- 5876
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Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitorsGhosh, Arun K. / Xi, Kai / Grum-Tokars, Valerie / Xu, Xiaoming / Ratia, Kiira / Fu, Wentao / Houser, Katherine V. / Baker, Susan C. / Johnson, Michael E. / Mesecar, Andrew D. et al. | 2007
- 5881
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NO donors. Part 16: Investigations on structure–activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent vasodilatorKoenig, Andreas / Roegler, Carolin / Lange, Kathrin / Daiber, Andreas / Glusa, Erika / Lehmann, Jochen et al. | 2007
- 5886
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The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitorsGraham Robinett, R. / Freemerman, Alex J. / Skinner, Michael A. / Shewchuk, Lisa / Lackey, Karen et al. | 2007
- 5894
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A straightforward stereoselective synthesis of meso-, (S,S)- and (R,R)-2,6-diaminopimelic acids from cis-1,4-diacetoxycyclohept-2-eneSaito, Yukako / Shinkai, Takumi / Yoshimura, Yuichi / Takahata, Hiroki et al. | 2007
- 5897
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Design, synthesis, and biological testing of pyrazoline derivatives of combretastatin-A4Johnson, Marlie / Younglove, Brent / Lee, Lauren / LeBlanc, Regan / Holt, Herman Jr. / Hills, Patrice / Mackay, Hilary / Brown, Toni / Mooberry, Susan L. / Lee, Moses et al. | 2007
- 5902
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Inactivation of soybean sterol 24-C-methyltransferase by elongated sterol side chains at C26Song, Zhihong / Nes, W. David et al. | 2007
- 5907
-
Fluorinated chloramphenicol acetyltransferase thermostability and activity profile: Improved thermostability by a single-isoleucine mutantVoloshchuk, Natalya / Lee, Man Xia / Zhu, Wan Wen / Tanrikulu, Ismet Caglar / Montclare, Jin Kim et al. | 2007
- 5912
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Synthesis and biological activities of glycosphingolipid analogues from marine sponge Aplysinella rhaxHada, Noriyasu / Nakashima, Taishi / Shrestha, Suraj Prakash / Masui, Ryo / Narukawa, Yuji / Tani, Kayoko / Takeda, Tadahiro et al. | 2007
- 5916
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5′-Halogenated analogs of oxymorphindoleMetcalf, Matthew D. / Coop, Andrew et al. | 2007
- 5916
-
5prime-Halogenated analogs of oxymorphindoleMetcalf, M. D. / Coop, A. et al. | 2007
- 5918
-
Novel orally active, dibenzazepinone-based g-secretase inhibitorsPeters, J. U. / Galley, G. / Jacobsen, H. / Czech, C. / David-Pierson, P. / Kitas, E. A. / Ozmen, L. et al. | 2007
- 5918
-
Novel orally active, dibenzazepinone-based γ-secretase inhibitorsPeters, Jens-Uwe / Galley, Guido / Jacobsen, Helmut / Czech, Christian / David-Pierson, Pascale / Kitas, Eric A. / Ozmen, Laurence et al. | 2007
- 5924
-
Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2Ulven, Trond / Gallen, Michael J. / Nielsen, Mads C. / Merten, Nicole / Schmidt, Carola / Mohr, Klaus / Tränkle, Christian / Kostenis, Evi et al. | 2007
- 5928
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Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagoguesHernández, Andrés S. / Cheng, Peter T.W. / Musial, Christa M. / Swartz, Stephen G. / George, Rocco J. / Grover, Gary / Slusarchyk, Dorothy / Seethala, R. Krishna / Smith, Mark / Dickinson, Kenneth et al. | 2007
- 5934
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Design, synthesis, and biological evaluation of triazolopiperazine-based β-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitorsKowalchick, Jennifer E. / Leiting, Barbara / Pryor, KellyAnn D. / Marsilio, Frank / Wu, Joseph K. / He, Huaibing / Lyons, Kathryn A. / Eiermann, George J. / Petrov, Aleksandr / Scapin, Giovanna et al. | 2007
- 5934
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Design, synthesis, and biological evaluation of triazolopiperazine-based b-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitorsKowalchick, J. E. / Leiting, B. / Pryor, K. D. / Marsilio, F. / Wu, J. K. / He, H. / Lyons, K. A. / Eiermann, G. J. / Petrov, A. / Scapin, G. et al. | 2007
- 5940
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Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxidesLory, Pedro M.J. / Estrella-Jimenez, Maria E. / Shashack, Matthew J. / Lokesh, Ganesh L. / Natarajan, Amarnath / Gilbertson, Scott R. et al. | 2007
- 5944
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Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitorsTao, Zhi-Fu / Li, Gaoquan / Tong, Yunsong / Stewart, Kent D. / Chen, Zehan / Bui, Mai-Ha / Merta, Philip / Park, Chang / Kovar, Peter / Zhang, Haiying et al. | 2007
- 5944
-
Discovery of 4prime-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4prime-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2prime-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitorsTao, Z. F. / Li, G. / Tong, Y. / Stewart, K. D. / Chen, Z. / Bui, M. H. / Merta, P. / Park, C. / Kovar, P. / Zhang, H. et al. | 2007
- 5952
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Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitorsShi, Yan / Sitkoff, Doree / Zhang, Jing / Han, Wei / Hu, Zilun / Stein, Philip D. / Wang, Ying / Kennedy, Lawrence J. / O’Connor, Stephen P. / Ahmad, Saleem et al. | 2007
- 5959
-
Conformationally constrained analogues of 2-arachidonoylglycerolVadivel, Subramanian K. / Vardarajan, Sundararaman / Duclos, Richard I. Jr. / Wood, JodiAnne T. / Guo, Jianxin / Makriyannis, Alexandros et al. | 2007
- 5964
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Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonistsXia, Mingde / Hou, Cuifen / Pollack, Scott / Brackley, James / DeMong, Duane / Pan, Meng / Singer, Monica / Matheis, Michele / Olini, Gil / Cavender, Druie et al. | 2007
- 5969
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An effective method for the in situ synthesis of DNA–CPG conjugates using chemical ligation technology as tools for SNP analysisOhkubo, Akihiro / Tanaka, Kunihiko / Taguchi, Haruhiko / Seio, Kohji / Nagasawa, Hiroshi / Tsukahara, Toshifumi / Sekine, Mitsuo et al. | 2007
- 5974
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Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)Arthurs, Claire L. / Raftery, James / Whitby, Helen L. / Whitehead, Roger C. / Wind, Natasha S. / Stratford, Ian J. et al. | 2007
- 5978
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Synthesis and structure–activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitorsPannala, Madhavi / Kher, Sunil / Wilson, Norma / Gaudette, John / Sircar, Ila / Zhang, Shao-Hui / Bakhirev, Alexei / Yang, Guang / Yuen, Phoebe / Gorcsan, Frank et al. | 2007
- 5983
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(1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum productionHu, Lain-Yen / Du, Daniel / Hoffman, Jennifer / Smith, Yvonne / Fedij, Victor / Kostlan, Catherine / Johnson, Theodore R. / Huang, Yun / Kesten, Steve / Harter, William et al. | 2007
- 5989
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Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitorsBrnardic, Edward J. / Garbaccio, Robert M. / Fraley, Mark E. / Tasber, Edward S. / Steen, Justin T. / Arrington, Kenneth L. / Dudkin, Vadim Y. / Hartman, George D. / Stirdivant, Steven M. / Drakas, Bob A. et al. | 2007
- 5995
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Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitorsAnandan, Sampath-Kumar / Ward, John S. / Brokx, Richard D. / Denny, Trisha / Bray, Mark R. / Patel, Dinesh V. / Xiao, Xiao-Yi et al. | 2007
- 6000
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Expedient synthesis of N-Z-pyroglutamyl-amino acid derivativesKatritzky, Alan R. / Angrish, Parul / Todadze, Ekaterina / Ghiviriga, Ion et al. | 2007
- 6003
-
Discovery of N-phenyl nicotinamides as potent inhibitors of KdrDominguez, Celia / Smith, Leon / Huang, Qi / Yuan, Chester / Ouyang, Xiaohu / Cai, Lynn / Chen, Paul / Kim, Joseph / Harvey, Timothy / Syed, Rashid et al. | 2007
- 6009
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On the search of new I2-IBS aliphatic ligands: Bis-guanidino carbonyl derivativesCorcoran, Jonathan / Rodriguez, Fernando / Rozas, Isabel / Meana, J. Javier / Callado, Luis F. et al. | 2007
- 6013
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From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosisSpringthorpe, Brian / Bailey, Andrew / Barton, Patrick / Birkinshaw, Timothy N. / Bonnert, Roger V. / Brown, Roger C. / Chapman, David / Dixon, John / Guile, Simon D. / Humphries, Robert G. et al. | 2007
- 6019
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High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitorsBoye, Søren V. / Ortega-Caballero, Fernando / Sinning, Steffen / Wiborg, Ove / Jensen, Henrik H. / Bols, Mikael et al. | 2007
- 6026
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Solid-phase synthesis and thermal denaturation study of cyclic PNAs targeting the HIV-1 TAR RNA loopUpert, Gregory / Mehiri, Mohamed / Giorgio, Audrey Di / Condom, Roger / Patino, Nadia et al. | 2007
- 6031
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Inhibitors of NF-κB derived from thalidomideCarcache de-Blanco, Esperanza J. / Pandit, Bulbul / Hu, Zhigen / Shi, Jiandong / Lewis, Andrew / Li, Pui-Kai et al. | 2007
- 6031
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Inhibitors of NF-kB derived from thalidomideCarcache de-Blanco, E. J. / Pandit, B. / Hu, Z. / Shi, J. / Lewis, A. / Li, P. K. et al. | 2007
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Instructions to contributors| 2007
- IFC
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Editorial board| 2007