Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis (English)
- New search for: Fu, Dong-Jun
- New search for: Li, Miaomiao
- New search for: Zhang, Sai-Yang
- New search for: Li, Jiang-Feng
- New search for: Sha, Beibei
- New search for: Wang, Longhao
- New search for: Zhang, Yan-Bing
- New search for: Chen, Ping
- New search for: Hu, Tao
- New search for: Fu, Dong-Jun
- New search for: Li, Miaomiao
- New search for: Zhang, Sai-Yang
- New search for: Li, Jiang-Feng
- New search for: Sha, Beibei
- New search for: Wang, Longhao
- New search for: Zhang, Yan-Bing
- New search for: Chen, Ping
- New search for: Hu, Tao
In:
Bioorganic Chemistry
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92
;
2019
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis
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Contributors:Fu, Dong-Jun ( author ) / Li, Miaomiao ( author ) / Zhang, Sai-Yang ( author ) / Li, Jiang-Feng ( author ) / Sha, Beibei ( author ) / Wang, Longhao ( author ) / Zhang, Yan-Bing ( author ) / Chen, Ping ( author ) / Hu, Tao ( author )
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Published in:Bioorganic Chemistry ; 92
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Publisher:
- New search for: Elsevier Inc.
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Publication date:2019-08-08
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 92
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
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Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMRFang, Wei-Shuo / Sun, De-yang / Yang, Shuang / Cheng, Chen / Moschke, Katrin / Li, Tianqi / Sun, Shanshan / Lichtenthaler, Stefan F. / Huang, Jian / Wang, Yinghong et al. | 2019
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Promising antibacterial agents against multidrug resistant Staphylococcus aureusGatadi, Srikanth / Madhavi, Y.V. / Chopra, Sidharth / Nanduri, Srinivas et al. | 2019
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A dual-emission fluorescent probe for discriminating cysteine from homocysteine and glutathione in living cells and zebrafish modelsLu, Zhengliang / Lu, Yanan / Sun, Xin / Fan, Chunhua / Long, Zongyi / Gao, Liying et al. | 2019
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In vitro assessment of 3-alkoxy-5-nitroindazole-derived ethylamines and related compounds as potential antileishmanial drugsMartín-Montes, Álvaro / Aguilera-Venegas, Benjamín / Mª Morales-Martín, Rosa / Martín-Escolano, Rubén / Zamora-Ledesma, Salvador / Marín, Clotilde / Arán, Vicente J. / Sánchez-Moreno, Manuel et al. | 2019
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Discovery of diverse diterpenoid scaffolds from Euphorbia antiquorum and their activity against RANKL-induced osteoclastogenesisYin, Zhi-Yong / Dai, Yan / Hua, Pei / Sun, Zhe-Jun / Cheng, Yan-Fang / Yuan, Sheng-Heng / Chen, Zi-Yang / Gu, Qiong et al. | 2019
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Novel pyridazinone derivatives as butyrylcholinesterase inhibitorsDundar, Yasemin / Kuyrukcu, Ozge / Eren, Gokcen / Senol Deniz, F. Sezer / Onkol, Tijen / Orhan, Ilkay Erdogan et al. | 2019
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Biscoumarin-1,2,3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro α-glucosidase inhibition, kinetic, and docking studiesAsgari, Mohammad Sadegh / Mohammadi-Khanaposhtani, Maryam / Kiani, Mitra / Ranjbar, Parviz Rashidi / Zabihi, Ebrahim / Pourbagher, Roghayeh / Rahimi, Rahmatollah / Faramarzi, Mohammad Ali / Biglar, Mahmood / Larijani, Bagher et al. | 2019
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Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agentsLi, Zheng / Hu, Lijun / Wang, Xuekun / Zhou, Zongtao / Deng, Liming / Xu, Yawen / Zhang, Luyong et al. | 2019
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Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screeningYang, Hongyu / Du, Chenxi / Li, Qihang / Chen, Tingkai / Lu, Xin / Li, Qi / Feng, Feng / Chen, Yao / Liu, Wenyuan / Sun, Haopeng et al. | 2019
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Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentialsTaslimi, Parham / Türkan, Fikret / Cetin, Adnan / Burhan, Hakan / Karaman, Muhammet / Bildirici, Ishak / Gulçin, İlhami / Şen, Fatih et al. | 2019
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Effects of Picrasma quassioides and its active constituents on Alzheimer's disease in vitro and in vivoGuo, Eryan / Hu, Yunwei / Du, Tao / Zhu, Huilin / Chen, Lei / Qu, Wei / Zhang, Jie / Xie, Ning / Liu, Wenyuan / Feng, Feng et al. | 2019
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A novel adaptive fluorescent probe for cell labellingComan, Anca G. / Paun, Anca / Popescu, Codruta C. / Hădade, Niculina D. / Hanganu, Anamaria / Chiritoiu, Gabriela / Farcasanu, Ileana C. / Matache, Mihaela et al. | 2019
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NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorumAn, Lijun / Liang, Yue / Yang, Xueyuan / Wang, Huimei / Zhang, Jie / Tuerhong, Muhetaer / Li, Dihua / Wang, Chunyan / Lee, Dongho / Xu, Jing et al. | 2019
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Synthesis and investigation of inhibitory activities of imidazole derivatives against the metallo-β-lactamase IMP-1Khalili Arjomandi, Omid / Kavoosi, Mahboubeh / Adibi, Hadi et al. | 2019
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New pyrimidine-benzoxazole/benzimidazole hybrids: Synthesis, antioxidant, cytotoxic activity, in vitro cyclooxygenase and phospholipase A2-V inhibitionAbdelgawad, Mohamed A. / Bakr, Rania B. / Ahmad, Waqas / Al-Sanea, Mohammad M. / Elshemy, Heba A.H. et al. | 2019
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Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationshipsPetrova, Yoana D. / Wadda, Katty / Nathubhai, Amit / Yevglevskis, Maksims / Mitchell, Paul J. / James, Tony D. / Threadgill, Michael D. / Woodman, Timothy J. / Lloyd, Matthew D. et al. | 2019
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Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogsAhmad, Gulraiz / Rasool, Nasir / Rizwan, Komal / Imran, Imran / Zahoor, Ameer Fawad / Zubair, Muhammad / Sadiq, Abdul / Rashid, Umer et al. | 2019
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Tyrosinase inhibitory effects of Vinca major and its secondary metabolites: Enzyme kinetics and in silico inhibition model of the metabolites validated by pharmacophore modellingSari, Suat / Barut, Burak / Özel, Arzu / Şöhretoğlu, Didem et al. | 2019
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Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longaQiao, Ming-Ming / Liu, Fei / Liu, Yu / Guo, Li / Zhou, Qin-Mei / Peng, Cheng / Xiong, Liang et al. | 2019
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Antiprotozoal activities of marine polyether triterpenoidsDíaz-Marrero, Ana R. / López-Arencibia, Atteneri / Bethencout-Estrella, Carlos J. / Cen-Pacheco, Francisco / Sifaoui, Ines / Hernández Creus, Alberto / Duque-Ramírez, María Clara / Souto, María L. / Hernández Daranas, Antonio / Lorenzo-Morales, Jacob et al. | 2019
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Corrigendum to “Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction” [Bioorg. Chem. 89 (2019) 103022]Reddy, G. Lakshma / Dar, Mohd. Ishaq / Hudwekar, Abhinandan D. / Mahajan, Priya / Nargotra, Amit / Baba, Adil Manzoor / Nandi, Utpal / Wazir, Priya / Singh, Gurdarshan / Bharate, Sonali S. et al. | 2019
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Design, synthesis and biological evaluation of theophylline containing variant acetylene derivatives as α-amylase inhibitorsRuddarraju, Radhakrishnam Raju / Kiran, Gangarapu / Murugulla, Adharvana Chari / Maroju, Ravichandar / Prasad, Devarakonda Krishna / Kumar, Boyina Hemanth / Bakshi, Vasudha / Reddy, Nukala Shravya et al. | 2019
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Chemical constituents from Alismatis Rhizoma and their anti-inflammatory activities in vitro and in vivoLiu, Shan-shan / Sheng, Wen-long / Li, Yun / Zhang, Shan-shan / Zhu, Jing-jing / Gao, Hui-min / Yan, Li-hua / Wang, Zhi-min / Gao, Lu / Zhang, Mei et al. | 2019
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Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agentsBayrak, Nilüfer / Yıldırım, Hatice / Yıldız, Mahmut / Radwan, Mohamed O. / Otsuka, Masami / Fujita, Mikako / Tuyun, Amaç Fatih / Ciftci, Halil I. et al. | 2019
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The modulating effect of lipid bilayer/p-coumaric acid interactions on electrical properties of model lipid membranes and human glioblastoma cellsNaumowicz, Monika / Kusaczuk, Magdalena / Kruszewski, Marcin Andrzej / Gál, Miroslav / Krętowski, Rafał / Cechowska-Pasko, Marzanna / Kotyńska, Joanna et al. | 2019
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Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of actionGouda, Ahmed M. / Beshr, Eman A. / Almalki, Faisal A. / Halawah, Hadeel H. / Taj, Batool Fawzi / Alnafaei, Athir Faiz / Alharazi, Rahaf Sulaiman / Kazi, Weam Mahmood / AlMatrafi, Malak M. et al. | 2019
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Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalisLiu, Na / Wu, Cong / Yu, Jin-hai / Zhu, Kong-kai / Song, Mei-na / Yang, Feng-ying / Feng, Run-liang / Zhang, Yu-ying / Chang, Wen-qiang / Zhang, Hua et al. | 2019
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Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2Manjula, Ramu / Gokhale, Nikhila / Unni, Sruthi / Deshmukh, Prashant / Reddyrajula, Rajkumar / Srinivas Bharath, M.M. / Dalimba, Udayakumar / Padmanabhan, Balasundaram et al. | 2019
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Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activitiesYang, Fang / Yu, Liang-Zhentian / Diao, Peng-Cheng / Jian, Xie-Er / Zhou, Ming-Feng / Jiang, Cui-Shan / You, Wen-Wei / Ma, Wei-Feng / Zhao, Pei-Liang et al. | 2019
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Disulfide bridge as a linker in nucleic acids’ bioconjugation. Part I: An overview of synthetic strategiesStasińska, Anna R. / Putaj, Piotr / Chmielewski, Marcin K. et al. | 2019
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Synthesis and comparative carbonic anhydrase inhibition of new Schiff’s bases incorporating benzenesulfonamide, methanesulfonamide, and methylsulfonylbenzene scaffoldsEl-Azab, Adel S. / Abdel-Aziz, Alaa A.-M. / Bua, Silvia / Nocentini, Alessio / Alanazi, Mohammed M. / AlSaif, Nawaf A. / Al-Suwaidan, Ibrahim A. / Hefnawy, Mohamed M. / Supuran, Claudiu T. et al. | 2019
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Novel inhibitors of leukocyte transendothelial migrationGetter, Tamar / Margalit, Raanan / Kahremany, Shirin / Levy, Laura / Blum, Eliav / Khazanov, Netaly / Keshet-Levy, Nimrod Y. / Tamir, Tigist Y. / Ben Major, M. / Lahav, Ron et al. | 2019
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Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studiesDige, Nilam C. / Mahajan, Prasad G. / Raza, Hussain / Hassan, Mubashir / Vanjare, Balasaheb D. / Hong, Hansol / Hwan Lee, Ki / latip, Jalifah / Seo, Sung-Yum et al. | 2019
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Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminaseYang, Kai-Yin / Wu, Can-Rong / Zheng, Meng-Zhu / Tang, Ruo-Tian / Li, Xing-Zhou / Chen, Li-Xia / Li, Hua et al. | 2019
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Identification of potential inflammatory inhibitors from Aster tataricusSu, Xiang Dong / Jang, Hyun-Jae / Li, Hong Xu / Kim, Young Ho / Yang, Seo Young et al. | 2019
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Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugsZhang, Jiyun / Wen, Hongmei / Shen, Fei / Wang, Xinzhi / Shan, Chenxiao / Chai, Chuan / Liu, Jian / Li, Wei et al. | 2019
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Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of UreaseAlomari, Munther / Taha, Muhammad / Imran, Syahrul / Jamil, Waqas / Selvaraj, Manikandan / Uddin, Nizam / Rahim, Fazal et al. | 2019
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New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking studyRahim, Fazal / Tariq, Sundas / Taha, Muhammad / Ullah, Hayat / Zaman, Khalid / Uddin, Imad / Wadood, Abdul / Khan, Aftab Ahmad / Rehman, Ashfaq Ur / Uddin, Nizam et al. | 2019
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Variedly connected 1,8-naphthalimide-7-chloroquinoline conjugates: Synthesis, anti-mycobacterial and cytotoxic evaluationShalini / Johansen, Matt D. / Kremer, Laurent / Kumar, Vipan et al. | 2019
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Recent advances in the synthetic and medicinal perspective of quinolones: A reviewDhiman, Prashant / Arora, Nidhi / Thanikachalam, Punniyakoti Veeraveedu / Monga, Vikramdeep et al. | 2019
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Anti-cancer activity of the cell membrane-permeable phytic acid prodrugMasunaga, Takuya / Murao, Naoki / Tateishi, Hiroshi / Koga, Ryoko / Ohsugi, Takeo / Otsuka, Masami / Fujita, Mikako et al. | 2019
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Chemical constituents from Lonicera japonica flower buds and their anti-hepatoma and anti-HBV activitiesGe, Lanlan / Xiao, Lingyun / Wan, Haoqiang / Li, Jiemei / Lv, Kongpeng / Peng, Shusong / Zhou, Boping / Li, Tiyuan / Zeng, Xiaobin et al. | 2019
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First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agentsOkasha, Rawda M. / Alsehli, Mosa / Ihmaid, Saleh / Althagfan, Sultan S. / El-Gaby, Mohamed S.A. / Ahmed, Hany E.A. / Afifi, Tarek H. et al. | 2019
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Issue TOC| 2019
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Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agentsYevglevskis, Maksims / Nathubhai, Amit / Wadda, Katty / Lee, Guat L. / Al-Rawi, Suzanne / Jiao, Tingying / Mitchell, Paul J. / James, Tony D. / Threadgill, Michael D. / Woodman, Timothy J. et al. | 2019
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Novel 3,4-dihydro-4-oxoquinazoline-based acetohydrazides: Design, synthesis and evaluation of antitumor cytotoxicity and caspase activation activityHuan, Le Cong / Tran, Phuong-Thao / Phuong, Cao Viet / Duc, Phan Huy / Anh, Duong Tien / Hai, Pham The / Huong, Le Thi Thu / Thuan, Nguyen Thi / Lee, Hye Jin / Park, Eun Jae et al. | 2019
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Xanthones from the stems of Cudrania tricuspidata and their inhibitory effects on pancreatic lipase and fat accumulationJo, Yang Hee / Kim, Seon Beom / Ahn, Jong Hoon / Turk, Ayman / Kwon, Eun-Bin / Kim, Mun-Ock / Hwang, Bang Yeon / Lee, Mi Kyeong et al. | 2019
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Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1BOttanà, Rosaria / Paoli, Paolo / Lori, Giulia / Adornato, Ilenia / Previti, Santo / Naß, Alexandra / Wolber, Gerhard / Maccari, Rosanna et al. | 2019
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Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cellsThongnest, Sanit / Chawengrum, Pornsuda / Keeratichamroen, Siriporn / Lirdprapamongkol, Kriengsak / Eurtivong, Chatchakorn / Boonsombat, Jutatip / Kittakoop, Prasat / Svasti, Jisnuson / Ruchirawat, Somsak et al. | 2019
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Geranylated carbazole alkaloids with potential neuroprotective activities from the stems and leaves of Clausena lansiumLiu, Yan-Ping / Guo, Jia-Ming / Wang, Xiao-Ping / Liu, Yun-Yao / Zhang, Wei / Wang, Ting / Qiang, Lei / Fu, Yan-Hui et al. | 2019
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Synthesis of d-desthiobiotin-AI-2 as a novel chemical probe for autoinducer-2 quorum sensing receptorsMiranda, Vanessa / Torcato, Inês M. / Xavier, Karina B. / Ventura, M. Rita et al. | 2019
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2-Styrylchromone derivatives as potent and selective monoamine oxidase B inhibitorsTakao, Koichi / Endo, Saki / Nagai, Junko / Kamauchi, Hitoshi / Takemura, Yuri / Uesawa, Yoshihiro / Sugita, Yoshiaki et al. | 2019
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Synthesis and investigation of polyhydroxylated pyrrolidine derivatives as novel chemotypes showing dual activity as glucosidase and aldose reductase inhibitorsGuazzelli, Lorenzo / D'Andrea, Felicia / Sartini, Stefania / Giorgelli, Francesco / Confini, Gianluca / Quattrini, Luca / Piano, Ilaria / Nencetti, Susanna / Orlandini, Elisabetta / Gargini, Claudia et al. | 2019
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Molecular interaction of manganese based carbon monoxide releasing molecule (MnCORM) with human serum albumin (HSA)Vidhyapriya, Pitchavel / Divya, Dhanaraj / Manimaran, Bala. / Sakthivel, Natarajan et al. | 2019
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The role of long noncoding RNA in major human diseaseZhang, Xiaoli / Hong, Ruiyun / Chen, Weiqiang / Xu, Minwen / Wang, Liefeng et al. | 2019
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Design, synthesis and biological evaluation of some tetrazole acetamide derivatives as novel non-carboxylic PTP1B inhibitorsMaheshwari, Neelesh / Karthikeyan, Chandrabose / Bhadada, Shraddha V. / Verma, Amit K. / Sahi, Chandan / Moorthy, N.S. Hari Narayana / Trivedi, Piyush et al. | 2019
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Targeted 8-hydroxyquinoline fragment based small molecule drug discovery against neglected botulinum neurotoxin type FChauhan, Ritika / Chauhan, Vinita / Sonkar, Priyanka / Vimal, Manorama / Dhaked, Ram Kumar et al. | 2019
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Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosisFu, Dong-Jun / Li, Miaomiao / Zhang, Sai-Yang / Li, Jiang-Feng / Sha, Beibei / Wang, Longhao / Zhang, Yan-Bing / Chen, Ping / Hu, Tao et al. | 2019
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Triazolopyridazine derivatives: Synthesis, cytotoxic evaluation, c-Met kinase activity and molecular dockingAhmed, Eman M. / Khalil, Nadia A. / Taher, Azza T. / Refaey, Rana H. / Nissan, Yassin M. et al. | 2019
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New carboxamides bearing benzenesulphonamides: Synthesis, molecular docking and pharmacological propertiesEze, Florence Uchenna / Okoro, Uchechukwu Chris / Ugwu, David Izuchukwu / Okafor, Sunday N. et al. | 2019
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Rational design of some substituted phenyl azanediyl (bis) methylene phosphonic acid derivatives as potential anticancer agents and imaging probes: Computational inputs, chemical synthesis, radiolabeling, biodistribution and gamma scintigraphyKhedr, Mohammed A. / Rashed, Hassan M. / Farag, Hamed / Sakr, Tamer M. et al. | 2019
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Discovery of 2-ethoxy-4-(methoxymethyl)benzamide derivatives as potent and selective PTP1B inhibitorsXie, Fangzhou / Liang, Yaoyao / Xia, Yu / Luo, Shuhua / Jiang, Faqin / Fu, Lei et al. | 2019
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Design, synthesis and molecular docking of novel pyrazolo[1,5-a][1,3,5]triazine derivatives as CDK2 inhibitorsOudah, Khulood H. / Najm, Mazin A.A. / Samir, Nermin / Serya, Rabah A.T. / Abouzid, Khaled A.M et al. | 2019
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Chemical constituents and synergistic anti-gout studies on Eurycoma longifolia and potential mechanisms evaluation based on systemic analysis approachLiu, Ying / Lai, Lantao / Ju, Yan / Liu, Caihong / Meng, Dali et al. | 2019
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Dihydro-β-agarofuran sesquiterpenoid derivatives with anti-inflammatory activity from the leaves of Tripterygium wilfordiiHe, Qing-Jun / Zhou, Le / Lu, Li-Wei / Zhao, Feng / Huang, Xiao-Xiao / Lin, Bin / Song, Shao-Jiang et al. | 2019
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Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulationElkamhawy, Ahmed / youn Kim, Nam / Hassan, Ahmed H.E. / Park, Jung-eun / Yang, Jeong-Eun / Elsherbeny, Mohamed H. / Paik, Sora / Oh, Kwang-Seok / Lee, Byung Ho / Lee, Mi Young et al. | 2019
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Synthesis, structural characterization and in vivo anti-diabetic evaluation of some new sulfonylurea derivatives in normal and silicate coated nanoparticle forms as anti-hyperglycemic agentsSroor, Farid M. / Abbas, Samir Y. / Basyouni, Wahid M. / El-Bayouki, Khairy A.M. / El-Mansy, Mohamed F. / Aly, Hanan F. / Ali, Sanaa A. / Arafa, Azza F. / Haroun, Ahmed A. et al. | 2019
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New A2A adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavityLambertucci, Catia / Spinaci, Andrea / Buccioni, Michela / Dal Ben, Diego / Ngouadjeu Ngnintedem, Michael Alliance / Kachler, Sonja / Marucci, Gabriella / Klotz, Karl-Norbert / Volpini, Rosaria et al. | 2019
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The application of safe for humans and the environment Polyversum antifungal agent containing living cells of Pythium oligandrum for biotransformation of prochiral ketonesKołodziejska, Renata / Studzińska, Renata / Tafelska-Kaczmarek, Agnieszka / Pawluk, Hanna / Kwit, Marcin / Stasiak, Bartosz / Woźniak, Alina et al. | 2019
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Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agentsZabiulla / Gulnaz, A.R. / Mohammed, Yasser Hussein Eissa / Khanum, Shaukath Ara et al. | 2019
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Synthesis of Mitomycin C and decarbamoylmitomycin C N 6 deoxyadenosine-adductsZheng, Maggie / Hwang, Seokjin / Snyder, Timothy / Aquilina, Jake / Proni, Gloria / Paz, Manuel M. / Pradhan, Padmanava / Cheng, Shu-Yuan / Champeil, Elise et al. | 2019
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Immunomodulatory activities of zinc(II)phthalocyanine on the mammalian macrophages through p38 pathway: Potential ex vivo immunomodulatory PDT reagentsYüzer, Abdulcelil / Ayaz, Furkan / Ince, Mine et al. | 2019
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Coumarin tethered cyclic imides as efficacious glucose uptake agents and investigation of hit candidate to probe its binding mechanism with human serum albuminReddy, Dinesh S. / Kongot, Manasa / Singh, Vishal / Maurya, Neha / Patel, Rajan / Kumar Singhal, Nitin / Avecilla, Fernando / Kumar, Amit et al. | 2019
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Synthesis and biological evaluation of thiazolidine-2,4-dione-pyrazole conjugates as antidiabetic, anti-inflammatory and antioxidant agentsBansal, Garima / Singh, Shamsher / Monga, Vikramdeep / Thanikachalam, Punniyakoti Veeraveedu / Chawla, Pooja et al. | 2019
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Design, synthesis, and molecular docking study of new piperazine derivative as potential antimicrobial agentsPatil, Mahadev / Noonikara Poyil, Anurag / Joshi, Shrinivas D. / Patil, Shivaputra A. / Patil, Siddappa A. / Bugarin, Alejandro et al. | 2019
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Spirocyclic sulfonamides with carbonic anhydrase inhibitory and anti-neuropathic pain activityKalisha Vali, Y. / Gundla, Rambabu / Singh, Om V. / Tamboli, Yasinalli / Di Cesare Manelli, Lorenzo / Ghelardini, Carla / Al-Tamimi, Abdul-Malek S. / Carta, Fabrizio / Angeli, Andrea / Supuran, Claudiu T. et al. | 2019
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Biflavones from Ginkgo biloba as inhibitors of human thrombinChen, Tian-Ran / Wei, Ling-Hua / Guan, Xiao-Qing / Huang, Chao / Liu, Zhe-Yi / Wang, Fang-Jun / Hou, Jie / Jin, Qiang / Liu, Yi-Fan / Wen, Pei-Hao et al. | 2019
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Bioactivity-based analysis and chemical characterization of hypoglycemic and antioxidant components from Artemisia argyiXiao, Jian-Qi / Liu, Wen-Yuan / Sun, Hao-peng / Li, Wei / Koike, Kazuo / Kikuchi, Takashi / Yamada, Takeshi / Li, Da / Feng, Feng / Zhang, Jie et al. | 2019
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Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffoldLi, Zheng / Ren, Qiang / Wang, Xuekun / Zhou, Zongtao / Hu, Lijun / Deng, Liming / Guan, Li / Qiu, Qianqian et al. | 2019
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Exploring antidiabetic potential of adamantyl-thiosemicarbazones via aldose reductase (ALR2) inhibitionShehzad, Muhammad Tariq / Hameed, Abdul / al-Rashida, Mariya / Imran, Aqeel / Uroos, Maliha / Asari, Asnuzilawati / Mohamad, Habsah / Islam, Muhammad / Iftikhar, Shafia / Shafiq, Zahid et al. | 2019
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Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design, synthesis and biological evaluationRizk, Ola H. / Teleb, Mohamed / Abu-Serie, Marwa M. / Shaaban, Omaima G. et al. | 2019
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Editorial Board| 2019
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Novel conjugates with dual suppression of glutathione S-transferases and tryptophan-2,3-dioxygenase activities for improving hepatocellular carcinoma therapyHua, Shixian / Wang, Xinyi / Chen, Feihong / Gou, Shaohua et al. | 2019
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Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agentsZhang, Ya-Liang / Yang, Rong / Xia, Lin-Ying / Man, Ruo-Jun / Chu, Yi-Chun / Jiang, Ai-Qin / Wang, Zhong-Chang / Zhu, Hai-Liang et al. | 2019
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New cytotoxic tricycloalternarenes from fungus Alternaria brassicicolaLi, Fengli / Tang, Ying / Sun, Weiguang / Guan, Jiankun / Lu, Yuanyuan / Zhang, Sitian / Lin, Shuang / Wang, Jianping / Hu, Zhengxi / Zhang, Yonghui et al. | 2019
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Anti-inflammatory flavonoids from root bark of Broussonetia papyrifera in LPS-stimulated RAW264.7 cellsRyu, Hyung Won / Park, Mi Hyeon / Kwon, Ok-Kyoung / Kim, Doo-Young / Hwang, Jung-Yeon / Jo, Yang Hee / Ahn, Kyung-Seop / Hwang, Bang Yeon / Oh, Sei-Ryang et al. | 2019
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Design and synthesis of novel pyridazinoquinazoline derivatives as potent VEGFR-2 inhibitors: In vitro and in vivo studyEl-Gazzar, Marwa G. / El-Hazek, Rania M. / Zaher, Nashwa H. / El-Ghazaly, Mona A. et al. | 2019
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Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidβ aggregation, and lipid peroxidationSeong, Su Hui / Ali, Md Yousof / Jung, Hyun Ah / Choi, Jae Sue et al. | 2019
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Synthesis and biological evaluation of tetrazole derivatives as TNF-α, IL-6 and COX-2 inhibitors with antimicrobial activity: Computational analysis, molecular modeling study and region-specific cyclization using 2D NMR toolsLamie, Phoebe F. / Azmey, Ahmed F. et al. | 2019
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Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitorsHu, Shengquan / Zhao, Zhichang / Yan, Hong et al. | 2019
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Synthesis, biological evaluation and molecular docking analysis of novel benzopyrimidinone derivatives as potential anti-tyrosinase agentsChortani, Sarra / Nimbarte, Vijaykumar D. / Horchani, Mabrouk / Ben Jannet, Hichem / Romdhane, Anis et al. | 2019
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Discovery of certain benzyl/phenethyl thiazolidinone-indole hybrids as potential anti-proliferative agents: Synthesis, molecular modeling and tubulin polymerization inhibition studySigalapalli, Dilep Kumar / Pooladanda, Venkatesh / Singh, Priti / Kadagathur, Manasa / Guggilapu, Sravanthi Devi / Uppu, Jaya Lakshmi / Tangellamudi, Neelima D. / Gangireddy, Pavan Kumar / Godugu, Chandraiah / Bathini, Nagendra Babu et al. | 2019
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Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitorsYamali, Cem / Gul, Halise Inci / Ece, Abdulilah / Bua, Silvia / Angeli, Andrea / Sakagami, Hiroshi / Sahin, Ertan / Supuran, Claudiu T. et al. | 2019
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Design and synthesis of fluorogenic substrate-based probes for detecting Cathepsin B activityWang, Shusheng / Vigliarolo, Brady G. / Chowdhury, Morshed A. / Nyarko, Jennifer N.K. / Mousseau, Darrell D. / Phenix, Christopher P. et al. | 2019
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Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteinsQiu, Yangyi / Chan, Shu Ting / Lin, Lin / Shek, Tsun Lam / Tsang, Tsz Fung / Zhang, Yufeng / Ip, Margaret / Chan, Paul Kay-sheung / Blanchard, Nicolas / Hanquet, Gilles et al. | 2019
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Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistanceHuang, Xiaochao / Wang, Meng / Wang, Chungu / Hu, Weiwei / You, Qinghong / Yang, Yong / Yu, Chunhao / Liao, Zhixin / Gou, Shaohua / Wang, Hengshan et al. | 2019
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Design, synthesis and antifungal activity evaluation of isocryptolepine derivativesLi, Jun-cai / Wang, Ren-xuan / Sun, Yu / Zhu, Jia-kai / Hu, Guan-fang / Wang, Yu-ling / Zhou, Rui / Zhao, Zhong-min / Liu, Ying-qian / Peng, Jing-wen et al. | 2019
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New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activitiesEl-Gohary, N.S. / Hawas, S.S. / Gabr, M.T. / Shaaban, M.I. / El-Ashmawy, M.B. et al. | 2019
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Novel N-benzylpyridinium moiety linked to arylisoxazole derivatives as selective butyrylcholinesterase inhibitors: Synthesis, biological evaluation, and docking studyVafadarnejad, Fahimeh / Karimpour-Razkenari, Elahe / Sameem, Bilqees / Saeedi, Mina / Firuzi, Omidreza / Edraki, Najmeh / Mahdavi, Mohammad / Akbarzadeh, Tahmineh et al. | 2019
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Synthesis, biological activity and molecular modeling of a new series of condensed 1,2,4-triazolesEl Bakri, Youness / Marmouzi, Ilias / El Jemli, Meryem / Anouar, El Hassane / Karthikeyan, Subramani / Harmaoui, Abdallah / Faouzi, My El Abbes / Mague, Joel T. / Essassi, El Mokhtar et al. | 2019
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Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3KαYin, Yong / Zhou, Yang / Sha, Shao / Wu, Xun / Wang, She-Feng / Qiao, Fang / Song, Zhong-Cheng / Zhu, Hai-Liang et al. | 2019
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Juniperanol: First total synthesis and evaluation in Type 2 Diabetes diseaseCarrër, A. / Turban, S. / Provost, N. / Caliez, A. / Lamarche, G. / Zanirato, G. / Beucher, M. / Pean, C. / Mirguet, O. / Perron-Sierra, F. et al. | 2019