1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate (English)
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In:
Bioorganic and Medicinal Chemistry Letters
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25
, 4
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976-981
;
2014
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ISSN:
- Article (Journal) / Electronic Resource
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Title:1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate
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Contributors:Bond, Silas ( author ) / Draffan, Alistair G. ( author ) / Fenner, Jennifer E. ( author ) / Lambert, John ( author ) / Lim, Chin Yu ( author ) / Lin, Bo ( author ) / Luttick, Angela ( author ) / Mitchell, Jeffrey P. ( author ) / Morton, Craig J. ( author ) / Nearn, Roland H. ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 25, 4 ; 976-981
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2014-11-06
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Size:6 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 25, Issue 4
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 733
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Graphical contents list| 2015
- 745
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Synthesis and transmembrane anion/cation symport activity of a rigid bis(choloyl) conjugate functionalized with guanidino groupsDeng, Li-Qun / Li, Zhi / Lu, Yong-Ming / Chen, Jin-Xiang / Zhou, Chun-Qiong / Wang, Bo / Chen, Wen-Hua et al. | 2015
- 749
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Synthesis of oolongtheanins and their inhibitory activity on micellar cholesterol solubility in vitroOgawa, Kazuki / Hirose, Sayumi / Yamamoto, Hitomi / Shimada, Masaya / Nagaoka, Satoshi / Yanase, Emiko et al. | 2015
- 753
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Synthesis and photophysical characterization of quasi push–pull dicyanodibenzodioxins and their anti-tumor activity against glioma cell line C6Banerjee, Subhadeep / Chattopadhyay, Anjan / Banerjee, Arnab / Haridas, Meera / Saini, Praveen / Das, Moitreyi / Majik, Mahesh S. / Maurya, Yogesh Kr. et al. | 2015
- 758
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Computer-aided identification of novel anticancer compounds with a possible dual HER1/HER2 inhibition mechanismElseginy, Samia A. / Lazaro, Glorianne / Nawwar, Galal A.M. / Amin, Kamilia M. / Hiscox, Stephen / Brancale, Andrea et al. | 2014
- 763
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Thiol-derivatized minihepcidins retain biological activityFung, Eileen / Chua, Kristine / Ganz, Tomas / Nemeth, Elizabeta / Ruchala, Piotr et al. | 2014
- 767
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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s diseaseChen, Jian Jeffrey / Liu, Qingyian / Yuan, Chester / Gore, Vijay / Lopez, Patricia / Ma, Vu / Amegadzie, Albert / Qian, Wenyuan / Judd, Ted C. / Minatti, Ana E. et al. | 2014
- 775
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Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitorsWu, Bin / Wang, Hui-Ling / Cee, Victor J. / Lanman, Brian A. / Nixey, Thomas / Pettus, Liping / Reed, Anthony B. / Wurz, Ryan P. / Guerrero, Nadia / Sastri, Christine et al. | 2014
- 781
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6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4BChen, Guangming / Ren, Hongyu / Zhang, Nanjing / Lennox, William / Turpoff, Anthony / Paget, Steven / Li, Chunshi / Almstead, Neil / Njoroge, F. George / Gu, Zhengxian et al. | 2014
- 787
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Structure–activity relationships of diverse ACGs against multidrug resistant human lung cancer cell line A549/TaxolYuan, Fei / Bai, Ganggang / Chen, Yong / Miao, Yunjie / Chen, Jianwei / Li, Xiang et al. | 2014
- 791
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Design of novel CSA analogues as potential safeners and fungicidesZheng, Yang / Liu, Bin / Gou, Zhaopin / Li, Yao / Zhang, Xiao / Wang, Yanqing / Yu, Shujing / Li, Yonghong / Sun, Dequn et al. | 2014
- 795
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Multidrug resistance–reversal effects of resin glycosides from Dichondra repensSong, Wei-bin / Wang, Wen-qiong / Zhang, Shu-wei / Xuan, Li-jiang et al. | 2014
- 799
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Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogsJeong, Hye-Jin / Lee, Chang Seok / Choi, Janggyoo / Hong, Yong Deog / Shin, Song Seok / Park, Jun Seong / Lee, John Hwan / Lee, Seokyong / Yoon, Kee Dong / Ko, Jaeyoung et al. | 2014
- 803
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6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonistsSun, Wei / Kim, Hyo-Shin / Lee, Sunho / Jung, Aeran / Kim, Sung-Eun / Ann, Jihyae / Yoon, Suyoung / Choi, Sun / Lee, Jin Hee / Blumberg, Peter M. et al. | 2014
- 807
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Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of ADDigiacomo, Maria / Chen, Ziwei / Wang, Shengnan / Lapucci, Annalina / Macchia, Marco / Yang, Xiaohong / Chu, Jiaqi / Han, Yifan / Pi, Rongbiao / Rapposelli, Simona et al. | 2014
- 811
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Evaluation of synthetic naphthalene derivatives as novel chemical chaperones that mimic 4-phenylbutyric acidMimori, Seisuke / Koshikawa, Yukari / Mashima, Yu / Mitsunaga, Katsuyoshi / Kawada, Koichi / Kaneko, Masayuki / Okuma, Yasunobu / Nomura, Yasuyuki / Murakami, Yasuoki / Kanzaki, Tetsuto et al. | 2014
- 815
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Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cellsIwata, Rintaro / Nakayama, Futoshi / Hirochi, Sakie / Sato, Kazuki / Piao, Wenying / Nishina, Kazutaka / Yokota, Takanori / Wada, Takeshi et al. | 2014
- 820
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Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting the β2 adrenoceptorSoriano-Ursúa, Marvin A. / Arias-Montaño, José A. / Correa-Basurto, José / Hernández-Martínez, Christian F. / López-Cabrera, Yessica / Castillo-Hernández, Maria C. / Padilla-Martínez, Itzia I. / Trujillo-Ferrara, José G. et al. | 2014
- 826
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Synthesis and membrane-protective activity of novel derivatives of α-mangostin at the C-4 positionBuravlev, Evgeny V. / Shevchenko, Oksana G. / Kutchin, Aleksandr V. et al. | 2014
- 830
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Iminosugars as a new class of cholinesterase inhibitorsDecroocq, Camille / Stauffert, Fabien / Pamlard, Olivier / Oulaïdi, Farah / Gallienne, Estelle / Martin, Olivier R. / Guillou, Catherine / Compain, Philippe et al. | 2014
- 834
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The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitorsWang, Hui-Ling / Cee, Victor J. / Chavez, Frank Jr. / Lanman, Brian A. / Reed, Anthony B. / Wu, Bin / Guerrero, Nadia / Lipford, J. Russell / Sastri, Christine / Winston, Jeff et al. | 2014
- 841
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SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer’s diseaseFlesch, Daniel / Ness, Julia / Lamers, Christina / Dehm, Friederike / Popella, Sven / Steri, Ramona / Ogorek, Isabella / Hieke, Martina / Dannhardt, Gerd / Werz, Oliver et al. | 2014
- 847
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The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitorsWurz, Ryan P. / Pettus, Liping H. / Jackson, Claire / Wu, Bin / Wang, Hui-Ling / Herberich, Brad / Cee, Victor / Lanman, Brian A. / Reed, Anthony B. / Chavez, Frank Jr. et al. | 2014
- 856
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The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and BakQian, Wei / Salamoun, Joseph / Wang, Jingnan / Roginskaya, Vera / Van Houten, Bennett / Wipf, Peter et al. | 2014
- 864
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The cryptophycins as potent payloads for antibody drug conjugatesVerma, Vishal A. / Pillow, Thomas H. / DePalatis, Laura / Li, Guangmin / Phillips, Gail Lewis / Polson, Andrew G. / Raab, Helga E. / Spencer, Susan / Zheng, Bing et al. | 2014
- 869
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Prodrugs of imidazotriazine and pyrrolotriazine C-nucleosides can increase anti-HCV activity and enhance nucleotide triphosphate concentrations in vitroTyndall, Edward M. / Draffan, Alistair G. / Frey, Barbara / Pool, Brett / Halim, Rosliana / Jahangiri, Saba / Bond, Silas / Wirth, Veronika / Luttick, Angela / Tilmanis, Danielle et al. | 2014
- 874
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Biofilm inhibition of linezolid-like Schiff bases: Synthesis, biological activity, molecular docking and in silico ADME predictionSangshetti, Jaiprakash N. / Khan, Firoz A. Kalam / Patil, Rajendra H. / Marathe, Sayali D. / Gade, Wasudev N. / Shinde, Devanand B. et al. | 2014
- 881
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Dithiocarbamate–thiourea hybrids useful as vaginal microbicides also show reverse transcriptase inhibition: Design, synthesis, docking and pharmacokinetic studiesBala, Veenu / Jangir, Santosh / Mandalapu, Dhanaraju / Gupta, Sonal / Chhonker, Yashpal S. / Lal, Nand / Kushwaha, Bhavana / Chandasana, Hardik / Krishna, Shagun / Rawat, Kavita et al. | 2014
- 887
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Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonistsSasmal, Pradip K. / Krishna, C. Vamsee / Adabala, S. Sudheerkumar / Roshaiah, M. / Rawoof, Khaji Abdul / Thadi, Emima / Sukumar, K. Pavan / Cheera, Srisailam / Abbineni, Chandrasekhar / Rao, K.V.L. Narasimha et al. | 2014
- 893
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Novel synthetic coumarins that targets NF-κB in Hepatocellular carcinomaNeelgundmath, Mahabaleshwaraiah / Dinesh, Koragere Rajashekar / Mohan, Chakrabhavi Dhananjaya / Li, Feng / Dai, Xiaoyun / Siveen, Kodappully Sivaraman / Paricharak, Shardul / Mason, Daniel J. / Fuchs, Julian E. / Sethi, Gautam et al. | 2014
- 898
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Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocyclesDongamanti, Ashok / Aamate, Vikas Kumar / Devulapally, Mohan Gandhi / Gundu, Srinivas / Kotni, Meena Kumari / Manga, Vijjulatha / Balasubramanian, Sridhar / Ernala, Prasad et al. | 2014
- 904
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Two new protein tyrosine phosphatase 1B inhibitors, hyattellactones A and B, from the Indonesian marine sponge Hyattella sp.Abdjul, Delfly B. / Yamazaki, Hiroyuki / Takahashi, Ohgi / Kirikoshi, Ryota / Mangindaan, Remy E.P. / Namikoshi, Michio et al. | 2014
- 908
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Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilinPettersson, Martin / Johnson, Douglas S. / Humphrey, John M. / am Ende, Christopher W. / Evrard, Edelweiss / Efremov, Ivan / Kauffman, Gregory W. / Stepan, Antonia F. / Stiff, Cory M. / Xie, Longfei et al. | 2014
- 914
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A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymeraseGarro, Hugo A. / García, Celina / Martín, Victor S. / Tonn, Carlos E. / Pungitore, Carlos R. et al. | 2014
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Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitorsYang, Hao / Murigi, Francis N. / Wang, Zhijian / Li, Junfeng / Jin, Hongjun / Tu, Zhude et al. | 2014
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- 940
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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1bGiroux, Simon / Bilimoria, Darius / Cadilhac, Caroline / Cottrell, Kevin M. / Denis, Francois / Dietrich, Evelyne / Ewing, Nigel / Henderson, James A. / L’Heureux, Lucille / Mani, Nagraj et al. | 2014
- 944
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Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potencyHenderson, James A. / Bilimoria, Darius / Bubenik, Monica / Cadilhac, Caroline / Cottrell, Kevin M. / Dietrich, Evelyne / Denis, Francois / Ewing, Nigel / Falardeau, Guy / Giroux, Simon et al. | 2014
- 948
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Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic coresHenderson, James A. / Bilimoria, Darius / Bubenik, Monica / Cadilhac, Caroline / Cottrell, Kevin M. / Denis, Francois / Dietrich, Evelyne / Ewing, Nigel / Falardeau, Guy / Giroux, Simon et al. | 2014
- 952
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Synthesis and biological evaluation of adamantane-based aminophenols as a novel class of antiplasmodial agentsChinnapattu, Murugan / Sathiyanarayanan, Kulathu Iyer / Iyer, Pravin S. et al. | 2014
- 956
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- 960
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- 963
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Development of novel Asf1–H3/H4 inhibitorsMiknis, Greg F. / Stevens, Sarah J. / Smith, Luke E. / Ostrov, David A. / Churchill, Mair E.A. et al. | 2014
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The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1Bond, Silas / Draffan, Alistair G. / Fenner, Jennifer E. / Lambert, John / Lim, Chin Yu / Lin, Bo / Luttick, Angela / Mitchell, Jeffrey P. / Morton, Craig J. / Nearn, Roland H. et al. | 2014
- 976
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1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidateBond, Silas / Draffan, Alistair G. / Fenner, Jennifer E. / Lambert, John / Lim, Chin Yu / Lin, Bo / Luttick, Angela / Mitchell, Jeffrey P. / Morton, Craig J. / Nearn, Roland H. et al. | 2014
- IFC
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Editorial board| 2015