Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone (English)
- New search for: Al-Salem, Huda S.A.
- New search for: Hegazy, Gehan H.
- New search for: El-Taher, Kamal E.H.
- New search for: El-Messery, Shahenda M.
- New search for: Al-Obaid, Abdulrahman M.
- New search for: El-Subbagh, Hussein I.
- New search for: Al-Salem, Huda S.A.
- New search for: Hegazy, Gehan H.
- New search for: El-Taher, Kamal E.H.
- New search for: El-Messery, Shahenda M.
- New search for: Al-Obaid, Abdulrahman M.
- New search for: El-Subbagh, Hussein I.
In:
Bioorganic and Medicinal Chemistry Letters
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25
, 7
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1490-1499
;
2015
-
ISSN:
- Article (Journal) / Electronic Resource
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Title:Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone
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Contributors:Al-Salem, Huda S.A. ( author ) / Hegazy, Gehan H. ( author ) / El-Taher, Kamal E.H. ( author ) / El-Messery, Shahenda M. ( author ) / Al-Obaid, Abdulrahman M. ( author ) / El-Subbagh, Hussein I. ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 25, 7 ; 1490-1499
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2015-02-11
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Size:10 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 25, Issue 7
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1357
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Graphical contents list| 2015
- 1373
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Synthesis and antitubercular evaluation of 4-carbonyl piperazine substituted 1,3-benzothiazin-4-one derivativesPeng, Cui-Ting / Gao, Chao / Wang, Ning-Yu / You, Xin-Yu / Zhang, Li-Dan / Zhu, Yong-Xia / Xv, Ying / Zuo, Wei-Qiong / Ran, Kai / Deng, Hong-Xia et al. | 2015
- 1377
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Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonistsBurkholder, Timothy P. / Cunningham, Brian E. / Clayton, Joshua R. / Lander, Peter A. / Brown, Matthew L. / Doti, Robert A. / Durst, Gregory L. / Montrose-Rafizadeh, Chahrzad / King, Constance / Osborne, Harold E. et al. | 2015
- 1381
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Product identification of non-reducing polyketide synthases with C-terminus methyltransferase domain from Talaromyces stipitatus using Aspergillus oryzae heterologous expressionHashimoto, Makoto / Wakana, Daigo / Ueda, Miki / Kobayashi, Daisuke / Goda, Yukihiro / Fujii, Isao et al. | 2015
- 1385
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The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic familiesDe Simone, Giuseppina / Di Fiore, Anna / Capasso, Clemente / Supuran, Claudiu T. et al. | 2015
- 1390
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Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activitiesSeebacher, Werner / Wolkinger, Volker / Faist, Johanna / Kaiser, Marcel / Brun, Reto / Saf, Robert / Bucar, Franz / Gröblacher, Barbara / Brantner, Adelheid / Merino, Virginia et al. | 2015
- 1394
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Streptococcus mutans sortase A inhibitory metabolites from the flowers of Sophora japonicaYang, Woo-Young / Won, Tae Hyung / Ahn, Chan-Hong / Lee, So-Hyoung / Yang, Hyeong-Cheol / Shin, Jongheon / Oh, Ki-Bong et al. | 2015
- 1398
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Synthesis, in vitro anticancer and antimycobacterial evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino derivativesPolkam, Naveen / Rayam, Parsharamulu / Anireddy, Jaya Shree / Yennam, Satyanarayana / Anantaraju, Hasitha Shilpa / Dharmarajan, Sriram / Perumal, Yogeeswari / Kotapalli, Sudha Sravanti / Ummanni, Ramesh / Balasubramanian, Sridhar et al. | 2015
- 1403
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Indirubin 3′-(O-oxiran-2-ylmethyl)oxime: A novel anticancer agentIchimaru, Yoshimi / Saito, Hiroaki / Uchiyama, Taketo / Metori, Koichi / Tabata, Keiichi / Suzuki, Takashi / Miyairi, Shinichi et al. | 2015
- 1407
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Synthesis of a chondroitin sulfate disaccharide library and a GAG-binding protein interaction analysisWakao, Masahiro / Obata, Rumi / Miyachi, Kento / Kaitsubata, Yuhei / Kondo, Takao / Sakami, Chiho / Suda, Yasuo et al. | 2015
- 1412
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Chemical constituents from Kandelia candel with their inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs)Dat, Le Duc / Thao, Nguyen Phuong / Tai, Bui Huu / Luyen, Bui Thi Thuy / Kim, Sohyun / Koo, Jung Eun / Koh, Young Sang / Cuong, Nguyen The / Thanh, Nguyen Van / Cuong, Nguyen Xuan et al. | 2015
- 1417
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An efficient synthesis of [1,3]dioxolo[4,5-g]thieno[3,4-b]quinolin-8(5H)-ones as novel thiazapodophyllotoxin analogues with potential anticancer activityLi, Tuanjie / Lu, Ting / Yu, Chenxia / Yao, Changsheng et al. | 2015
- 1420
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Rapid ‘one-pot’ synthesis of a novel benzimidazole-5-carboxylate and its hydrazone derivatives as potential anti-inflammatory and antimicrobial agentsVasantha, Kumar / Basavarajaswamy, Guru / Vaishali Rai, M. / Boja, Poojary / Pai, Vinitha R. / Shruthi, N. / Bhat, Mahima et al. | 2015
- 1427
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Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligandsModica, Maria N. / Intagliata, Sebastiano / Pittalà, Valeria / Salerno, Loredana / Siracusa, Maria A. / Cagnotto, Alfredo / Salmona, Mario / Romeo, Giuseppe et al. | 2015
- 1427
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Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligandsModica, Maria N et al. | 2015
- 1431
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8-(3-Chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitorsSakamoto, Toshiaki / Koga, Yuichi / Hikota, Masataka / Matsuki, Kenji / Mochida, Hideki / Kikkawa, Kohei / Fujishige, Kotomi / Kotera, Jun / Omori, Kenji / Morimoto, Hiroshi et al. | 2015
- 1436
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Loratadine analogues as MAGL inhibitorsPatel, Jayendra Z. / Ahenkorah, Stephen / Vaara, Miia / Staszewski, Marek / Adams, Yahaya / Laitinen, Tuomo / Navia-Paldanius, Dina / Parkkari, Teija / Savinainen, Juha R. / Walczyński, Krzysztof et al. | 2015
- 1443
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The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disordersBi, Yingzhi / Dzierba, Carolyn D. / Fink, Cynthia / Garcia, Yudith / Green, Michael / Han, Jianxin / Kwon, Soojin / Kumi, Godwin / Liang, Zhi / Liu, Ying et al. | 2015
- 1448
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Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88Dzierba, Carolyn D. / Bi, Yingzhi / Dasgupta, Bireshwar / Hartz, Richard A. / Ahuja, Vijay / Cianchetta, Giovanni / Kumi, Godwin / Dong, Li / Aleem, Saadat / Fink, Cynthia et al. | 2015
- 1453
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Oxidative calcium release from catecholRiley, Patrick A. / Stratford, Michael R.L. et al. | 2015
- 1455
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Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studiesCouturier, Cédric / Silve, Sandra / Morales, Renaud / Pessegue, Bernard / Llopart, Sylvie / Nair, Anil / Bauer, Armin / Scheiper, Bodo / Pöverlein, Christoph / Ganzhorn, Axel et al. | 2015
- 1460
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Tandem DNAzymes for mRNA cleavage: Choice of enzyme, metal ions and the antisense effectWang, Feng / Saran, Runjhun / Liu, Juewen et al. | 2015
- 1464
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3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of α-synuclein in PC12 cellsXue, Danfeng / Wang, Quanxin / Chen, Ziheng / Cai, Lei / Bao, Li / Qi, Qiuyue / Liu, Lei / Wang, Xiaohui / Jin, Haijing / Wang, Jun et al. | 2015
- 1471
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Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitorsHan, Kailin / Li, Yashan / Zhang, Yazhou / Teng, Yuou / Ma, Ying / Wang, Meiyan / Wang, Runling / Xu, Weiren / Yao, Qingwei / Zhang, Yongmin et al. | 2015
- 1476
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Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cellsWu, Yan / Wu, Zheng-Rong / Chen, Peng / Yang-Li / Deng, Wan-Rong / Wang, You-Quan / Li, Hong-Yu et al. | 2015
- 1479
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Discovery of novel S1P2 antagonists. Part 1: Discovery of 1,3-bis(aryloxy)benzene derivativesKusumi, Kensuke / Shinozaki, Koji / Kanaji, Toshiya / Kurata, Haruto / Naganawa, Atsushi / Otsuki, Kazuhiro / Matsushita, Takeshi / Sekiguchi, Tetsuya / Kakuuchi, Akito / Seko, Takuya et al. | 2015
- 1483
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Nine new diterpenes from the leaves of plantation-grown Cunninghamia lanceolataZhao, Shuangshuang / Ling, Junhong / Li, Zhanlin / Wang, Silong / Hu, Jiangchun / Wang, Nan et al. | 2015
- 1490
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Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinoneAl-Salem, Huda S.A. / Hegazy, Gehan H. / El-Taher, Kamal E.H. / El-Messery, Shahenda M. / Al-Obaid, Abdulrahman M. / El-Subbagh, Hussein I. et al. | 2015
- 1500
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Design, synthesis and biological evaluation of GY3-based derivatives for anti-type 2 diabetes activityFan, Lingling / Wang, Jianta / Ma, Xiao / Xiao, Wan / Li, Zhiyan / Zhong, Gang / Tang, Lei / Wu, Haoshu et al. | 2015
- 1506
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A coumarin lignanoid from the stems of Kadsura heteroclitaSu, Wei / Zhao, Jianping / Yang, Min / Yan, Hui-Wen / Pang, Tao / Chen, Sheng-Huang / Huang, Hui-Yong / Zhang, Shui-Han / Ma, Xiao-Chi / Guo, De-An et al. | 2015
- 1509
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Isolation, synthesis and anti-hepatitis B virus evaluation of p-hydroxyacetophenone derivatives from Artemisia capillarisZhao, Yong / Geng, Chang-An / Chen, Hao / Ma, Yun-Bao / Huang, Xiao-Yan / Cao, Tuan-Wu / He, Kang / Wang, Hao / Zhang, Xue-Mei / Chen, Ji-Jun et al. | 2015
- 1515
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Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studiesYao, Zhong-Ke / Krai, Priscilla M. / Merino, Emilio F. / Simpson, Morgan E. / Slebodnick, Carla / Cassera, Maria Belen / Carlier, Paul R. et al. | 2015
- 1520
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Molecular recognition of pyrimidine nucleobases by triplex DNA receptorsZhuang, Zixing / Pan, Rui / Zhang, Qian / Huang, Haidong et al. | 2015
- 1525
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Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agentsWada, Koji / Ohkoshi, Emika / Zhao, Yu / Goto, Masuo / Morris-Natschke, Susan L. / Lee, Kuo-Hsiung et al. | 2015
- 1532
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SAH derived potent and selective EZH2 inhibitorsKung, Pei-Pei / Huang, Buwen / Zehnder, Luke / Tatlock, John / Bingham, Patrick / Krivacic, Cody / Gajiwala, Ketan / Diehl, Wade / Yu, Xiu / Maegley, Karen A. et al. | 2015
- 1538
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Ritonavir-boosted indinavir but not lopinavir inhibits erythrocytic stage Plasmodium knowlesi malaria in rhesus macaquesQin, Li / Qin, Limei / Xu, Wanwan / Zhao, Siting / Chen, Xiaoping et al. | 2015
- 1541
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Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone–6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer’s diseaseLiao, Shixian / Deng, Hui / Huang, Shengbin / Yang, Jingyuan / Wang, Siqian / Yin, Baodi / Zheng, Tieli / Zhang, Dafeng / Liu, Jinsong / Gao, Guohui et al. | 2015
- 1546
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Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonistsHuang, Minghua / Suk, Dae-Hwan / Cho, Nam-Chul / Bhattarai, Deepak / Kang, Soon Bang / Kim, Youseung / Pae, Ae Nim / Rhim, Hyewhon / Keum, Gyochang et al. | 2015
- 1546
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Synthesis and biological evaluation of isoxazoline derivatives as potent M₁ muscarinic acetylcholine receptor agonistsHuang, Minghua et al. | 2015
- 1552
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Syntheses of chondroitin sulfate tetrasaccharide structures containing 4,6-disulfate patterns and analysis of their interaction with glycosaminoglycan-binding proteinMiyachi, Kento / Wakao, Masahiro / Suda, Yasuo et al. | 2015
- 1556
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Design, synthesis and preliminary biological evaluation of C-8 substituted guanine derivatives as small molecular inhibitors of FGFRsYe, Faqing / Chen, Liangfang / Hu, Lichuan / Xiao, Tong / Yu, Shufang / Chen, Di / Wang, Yu / Liang, Guang / Liu, Zhiguo / Wang, Sicen et al. | 2015
- 1561
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Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discoveryBharate, Sonali S. / Vishwakarma, Ram A. et al. | 2015
- 1568
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Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitorsGeng, Chang-An / Huang, Xiao-Yan / Ma, Yun-Bao / Zhang, Xue-Mei / Chen, Ji-Jun et al. | 2015
- 1572
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Novel β-amyloid aggregation inhibitors possessing a turn mimicHamada, Yoshio / Miyamoto, Naoko / Kiso, Yoshiaki et al. | 2015
- 1577
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N-Acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXRGadakh, Bharat / Pouyez, Jenny / Wouters, Johan / Venkatesham, Akkaladevi / Cos, Paul / Van Aerschot, Arthur et al. | 2015
- 1580
-
In vitro and in silico evaluation of twelve newly-synthesized 1-acetamide-5-methoxy-2-oxindoles as 5-Ht7 receptor ligandsDíaz-Cervantes, Erik / Islas-Jácome, Alejandro / Rentería-Gómez, Angel / Robles, Juvencio / Gámez-Montaño, Rocío et al. | 2015
- 1580
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In vitro and in silico evaluation of twelve newly-synthesized 1-acetamide-5-methoxy-2-oxindoles as 5-Ht₇ receptor ligandsDíaz-Cervantes, Erik et al. | 2015
- 1586
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Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureumKubo, Miwa / Gima, Minori / Baba, Kohei / Nakai, Megumi / Harada, Kenichi / Suenaga, Midori / Matsunaga, Yoichi / Kato, Eishin / Hosoda, Shinya / Fukuyama, Yoshiyasu et al. | 2015
- 1592
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Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitorsMcKittrick, Brian A. / Caldwell, John P. / Bara, Thomas / Boykow, George / Chintala, Madhu / Clader, John / Czarniecki, Michael / Courneya, Brandy / Duffy, Ruth / Fleming, Linda et al. | 2015
- 1597
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Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitorsDorsch, Dieter / Schadt, Oliver / Stieber, Frank / Meyring, Michael / Grädler, Ulrich / Bladt, Friedhelm / Friese-Hamim, Manja / Knühl, Christine / Pehl, Ulrich / Blaukat, Andree et al. | 2015
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Benzofused hydroxamic acids: Useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-Fluorobenzothiophenes and benzofuransMarastoni, Elena / Bartoli, Sandra / Berettoni, Marco / Cipollone, Amalia / Ettorre, Alessandro / Fincham, Christopher I. / Mauro, Sandro / Paris, Marielle / Porcelloni, Marina / Bigioni, Mario et al. | 2015
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- 1611
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Molecular dynamics simulation to rationalize regioselective hydroxylation of aromatic substrates by soluble methane monooxygenaseSigdel, Sujan / Hui, Gao / Smith, Thomas J. / Murrell, J. Colin / Lee, Jung-Kul et al. | 2015
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- 1621
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- 1627
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Discovery of hydroxyaniline amides as selective Extracellular Regulated Kinase (Erk) inhibitorsZhu, Hugh Y. / Desai, Jagdish / Deng, Yongqi / Cooper, Alan / Wang, James / Shipps, Jerry / Samatar, Ahmed / Carr, Donna / Windsor, William et al. | 2015
- 1630
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Environmentally benign synthesis, molecular properties prediction and anti-inflammatory activity of novel isoxazolo[5,4-d]isoxazol-3-yl-aryl-methanones via vinylogous Henry nitroaldol adducts as synthonsRajanarendar, E. / Rama Krishna, S. / Nagaraju, D. / Govardhan Reddy, K. / Kishore, B. / Reddy, Y.N. et al. | 2015
- 1635
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Structure-based design of inhibitors of coagulation factor XIa with novel P1 moietiesPinto, Donald J.P. / Smallheer, Joanne M. / Corte, James R. / Austin, Erin J.D. / Wang, Cailan / Fang, Tianan / Smith, Leon M. II / Rossi, Karen A. / Rendina, Alan R. / Bozarth, Jeffrey M. et al. | 2015
- 1643
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Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivativesKonda, Saidulu / Raparthi, Srujana / Bhaskar, K. / Munaganti, Rajesh Kumar / Guguloth, Vijayacharan / Nagarapu, Lingaiah / Akkewar, Dattatray M. et al. | 2015
- 1647
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99mTc-HYNIC-MPG: A novel SPECT probe for targeting mutated EGFRYan, Yan / Xiao, Zun-Yu / Song, Yan / Kang, Zhao-Ting / Wang, Ping / Sun, Xi-Lin / Shen, Bao-Zhong et al. | 2014
- 1647
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mTc-HYNIC-MPG: a novel SPECT probe for targeting mutated EGFRYan, Yan et al. | 2015
- 1653
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Erratum to “Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay” [Bioorg. Med. Chem. Lett. 24 (2014) 3914–3918]Semenova, Marina N. / Tsyganov, Dmitry V. / Malyshev, Oleg R. / Ershov, Oleg V. / Bardasov, Ivan N. / Semenov, Roman V. / Kiselyov, Alex S. / Semenov, Victor V. et al. | 2015
- IFC
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Editorial board| 2015