Stelleranoids A–M, guaiane-type sesquiterpenoids based on [5,7] bicyclic system from Stellera chamaejasme and their cytotoxic activity (English)
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In:
Bioorganic Chemistry
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115
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2021
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Stelleranoids A–M, guaiane-type sesquiterpenoids based on [5,7] bicyclic system from Stellera chamaejasme and their cytotoxic activity
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Contributors:Pan, Jun ( author ) / Su, Jun-Cheng ( author ) / Liu, Yi-Hui ( author ) / Deng, Bin ( author ) / Hu, Zhuo-Fan ( author ) / Wu, Jia-Le ( author ) / Xia, Ru-Feng ( author ) / Chen, Chen ( author ) / He, Qian ( author ) / Chen, Jia-Chun ( author )
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Published in:Bioorganic Chemistry ; 115
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Publication date:2021-08-03
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 115
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
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Design, Hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarolLaamari, Yassine / Oubella, Ali / Bimoussa, Abdoullah / El Mansouri, Az-Eddine / Ketatni, El Mostafa / Mentre, Olivier / Ait Itto, My Youssef / Morjani, Hamid / Khouili, Mostafa / Auhmani, Aziz et al. | 2021
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Synthesis and evaluation of curcumin-based near-infrared fluorescent probes for the in vivo optical imaging of amyloid-β plaquesPark, Yong Dae / Kinger, Mayank / Min, Changho / Lee, Sang Yeob / Byun, Youngjoo / Park, Jin Woo / Jeon, Jongho et al. | 2021
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Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design, synthesis and in vitro/in vivo biological evaluationHassan, Rasha M. / Aboutabl, Mona E. / Bozzi, Manuela / El-Behairy, Mohammed F. / El Kerdawy, Ahmed M. / Sampaolese, Beatrice / Desiderio, Claudia / Vincenzoni, Federica / Sciandra, Francesca / Ghannam, Iman A.Y. et al. | 2021
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N-(3-cyano-1H-indol-5-yl)isonicotinamide and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide derivatives: Novel amide-based xanthine oxidase inhibitorsTu, Shun / Zhang, Ting-jian / Zhang, Yi / Zhang, Xu / Zhang, Zhen-hao / Meng, Fan-hao et al. | 2021
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Identification, characterization and evaluation of novel antifungal cyclic peptides from Neobacillus drentensisRouthu, Sunitha Rani / Ragi, Nagarjuna Chary / Yedla, Poornachandra / Shaik, Anver Basha / Venkataraman, Ganesh / Cheemalamarri, Chandrasekhar / Chityala, Ganesh Kumar / Amanchy, Ramars / Sripadi, Prabhakar / Kamal, Ahmed et al. | 2021
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Design, synthesis, and biological evaluation of novel FXR agonists based on aurapteneQiu, Qianqian / Wang, Yanjuan / Gu, Guolong / Yu, Fan / Zhang, Shichao / Zhao, Yining / Ling, Bai et al. | 2021
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New thieno[3,2-d]pyrimidine-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents, EGFR and ARO inhibitors inducing apoptosis in breast cancer cellsFarghaly, Ahmed M. / AboulWafa, Omaima M. / Baghdadi, Hoda H. / Abd El Razik, Heba A. / Sedra, Samir M.Y. / Shamaa, Marium M. et al. | 2021
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Multicomponent reaction for the synthesis of new 1,3,4-thiadiazole-thiazolidine-4-one molecular hybrids as promising antidiabetic agents through α-glucosidase and α-amylase inhibitionGummidi, Lalitha / Kerru, Nagaraju / Ebenezer, Oluwakemi / Awolade, Paul / Sanni, Olakunle / Islam, Md. Shahidul / Singh, Parvesh et al. | 2021
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Pentacyclic triterpene carboxylic acids derivatives integrated piperazine-amino acid complexes for α-glucosidase inhibition in vitroHuang, Jinxiang / Zang, Xufeng / Yang, Wuying / Yin, Xiaoli / Huang, Jianping / Wu, Shumin / Hong, Yanping et al. | 2021
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Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson's disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studiesElkamhawy, Ahmed / Paik, Sora / Park, Jong-Hyun / Kim, Hyeon Jeong / Hassan, Ahmed H.E. / Lee, Kyeong / Park, Ki Duk / Roh, Eun Joo et al. | 2021
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Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activityHalim, Peter A. / Georgey, Hanan H. / George, Mina Y. / El Kerdawy, Ahmed M. / Said, Mona F. et al. | 2021
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An overview of triazoloquinazolines: Pharmacological significance and recent developmentsAbuelizz, Hatem A. / Al-Salahi, Rashad et al. | 2021
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CuCl2-catalyzed inexpensive, faster and ligand/additive free synthesis of isoquinolin-1(2H)-one derivatives via the coupling–cyclization strategy: Evaluation of a new class of compounds as potential PDE4 inhibitorsThirupataiah, B. / Mounika, Guntipally / Sujeevan Reddy, Gangireddy / Sandeep Kumar, Jetta / Kapavarapu, Ravikumar / Medishetti, Raghavender / Mudgal, Jayesh / Mathew, Jessy E. / Shenoy, Gautham G. / Mallikarjuna Rao, C. et al. | 2021
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Novel thiomorpholine tethered isatin hydrazones as potential inhibitors of resistant Mycobacterium tuberculosisKarunanidhi, Sivanandhan / Chandrasekaran, Balakumar / Karpoormath, Rajshekhar / Patel, Harun M. / Kayamba, Francis / Merugu, Srinivas Reddy / Kumar, Vishal / Dhawan, Sanjeev / Kushwaha, Babita / Mahlalela, Mavela Cleopus et al. | 2021
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Design, synthesis and biological evaluation of novel 5-(imidazolyl-methyl) thiazolidinediones as antidiabetic agentsShakour, Neda / Sahebkar, Amirhossein / Karimi, Gholamreza / Paseban, Maryam / Tasbandi, Aida / Mosaffa, Fatemeh / Tayarani-Najaran, Zahra / Ghodsi, Razieh / Hadizadeh, Farzin et al. | 2021
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Absolute configuration and protein tyrosine phosphatase 1B inhibitory activity of xanthoepocin, a dimeric naphtopyrone from Penicillium sp. IQ-429Martínez-Aldino, Ingrid Y. / Villaseca-Murillo, Martha / Morales-Jiménez, Jesús / Rivera-Chávez, José et al. | 2021
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A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathwayTan, Qingyun / Fang, Yuying / Peng, Xing / Zhou, Huihao / Xu, Jun / Gu, Qiong et al. | 2021
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Discovery of 1,2,3-selenadiazole analogues as antifungal agents using a scaffold hopping approachXu, Hang / Cao, Chun / Wang, Xin / Guo, Meng-bi / Yan, Zhong-zuo / An, Ran / Zhang, Rui / Dong, En-hui / Mou, Yan-hua / Hou, Zhuang et al. | 2021
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Stereoselective synthesis of (26R)-26-hydroxydiosgenin and its effect on the regulation of rat ovarian functionHilario-Martínez, J. Ciciolil / Huerta, Aurora / Amaro-López, Julio C. / Alatriste, Victorino / De los Santos, María G. / Martínez, Isabel / Bernès, Sylvain / Sandoval-Ramírez, Jesús / Merino, Gabriel / Luna, Félix et al. | 2021
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Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stageWang, Kun / Wu, Jia–Jing / Xin–Zhang / Zeng, Qing–Xuan / Zhang, Na / Huang, Wei–Jin / Tang, Sheng / Wang, Yan–Xiang / Kong, Wei–Jia / Wang, You–Chun et al. | 2021
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DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative targetButrón, Daniel / Zamora-Carreras, Héctor / Devesa, Isabel / Treviño, Miguel A. / Abian, Olga / Velázquez-Campoy, Adrián / Bonache, M. Ángeles / Lagartera, Laura / Martín-Martínez, Mercedes / González-Rodríguez, Sara et al. | 2021
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Structure-guided discovery of novel potent and efficacious proteolysis targeting chimera (PROTAC) degrader of BRD4Xiang, Wang / Wang, Qiwei / Ran, Kai / Ren, Jing / Shi, Yaojie / Yu, Luoting et al. | 2021
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Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluationXie, Hong-Xu / Zhang, Juan / Li, Yue / Zhang, Jin-He / Liu, Shan-Kui / Zhang, Jie / Zheng, Hua / Hao, Gui-Zhou / Zhu, Kong-Kai / Jiang, Cheng-Shi et al. | 2021
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Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cellsLi, Yanchun / Ai, Xinyu / Zou, Chunyang / Liu, Yutong / Ma, Lili / Men, Jinyu / Liu, Dongyue / Sheng, Lei / Ruan, Xinhui / Liu, Haihan et al. | 2021
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Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinitiesEmam, Aya M. / Peigneur, Steve / Depuydt, Anne-Sophie / Ibrahim, Samy M. / Lopes Pinheiro-Junior, Ernesto / El-Sadek, Mohamed / Hendrickx, Louise / Tytgat, Jan / Kothayer, Hend et al. | 2021
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Purified recombinant human Chromogranin A N46 peptide with remarkable anticancer effect on human colon cancer cellsOkasha, Hend / Samir, Safia / Nasr, Sami Mohamed et al. | 2021
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Editorial Board| 2021
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Identification of novel anti-cancer agents by the synthesis and cellular screening of a noscapine-based libraryNemati, Faezeh / Bischoff-Kont, Iris / Salehi, Peyman / Nejad-Ebrahimi, Samad / Mohebbi, Maryam / Bararjanian, Morteza / Hadian, Nasim / Hassanpour, Zahra / Jung, Yvonne / Schaerlaekens, Sofie et al. | 2021
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New N-(1,3,4-thiadiazol-2-yl)furan-2-carboxamide derivatives as potential inhibitors of the VEGFR-2Hekal, Mohamed H. / Farag, Paula S. / Hemdan, Magdy M. / El-Sayed, Wael M. et al. | 2021
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Synthesis of new 2-(thiazol-4-yl)thiazolidin-4-one derivatives as potential anti-mycobacterial agentsAbhale, Yogita K. / Shinde, Abhijit / Shelke, Monika / Nawale, Laxman / Sarkar, Dhiman / Mhaske, Pravin C. et al. | 2021
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Selective targeting of cancer cells using a hydrogen peroxide-activated Hsp90 inhibitorOh, Yong Jin / Park, Sun You / Seo, Young Ho et al. | 2021
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Exploring of tumor-associated carbonic anhydrase isoenzyme IX and XII inhibitory effects and cytotoxicities of the novel N-aryl-1-(4-sulfamoylphenyl)-5-(thiophen-2-yl)-1H-pyrazole-3-carboxamidesYamali, Cem / Inci Gul, Halise / Ozli, Gulsen / Angeli, Andrea / Ballar Kirmizibayrak, Petek / Erbaykent Tepedelen, Burcu / Sakagami, Hiroshi / Bua, Silvia / Supuran, Claudiu T. et al. | 2021
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Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico studyZaman, Khalid / Rahim, Fazal / Taha, Muhammad / Sajid, Muhammad / Hayat, Shawkat / Nawaz, Muhammad / Salahuddin, Mohammed / Iqbal, Naveed / Khan, Naqeeb Ullah / Shah, Syed Adnan Ali et al. | 2021
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Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular docking, and kinetic studiesQazi, Syeda Uroos / Naz, Asia / Hameed, Abdul / Osra, Faisal Abdulrhman / Jalil, Saquib / Iqbal, Jamshed / Shah, Syed Adnan Ali / Mirza, Agha Zeeshan et al. | 2021
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Evaluation of N-aryl-β-alanine derivatives as anticancer agents in triple-negative breast cancer and glioblastoma in vitro modelsŽukauskas, Mindaugas / Grybaitė, Birutė / Jonutė, Paulina / Vaickelionienė, Rita / Gibieža, Paulius / Vaickelionis, Giedrius / Dragūnaitė, Bertina / Anusevičius, Kazimieras / Mickevičius, Vytautas / Petrikaitė, Vilma et al. | 2021
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Design, synthesis and bioevaluation of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitorsLiu, Runlai / Zhang, Shuai / Huang, Mingxin / Guo, Zhenpeng / Li, Long / Li, Mi / Wu, Lan / Guan, Qi / Zhang, Weige et al. | 2021
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Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamideDrop, Marcin / Jacquot, Florian / Canale, Vittorio / Chaumont-Dubel, Severine / Walczak, Maria / Satała, Grzegorz / Nosalska, Klaudia / Mahoro, Gilbert Umuhire / Słoczyńska, Karolina / Piska, Kamil et al. | 2021
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Essential moieties of myricetins, quercetins and catechins for binding and inhibitory activity against α-GlucosidaseFu, Minghai / Shen, Wenxiang / Gao, Wenzhe / Namujia, Laxi / Yang, Xi / Cao, Junwei / Sun, Lijun et al. | 2021
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Discovery of bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum wilsoniiDuan, Yulin / Deng, Yanfang / Bu, Pengfei / Guo, Yi / Shi, Zhengyi / Cao, Yunfang / Zhang, Yeting / Hu, Hong / Hu, Zhengxi / Qi, Changxing et al. | 2021
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Analysis of Hsp90 allosteric modulators interactome reveals a potential dual action mode involving mitochondrial MDH2Cassiano, Chiara / Morretta, Elva / Costantini, Matteo / Fassi, Enrico M.A. / Colombo, Giorgio / Sattin, Sara / Casapullo, Agostino et al. | 2021
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Synergistic effect of curcumin-Cu and curcumin-Ag nanoparticle loaded niosome: Enhanced antibacterial and anti-biofilm activitiesTarghi, Arefeh Abolhassani / Moammeri, Ali / Jamshidifar, Elham / Abbaspour, Koorosh / Sadeghi, Somayeh / Lamakani, Lida / Akbarzadeh, Iman et al. | 2021
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Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9Kirchhain, Arno / Zubrienė, Asta / Kairys, Visvaldas / Vivaldi, Federico / Bonini, Andrea / Biagini, Denise / Santalucia, Delio / Matulis, Daumantas / Di Francesco, Fabio et al. | 2021
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Preparation, spectroscopic, characterizations and biological studies of new charge transfer complexes formed between fluconazole drug with various acceptorsAli, Mahmoud M. / Ali, Mohamed / Gaballa, Akmal S. / El-korashy, Sabry A. / Teleb, Said M. et al. | 2021
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Pyridazinones containing dithiocarbamoyl moieties as a new class of selective MAO-B inhibitorsBesada, Pedro / Viña, Dolores / Costas, Tamara / Costas-Lago, María Carmen / Vila, Noemí / Torres-Terán, Iria / Sturlese, Mattia / Moro, Stefano / Terán, Carmen et al. | 2021
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Synthesis, molecular docking and molecular dynamics studies of novel tacrine-carbamate derivatives as potent cholinesterase inhibitorsOzten, Ozge / Zengin Kurt, Belma / Sonmez, Fatih / Dogan, Berna / Durdagi, Serdar et al. | 2021
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Bisabolane, cadinane, and cyclonerane sesquiterpenes from an algicolous strain of Trichoderma asperelloidesZou, Ji-Xue / Song, Yin-Ping / Liu, Xiang-Hong / Li, Xiao-Nian / Ji, Nai-Yun et al. | 2021
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Free energy perturbation guided Synthesis with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S mutant EGFR inhibitors targeting resistance in Non-Small Cell Lung Cancer (NSCLC)Karnik, Kshipra S. / Sarkate, Aniket P. / Tiwari, Shailee V. / Azad, Rajaram / Wakte, Pravin S. et al. | 2021
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Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensisLiu, Bo / Li, Bingxin / Zhou, Di / Wen, Xiaoyan / Wang, Yajun / Chen, Gang / Li, Ning et al. | 2021
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Eremophilane sesquiterpenoids from the whole plant of Parasenecio albus with immunosuppressive activityZhou, Ming / Duan, Fangfang / Gao, Ying / Peng, Xiaogang / Meng, Xianggao / Ruan, Hanli et al. | 2021
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Photochemical synthesis, intercalation with DNA and antitumor evaluation in vitro of benzo[d]thiazolo[3,2-a]quinolin-10-ium derivativesSaifutiarova, Alina E. / Fedorov, Yuri V. / Tsvetkov, Vladimir B. / Rustamova, Dina A. / Gulakova, Elena N. / Chmelyuk, Nelly S. / Abakumov, Maxim A. / Aliev, Teimur M. / Fedorova, Olga A. et al. | 2021
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Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictionsKardile, Ramakant A. / Sarkate, Aniket P. / Borude, Avinash S. / Mane, Rajendra S. / Lokwani, Deepak K. / Tiwari, Shailee V. / Azad, Rajaram / Burra, Prasad V.L.S. / Thopate, Shankar R. et al. | 2021
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Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonistsHu, Jing / Gao, Mengkang / Zhang, Yang / Wang, Yusui / Qiao, Zhenrui / Zhang, Weiya / Wang, Qiang / Yan, Lin / Qian, Hai et al. | 2021
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Voltage gated sodium channel inhibitors as anticonvulsant drugs: A systematic review on recent developments and structure activity relationship studiesPal, Rohit / Kumar, Bhupinder / Akhtar, Md. Jawaid / Chawla, Pooja A. et al. | 2021
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Synthesis of trans- methyl ferulate bearing an oxadiazole ether as potential activators for controlling plant virusHe, Feng / Wei, Panpan / Yu, Gang / Guo, Shengxin / Zheng, Zhiguo / Chen, Shunhong / Dai, Ali / Zhang, Renfeng / Wu, Zengxue / Wu, Jian et al. | 2021
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New lignans from the fruits of Leonurus japonicus and their hepatoprotective activitiesTian, Zhi-Hao / Liu, Fei / Peng, Fang / He, Yu-Lin / Shu, Hong-Zhen / Lin, Sheng / Chen, Jin-Feng / Peng, Cheng / Xiong, Liang et al. | 2021
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N-salicyloyl tryptamine derivatives as potential therapeutic agents for Alzheimer's disease with neuroprotective effectsBai, Yinliang / Liu, Dan / Zhang, Honghua / Wang, Yuying / Wang, Degui / Cai, Hongbin / Wen, Huaixiu / Yuan, Guoqiang / An, Hui / Wang, Yali et al. | 2021
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Ronald C.D. Breslow (1931–2017): A career in reviewJoseph, Vincent / Levine, Mindy et al. | 2021
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Design, synthesis and biological evaluation of 2,3-dihydroimidazo[2,1-b]thiazoles as dual EGFR and IGF1R inhibitorsGadekar, Pradip K. / Urunkar, Ganesh / Roychowdhury, Abhijit / Sharma, Rajiv / Bose, Julie / Khanna, Smriti / Damre, Anagha / Sarveswari, S. et al. | 2021
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Natural STAT3 inhibitors: A mini perspectiveWang, Zhuo / Hui, Chunngai / Xie, Yusheng et al. | 2021
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Structurally diversified ent-kaurane and abietane diterpenoids from the stems of Tripterygium wilfordii and their anti-inflammatory activityZhou, Xiao-Qiong / Li, Si-Qi / Liao, Cai-Ceng / Dai, Wei-Feng / Rao, Kai-Rui / Ma, Xiu-Rong / Li, Rong-Tao / Chen, Xuan-Qin et al. | 2021
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An overall framework for the E. coli γ-glutamyltransferase-catalyzed transpeptidation reactionsSomma, Valeria / Calvio, Cinzia / Rabuffetti, Marco / Rama, Erlinda / Speranza, Giovanna / Morelli, Carlo F. et al. | 2021
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Selective MOR activity of DAPEA and Endomorphin-2 analogues containing a (R)-γ-Freidinger lactam in position twoDella Valle, Alice / Stefanucci, Azzurra / Scioli, Giuseppe / Szűcs, Edina / Benyhe, Sándor / Pieretti, Stefano / Minosi, Paola / Sturaro, Chiara / Calò, Girolamo / Zengin, Gokhan et al. | 2021
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Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulatorsThissera, Bathini / Hallyburton, Irene / Ngwa, Che Julius / Cherif-Silini, Hafsa / Hassane, Ahmed S.I. / Anderson, Mark / Campbell, Lorna A. / Mutter, Nicole / Eshelli, Manal / Abdelmohsen, Usama R. et al. | 2021
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Identification of phenylcarbamoylazinane-1,3,4-oxadiazole amides as lipoxygenase inhibitors with expression analysis and in silico studiesBashir, Bushra / Shahid, Wardah / Ashraf, Muhammad / Saleem, Muhammad / Aziz-ur-Rehman / Muzaffar, Saima / Imran, Muhammad / Amjad, Hira / Bhattarai, Keshab / Riaz, Naheed et al. | 2021
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Synthesis, molecular docking, and evaluation of antibacterial activity of 1,2,4-triazole-norfloxacin hybridsYang, Ping / Luo, Jia-Bao / Wang, Zi-Zhou / Zhang, Li-Lei / Feng, Jin / Xie, Xiao-Bao / Shi, Qing-Shan / Zhang, Xin-Guo et al. | 2021
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Phomaligols F–I, polyoxygenated cyclohexenone derivatives from marine-derived fungus Aspergillus flavus BB1Liu, Xiao-Jing / Li, Hou-Jin / Ma, Wen-Zhe / Zhang, Fu-Ming / Xu, Meng-Yang / Mahmud, Taifo / Lan, Wen-Jian et al. | 2021
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Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agentsEl Abbouchi, Abdelmoula / El Brahmi, Nabil / Hiebel, Marie-Aude / Bignon, Jérôme / Guillaumet, Gérald / Suzenet, Franck / El Kazzouli, Saïd et al. | 2021
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Synthesis, antitubercular, antimicrobial activities and molecular docking study of quinoline bearing dihydropyrimidinesDesai, Nisheeth C. / Kotadiya, Ghanshyam M. / Jadeja, Krunalsinh A. / Shah, Keyur N. / Malani, Alimamad H. / Manga, Vijjulatha / Vani, Tamalapakula et al. | 2021
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Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivativesZhang, Jian / Mu, Keman / Yang, Peng / Feng, Xinqian / Zhang, Di / Fan, Xiangyu / Wang, Qiantao / Mao, Shengjun et al. | 2021
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Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studiesBala, Sandeepchowdary / Yellamanda, Kalisha vali / Kadari, Anilkumar / Ravinuthala, Venkata.S.U. / Kattula, Bhavita / Singh, Om V. / Gundla, Rambabu / Addlagatta, Anthony et al. | 2021
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Discovery of natural 15-LOX small molecule inhibitors from Chinese herbal medicine using virtual Screening, biological evaluation and molecular dynamics studiesLi, Yatong / Zhang, Yuxin / Wu, Xia / Gao, Yanbin / Guo, Junfang / Tian, Yulang / Lin, Ziyue / Wang, Xing et al. | 2021
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Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR)González, Carmen M. / Gaikwad, Sunil / Lasanta, Gonzalo / Loureiro, Julian / Nilsson, Niclas / Peluso-Iltis, Carole / Rochel, Natacha / Mouriño, Antonio et al. | 2021
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3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulationsEwida, Menna A. / Ewida, Heba A. / Ahmed, Mahmoud S. / Allam, Heba Abdelrasheed / ElBagary, Ramzia I. / George, Riham F. / Georgey, Hanan H. / El-Subbagh, Hussein I. et al. | 2021
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Computational design of binder as the LC3-p62 protein‐protein interactionLyu, Weiping / Li, Qihang / Wang, Yingming / Du, Chenxi / Feng, Feng / Chi, Heng / Li, Yuan / Liu, Wenyuan / Sun, Haopeng et al. | 2021
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Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitorsLiang, Yuru / Zhang, Mao / Zhou, Pengfei / Liu, Mingming / Li, Jianqi / Wang, Yang et al. | 2021
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Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused librariesTao, Yucen / Hao, Xia / Jing, Lanlan / Sun, Lin / Cherukupalli, Srinivasulu / Liu, Shugong / Wu, Gaochan / Xu, Shujing / Zhang, Xujie / Shi, Xiaoyu et al. | 2021
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Citral derivative activates cell cycle arrest and apoptosis signaling pathways in Candida albicans by generating oxidative stressWani, Mohmmad Younus / Ahmad, Aijaz / Aqlan, Faisal Mohammed / Al-Bogami, Abdullah Saad et al. | 2021
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Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitorsSi, Dongjuan / Luo, Huijuan / Zhang, Xiaomeng / Yang, Kundi / Wen, Hongmei / Li, Wei / Liu, Jian et al. | 2021
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Current development of sigma-2 receptor radioligands as potential tumor imaging agentsShaghaghi, Zahra / Alvandi, Maryam / Ghanbarimasir, Zahra / Farzipour, Soghra / Emami, Saeed et al. | 2021
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Discovery of new anticancer thiourea-azetidine hybrids: design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity, and DFT studiesParmar, Deepa R. / Soni, Jigar Y. / Guduru, Ramakrishna / Rayani, Rahul H. / Kusurkar, Rakesh V. / Vala, Anand G. / Talukdar, Sahista N. / Eissa, Ibrahim H. / Metwaly, Ahmed M. / Khalil, Ahmed et al. | 2021
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Novel manganese carbon quantum dots as a nano-probe: Facile synthesis, characterization and their application in naproxen delivery (Mn/CQD/SiO2@naproxen)Ardestani, Mehdi Shafiee / Zaheri, Zahra / Mohammadzadeh, Pardis / Bitarafan-Rajabi, Ahmad / Ghoreishi, Seyedeh Masoumeh et al. | 2021
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Microwave prompted solvent-free synthesis of new series of heterocyclic tagged 7-arylidene indanone hybrids and their computational, antifungal, antioxidant, and cytotoxicity studyAdole, Vishnu A. / More, Rahul A. / Jagdale, Bapu S. / Pawar, Thansing B. / Chobe, Santosh S. / Shinde, Rahul A. / Dhonnar, Sunil L. / Koli, Prashant B. / Patil, Arun V. / Bukane, Abhijit R. et al. | 2021
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Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposideEl-Wakil, Marwa H. / Teleb, Mohamed / Abu-Serie, Marwa.M. / Huang, Sun / Zamponi, Gerald W. / Fahmy, Hesham et al. | 2021
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Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategyZhou, Xia / Tan, Yuping / Gou, Kun / Tao, Lei / Luo, Yuan / Zhou, Yue / Zuo, Zeping / Sun, Qingxiang / Luo, Youfu / Zhao, Yinglan et al. | 2021
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Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluationImran, Aqeel / Tariq Shehzad, Muhammad / al Adhami, Taha / Miraz Rahman, Khondaker / Hussain, Dilawar / Alharthy, Rima D. / Shafiq, Zahid / Iqbal, Jamshed et al. | 2021
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Synthesis, biological evaluation (antioxidant, antimicrobial, enzyme inhibition, and cytotoxic) and molecular docking study of hydroxy methoxy benzoin/benzil analogousYaylı, Nurettin / Kılıç, Gözde / Kahriman, Nuran / Kanbolat, Şeyda / Bozdeveci, Arif / Alpay Karaoğlu, Şengül / Aliyazıcıoğlu, Rezzan / Erdinç Sellitepe, Hasan / Selin Doğan, İnci / Aydın, Ali et al. | 2021
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Design, synthesis, molecular docking and in silico ADMET profile of pyrano[2,3-d]pyrimidine derivatives as antimicrobial and anticancer agentsAbd El-Sattar, Nour E.A. / El‐Adl, Khaled / El-Hashash, Maher A. / Salama, Samir A. / Elhady, Mostafa M. et al. | 2021
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Alkaloid derivative ION-31a inhibits breast cancer metastasis and angiogenesis by targeting HSP90αNi, Tian-Wen / Duan, Xiao-Chuan / Wang, Meng / Jia, Mei-Qi / Chen, Ying / Yu, Yang / Qin, Nan / Duan, Hong-Quan et al. | 2021
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New alkali tolerant β-galactosidase from Paracoccus marcusii KGP – A promising biocatalyst for the synthesis of oligosaccharides derived from lactulose (OsLu), the new generation prebioticsKalathinathan, Pooja / Pulicherla, Krishnakanth / Sain, Avtar / Gomathinayagam, Sankaranarayanan / Jayaraj, Rama / Thangaraj, Suresh / Kodiveri Muthukaliannan, Gothandam et al. | 2021
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Squaraine dyes as serum albumins probes: Synthesis, photophysical experiments and molecular docking studiesS.D. Gomes, Vanessa / E.F. Boto, Renato / Almeida, Paulo / J.G. Coutinho, Paulo / Rui Pereira, Mário / Sameiro T. Gonçalves, M. / V. Reis, Lucinda et al. | 2021
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Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitorMurtaza, Amna / Afzal, Saira / Zaman, Gohar / Saeed, Aamer / Pelletier, Julie / Sévigny, Jean / Iqbal, Jamshed / Hassan, Abbas et al. | 2021
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Mycobacterium enoyl acyl carrier protein reductase (InhA): A key target for antitubercular drug discoveryPrasad, Mayuri S. / Bhole, Ritesh P. / Khedekar, Pramod B. / Chikhale, Rupesh V. et al. | 2021
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Design and synthesis of novel mitochondria-targeted CDDO derivatives as potential anti-cancer agentsJu, Wei / Li, Na / Wang, Junjie / Yu, Nairong / Lei, Zhichao / Zhang, Lulu / Sun, Jianbo / Chen, Li et al. | 2021
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Novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagyXu, Ting / Tian, Wenyue / Zhang, Qian / Liu, Jiazheng / Liu, Zhiyan / Jin, Jing / Guo, Yong / Bai, Li-Ping et al. | 2021
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Promising potential of a 18F-labelled small-molecular radiotracer to evaluate PD-L1 expression in tumors by PET imagingLv, Gaochao / Miao, Yinxing / Chen, Yinfei / Lu, Chunmei / Wang, Xiuting / Xie, Minhao / Qiu, Ling / Lin, Jianguo et al. | 2021
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Antimicrobial properties of novel ionic liquids derived from imidazolium cation with phenolic functional groupsGuzmán, Luis / Parra-Cid, Cristóbal / Guerrero-Muñoz, Etiennette / Peña-Varas, Carlos / Polo-Cuadrado, Efraín / Duarte, Yorley / Castro, Ricardo I. / Nerio, Luz Stella / Araya-Maturana, Ramiro / Asefa, Tewodros et al. | 2021
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Issue TOC| 2021
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Novel insights on the molecular mechanism of action of the anti-angiogenic pyrazolyl-urea GeGe-3 by functional proteomicsMorretta, Elva / Belvedere, Raffaella / Petrella, Antonello / Spallarossa, Andrea / Rapetti, Federica / Bruno, Olga / Brullo, Chiara / Monti, Maria Chiara et al. | 2021
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Thiazolidinone-linked1,2,3-triazoles with monoterpenic skeleton as new potential anticancer agents: Design, synthesis and molecular docking studiesOubella, Ali / El Mansouri, Az-Eddine / Fawzi, Mourad / Bimoussa, Abdoullah / Laamari, Yassine / Auhmani, Aziz / Morjani, Hamid / Robert, Anthony / Riahi, Abdelkhalek / Youssef Ait Itto, My et al. | 2021
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Biphenylpiperazine Based MAO Inhibitors: Synthesis, Biological Evaluation, Reversibility and Molecular Modeling StudiesEl-Halaby, Lamiaa O. / El-Husseiny, Walaa M. / El-Messery, Shahenda M. / Goda, Fatma E. et al. | 2021
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Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymesEl-Miligy, Mostafa M.M. / Al-Kubeisi, Ahmed K. / El-Zemity, Saad R. / Nassra, Rasha A. / Abu-Serie, Marwa M. / Hazzaa, Aly A. et al. | 2021
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Design, synthesis and evaluation of tetrahydrocarbazole derivatives as potential hypoglycemic agentsWang, Li-Li / Du, Yao / Li, Shu-Min / Cheng, Fei / Zhang, Na-Na / Chen, Rui / Cui, Xing / Yang, Sheng-Gang / Fan, Ling-Ling / Wang, Jian-Ta et al. | 2021
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Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studiesZha, Gao-Feng / Preetham, Habbanakuppe D. / Rangappa, Shobith / Sharath Kumar, Kothanahally S. / Girish, Yarabahally R. / Rakesh, Kadalipura P. / Ashrafizadeh, Milad / Zarrabi, Ali / Rangappa, Kanchugarakoppal S. et al. | 2021
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Synthesis, characterization, cytotoxicity studies, theoretical approach of adsorptive removal and molecular calculations of four new phosphoramide derivatives and related graphene oxideGholivand, Khodayar / Sabaghian, Marzie / Eshaghi Malekshah, Rahime et al. | 2021
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Novel Dy2O3/ZnO-Au ternary nanocomposites: Green synthesis using pomegranate fruit extract, characterization and their photocatalytic and antibacterial propertiesKhormali, Keyvan / Mizwari, Zirar M. / Masoumeh Ghoreishi, Seyedeh / Mortazavi-Derazkola, Sobhan / Khezri, Behrooz et al. | 2021
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Synthesis and kinetic characterization of hyperbolic inhibitors of human cathepsins K and S based on a succinimide scaffoldGoričan, Tjaša / Ciber, Luka / Petek, Nejc / Svete, Jurij / Novinec, Marko et al. | 2021
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New diphenyl ethers from a fungus Epicoccum sorghinum L28 and their antifungal activity against phytopathogensZhu, Junjie / Li, Ziyang / Lu, Haihong / Liu, Shengquan / Ding, Weijia / Li, Jiazhong / Xiong, Yahong / Li, Chunyuan et al. | 2021
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Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC)Pawara, Rahul / Ahmad, Iqrar / Nayak, Deepika / Wagh, Shivani / Wadkar, Avinash / Ansari, Azim / Belamkar, Sateesh / Surana, Sanjay / Nath Kundu, Chanakya / Patil, Chandragauda et al. | 2021
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Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activityBailey, Brodie L. / Nguyen, William / Ngo, Anna / Goodman, Christopher D. / Gancheva, Maria R. / Favuzza, Paola / Sanz, Laura M. / Gamo, Francisco-Javier / Lowes, Kym N. / McFadden, Geoffrey I. et al. | 2021
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Design, synthesis and antitumor activities of thiazole-containing mitochondrial targeting agentsZhang, Dongdong / Hu, Yixin / Hao, Zhiqiang / Zhang, Yang / Luo, Shuhua / Dang, Xin / Sun, Ran / Duan, Shixin / Lv, Dan / Jiang, Faqin et al. | 2021
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Absolute configuration of polypropionate derivatives: Decempyrones A–J and their MptpA inhibition and anti-inflammatory activitiesGuo, Heng / Wu, Qilin / Chen, Dongni / Jiang, Minghua / Chen, Bin / Lu, Yongjun / Li, Jing / Liu, Lan / Chen, Senhua et al. | 2021
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Integrating systematic pharmacology-based strategy and experimental validation to explore the synergistic pharmacological mechanisms of Guanxin V in treating ventricular remodelingLiang, Bo / Liang, Yi / Li, Rui / Zhang, Hui / Gu, Ning et al. | 2021
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Nucleus-targeting imaging and enhanced cytotoxicity based on naphthalimide derivativesWang, Shan-Shan / Du, Shao-Ying / He, Xu / Qi, Yu-Ming / Li, Xiao-Liu / Rong, Rui-Xue / Cao, Zhi-Ran / Wang, Ke-Rang et al. | 2021
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Beta-Carotene derivatives as novel therapy for the prevention and treatment of autistic symptomsAvraham, Yosefa / Mankuta, David / Lipsker, Leah / Vorobiev, Lia / Patael, Sigalit / Hassid, Golda / Berry, Elliot M. / Albeck, Amnon et al. | 2021
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Pseudopeptides with aldehyde or vinylsulfone warheads: Synthesis and antiproteasomal activityJorda, Radek / Molitorová, Veronika / Pilařová, Eliška / Vojáčková, Veronika / Řezníčková, Eva / Svobodová, Klára / Pauk, Karel / Imramovský, Aleš / Kryštof, Vladimír et al. | 2021
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Stelleranoids A–M, guaiane-type sesquiterpenoids based on [5,7] bicyclic system from Stellera chamaejasme and their cytotoxic activityPan, Jun / Su, Jun-Cheng / Liu, Yi-Hui / Deng, Bin / Hu, Zhuo-Fan / Wu, Jia-Le / Xia, Ru-Feng / Chen, Chen / He, Qian / Chen, Jia-Chun et al. | 2021
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Exploring phenylcarbamoylazinane-1,2,4-triazole thioethers as lipoxygenase inhibitors supported with in vitro, in silico and cytotoxic studiesShahid, Wardah / Ashraf, Muhammad / Saleem, Muhammad / Bashir, Bushra / Muzaffar, Saima / Ali, Mudassar / Kaleem, Ayesha / Aziz-ur-Rehman / Amjad, Hira / Bhattarai, Keshab et al. | 2021
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Inhibitory effect of triterpenoids from the mushroom Inonotus obliquus against α-glucosidase and their interaction: Inhibition kinetics and molecular stimulationsChen, Shao-Dan / Yong, Tian-Qiao / Xiao, Chun / Gao, Xiong / Xie, Yi-Zhen / Hu, Hui-Ping / Li, Xiang-Min / Chen, Di-Ling / Pan, Hong-Hui / Wu, Qing-Ping et al. | 2021
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Dibenzocyclooctadiene lignans from Kadsura coccinea alleviate APAP-induced hepatotoxicity via oxidative stress inhibition and activating the Nrf2 pathway in vitroYang, Yupei / Jian, Yuqing / Cheng, Shaowu / Jia, Yanzhe / Liu, Yongbei / Yu, Huanghe / Cao, Liang / Li, Bin / Peng, Caiyun / Iqbal Choudhary, Muhammad et al. | 2021
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Anticancer effect evaluation in vitro and in vivo of iridium(III) polypyridyl complexes targeting DNA and mitochondriaZhang, Huiwen / Tian, Li / Xiao, Rongxing / Zhou, Yi / Zhang, Yuanyuan / Hao, Jing / Liu, Yunjun / Wang, Juping et al. | 2021