本发明提出了龋齿标志微生物及其应用,该龋齿标志微生物包括第一微生物集,进一步提出一种试剂盒,包括适于检测第一微生物集中至少一种菌种的试剂,所述第一微生物集由以下菌种组成:神秘杆菌(Cryptobacterium curtum)、牙龈欧陆森氏菌(Olsenella uli)、居齿副斯卡尔维氏菌(Parascardovia denticolens)、栖牙普雷沃菌(Prevotella denticola)、变黑普雷沃菌(Prevotella nigrescens)、变形链球菌(Streptococcus mutans)、嗜糖普雷沃菌(Prevotella multisaccharivorax)、沙特尔沃思菌(Shuttleworthia satelles)。本发明提出的微生物相较于健康群体,在龋齿患者群体中显著富集,能够作为健康群体和龋齿患者群体的区分标志,可以作为检测和/或治疗龋齿的标志物。
The invention provides a dental caries marking microorganism and application thereof, the dental caries marking microorganism comprises a first microorganism set, and further provides a kit which comprises a reagent suitable for detecting at least one strain in the first microorganism set, the first microbial set is composed of the following strains: (Cryptobacterium curriculum), (Olsenella uli), (Parakali), (Prevotella dentata), (Prevotella dentata), (Prevotella nigra), (Streptococcus mutans), (Prevotella mutans), (Prevotella mutans) and (Shuttleworth), and the first microbial set is composed of the following strains: (Cryptobacterium), (Olsenella uli), (Pseudococcus mutans), (Pseudococcus mutans), (Pseudococcus mutans), (Pseudococcus mutans), (Pseudococcus mutans), (Pseudococcus mutans), (Pseudococcus Compared with a healthy group, the microorganism provided by the invention is remarkably enriched in a decayed tooth patient group, can be used as a distinguishing mark of the healthy group and the decayed tooth patient group, and can be used as a marker for detecting and/or treating decayed teeth.