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In long-duration space missions, skill retention and generalizability become ever more important as mission length increases, for it is through these capabilities that astronaut crews achieve autonomy. A framework is proposed for future research based on three types of training commonly found in operational scenarios: initial training, refresher training, and just-in-time training. One of the key points of interest identified from the body of literature is the need for a structured and quantifiable approach to characterize skill decay. Such an approach would allow gaining a deeper understanding of the mechanisms through which skill decay operates. Because simulators are used extensively in all types of training, the effects of simulator fidelity on skill retention and generalizability are paramount to understand. Some common fidelity types are defined and their effects on the human operator are discussed. From a review of the literature on all these topics, several research gaps were identified that led to three key opportunities for future research: (1) developing skill decay functions provides theoretical insights into skill decay and allows for several practical applications, such as planning refresher training, (2) the effects of simulator fidelity on skill decay functions should be investigated empirically, and (3) investigating the generalizability of skills learned in initial training to other tasks could provide space crews with greater autonomy. A cybernetic approach might give new insights.