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As policy objectives change from administration to administration, the acquisition process within the Department of Defense (DOD) must adapt to the changes to maintain modernization and readiness efforts. The National Security Strategy (NSS) outlines the use of national power, to include the diplomatic, informational, military, and economic instruments. Although the military instrument is the primary focus for policy changes within the DOD, it is important to recognize that economic objective shifts may impact acquisition processes. The methodology for the research was an applied professional case study method, using professionally accepted documentation to determine causal or correlative relationships between economic policy objectives and acquisition efforts. This research includes a review of NSS and economic policy documents from the Bush, Obama, and Trump Administrations, as well as acquisition efforts and policy updates from 2001-2018. The goal of the research is to determine if a predictive model can be developed for acquisition leaders that guides policy development based on the economic instrument of national power as outlined in the NSS.