Toxicity Studies on Truett Laboratories L-Asparaginase, Nsc 109229, Sample Mhb 5700, Vial No. B, 092668 and 18115A, AND Sample Mkv 3000, Vial No. V, 092668 and 18115B, Following Daily I. V. Administration to Rhesus Monkeys
(English)
There is an Open Access version for this licensed article that can be read free of charge and without license restrictions. The content of the Open Access version may differ from that of the licensed version.
Pricing information
Please choose your delivery country and your customer group
A single Rhesus monkey was treated with a dosage schedule of 500 I.U./kg, B.I.D. x 5, I.V. and sacrificed seven days post Rx. During the course of treatment the animal showed a decrease in body weight which was associated with a decrease in food consumption. The sample was not pyrogenic. Drug treatment resulted in a fatty liver which was seen both on gross and histological examination. On the third day of drug treatment a BSP retention was noted and this continued through the observation period. There were no other biochemical changes indicative of hepatotoxicity; no change in prothrombin or clotting time; there were no significant alterations in serum proteins or cholesterol except that the cholesterol was down on the 12th day of the study and this was associated with an increase in triglycerides. The WBC was down slightly following the last dose but returned to original values three days later. There was a slight anemia which was first noted following the last dose of the drug and this continued through the duration of the study and related to this there was an increase in reticulocytes on the 7th day following the last dose. (Author)
Toxicity Studies on Truett Laboratories L-Asparaginase, Nsc 109229, Sample Mhb 5700, Vial No. B, 092668 and 18115A, AND Sample Mkv 3000, Vial No. V, 092668 and 18115B, Following Daily I. V. Administration to Rhesus Monkeys