Please choose your delivery country and your customer group
Neutrophil function was evaluated during the course of experimental infection with sandfly fever virus in volunteers by in vitro assay of quantitative nitroblue tetrazolium (NBT) dye reduction, leukocyte glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconic dehydrogenase (6-PGD) activities and by a factericidal assay utilizing a strain of Staphylococcus aureus as a test organism. In the first study group in six infected subjects, leukocyte G-6-PD ACTIVITY WAS REDUCED TO AS LOW AS % TO 6% and quantitative NBT dye reduction was depressed to 20 to 30% of baselin values in comparison to two uninfected subjects who did not show these changes. In a second study group of nine men, in each of seven infected subjects bactericidal activity was diminished by as much as 45% of baseline values, usually by the 7th to the 25th day in comparison to two uninfected subjects who did not show these changes. These changes in leukocyte function were unrelated to total leukocyte count and occurred following the neutropenia characteristic of the disease.