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Biomedical science clearly depends on ideas and on the researchers who pursue them: individual scientists, driven by hypotheses and dedicated to rigorous research methods that, over the course of time, lead to scientific discovery. These are dedicated women and men who work at the laboratory bench or in the clinic (or, in some cases, both), in the belief that intense investigation will make a life altering difference for cancer patients. At NCI, the RPG, or Research Project Grant, has long been the mainstay of scientific investment and progress. The researchers NCI supports, the majority of whom work in our countrys great research universities, are also the professors who nurture, develop, and mentor new, young scientists. Those scientific careers both established and emerging have been of great concern during the past five years. As budgets remained flat, when adjusted for medical inflation, NCI was required to reduce spending by up to $175 million per year, in order to redirect or reprogram funds to be able to fund new initiatives. Over the past decade, anecdotes of dwindling laboratory staffs and young scientists turning away from biomedical research have echoed more and more frequently through the cancer community.