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After a brief review of earlier work in rats, experiments are reported to investigate whether persistence of soman also exists in guinea pigs and marmosets and whether pinacolyl dimethylphosphinate (PDP), most active in rats, counteracts persistence in these other species. The activity-loss of electric eel AChE was measured: in blood of the three species, when the enzyme was i.v. injected into anesthesized, atropinized animals to assess the availability of soman in blood 90 min after intoxication, and in medium when incubated with diaphragm muscle from identically treated animals 30 or 90 min after poisoning, to assess the release of soman. In both cases PDP was tested, mostly when given 10 min before soman. Soman persistence was found in all three species. (Copyright (c) TNO Medical Biological Laboratory 1987.)