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The 1975 Edition of the Registry of Toxic Effects of Chemical Substances, formerly known as the Toxic Substances List is the fourth revision of the list of toxic substances prepared at least annually in accordance with Section 20(a)(6) of the Occupational Safety and Health Act of 1970, Public Law 91-596. The Registry includes the original list published in June 1971 and the offerings of the subsequent publications. The Registry contains 64,300 listings of chemical substances: 16,500 are names of different chemicals with qualifying toxic dose information and 47,800 consist of synonymous names and codes which have been acquired from published literature, cooperating industries, and the American Chemical Society. The revision contains approximately 4,000 new compounds which had not appeared in the 1974 edition. The specific data provided on the toxicity of each substance related to: route of administration, animal species involved, type of exposure reported (e.g. lethal), dose which caused toxic response, and body system affected. The bibliographical sources from which the toxicity data were extracted are all listed. Absence of a substance does not imply that it is innocuous.