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This document addresses the following objectives regarding the availability and safety of the U.S. blood supply: determine the adequacy of the current blood supply and describe recent trends in supply and demand, describe blood suppliers response to the September 11 terrorist attacks and their planning for future emergencies, evaluate the potential impact of the new variant Creutzfeldt-Jakob Disease (vCJD) donor restrictions on the U.S. blood supply, and describe recent changes in the price of blood. To address these objectives, we measured supply and demand trends before and after September 11 by obtaining national data on the collection and distribution of blood from the National Blood Data Resource Center (NBDRC), a nonprofit research group, and the two major national blood suppliers--the American National Red Cross and America's Blood Centers (ABC).