Design, Synthesis, and Discovery of Novel trans-Stilbene Analogues as Potent and Selective Human Cytochrome P450 1B1 Inhibitors (English)
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In:
Journal of medicinal chemistry
;
45
, 1
; 160-164
;
2002
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ISSN:
- Article (Journal) / Print
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Title:Design, Synthesis, and Discovery of Novel trans-Stilbene Analogues as Potent and Selective Human Cytochrome P450 1B1 Inhibitors
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Contributors:
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Published in:Journal of medicinal chemistry ; 45, 1 ; 160-164
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Publisher:
- New search for: American Chemical Society
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Place of publication:Easton, Pa.
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Publication date:2002
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 770/4230
- New search for: 44.42 / 44.42
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Table of contents – Volume 45, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxohexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and ChiralityBorthwick, Alan D. / Crame, Andrew J. / Ertl, Peter F. / Exall, Anne M. / Haley, Terry M. / Hart, Graham J. / Mason, Andrew M. / Pennell, Andrew M. K. / Singh, Onkar M. P. / Weingarten, Gordon G. et al. | 2002
- 19
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Novel 1-Hydroxyazole Bioisosteres of Glutamic Acid. Synthesis, Protolytic Properties, and PharmacologyStensbøl, Tine B. / Uhlmann, Peter / Morel, Sandrine / Eriksen, Birgitte L. / Felding, Jakob / Kromann, Hasse / Hermit, Mette B. / Greenwood, Jeremy R. / Braüner-Osborne, Hans / Madsen, Ulf et al. | 2002
- 32
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α2-Adrenoreceptors Profile Modulation and High Antinociceptive Activity of (S)-(−)-2-[1-(Biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazoleGentili, Francesco / Bousquet, Pascal / Brasili, Livio / Caretto, Mariangela / Carrieri, Antonio / Dontenwill, Monique / Giannella, Mario / Marucci, Gabriella / Perfumi, Marina / Piergentili, Alessandro et al. | 2002
- 32
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a2-Adrenoreceptors Profile Modulation and High Antinociceptive Activity of (S)-(-)-2-(1-(Biphenyl-2-yloxy)ethyl)-4,5-dihydro-1H-imidazoleGentili, F. et al. | 2002
- 41
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Pharmacophore Mapping of a Series of 2,4-Diamino-5-deazapteridine Inhibitors of Mycobacterium avium Complex Dihydrofolate ReductaseDebnath, Asim Kumar et al. | 2002
- 54
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New Serotonin 5-HT2A, 5-HT2B, and 5-HT2C Receptor Antagonists: Synthesis, Pharmacology, 3D-QSAR, and Molecular Modeling of (Aminoalkyl)benzo and HeterocycloalkanonesBrea, José / Rodrigo, Jordi / Carrieri, Antonio / Sanz, Ferran / Cadavid, M. Isabel / Enguix, María J. / Villazón, María / Mengod, Guadalupe / Caro, Yolanda / Masaguer, Christian F. et al. | 2002
- 72
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Hierarchy of Simulation Models in Predicting Structure and Energetics of the Src SH2 Domain Binding to Tyrosyl PhosphopeptidesVerkhivker, Gennady M. / Bouzida, Djamal / Gehlhaar, Daniel K. / Rejto, Paul A. / Schaffer, Lana / Arthurs, Sandra / Colson, Anthony B. / Freer, Stephan T. / Larson, Veda / Luty, Brock A. et al. | 2002
- 90
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Structure-Based Design and Characterization of Novel Platforms for Ricin and Shiga Toxin InhibitionMiller, Darcie J. / Ravikumar, Kabyadi / Shen, Huafeng / Suh, Jung-Keun / Kerwin, Sean M. / Robertus, Jon D. et al. | 2002
- 99
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Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene TransferHeyes, James A. / Niculescu-Duvaz, Dan / Cooper, Robert G. / Springer, Caroline J. et al. | 2002
- 115
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7-Substituted 5-Amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A Adenosine Receptor Antagonists: A Study on the Importance of Modifications at the Side Chain on the Activity and SolubilityBaraldi, Pier Giovanni / Cacciari, Barbara / Romagnoli, Romeo / Spalluto, Giampiero / Monopoli, Angela / Ongini, Ennio / Varani, Katia / Borea, Pier Andrea et al. | 2002
- 127
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Inotropic Activity of Hydroindene AmidinohydrazonesSevillano, Luis G. / Melero, Concepción P. / Caballero, Esther / Tomé, Fernando / Lelièvre, Lionel G. / Geering, Käthi / Crambert, Gilles / Carrón, Rosalía / Medarde, Manuel / San Feliciano, Arturo et al. | 2002
- 137
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Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound LibrariesRoche, Olivier / Schneider, Petra / Zuegge, Jochen / Guba, Wolfgang / Kansy, Manfred / Alanine, Alexander / Bleicher, Konrad / Danel, Franck / Gutknecht, Eva-Maria / Rogers-Evans, Mark et al. | 2002
- 143
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Anti-Helicobacter p ylori Agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and Aryloxazole AnaloguesKatsura, Yousuke / Nishino, Shigetaka / Inoue, Yoshikazu / Sakane, Kazuo / Matsumoto, Yoshimi / Morinaga, Chizu / Ishikawa, Hirohumi / Takasugi, Hisashi et al. | 2002
- 151
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Rational Determination of Transfer Free Energies of Small Drugs across the Water−Oil InterfaceBas, Delphine / Dorison-Duval, Delphine / Moreau, Stéphanie / Bruneau, Pierre / Chipot, Christophe et al. | 2002
- 160
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Design, Synthesis, and Discovery of Novel trans-Stilbene Analogues as Potent and Selective Human Cytochrome P450 1B1 InhibitorsKim, Sanghee / Ko, Hyojin / Park, Jae Eun / Jung, Sungkyu / Lee, Sang Kwang / Chun, Young-Jin et al. | 2002
- 165
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Improvement in the Selectivity and Metabolic Stability of the Serotonin 5-HT1A Ligand, S 15535: A Series of cis- and trans-2-(Arylcycloalkylamine) 1-IndanolsPeglion, Jean-Louis / Goument, Bertrand / Despaux, Nicole / Charlot, Valérie / Giraud, Hélène / Nisole, Christian / Newman-Tancredi, Adrian / Dekeyne, Anne / Bertrand, Marc / Genissel, Patrick et al. | 2002
- 177
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Design and Synthesis of Potent Nonpeptidic Farnesyltransferase Inhibitors Based on a Terphenyl ScaffoldOhkanda, Junko / Lockman, Jeffrey W. / Kothare, Mohit A. / Qian, Yimin / Blaskovich, Michelle A. / Sebti, Said M. / Hamilton, Andrew D. et al. | 2002
- 189
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Synthesis and Inotropic Activity of 1-(O-Aminoalkyloximes) of Perhydroindene Derivatives as Simplified Digitalis-like Compounds Acting on the Na+,K+-ATPaseCerri, Alberto / Almirante, Nicoletta / Barassi, Paolo / Benicchio, Alessandra / De Munari, Sergio / Marazzi, Giuseppe / Molinari, Isabella / Serra, Fulvio / Melloni, Piero et al. | 2002
- 208
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Methanocarba Modification of Uracil and Adenine Nucleotides: High Potency of Northern Ring Conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but Not P2Y6 ReceptorsKim, Hak Sung / Ravi, R. Gnana / Marquez, Victor E. / Maddileti, Savitri / Wihlborg, Anna-Karin / Erlinge, David / Malmsjö, Malin / Boyer, José L. / Harden, T. Kendall / Jacobson, Kenneth A. et al. | 2002
- 219
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Phenoxyphenyl Sulfone N-Formylhydroxylamines (Retrohydroxamates) as Potent, Selective, Orally Bioavailable Matrix Metalloproteinase InhibitorsWada, Carol K. / Holms, James H. / Curtin, Michael L. / Dai, Yujia / Florjancic, Alan S. / Garland, Robert B. / Guo, Yan / Heyman, H. Robin / Stacey, Jamie R. / Steinman, Douglas H. et al. | 2002
- 233
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Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductases by 2,4-Diamino-5-[2-methoxy-5-(ω-carboxyalkyloxy)benzyl]pyrimidines: Marked Improvement in Potency Relative to Trimethoprim and Species Selectivity Relative to PiritreximRosowsky, Andre / Forsch, Ronald A. / Queener, Sherry F. et al. | 2002
- 233
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Inhibition of Pneumocystis carinii, Toxoplasmagondii, and Mycobacterium avium Dihydrofolate Reductases by 2,4-Diamino-5-(2-methoxy-5-(w-carboxyalkyloxy)benzyl)pyrimidines: Marked Improvement in Potency Relative to Trimethoprim and Species Selectivity Relative to PiritreximRosowsky, A. et al. | 2002
- 242
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Synthesis of New Dihydroindeno[1,2-c]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal ModelJayaraman, Muthusamy / Fox, Brian M. / Hollingshead, Melinda / Kohlhagen, Glenda / Pommier, Yves / Cushman, Mark et al. | 2002