Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists (English)
- New search for: Ando, Makoto
- New search for: Ando, Makoto
- New search for: Sekino, Etsuko
- New search for: Haga, Yuji
- New search for: Moriya, Minoru
- New search for: Ito, Masahiko
- New search for: Ito, Junko
- New search for: Iwaasa, Hisashi
- New search for: Ishihara, Akane
- New search for: Kanatani, Akio
- New search for: Ohtake, Norikazu
In:
Bioorganic & medicinal chemistry letters
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19
, 17
; 5186-5190
;
2009
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ISSN:
- Article (Journal) / Print
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Title:Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists
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Contributors:Ando, Makoto ( author ) / Sekino, Etsuko / Haga, Yuji / Moriya, Minoru / Ito, Masahiko / Ito, Junko / Iwaasa, Hisashi / Ishihara, Akane / Kanatani, Akio / Ohtake, Norikazu
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Published in:Bioorganic & medicinal chemistry letters ; 19, 17 ; 5186-5190
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Publisher:
- New search for: Elsevier
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Place of publication:Amsterdam [u.a.]
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Publication date:2009
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 35.70 / 44.33 / 44.42
- Further information on Basic classification
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Keywords:
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Classification:
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Source:
Table of contents – Volume 19, Issue 17
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4887
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Graphical contents list| 2009
- 4909
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Site-specific incorporation of PEGylated amino acids into proteins using nonnatural amino acid mutagenesisShozen, Naoki / Iijima, Issei / Hohsaka, Takahiro et al. | 2009
- 4912
-
Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibitionRyu, Young Bae / Curtis-Long, Marcus J. / Lee, Ji Won / Ryu, Hyung Won / Kim, Jun Young / Lee, Woo Song / Park, Ki Hun et al. | 2009
- 4916
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2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonistsWang, Yonghui / Duraiswami, Chaya / Madauss, Kevin P. / Tran, Thuy B. / Williams, Shawn P. / Deng, Su-Jun / Graybill, Todd L. / Hammond, Marlys / Jones, David G. / Grygielko, Eugene T. et al. | 2009
- 4916
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2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2prime,3prime:4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonistsWang, Y. / Duraiswami, C. / Madauss, K. P. / Tran, T. B. / Williams, S. P. / Deng, S. J. / Graybill, T. L. / Hammond, M. / Jones, D. G. / Grygielko, E. T. et al. | 2009
- 4920
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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline g-secretase inhibitorsTruong, A. P. / Aubele, D. L. / Probst, G. D. / Neitzel, M. L. / Semko, C. M. / Bowers, S. / Dressen, D. / Hom, R. K. / Konradi, A. W. / Sham, H. L. et al. | 2009
- 4920
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Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitorsTruong, Anh P. / Aubele, Danielle L. / Probst, Gary D. / Neitzel, Martin L. / Semko, Chris M. / Bowers, Simeon / Dressen, Darren / Hom, Roy K. / Konradi, Andrei W. / Sham, Hing L. et al. | 2009
- 4924
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Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cellsAllen, John G. / Lee, Matthew R. / Han, Chun-Ya E. / Scherrer, Jon / Flynn, Shaun / Boucher, Christy / Zhao, Huilin / O’Connor, Anne B. / Roveto, Philip / Bauer, David et al. | 2009
- 4929
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Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 b-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamidesMaresca, A. / Carta, F. / Vullo, D. / Scozzafava, A. / Supuran, C. T. et al. | 2009
- 4929
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Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 β-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamidesMaresca, Alfonso / Carta, Fabrizio / Vullo, Daniela / Scozzafava, Andrea / Supuran, Claudiu T. et al. | 2009
- 4933
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Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolonesZhu, Bin / Marinelli, Brett A. / Goldschmidt, Raul / Foleno, Barbara D. / Hilliard, Jamese J. / Bush, Karen / Macielag, Mark J. et al. | 2009
- 4937
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Antitubercular activity of α,ω-diaminoalkanes, H2N(CH2)nNH2Vergara, Fátima M.F. / Henriques, Maria das G.M.O. / Candea, André L.P. / Wardell, Jim L. / De Souza, Marcus V.N. et al. | 2009
- 4937
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Antitubercular activity of a,-diaminoalkanes, H2N(CH2)nNH2Vergara, F. M. / Henriques, M. d. / Candea, A. L. / Wardell, J. L. / De Souza, M. V. et al. | 2009
- 4939
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Unsaturated genistein disaccharide glycoside as a novel agent affecting microtubulesRusin, Aleksandra / Gogler, Agnieszka / Głowala-Kosińska, Magdalena / Bochenek, Daria / Gruca, Aleksandra / Grynkiewicz, Grzegorz / Zawisza, Jadwiga / Szeja, Wiesław / Krawczyk, Zdzisław et al. | 2009
- 4944
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Formation of spiroiminodihydantoin nucleoside from 8-oxo-7,8-dihydro-2prime-deoxyguanosine by nitric oxide under aerobic conditionsSuzuki, T. et al. | 2009
- 4944
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Formation of spiroiminodihydantoin nucleoside from 8-oxo-7,8-dihydro-2′-deoxyguanosine by nitric oxide under aerobic conditionsSuzuki, Toshinori et al. | 2009
- 4948
-
The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activityLeboho, Tlabo C. / Michael, Joseph P. / van Otterlo, Willem A.L. / van Vuuren, Sandy F. / de Koning, Charles B. et al. | 2009
- 4952
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A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-βReinke, Ashley A. / Seh, Han Yiau / Gestwicki, Jason E. et al. | 2009
- 4952
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A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-bReinke, A. A. / Seh, H. Y. / Gestwicki, J. E. et al. | 2009
- 4958
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Schisanwilsonins A–G and related anti-HBV lignans from the fruits of Schisandra wilsonianaMa, Wen-Hui / Lu, Yan / Huang, Hai / Zhou, Pei / Chen, Dao-Feng et al. | 2009
- 4963
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Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)Kümmerle, Arthur E. / Vieira, Marina M. / Schmitt, Martine / Miranda, Ana L.P. / Fraga, Carlos A.M. / Bourguignon, Jean-Jacques / Barreiro, Eliezer J. et al. | 2009
- 4967
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Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)Williams, Richard / Johnson, Kari A. / Gentry, Patrick R. / Niswender, Colleen M. / Weaver, Charles D. / Conn, P. Jeffrey / Lindsley, Craig W. / Hopkins, Corey R. et al. | 2009
- 4971
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Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N→N proton transferDonahue, Matthew G. / Hong, Ki Bum / Johnston, Jeffrey N. et al. | 2009
- 4971
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Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Bronsted bases in NN proton transferDonahue, M. G. / Hong, K. B. / Johnston, J. N. et al. | 2009
- 4974
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Triple recognition of B-DNAWillis, Bert / Arya, Dev P. et al. | 2009
- 4980
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2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancerChen, Zecheng / Venkatesan, Aranapakam M. / Dehnhardt, Christoph M. / Santos, Osvaldo Dos / Santos, Efren Delos / Ayral-Kaloustian, Semiramis / Chen, Lei / Geng, Yi / Arndt, Kim T. / Lucas, Judy et al. | 2009
- 4980
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2,4-Diamino-quinazolines as inhibitors of b-catenin/Tcf-4 pathway: Potential treatment for colorectal cancerChen, Z. / Venkatesan, A. M. / Dehnhardt, C. M. / Santos, O. D. / Santos, E. D. / Ayral-Kaloustian, S. / Chen, L. / Geng, Y. / Arndt, K. T. / Lucas, J. et al. | 2009
- 4984
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Development of a novel expression, ZIMAX/KZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium saltsIngalsbe, Michelle L. / Denis, Jeffrey D.St. / McGahan, Megan E. / Steiner, Walter W. / Priefer, Ronny et al. | 2009
- 4988
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4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agentsDuan, Maosheng / Aquino, Christopher / Dorsey, George F. Jr. / Ferris, Robert / Kazmierski, Wieslaw M. et al. | 2009
- 4993
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A conformational constraint improves a β-secretase inhibitor but for an unexpected reasonHills, Ivory D. / Katharine Holloway, M. / de León, Pablo / Nomland, Ashley / Zhu, Hong / Rajapakse, Hemaka / Allison, Tim J. / Munshi, Sanjeev K. / Colussi, Dennis / Pietrak, Beth L. et al. | 2009
- 4993
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A conformational constraint improves a b-secretase inhibitor but for an unexpected reasonHills, I. D. / Katharine Holloway, M. / de Leon, P. / Nomland, A. / Zhu, H. / Rajapakse, H. / Allison, T. J. / Munshi, S. K. / Colussi, D. / Pietrak, B. L. et al. | 2009
- 4996
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Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporterJobson, Nicola K. / Crawford, Andrew R. / Dewar, Deborah / Pimlott, Sally L. / Sutherland, Andrew et al. | 2009
- 4999
-
Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinenceBrennan, Paul E. / Whitlock, Gavin A. / Ho, Danny K.H. / Conlon, Kelly / McMurray, Gordon et al. | 2009
- 5004
-
Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonistsWorm, Karin / Weaver, Damian G. / Green, Rosalyn C. / Saeui, Christopher T. / Dulay, Doreen-Marie S. / Barker, William M. / Cassel, Joel A. / Stabley, Gabriel J. / DeHaven, Robert N. / LaBuda, Christopher J. et al. | 2009
- 5009
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Characterization of α-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase AWang, Shou-Feng / Tian, Guan Rong / Zhang, Wen-Zheng / Jin, Jing-Yi et al. | 2009
- 5009
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Characterization of a-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase AWang, S. F. / Tian, G. R. / Zhang, W. Z. / Jin, J. Y. et al. | 2009
- 5012
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In vivo evaluation of diaminodiphenyls: Anticonvulsant agents with minimal acute neurotoxicityWorthen, David R. / Bence, Aimee K. / Stables, James P. / Crooks, Peter A. et al. | 2009
- 5016
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Human plasma-mediated hypoxic activation of indolequinone-based naloxone pro-drugsHuang, Baohua / Tang, Shengzhuang / Desai, Ankur / Cheng, Xue-min / Kotlyar, Alina / Spek, Abraham Van Der / Thomas, Thommey P. / Baker, James R. Jr. et al. | 2009
- 5021
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Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitorGupta, Ramesh C. / Chhipa, Laxmikant / Mandhare, Appaji B. / Zambad, Shitalkumar P. / Chauthaiwale, Vijay / Nadkarni, Sunil S. / Dutt, Chaitanya et al. | 2009
- 5026
-
Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2Zhu, Lin / Liu, Jingying / Kung, Hank F. et al. | 2009
- 5029
-
Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-olsKim, Callain Y. / Mahaney, Paige E. / McConnell, Oliver / Zhang, Yingru / Manas, Eric / Ho, Douglas M. / Deecher, Darlene C. / Trybulski, Eugene J. et al. | 2009
- 5033
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Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligandSimeone, Joseph P. / Braun, Matthew P. / Leone, Joseph F. / Lin, Peter / DeVita, Robert J. / Garcia-Calvo, Margarita / Bull, Herb G. / Lisnock, JeanMarie / Dean, Dennis C. et al. | 2009
- 5037
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Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moietyLi, Yun-Long / Shi, Eric / Burns, David / Li, Yanlong / Covington, Maryanne B. / Pan, Maxwell / Scherle, Peggy / Friedman, Steve / Metcalf, Brian / Yao, Wenqing et al. | 2009
- 5043
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Structural determinants for histamine H1 affinity, hERG affinity and QTc prolongation in a series of terfenadine analogsAslanian, Robert / Piwinski, John J. / Zhu, Xiaohong / Priestley, Tony / Sorota, Steve / Du, Xiao-Yi / Zhang, Xue-Song / McLeod, Robbie L. / West, Robert E. / Williams, Shirley M. et al. | 2009
- 5048
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Amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines as CXCR4 antagonists with potent activity against HIV-1Gudmundsson, Kristjan S. / Sebahar, Paul R. / Richardson, Leah D’Aurora / Miller, John F. / Turner, Elizabeth M. / Catalano, John G. / Spaltenstein, Andrew / Lawrence, Wendell / Thomson, Michael / Jenkinson, Stephen et al. | 2009
- 5053
-
Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitorsMatos, Maria Joao / Viña, Dolores / Picciau, Carmen / Orallo, Francisco / Santana, Lourdes / Uriarte, Eugenio et al. | 2009
- 5056
-
Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studiesBennacef, Idriss / Salinas, Cristian A. / Bonasera, Thomas A. / Gunn, Roger N. / Audrain, Hélène / Jakobsen, Steen / Nabulsi, Nabeel / Weinzimmer, David / Carson, Richard E. / Huang, Yiyun et al. | 2009
- 5060
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Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinonesVásquez, David / Rodríguez, Jaime A. / Theoduloz, Cristina / Verrax, Julien / Calderon, Pedro Buc / Valderrama, Jaime A. et al. | 2009
- 5063
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Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studiesWan, Honghe / Huynh, Tram / Pang, Suhong / Geng, Jieping / Vaccaro, Wayne / Poss, Michael A. / Trainor, George L. / Lorenzi, Matthew V. / Gottardis, Marco / Jayaraman, Lata et al. | 2009
- 5067
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Chemically engineered extracts: Bioactivity alteration through sulfonylationSalazar, Mario O. / Ramallo, I. Ayelen / Micheloni, Oscar / Sierra, Manuel Gonzalez / Furlan, Ricardo L.E. et al. | 2009
- 5071
-
4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitorsZhang, Nan / Wu, Biqi / Boschelli, Diane H. / Golas, Jennifer M. / Boschelli, Frank et al. | 2009
- 5075
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Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analoguesAli, Mohamed Ashraf / Yar, Mohammad Shahar / Hasan, Mohamed Zaheen / Ahsan, Mohamed Jawed / Pandian, Suresh et al. | 2009
- 5078
-
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetrationWakenhut, Florian / Allan, Gill A. / Fish, Paul V. / Jonathan Fray, M. / Harrison, Anthony C. / McCoy, Rachel / Phillips, Stephen C. / Stobie, Alan / Westbrook, Dominique / Westbrook, Simon L. et al. | 2009
- 5082
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Carbonic anhydrase inhibitors; Fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and IIWinum, Jean-Yves / Innocenti, Alessio / Vullo, Daniela / Montero, Jean-Louis / Supuran, Claudiu T. et al. | 2009
- 5086
-
Design, syntheses, and evaluation of Taspase1 inhibitorsLee, Jeong Tae / Chen, David Y. / Yang, Zhimou / Ramos, Alexander D. / Hsieh, James J.-D. / Bogyo, Matthew et al. | 2009
- 5091
-
Atovaquone derivatives as potent cytotoxic and apoptosis inducing agentsZhou, Jing / Duan, Lei / Chen, Huaming / Ren, Xiaomei / Zhang, Zhang / Zhou, Fengtao / Liu, Jinsong / Pei, Duanqing / Ding, Ke et al. | 2009
- 5095
-
Crystal structure, antitumour and antimetastatic activities of disubstituted fused 1,2,4-triazinonesSztanke, Krzysztof / Pasternak, Kazimierz / Sztanke, Małgorzata / Kandefer-Szerszeń, Martyna / Kozioł, Anna E. / Dybała, Izabela et al. | 2009
- 5101
-
New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesteraseBharate, Sandip B. / Guo, Lilu / Reeves, Tony E. / Cerasoli, Douglas M. / Thompson, Charles M. et al. | 2009
- 5105
-
Synthesis of sialic acid derivatives having a CC double bond substituted at the C-5 position and their glycopolymersSuzuki, Kaori / Sakamoto, Jun-Ichi / Koyama, Tetsuo / Yingsakmongkon, Sangchai / Suzuki, Yasuo / Hatano, Ken / Terunuma, Daiyo / Matsuoka, Koji et al. | 2009
- 5109
-
Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cellsCuenca, Francisco / Moore, Michael J.B. / Johnson, Karin / Guyen, Bérangère / De Cian, Anne / Neidle, Stephen et al. | 2009
- 5114
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Optimization of a series of quinazolinone-derived antagonists of CXCR3Liu, Jiwen / Fu, Zice / Li, An-Rong / Johnson, Michael / Zhu, Liusheng / Marcus, Andrew / Danao, Jay / Sullivan, Tim / Tonn, George / Collins, Tassie et al. | 2009
- 5119
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Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutantsSu, Dai-Shi / Lim, John J. / Tinney, Elizabeth / Wan, Bang-Lin / Young, Mary Beth / Anderson, Kenneth D. / Rudd, Deanne / Munshi, Vandna / Bahnck, Carolyn / Felock, Peter J. et al. | 2009
- 5124
-
Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptorsKameda, Minoru / Ando, Makoto / Nakama, Chisato / Kobayashi, Kensuke / Kawamoto, Hiroshi / Ito, Sayaka / Suzuki, Tomoki / Tani, Takeshi / Ozaki, Satoshi / Tokita, Shigeru et al. | 2009
- 5128
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Antiparasitic activities of novel, orally available fumagillin analogsArico-Muendel, Christopher / Centrella, Paolo A. / Contonio, Brooke D. / Morgan, Barry A. / O’Donovan, Gary / Paradise, Christopher L. / Skinner, Steven R. / Sluboski, Barbara / Svendsen, Jennifer L. / White, Kerry F. et al. | 2009
- 5132
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Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonistsMcIntyre, Charles J. / McCauley, John A. / Bednar, Bohumil / Bednar, Rodney A. / Butcher, John W. / Claremon, David A. / Cunningham, Michael E. / Freidinger, Roger M. / Gaul, Stanley L. / Homnick, Carl F. et al. | 2009
- 5136
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Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activityMeanwell, Nicholas A. / Wallace, Owen B. / Wang, Henry / Deshpande, Milind / Pearce, Bradley C. / Trehan, Ashok / Yeung, Kap-Sun / Qiu, Zhilei / Wright, J.J. Kim / Robinson, Brett A. et al. | 2009
- 5140
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Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivativesWang, Tao / Kadow, John F. / Zhang, Zhongxing / Yin, Zhiwei / Gao, Qi / Wu, Dedong / Parker, Dawn DiGiugno / Yang, Zheng / Zadjura, Lisa / Robinson, Brett A. et al. | 2009
- 5146
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Synthesis of chiral fluorine-tagged reference standards for the 19F NMR-based stereochemical analysis of sulfoxides at trace analytical levelsTremblay, Amy E. / Lao, Kim Y.Y. / Hodgson, Derek J. / Dawson, Brian / Buist, Peter H. et al. | 2009
- 5151
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Towards to hENT1-nucleoside transporter selective imaging agents. Synthesis and in vitro evaluation of the radiolabeled SAENTA analoguesZlatopolskiy, Boris D. / Morgenroth, Agnieszka / Urusova, Elizaveta A. / Dinger, Cornelia / Kull, Thomas / Pape, Manuela / Glatting, Gerhard / Reske, Sven N. et al. | 2009
- 5155
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Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1BYoon, Goo / Lee, Woojung / Kim, Su-Nam / Cheon, Seung Hoon et al. | 2009
- 5158
-
2-Aminobenzimidazoles as potent Aurora kinase inhibitorsZhong, Min / Bui, Minna / Shen, Wang / Baskaran, Subramanian / Allen, Darin A. / Elling, Robert A. / Flanagan, W. Michael / Fung, Amy D. / Hanan, Emily J. / Harris, Shannon O. et al. | 2009
- 5162
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Metallo-β-lactamase inhibitory activity of phthalic acid derivativesHiraiwa, Yukiko / Morinaka, Akihiro / Fukushima, Takayoshi / Kudo, Toshiaki et al. | 2009
- 5162
-
Metallo-b-lactamase inhibitory activity of phthalic acid derivativesHiraiwa, Y. / Morinaka, A. / Fukushima, T. / Kudo, T. et al. | 2009
- 5166
-
Synthesis of biotinylated OSW-1Kang, Ying / Lou, Changgang / Ahmed, Kausar Begam Riaz / Huang, Peng / Jin, Zhendong et al. | 2009
- 5169
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Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: A double diversity for the identification of new antitubercular compoundsNefzi, Adel / Appel, Jon / Arutyunyan, Sergey / Houghten, Richard A. et al. | 2009
- 5176
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Semi-rigid tripeptide agonists of melanocortin receptorsRuwe, Andrew R. / Koikov, Leonid / Abdel-Malek, Zalfa / Haskell-Luevano, Carrie / Dirain, Marvin L. / Portillo, Federico / Xiang, Zhimin / Wortman, Matt / Knittel, James J. et al. | 2009
- 5182
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Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitorsPatel, Hitesh K. / Grotzfeld, Robert M. / Lai, Andiliy G. / Mehta, Shamal A. / Milanov, Zdravko V. / Chao, Qi / Sprankle, Kelly G. / Carter, Todd A. / Velasco, Anne Marie / Fabian, Miles A. et al. | 2009
- 5186
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Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonistsAndo, Makoto / Sekino, Etsuko / Haga, Yuji / Moriya, Minoru / Ito, Masahiko / Ito, Junko / Iwaasa, Hisashi / Ishihara, Akane / Kanatani, Akio / Ohtake, Norikazu et al. | 2009
- 5191
-
4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Potent and selective p70S6 kinase inhibitorsBandarage, Upul / Hare, Brian / Parsons, Jonathan / Pham, Ly / Marhefka, Craig / Bemis, Guy / Tang, Qing / Moody, Cameron Stuver / Rodems, Steve / Shah, Sundeep et al. | 2009
- 5195
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Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonistsDu, Wu / Jewell, James P. / Lin, Linus S. / Colandrea, Vincent J. / Xiao, Jing C. / Lao, Julie / Shen, Chun-Pyn / Bateman, Thomas J. / Reddy, Vijay B.G. / Ha, Sookhee N. et al. | 2009
- 5200
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Imidazo-pyrazine derivatives as potent CXCR3 antagonistsDu, Xiaohui / Gustin, Darin J. / Chen, Xiaoqi / Duquette, Jason / McGee, Lawrence R. / Wang, Zhulun / Ebsworth, Karen / Henne, Kirk / Lemon, Bryan / Ma, Ji et al. | 2009
- 5205
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Novel CXCR3 antagonists with a piperazinyl-piperidine coreMcGuinness, Brian F. / Carroll, Carolyn DiIanni / Zawacki, Lisa Guise / Dong, Guizhen / Yang, Cangming / Hobbs, Doug W. / Jacob-Samuel, Biji / Hall, James W. III / Jenh, Chung-Her / Kozlowski, Joseph A. et al. | 2009
- 5209
-
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-oneHughes, Robert O. / Walker, John K. / Joseph Rogier, D. / Heasley, Steve E. / Blevis-Bal, Rhadika M. / Benson, Alan G. / Jon Jacobsen, E. / Cubbage, Jerry W. / Fobian, Yvette M. / Owen, Dafydd R. et al. | 2009
- 5214
-
Thiazole analog as stearoyl-CoA desaturase 1 inhibitorLi, Chun Sing / Belair, Liette / Guay, Jocelyne / Murgasva, Renata / Sturkenboom, Wayne / Ramtohul, Yeeman K. / Zhang, Lei / Huang, Zheng et al. | 2009
- 5218
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Design and discovery of 1,3-benzodiazepines as novel dopamine antagonistsZhu, Zhaoning / Sun, Zhong-Yue / Ye, Yuanzan / McKittrick, Brian / Greenlee, William / Czarniecki, Michael / Fawzi, Ahmad / Zhang, Hongtao / Lachowicz, Jean E. et al. | 2009
- 5222
-
Protein–DNA photo-crosslinking with a genetically encoded benzophenone-containing amino acidLee, Hyun Soo / Dimla, Romerson D. / Schultz, Peter G. et al. | 2009
- 5225
-
Benzo[c][2,7]naphthyridines as inhibitors of PDK-1Kim, Kyung-Hee / Wissner, Allan / Floyd, Middleton B. Jr. / Fraser, Heidi L. / Wang, Yanong D. / Dushin, Russell G. / Hu, Yongbo / Olland, Andrea / Guo, Bing / Arndt, Kim et al. | 2009
- 5229
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Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitorsJin, Haihong / Cianchetta, Giovanni / Devasagayaraj, Arokiasamy / Gu, Kunjian / Marinelli, Brett / Samala, Lakshman / Scott, Sheldon / Stouch, Terry / Tunoori, Ashok / Wang, Ying et al. | 2009
- 5233
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N-substituted bis-C-alkyloxadiazolones as dual effectors: Efficient intermediates to amidoximes or amidines and prodrug candidates of potent antimalarialsDegardin, Mélissa / Wein, Sharon / Durand, Thierry / Escale, Roger / Vial, Henry / Vo-Hoang, Yen et al. | 2009
- 5237
-
Studies towards topical selective β2-adrenoceptor agonists with a long duration of actionBouyssou, Thierry / Rudolf, Klaus / Hoenke, Christoph / Lustenberger, Philipp / Schnapp, Andreas / Konetzki, Ingo et al. | 2009
- 5237
-
Studies towards topical selective b2-adrenoceptor agonists with a long duration of actionBouyssou, T. / Rudolf, K. / Hoenke, C. / Lustenberger, P. / Schnapp, A. / Konetzki, I. et al. | 2009
- 5241
-
Click chemistry based rapid one-pot synthesis and evaluation for protease inhibition of new tetracyclic triazole fused benzodiazepine derivativesMohapatra, Debendra K. / Maity, Pradip K. / Shabab, M. / Khan, M.I. et al. | 2009
- 5246
-
Discovery of a small molecule inhibitor through interference with the gp120–CD4 interactionWilliams, David H. / Adam, Fiona / Fenwick, David R. / Fok-Seang, Juin / Gardner, Iain / Hay, Duncan / Jaiessh, Rawal / Middleton, Donald S. / Mowbray, Charles E. / Parkinson, Tanya et al. | 2009
- 5250
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Design and optimisation of potent gp120-CD4 inhibitorsTran, Thien-Duc / Adam, Fiona M. / Calo, Frederick / Fenwick, David R. / Fok-Seang, Juin / Gardner, Iain / Hay, Duncan A. / Perros, Manos / Rawal, Jaiessh / Middleton, Donald S. et al. | 2009
- 5256
-
Effects of halogen substitution on Watson–Crick base pairing: A possible mechanism for radiosensitivityHeshmati, Emran / Abdolmaleki, Parviz / Mozdarani, Hossein / Sarvestani, Amir Sabet et al. | 2009
- 5261
-
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administrationWoodrow, Michael D. / Ballantine, Stuart P. / Barker, Michael D. / Clarke, Beth J. / Dawson, John / Dean, Tony W. / Delves, Christopher J. / Evans, Brian / Gough, Sharon L. / Guntrip, Steven B. et al. | 2009
- 5266
-
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitorsLacombe, Patrick / Chauret, Nathalie / Claveau, David / Day, Stephen / Deschênes, Denis / Dubé, Daniel / Gallant, Michel / Girard, Yves / Huang, Zheng / Laliberté, France et al. | 2009
- 5270
-
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitorsGonzález, Asensio / Quirante, Josefina / Nieto, Joan / Almeida, Maria Rosário / Saraiva, Maria Joao / Planas, Antoni / Arsequell, Gemma / Valencia, Gregorio et al. | 2009
- IFC
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Editorial board| 2009