Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates (English)
- New search for: Huang, Ruiqi
- New search for: Huang, Ruiqi
- New search for: Hippauf, Frank
- New search for: Rohrbeck, Diana
- New search for: Haustein, Maria
- New search for: Wenke, Katrin
- New search for: Feike, Janie
- New search for: Sorrelle, Noah
- New search for: Piechulla, Birgit
- New search for: Barkman, Todd J.
In:
Proceedings of the National Academy of Sciences of the United States of America
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109
, 8
; 2966-2972
;
2012
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ISSN:
- Article (Journal) / Print
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Title:Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates
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Contributors:Huang, Ruiqi ( author ) / Hippauf, Frank / Rohrbeck, Diana / Haustein, Maria / Wenke, Katrin / Feike, Janie / Sorrelle, Noah / Piechulla, Birgit / Barkman, Todd J.
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Published in:Proceedings of the National Academy of Sciences of the United States of America ; 109, 8 ; 2966-2972
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Publisher:
- New search for: NAS
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Place of publication:Washington, DC
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Publication date:2012
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 31.00 / 30.00 / 44.00
- Further information on Basic classification
- New search for: 770/3015
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Keywords:
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Classification:
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Source:
Table of contents – Volume 109, Issue 8
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 2685
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Actin bends over backward for directional branchingSvitkina, Tatyana M. et al. | 2012
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Shifting pharmacology of nicotine use and withdrawal: Breaking the cycle of drug abuseSesia, Thibaut et al. | 2012
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AgRP neurons: The foes of reproduction in leptin-deficient obese subjectsDietrich, Marcelo O. et al. | 2012
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Phoneme and word recognition in the auditory ventral streamDeWitt, Iain et al. | 2012
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Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretionKyriazis, George A. et al. | 2012
- 2715
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Progress in breast cancer researchPolyak, Kornelia et al. | 2012
- 2718
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Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitorsChakrabarty, Anindita et al. | 2012
- 2724
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Subtype and pathway specific responses to anticancer compounds in breast cancerHeiser, Laura M. et al. | 2012
- 2730
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Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifenMendes-Pereira, Ana M. et al. | 2012
- 2736
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The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathwayJin, Kideok et al. | 2012
- 2742
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Maintenance of hormone responsiveness in luminal breast cancers by suppression of NotchHaughian, James M. et al. | 2012
- 2748
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Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cellsHolmes, Kelly A. et al. | 2012
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Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteinsLiberal, Vasco et al. | 2012
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Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responsesChiba, Naokazu et al. | 2012
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Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737Oakes, Samantha R. et al. | 2012
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Defining the cellular precursors to human breast cancerKeller, Patricia J. et al. | 2012
- 2778
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Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cellsHerschkowitz, Jason I. et al. | 2012
- 2784
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Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxiaConley, Sarah J. et al. | 2012
- 2790
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Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expressionZhang, Xiaoli et al. | 2012
- 2796
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Leukocyte composition of human breast cancerRuffell, Brian et al. | 2012
- 2802
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Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signalingKristensen, Vessela N. et al. | 2012
- 2808
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Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesisMarcotte, Richard et al. | 2012
- 2814
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Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediatorsOwens, Philip et al. | 2012
- 2820
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Altered antisense-to-sense transcript ratios in breast cancerMaruyama, Reo et al. | 2012
- 2825
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A small world of weak ties provides optimal global integration of self-similar modules in functional brain networksGallos, Lazaros K. et al. | 2012
- 2831
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A serpentinite-hosted ecosystem in the Southern Mariana ForearcOhara, Yasuhiko et al. | 2012
- 2836
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Nonequilibrium atmospheric secondary organic aerosol formation and growthPerraud, Véronique et al. | 2012
- 2842
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Approximately diagonalizing matrices over C(Y)Lin, Huaxin et al. | 2012
- 2848
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Significance analysis of xMap cytokine bead arraysWon, Joong-Ho et al. | 2012
- 2854
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Maternal support in early childhood predicts larger hippocampal volumes at school ageLuby, Joan L. et al. | 2012
- 2860
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STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viabilityLuo, Tuoping et al. | 2012
- 2866
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Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interactionJiao, Yue et al. | 2012
- 2872
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Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophanFloor, Stephen N. et al. | 2012
- 2878
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Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assemblyYeo, Giselle C. et al. | 2012
- 2884
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Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modelingKalisman, Nir et al. | 2012
- 2890
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Modeling and design by hierarchical natural movesSim, Adelene Y. L. et al. | 2012
- 2896
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Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatusKozlov, Andrei S. et al. | 2012
- 2902
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Entropic origin of Mg2+-facilitated RNA foldingFiore, Julie L. et al. | 2012
- 2908
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Structure of saposin A lipoprotein discsPopovic, Konstantin et al. | 2012
- 2913
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Actin filament curvature biases branching directionRisca, Viviana I. et al. | 2012
- 2919
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Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz ratesBotcherby, Edward J. et al. | 2012
- 2925
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DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNALee, Sanghwa et al. | 2012
- 2925
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DNA cleavage and opening reactions of human topoisomerase II alpha are regulated via Mg^2^+-mediated dynamic bending of gate-DNALee, S. / Jung, S.-R. / Heo, K. / Byl, J.A.W. / Deweese, J.E. / Osheroff, N. / Hohng, S. et al. | 2012
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Skeletal muscle transcriptional coactivator PGC-1 alpha mediates mitochondrial, but not metabolic, changes during calorie restrictionFinley, L.W.S. / Lee, J. / Souza, A. / Desquiret-Dumas, V. / Bullock, K. / Rowe, G.C. / Procaccio, V. / Clish, C.B. / Arany, Z. / Haigis, M.C. et al. | 2012
- 2931
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Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restrictionFinley, Lydia W. S. et al. | 2012
- 2937
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Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activityTsutsumi, Shinji et al. | 2012
- 2943
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Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy productionFu, Ming et al. | 2012
- 2949
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Control of target gene specificity during metamorphosis by the steroid response gene E93Mou, Xiaochun et al. | 2012
- 2955
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A Y-linked anti-Müllerian hormone duplication takes over a critical role in sex determinationHattori, Ricardo S. et al. | 2012
- 2955
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A Y-linked anti-Mullerian hormone duplication takes over a critical role in sex determinationHattori, R.S. / Murai, Y. / Oura, M. / Masuda, S. / Majhi, S.K. / Sakamoto, T. / Fernandino, J.I. / Somoza, G.M. / Yokota, M. / Strussmann, C.A. et al. | 2012
- 2960
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"Evolution Canyon," a potential microscale monitor of global warming across lifeNevo, Eviatar et al. | 2012
- 2966
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Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substratesHuang, Ruiqi et al. | 2012
- 2972
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Human genetic variation altering anthrax toxin sensitivityMartchenko, Mikhail et al. | 2012
- 2978
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Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomesRussell, Meaghan K. et al. | 2012
- 2984
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Exposure to anticancer drugs can result in transgenerational genomic instability in miceGlen, Colin D. et al. | 2012
- 2989
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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)McCabe, Michael T. et al. | 2012
- 2995
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- 3001
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- 3006
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- 3012
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- 3018
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Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesisFeng, Haizhong et al. | 2012
- 3024
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Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNAVolinia, Stefano et al. | 2012
- 3030
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Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor βGabbi, Chiara et al. | 2012
- 3030
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Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor betaGabbi, C. / Kong, X. / Suzuki, H. / Kim, H.-J. / Gao, M. / Jia, X. / Ohnishi, H. / Ueta, Y. / Warner, M. / Guan, Y. et al. | 2012
- 3035
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Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivoPillai, Satish K. et al. | 2012
- 3035
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Role of retroviral restriction factors in the interferon- alpha -mediated suppression of HIV-1 in vivoPillai, S.K. / Abdel-Mohsen, M. / Guatelli, J. / Skasko, M. / Monto, A. / Fujimoto, K. / Yukl, S. / Greene, W.C. / Kovari, H. / Rauch, A. et al. | 2012
- 3041
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Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor responseSzerlip, Nicholas J. et al. | 2012
- 3047
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Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signalingBonnans, Caroline et al. | 2012
- 3047
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Essential requirement for beta -arrestin2 in mouse intestinal tumors with elevated Wnt signalingBonnans, C. / Flaceliere, M. / Grillet, F. / Dantec, C. / Desvignes, J.-P. / Pannequin, J. / Severac, D. / Dubois, E. / Bibeau, F. / Escriou, V. et al. | 2012
- 3053
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Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesisWang, Zehua et al. | 2012
- 3059
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The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissueHarman, Michael W. et al. | 2012
- 3065
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Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011Grad, Yonatan H. et al. | 2012
- 3071
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Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infectionTerry, Laura J. et al. | 2012
- 3077
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RNA virus microRNA that mimics a B-cell oncomiRKincaid, Rodney P. et al. | 2012
- 3083
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Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferationPrice, Paul A. et al. | 2012
- 3089
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Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical interventionMagro, Margarita et al. | 2012
- 3095
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A neurophysiological-metabolic model for burst suppressionChing, ShiNung et al. | 2012
- 3101
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Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawalGrieder, Taryn E. et al. | 2012
- 3107
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Cortical topography of intracortical inhibition influences the speed of decision makingWilimzig, Claudia et al. | 2012
- 3113
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Highly neurotoxic monomeric α-helical prion proteinZhou, Minghai et al. | 2012
- 3113
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Highly neurotoxic monomeric alpha -helical prion proteinZhou, M. / Ottenberg, G. / Sferrazza, G.F. / Lasmezas, C.I. et al. | 2012
- 3119
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Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatumLopes, Rita et al. | 2012
- 3125
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MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain functionMiller, Brooke H. et al. | 2012
- 3131
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Temporally-independent functional modes of spontaneous brain activitySmith, Stephen M. et al. | 2012
- 3137
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Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membraneZuckerman, Jonathan E. et al. | 2012
- 3143
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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γWei, Wei et al. | 2012
- 3143
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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gammaWei, W. / Dutchak, P.A. / Wang, X. / Ding, X. / Bookout, A.L. / Goetz, R. / Mohammadi, M. / Gerard, R.D. / Dechow, P.C. et al. | 2012
- 3149
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Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2Jiang, Jianxiong et al. | 2012
- 3155
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Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertilityWu, Qi et al. | 2012
- 3161
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Membrane-localized beta -subunits alter the PIP~2 regulation of high-voltage activated Ca^2^+ channelsSuh, B.-C. / Kim, D.-I. / Falkenburger, B.H. / Hille, B. et al. | 2012
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Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channelsSuh, Byung-Chang et al. | 2012
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Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factorGendron, Joshua M. et al. | 2012
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Impact of cross-protective vaccines on epidemiological and evolutionary dynamics of influenzaArinaminpathy, Nimalan et al. | 2012
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Optimal inference of samenessvan den Berg, Ronald et al. | 2012
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Integrated cross-species transcriptional network analysis of metastatic susceptibilityHu, Ying et al. | 2012
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Reply to Karapetyan: Viral synthesis and assembly is unlikely to occur under cell-free PMCA conditionsChesebro, Bruce et al. | 2012
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Viruses do replicate in cell-free systemsKarapetyan, Yervand E. et al. | 2012