The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α (English)
- New search for: Heffron, Timothy P.
- New search for: Heffron, Timothy P.
- New search for: Salphati, Laurent
- New search for: Alicke, Bruno
- New search for: Cheong, Jonathan
- New search for: Dotson, Jennafer
- New search for: Edgar, Kyle
- New search for: Goldsmith, Richard
- New search for: Gould, Stephen E.
- New search for: Lee, Leslie B.
- New search for: Lesnick, John D.
- New search for: Lewis, Cristina
- New search for: Ndubaku, Chudi
- New search for: Nonomiya, Jim
- New search for: Olivero, Alan G.
- New search for: Pang, Jodie
- New search for: Plise, Emile G.
- New search for: Sideris, Steve
- New search for: Trapp, Sean
- New search for: Wallin, Jeffrey
- New search for: Wang, Lan
- New search for: Zhang, Xiaolin
In:
Journal of medicinal chemistry
;
55
, 18
; 8007-8021
;
2012
-
ISSN:
- Article (Journal) / Print
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Title:The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α
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Contributors:
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Published in:Journal of medicinal chemistry ; 55, 18 ; 8007-8021
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Publisher:
- New search for: American Chemical Society
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Place of publication:Easton, Pa.
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Publication date:2012
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 770/4230
- New search for: 44.42 / 44.42
- Further information on Basic classification
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Keywords:
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Classification:
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Source:
Table of contents – Volume 55, Issue 18
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 7945
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Application of Lipid-Based Formulations in Drug DiscoveryChen, Xue-Qing / Gudmundsson, Olafur S. / Hageman, Michael J. et al. | 2012
- 7957
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Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Diabetic NephropathyPiotrowski, David W. et al. | 2012
- 7967
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7‑Alkyl-3-benzylcoumarins: A Versatile Scaffold for the Development of Potent and Selective Cannabinoid Receptor Agonists and AntagonistsRempel, Viktor / Volz, Nicole / Hinz, Sonja / Karcz, Tadeusz / Meliciani, Irene / Nieger, Martin / Wenzel, Wolfgang / Bräse, Stefan / Müller, Christa E. et al. | 2012
- 7978
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Pharmacophore-Based Virtual Screening and Biological Evaluation of Small Molecule Inhibitors for Protein Arginine MethylationWang, Juxian / Chen, Limin / Sinha, Sarmistha Halder / Liang, Zhongjie / Chai, Huifang / Muniyan, Sakthivel / Chou, Yu-Wei / Yang, Chao / Yan, Leilei / Feng, You et al. | 2012
- 7988
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Chemical Functionalization of Bioceramics To Enhance Endothelial Cells Adhesion for Tissue EngineeringBorcard, Françoise / Staedler, Davide / Comas, Horacio / Juillerat, Franziska Krauss / Sturzenegger, Philip N. / Heuberger, Roman / Gonzenbach, Urs T. / Juillerat-Jeanneret, Lucienne / Gerber-Lemaire, Sandrine et al. | 2012
- 7998
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Small Molecule Inhibitors of Bacillus anthracis Protective Antigen Proteolytic Activation and OligomerizationWein, Alexander N. / Williams, Brian N. / Liu, Shihui / Ermolinsky, Boris / Provenzano, Daniele / Abagyan, Ruben / Orry, Andrew / Leppla, Stephen H. / Peredelchuk, Michael et al. | 2012
- 8007
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The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase alphaHeffron, T.P. / Salphati, L. / Alicke, B. / Cheong, J. / Dotson, J. / Edgar, K. / Goldsmith, R. / Gould, S.E. / Lee, L.B. / Lesnick, J.D. et al. | 2012
- 8007
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The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3‑Kinase αHeffron, Timothy P. / Salphati, Laurent / Alicke, Bruno / Cheong, Jonathan / Dotson, Jennafer / Edgar, Kyle / Goldsmith, Richard / Gould, Stephen E. / Lee, Leslie B. / Lesnick, John D. et al. | 2012
- 8021
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Structural Analysis of Bengamide Derivatives as Inhibitors of Methionine AminopeptidasesXu, Wei / Lu, Jing-Ping / Ye, Qi-Zhuang et al. | 2012
- 8028
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Insights into the Structural Determinants Required for High-Affinity Binding of Chiral Cyclopropane-Containing Ligands to alpha 4 beta 2-Nicotinic Acetylcholine Receptors: An Integrated Approach to Behaviorally Active Nicotinic LigandsZhang, H.-K. / Eaton, J.B. / Yu, L.-F. / Nys, M. / Mazzolari, A. / van Elk, R. / Smit, A.B. / Alexandrov, V. / Hanania, T. / Sabath, E. et al. | 2012
- 8028
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Insights into the Structural Determinants Required for High-Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors: An Integrated Approach to Behaviorally Active Nicotinic LigandsZhang, Han-Kun / Eaton, J. Brek / Yu, Li-Fang / Nys, Mieke / Mazzolari, Angelica / van Elk, René / Smit, August B. / Alexandrov, Vadim / Hanania, Taleen / Sabath, Emily et al. | 2012
- 8038
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Synthesis and Characterization of a Novel Prostate Cancer-Targeted Phosphatidylinositol-3-kinase Inhibitor ProdrugBaiz, Daniele / Pinder, Tanya A. / Hassan, Sazzad / Karpova, Yelena / Salsbury, Freddie / Welker, Mark E. / Kulik, George et al. | 2012
- 8047
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Pd-Catalyzed Direct C–H Bond Functionalization of Spirocyclic σ1 Ligands: Generation of a Pharmacophore Model and Analysis of the Reverse Binding Mode by Docking into a 3D Homology Model of the σ1 ReceptorMeyer, Christina / Schepmann, Dirk / Yanagisawa, Shuichi / Yamaguchi, Junichiro / Dal Col, Valentina / Laurini, Erik / Itami, Kenichiro / Pricl, Sabrina / Wünsch, Bernhard et al. | 2012
- 8047
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Pd-Catalyzed Direct C-H Bond Functionalization of Spirocyclic sigma ~1 Ligands: Generation of a Pharmacophore Model and Analysis of the Reverse Binding Mode by Docking into a 3D Homology Model of the sigma ~1 ReceptorMeyer, C. / Schepmann, D. / Yanagisawa, S. / Yamaguchi, J. / Col, V.D. / Laurini, E. / Itami, K. / Pricl, S. / Wunsch, B. et al. | 2012
- 8066
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Synthesis and Structure–Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1LAnglin, Justin L. / Deng, Lisheng / Yao, Yuan / Cai, Guobin / Liu, Zhen / Jiang, Hong / Cheng, Gang / Chen, Pinhong / Dong, Shuo / Song, Yongcheng et al. | 2012
- 8075
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Structural Sweet Spot for A1 Adenosine Receptor Activation by Truncated (N)-Methanocarba Nucleosides: Receptor Docking and Potent Anticonvulsant ActivityTosh, Dilip K. / Paoletta, Silvia / Deflorian, Francesca / Phan, Khai / Moss, Steven M. / Gao, Zhan-Guo / Jiang, Xiaohui / Jacobson, Kenneth A. et al. | 2012
- 8091
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Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2‑(4-(1-(Quinolin-6-ylmethyl)‑1H‑[1,2,3]triazolo[4,5‑b]pyrazin-6-yl)‑1H‑pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of CancerCui, J. Jean / McTigue, Michele / Nambu, Mitchell / Tran-Dubé, Michelle / Pairish, Mason / Shen, Hong / Jia, Lei / Cheng, Hengmiao / Hoffman, Jacqui / Le, Phuong et al. | 2012
- 8110
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Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human TumorsBlake, James F. / Xu, Rui / Bencsik, Josef R. / Xiao, Dengming / Kallan, Nicholas C. / Schlachter, Stephen / Mitchell, Ian S. / Spencer, Keith L. / Banka, Anna L. / Wallace, Eli M. et al. | 2012
- 8128
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Anti-AIDS Agents 90. Novel C‑28 Modified Bevirimat Analogues as Potent HIV Maturation InhibitorsQian, Keduo / Bori, Ibrahim D. / Chen, Chin-Ho / Huang, Li / Lee, Kuo-Hsiung et al. | 2012
- 8137
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Structure–Activity Relationships in Human Toll-like Receptor 8‑Active 2,3-Diamino-furo[2,3‑c]pyridinesSalunke, Deepak B. / Yoo, Euna / Shukla, Nikunj M. / Balakrishna, Rajalakshmi / Malladi, Subbalakshmi S. / Serafin, Katelyn J. / Day, Victor W. / Wang, Xinkun / David, Sunil A. et al. | 2012
- 8152
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Design and Synthesis of Indomethacin Analogues That Inhibit P‑Glycoprotein and/or Multidrug Resistant Protein without Cox Inhibitory ActivityArisawa, Mitsuhiro / Kasaya, Yayoi / Obata, Tohru / Sasaki, Takuma / Nakamura, Tomonori / Araki, Takuya / Yamamoto, Koujirou / Sasaki, Akito / Yamano, Akihito / Ito, Mika et al. | 2012
- 8164
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Modulation in Selectivity and Allosteric Properties of Small-Molecule Ligands for CC-Chemokine ReceptorsThiele, Stefanie / Malmgaard-Clausen, Mikkel / Engel-Andreasen, Jens / Steen, Anne / Rummel, Pia C. / Nielsen, Mads C. / Gloriam, David E. / Frimurer, Thomas M. / Ulven, Trond / Rosenkilde, Mette M. et al. | 2012
- 8178
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Design and Synthesis of a Stable Oxidized Phospholipid Mimic with Specific Binding Recognition for Macrophage Scavenger ReceptorsTurner, William W. / Hartvigsen, Karsten / Boullier, Agnes / Montano, Erica N. / Witztum, Joseph L. / VanNieuwenhze, Michael S. et al. | 2012
- 8183
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Potent HGF/c-Met Axis Inhibitors from Eucalyptus globulus: the Coupling of Phloroglucinol and Sesquiterpenoid Is Essential for the ActivityYang, Sheng-Ping / Zhang, Xiao-Wei / Ai, Jing / Gan, Li-She / Xu, Jin-Biao / Wang, Ying / Su, Zu-Shang / Wang, Lu / Ding, Jian / Geng, Mei-Yu et al. | 2012
- 8188
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Exploration of Novel 3‑Substituted Azetidine Derivatives As Triple Reuptake InhibitorsHan, Younghue / Han, Minsoo / Shin, Dongyun / Song, Chiman / Hahn, Hoh-Gyu et al. | 2012
- 8193
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Benzodeazaoxaflavins as Sirtuin Inhibitors with Antiproliferative Properties in Cancer Stem CellsRotili, Dante / Tarantino, Domenico / Carafa, Vincenzo / Paolini, Chantal / Schemies, Jörg / Jung, Manfred / Botta, Giorgia / Di Maro, Salvatore / Novellino, Ettore / Steinkühler, Christian et al. | 2012