Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors (English)
- New search for: Ma, Shuang
- New search for: Ma, Shuang
- New search for: Li, Lin-Li
- New search for: Yang, Sheng-Yong
- New search for: Ji, Sen
- New search for: Zhong, Lei
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In:
Bioorganic & medicinal chemistry letters
;
25
, 22
; 5449-5453
;
2015
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ISSN:
- Article (Journal) / Print
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Title:Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors
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Contributors:Ma, Shuang ( author ) / Li, Lin-Li / Yang, Sheng-Yong / Ji, Sen / Zhong, Lei / Wu, Xiao-Ai / Tang, Yun / Fu, Zheng-Yan / Zhang, Chun-Hui / Yu, Xu-Ri
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Published in:Bioorganic & medicinal chemistry letters ; 25, 22 ; 5449-5453
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Publisher:
- New search for: Elsevier
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Place of publication:Amsterdam [u.a.]
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Publication date:2015
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ISSN:
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ZDBID:
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DOI:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 35.70 / 44.33 / 44.42
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Keywords:
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Source:
Table of contents – Volume 25, Issue 22
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 5001
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Graphical contents list| 2015
- 5025
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Synthesis and evaluation of antibacterial activity of (R)-2-methylheptyl isonicotinate, a putative naturally occurring bioactive agentCao, Jia / Adler, Ben / Perlmutter, Patrick et al. | 2015
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Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activityTheodosis-Nobelos, Panagiotis / Kourti, Malamati / Tziona, Paraskevi / Kourounakis, Panos N. / Rekka, Eleni A. et al. | 2015
- 5032
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Muscarinic acetylcholine receptor binding affinities of pethidine analogsLee, Na-Ra / Zhang, Xuan / Darna, Mahesh / Dwoskin, Linda P. / Zheng, Guangrong et al. | 2015
- 5036
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Adenosine/guanosine preferring nucleoside ribohydrolase is a distinct, druggable antitrichomonal targetBeck, Sierra / Muellers, Samantha N. / Benzie, Annie Laurie / Parkin, David W. / Stockman, Brian J. et al. | 2015
- 5040
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Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)Boy, Kenneth M. / Guernon, Jason M. / Wu, Yong-Jin / Zhang, Yunhui / Shi, Joe / Zhai, Weixu / Zhu, Shirong / Gerritz, Samuel W. / Toyn, Jeremy H. / Meredith, Jere E. et al. | 2015
- 5048
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New fluorinated agonists for targeting the sphingosin-1-phosphate receptor 1 (S1P1)Shaikh, Rizwan S. / Keul, Petra / Schäfers, Michael / Levkau, Bodo / Haufe, Günter et al. | 2015
- 5052
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Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agentsLi, Ya-Ru / Li, Chao / Liu, Jia-Chun / Guo, Meng / Zhang, Tian-Yi / Sun, Liang-Peng / Zheng, Chang-Ji / Piao, Hu-Ri et al. | 2015
- 5058
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Synthesis, antimycobacterial and antibacterial activity of l-[(1R,2S)-2-fluorocyclopropyl]naphthyridone derivatives containing an oxime-functionalized pyrrolidine moietyHuang, Ju / Liu, Hongtao / Liu, Mingliang / Zhang, Rui / Li, Linhu / Wang, Bin / Wang, Minghua / Wang, Chunlan / Lu, Yu et al. | 2015
- 5064
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Watson–Crick hydrogen bonding of unlocked nucleic acidsLangkjær, Niels / Wengel, Jesper / Pasternak, Anna et al. | 2015
- 5067
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Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteriaSanabria-Ríos, David J. / Rivera-Torres, Yaritza / Rosario, Joshua / Gutierrez, Ricardo / Torres-García, Yeireliz / Montano, Nashbly / Ortíz-Soto, Gabriela / Ríos-Olivares, Eddy / Rodríguez, José W. / Carballeira, Néstor M. et al. | 2015
- 5072
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X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug designSt. John, Sarah E. / Therkelsen, Matthew D. / Nyalapatla, Prasanth R. / Osswald, Heather L. / Ghosh, Arun K. / Mesecar, Andrew D. et al. | 2015
- 5078
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Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cellsZhang, Cheng-Chen / Yin, Xia / Cao, Chen-Yu / Wei, Jing / Zhang, Qiang / Gao, Jin-Ming et al. | 2015
- 5083
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Pontemazines A and B, phenazine derivatives containing a methylamine linkage from Streptomyces sp. UT1123 and their protective effect to HT-22 neuronal cellsCha, Jin Wook / Lee, Seung Il / Kim, Min Cheol / Thida, Mya / Lee, Jae Wook / Park, Jin-Soo / Kwon, Hak Cheol et al. | 2015
- 5087
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Inhibitory effects of compounds from Styrax obassia on NO productionCao, Thao Quyen / Tran, Manh Hung / Kim, Jeong Ah / Tran, Phuong Thao / Lee, Jeong-Hyung / Woo, Mi Hee / Lee, Hyeong-Kyu / Min, Byung Sun et al. | 2015
- 5092
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Synthesis of heterocycle-attached methylidenebenzenesulfonohydrazones as antifungal agentsGao, Zhinan / Lv, Min / Li, Qin / Xu, Hui et al. | 2015
- 5097
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Constituents of the seeds of Cassia tora with inhibitory activity on soluble expoxide hydroleaseLee, Ga Young / Kim, Jang Hoon / Choi, Seung-Kook / Kim, Young Ho et al. | 2015
- 5102
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Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT2A receptorPonnala, Shashikanth / Kapadia, Nirav / Madapa, Sudharshan / Alberts, Ian L. / Harding, Wayne W. et al. | 2015
- 5107
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Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl coreGarcia-Barrantes, Pedro M. / Cho, Hyekyung P. / Blobaum, Anna L. / Niswender, Colleen M. / Conn, P. Jeffrey / Lindsley, Craig W. et al. | 2015
- 5111
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Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptorsStehouwer, Jeffrey S. / Bourke, Chase H. / Owens, Michael J. / Voll, Ronald J. / Kilts, Clinton D. / Goodman, Mark M. et al. | 2015
- 5115
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Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulatorsMalosh, Chrysa / Turlington, Mark / Bridges, Thomas M. / Rook, Jerri M. / Noetzel, Meredith J. / Vinson, Paige N. / Steckler, Thomas / Lavreysen, Hilde / Mackie, Claire / Bartolomé-Nebreda, José M. et al. | 2015
- 5121
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Molecular hybridization yields triazole bronchodilators for the treatment of COPDJones, Lyn H. / Burrows, Jane / Feeder, Neil / Glossop, Paul / James, Kim / Jones, Rhys M. / Kenyon, Amy S. / Patel, Sheena / Roberts, Dannielle F. / Selby, Matthew D. et al. | 2015
- 5127
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Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitorsKonno, Hiroyuki / Sato, Taki / Saito, Yugo / Sakamoto, Iori / Akaji, Kenichi et al. | 2015
- 5133
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Novel concept of enzyme selective nicotinamide adenine dinucleotide (NAD)-modified inhibitors based on enzyme taxonomy from the diphosphate conformation of NADFujii, Mikio / Kitagawa, Yasuyuki / Iida, Shui / Kato, Keisuke / Ono, Machiko et al. | 2015
- 5137
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Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylasePeng, Fan-Wei / Wu, Ting-Ting / Ren, Zi-Wei / Xue, Jia-Yu / Shi, Lei et al. | 2015
- 5142
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Design and synthesis of aloe-emodin derivatives as potent anti-tyrosinase, antibacterial and anti-inflammatory agentsLiu, Jinbing / Wu, Fengyan / Chen, Changhong et al. | 2015
- 5147
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Targeting EGFR/HER2 tyrosine kinases with a new potent series of 6-substituted 4-anilinoquinazoline hybrids: Design, synthesis, kinase assay, cell-based assay, and molecular dockingElkamhawy, Ahmed / Farag, Ahmed Karam / Viswanath, Ambily Nath Indu / Bedair, Tarek M. / Leem, Dong Gyu / Lee, Kyung-Tae / Pae, Ae Nim / Roh, Eun Joo et al. | 2015
- 5155
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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancersBarlaam, Bernard / Cosulich, Sabina / Delouvrié, Bénédicte / Ellston, Rebecca / Fitzek, Martina / Germain, Hervé / Green, Stephen / Hancox, Urs / Harris, Craig S. / Hudson, Kevin et al. | 2015
- 5163
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Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograftGovek, Steven P. / Nagasawa, Johnny Y. / Douglas, Karensa L. / Lai, Andiliy G. / Kahraman, Mehmet / Bonnefous, Celine / Aparicio, Anna M. / Darimont, Beatrice D. / Grillot, Katherine L. / Joseph, James D. et al. | 2015
- 5168
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Novel cycloartane triterpenoids from the Nepal native plant Caragana sukiensisMandal, Reeta / Siva, Bandi / Phani Babu, V.S. / Suresh Babu, K. / Jagadeesh, B. / Ranjit, Rosa / Shrestha, Kanti / Gewali, Mohan Bikram et al. | 2015
- 5172
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Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR developmentMurphy-Benenato, Kerry E. / Gingipalli, Lakshmaiah / Boriack-Sjodin, P. Ann / Martinez-Botella, Gabriel / Carcanague, Dan / Eyermann, Charles J. / Gowravaram, Madhu / Harang, Jenna / Hale, Michael R. / Ioannidis, Georgine et al. | 2015
- 5178
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Discovery of the disubstituted oxazole analogues as a novel class anti-tuberculotic agents against MDR- and XDR-MTBLi, Dongsheng / Gao, Nana / Zhu, Ningyu / Lin, Yuan / Li, Yan / Chen, Minghua / You, Xuefu / Lu, Yu / Wan, Kanglin / Jiang, Jian-Dong et al. | 2015
- 5182
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Synthesis and anti-proliferative activity of novel azazerumbone conjugates with chalconesTruong, Vuong Van / Nam, Tran Duy / Hung, Truong Ngoc / Nga, Nguyen Thi / Quan, Pham Minh / Chinh, Luu Van / Jung, Sang-Hun et al. | 2015
- 5186
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Discovery of wrightiadione as a novel template for the TrkA kinase inhibitorsJeong, Yujeong / Lim, Sang Min / Hong, Sungwoo et al. | 2015
- 5190
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Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptideRosa, Mònica / Marcelo, Filipa / Calle, Luis P. / Rougeot, Catherine / Jiménez-Barbero, Jesús / Arsequell, Gemma / Valencia, Gregorio et al. | 2015
- 5194
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Anion inhibition studies of the dandruff-producing fungus Malassezia globosa β-carbonic anhydrase MgCADel Prete, Sonia / Vullo, Daniela / Osman, Sameh M. / AlOthman, Zeid / Capasso, Clemente / Supuran, Claudiu T. et al. | 2015
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Developing structure–activity relationships from an HTS hit for inhibition of the Cks1–Skp2 protein–protein interactionSingh, Rajinder / Sran, Arvinder / Carroll, David C. / Huang, Jianing / Tsvetkov, Lyuben / Zhou, Xiulan / Sheung, Julie / McLaughlin, John / Issakani, Sarkiz D. / Payan, Donald G. et al. | 2015
- 5203
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Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrileRajamuthiah, Rajmohan / Jayamani, Elamparithi / Majed, Hiwa / Conery, Annie L. / Kim, Wooseong / Kwon, Bumsup / Fuchs, Beth Burgwyn / Kelso, Michael J. / Ausubel, Frederick M. / Mylonakis, Eleftherios et al. | 2015
- 5208
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Synthesis of oligonucleotides carrying fluorescently labelled O6-alkylguanine for measuring hAGT activityTintoré, Maria / Grijalvo, Santiago / Eritja, Ramon / Fàbrega, Carme et al. | 2015
- 5212
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Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitorsWang, Chaolei / Wu, Zheng / Cai, Hao / Xu, Shengtao / Liu, Jie / Jiang, Jieyun / Yao, Hequan / Wu, Xiaoming / Xu, Jinyi et al. | 2015
- 5217
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The quorum-sensing inhibiting effects of stilbenoids and their potential structure–activity relationshipSheng, Ji-Yang / Chen, Tong-Tong / Tan, Xiao-Juan / Chen, Ting / Jia, Ai-Qun et al. | 2015
- 5221
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Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid spongeKubota, Takaaki / Watase, Shinya / Sakai, Kanae / Fromont, Jane / Gonoi, Tohru / Kobayashi, Jun’ichi et al. | 2015
- 5224
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Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffoldBalaraju, Tuniki / Konreddy, Ananda Kumar / Parveen, Afsana / Toyama, Massaki / Ito, Wataru / Karampuri, Srinivas / Baba, Masanori / Sharon, Ashoke / Bal, Chandralata et al. | 2015
- 5228
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Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type I receptor kinaseKrishnaiah, Maddeboina / Jin, Cheng Hua / Sheen, Yhun Yhong / Kim, Dae-Kee et al. | 2015
- 5232
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Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II: Synthesis and structural characterizationYoun, Sihyun / Kim, Kyung Im / Ptacek, Jakub / Ok, Kiwon / Novakova, Zora / Kim, YunHye / Koo, JaeHyung / Barinka, Cyril / Byun, Youngjoo et al. | 2015
- 5237
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Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5Seo, Woo-Duck / Lee, Ji Hae / Jia, Yaoyao / Wu, Chunyan / Lee, Sung-Joon et al. | 2015
- 5243
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Probing metallo-β-lactamases with molecular fragments identified by consensus dockingKlingler, Franca-Maria / Moser, Daniel / Büttner, Dominik / Wichelhaus, Thomas A. / Löhr, Frank / Dötsch, Volker / Proschak, Ewgenij et al. | 2015
- 5247
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Dendronylation: Residue-specific chemoselective attachment of oligoglycerol dendrimers on proteins with noncanonical amino acidsMa, Ying / Thota, Bala N.S. / Haag, Rainer / Budisa, Nediljko et al. | 2015
- 5250
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Novel water-soluble methanofullerenes C60[C13H18O4(OH)4]6 and C60[C9H10O4(OH)4]6: Promising uncouplers of respiration and phosphorylationKalacheva, Natalia V. / Gubskaya, Valentina P. / Fazleeva, Guzel M. / Igtisamova, Gulzada R. / Nuretdinov, Ildus A. / Rizvanov, Albert A. / Cherepnev, Georgi V. et al. | 2015
- 5254
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Discovery of an l-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100Kim, Se-Ho / Tangallapally, Rajendra / Kim, In Chul / Trovato, Richard / Parker, Daniel / Patton, J. Scott / Reeves, Leslie / Bradford, Chad / Wettstein, Daniel / Baichwal, Vijay et al. | 2015
- 5258
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Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitorsHu, Huiyong / Wang, Xiaojing / Chan, Grace Ka Yan / Chang, Jae H. / Do, Steven / Drummond, Jake / Ebens, Allen / Lee, Wendy / Ly, Justin / Lyssikatos, Joseph P. et al. | 2015
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Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitorsFu, Huansheng / Hou, Xuben / Wang, Lei / Dun, Yanyan / Yang, Xinying / Fang, Hao et al. | 2015
- 5270
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Monoamine oxidase inhibitory activities of heterocyclic chalconesMinders, Corné / Petzer, Jacobus P. / Petzer, Anél / Lourens, Anna C.U. et al. | 2015
- 5277
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Site-specific incorporation of a fluorescent terphenyl unnatural amino acidLampkowski, Jessica S. / Uthappa, Diya M. / Young, Douglas D. et al. | 2015
- 5281
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Design, synthesis, and biological evaluation of oxindole derivatives as antidepressive agentsSuthar, Sharad Kumar / Bansal, Sumit / Alam, Md. Maqusood / Jaiswal, Varun / Tiwari, Amit / Chaudhary, Anil / Alex, Angel Treasa / Joseph, Alex et al. | 2015
- 5286
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Single excitation three color folded DNA probe for SNP typingJoo, Han Na / Seo, Young Jun et al. | 2015
- 5291
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Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonistsDai, Xing / Stamford, Andrew / Liu, Hong / Neustadt, Bernard / Hao, Jingsong / Kowalski, Tim / Hawes, Brian / Xu, Xiaoying / Baker, Hana / O’Neill, Kim et al. | 2015
- 5295
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Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblagesIwasaki, Arihiro / Ohno, Osamu / Katsuyama, Shun / Morita, Maho / Sasazawa, Yukiko / Dan, Shingo / Simizu, Siro / Yamori, Takao / Suenaga, Kiyotake et al. | 2015
- 5299
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Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychoticsHuang, Ling / Zhang, Wenjun / Zhang, Xiaohua / Yin, Lei / Chen, Bangyin / Song, Jinchun et al. | 2015
- 5306
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A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonistEricson, Mark D. / Schnell, Sathya M. / Freeman, Katie T. / Haskell-Luevano, Carrie et al. | 2015
- 5309
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Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitorsGoswami, Rajeev / Wohlfahrt, Gerd / Törmäkangas, Olli / Moilanen, Anu / Lakshminarasimhan, Anirudha / Nagaraj, Jwala / Arumugam, Karthikeyan N. / Mukherjee, Subhendu / Chacko, Anita R. / Krishnamurthy, Narasimha R. et al. | 2015
- 5315
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Novel arylalkylamine compounds exhibits potent selective antiparasitic activity against Leishmania majorIniguez, Eva A. / Perez, Andrea / Maldonado, Rosa A. / Skouta, Rachid et al. | 2015
- 5321
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New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginsengMa, Li-Yuan / Zhou, Qi-Le / Yang, Xiu-Wei et al. | 2015
- 5326
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Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalinesMolenveld, Peter / Bouzanne des Mazery, Renaud / Sterk, Geert Jan / Storcken, Roy P.M. / Autar, Reshma / van Oss, Bram / van der Haas, Richard N.S. / Fröhlich, Roland / Schepmann, Dirk / Wünsch, Bernhard et al. | 2015
- 5331
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Liquid scintillators with near infrared emission based on organoboron conjugated polymersTanaka, Kazuo / Yanagida, Takayuki / Yamane, Honami / Hirose, Amane / Yoshii, Ryousuke / Chujo, Yoshiki et al. | 2015
- 5335
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Highly efficient and fast pre-activation cyclization of the long peptide: Succinimidyl ester-amine reaction revisitedChoi, Se-Hwan / Jeong, Woo-jin / Choi, Sung-ju / Lim, Yong-beom et al. | 2015
- 5339
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Synthesis and preliminary biological evaluation of a small library of hybrid compounds based on Ugi isocyanide multicomponent reactions with a marine natural product scaffoldAvilés, Edward / Prudhomme, Jacques / Le Roch, Karine G. / Franzblau, Scott G. / Chandrasena, Kevin / Mayer, Alejandro M.S. / Rodríguez, Abimael D. et al. | 2015
- 5344
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Synthesis and initial evaluation of quinoline-based inhibitors of the SH2-containing inositol 5′-phosphatase (SHIP)Russo, Christopher M. / Adhikari, Arijit A. / Wallach, Daniel R. / Fernandes, Sandra / Balch, Amanda N. / Kerr, William G. / Chisholm, John D. et al. | 2015
- 5349
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Benzophenone and its analogs bind to human glyoxalase 1Mihai, Doina M. / Hall, Steven / Deng, Haiteng / Welch, Christopher J. / Kawamura, Akira et al. | 2015
- 5352
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Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylaseKung, Daniel W. / Griffith, David A. / Esler, William P. / Vajdos, Felix F. / Mathiowetz, Alan M. / Doran, Shawn D. / Amor, Paul A. / Bagley, Scott W. / Banks, Tereece / Cabral, Shawn et al. | 2015
- 5357
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Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M1 and M4 muscarinic acetylcholine receptors agonistsUruno, Yoshiharu / Konishi, Yasuko / Suwa, Atsushi / Takai, Kentaro / Tojo, Kengo / Nakako, Tomokazu / Sakai, Mutsuko / Enomoto, Takeshi / Matsuda, Harumi / Kitamura, Atsushi et al. | 2015
- 5362
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Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeletonMisawa, Takashi / Yorioka, Momoko / Demizu, Yosuke / Noguchi-Yachide, Tomomi / Ohoka, Nobumichi / Kurashima-Kinoshita, Megumi / Motoyoshi, Hitomi / Nojiri, Hisao / Kittaka, Atsushi / Makishima, Makoto et al. | 2015
- 5367
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Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responsesKulkarni, Roshan R. / Lee, Wonhwa / Jang, Tae Su / Lee, JungIn / Kwak, Soyoung / Park, Mi Seon / Lee, Hyun-Shik / Bae, Jong-Sup / Na, MinKyun et al. | 2015
- 5372
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Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agentsMagri, Andrea / Reilly, Roisin / Scalacci, Nicolò / Radi, Marco / Hunter, Michael / Ripoll, Manon / Patel, Arvind H. / Castagnolo, Daniele et al. | 2015
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Synthesis, biological evaluation and structure–activity relationship studies of isoflavene based Mannich bases with potent anti-cancer activityChen, Yilin / Cass, Shelley L. / Kutty, Samuel K. / Yee, Eugene M.H. / Chan, Daniel S.H. / Gardner, Christopher R. / Vittorio, Orazio / Pasquier, Eddy / Black, David StC. / Kumar, Naresh et al. | 2015
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Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modificationsLim, Jongwon / Altman, Michael D. / Baker, James / Brubaker, Jason D. / Chen, Hongmin / Chen, Yiping / Kleinschek, Melanie A. / Li, Chaomin / Liu, Duan / Maclean, John K.F. et al. | 2015
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Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophagesEguchi, Keisuke / Kato, Hikaru / Fujiwara, Yukio / Losung, Fitje / Mangindaan, Remy E.P. / de Voogd, Nicole J. / Takeya, Motohiro / Tsukamoto, Sachiko et al. | 2015
- 5393
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Design, synthesis, and evaluation of new endomorphin analogs with enhanced central antinociception after peripheral administrationLiu, Xin / Zhao, Long / Wang, Yuan / Mou, Lingyun / Yang, Junxian / Zhang, Yixin / Wang, Dan / Wang, Rui et al. | 2015
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Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005Kim, Jong Won / Ko, Sung-Kyun / Son, Sangkeun / Shin, Kee-Sun / Ryoo, In-Ja / Hong, Young-Soo / Oh, Hyuncheol / Hwang, Bang Yeon / Hirota, Hiroshi / Takahashi, Shunji et al. | 2015
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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)Lin, Songnian / Malkani, Sunita / Lombardo, Matthew / Yang, Lihu / Mills, Sander G. / Chapman, Kevin / Thompson, James E. / Zhang, Wen Xiao / Wang, Ruixiu / Cubbon, Rose M. et al. | 2015
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Sesquiterpenes from Carpesium macrocephalum inhibit Candida albicans biofilm formation and dimorphismXie, Chunfeng / Sun, Lingmei / Meng, Linghao / Wang, Meicheng / Xu, Jing / Bartlam, Mark / Guo, Yuanqiang et al. | 2015
- 5412
-
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agentsBrogi, Simone / Brindisi, Margherita / Joshi, Bhupendra P. / Sanna Coccone, Salvatore / Parapini, Silvia / Basilico, Nicoletta / Novellino, Ettore / Campiani, Giuseppe / Gemma, Sandra / Butini, Stefania et al. | 2015
- 5419
-
Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitorsSuzuki, Sayaka / Kuroda, Takeshi / Kimoto, Hiroko / Domon, Yuki / Kubota, Kazufumi / Kitano, Yutaka / Yokoyama, Tomihisa / Shimizugawa, Akiko / Sugita, Ryusuke / Koishi, Ryuta et al. | 2015
- 5424
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Protective effects of the bioactive natural product N-trans-Caffeoyldopamine on hepatotoxicity induced by isoniazid and rifampicinWu, Zheng-Rong / Bai, Zhong-Tian / Sun, Ying / Chen, Peng / Yang, Zhi-Gang / Zhi, De-Juan / Li, Yang / Wang, Xing / Du, Jing-Jing / Yang, Rui et al. | 2015
- 5427
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Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320Parsy, Christophe C. / Alexandre, François-René / Bidau, Valérie / Bonnaterre, Florence / Brandt, Guillaume / Caillet, Catherine / Cappelle, Sylvie / Chaves, Dominique / Convard, Thierry / Derock, Michel et al. | 2015
- 5437
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Development of a novel tricyclic class of potent and selective FIXa inhibitorsMeng, Dongfang / Andre, Patrick / Bateman, Thomas J. / Berger, Richard / Chen, Yi-Heng / Desai, Kunal / Dewnani, Sunita / Ellsworth, Kenneth / Feng, Daming / Geissler, Wayne M. et al. | 2015
- 5444
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Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of actionKim, Kyeojin / Kim, Su-Jung / Han, Young Taek / Hong, Sung-Jun / An, Hongchan / Chang, Dong-Jo / Kim, Taewoo / Lim, Bumhee / Lee, Jeeyeon / Surh, Young-Joon et al. | 2015
- 5449
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Discovery and structure–activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitorsYu, Xu-Ri / Tang, Yun / Wang, Wen-Jing / Ji, Sen / Ma, Shuang / Zhong, Lei / Zhang, Chun-Hui / Yang, Jiao / Wu, Xiao-Ai / Fu, Zheng-Yan et al. | 2015
- IFC
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Editorial board| 2015