From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling (English)
- New search for: Drusano, G.L
- New search for: Drusano, G.L
In:
Bioorganic & medicinal chemistry
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24
, 24
; 6401-6408
;
2016
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ISSN:
- Article (Journal) / Print
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Title:From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling
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Contributors:Drusano, G.L ( author )
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Published in:Bioorganic & medicinal chemistry ; 24, 24 ; 6401-6408
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Publisher:
- New search for: Elsevier
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Place of publication:Amsterdam [u.a.]
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Publication date:2016
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ISSN:
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ZDBID:
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DOI:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 35.70 / 44.33 / 44.40
- Further information on Basic classification
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Source:
Table of contents – Volume 24, Issue 24
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 6225
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Discovery of novel antibacterialsRomesberg, Floyd E. / Craney, Arryn et al. | 2016
- 6227
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New antibiotics from Nature’s chemical inventoryWencewicz, Timothy A. et al. | 2016
- 6253
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The action mechanism of daptomycinTaylor, Scott D. / Palmer, Michael et al. | 2016
- 6269
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Tetrodecamycin: An unusual and interesting tetronate antibioticGverzdys, Tomas / Kramer, Glenna / Nodwell, Justin R. et al. | 2016
- 6276
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Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural productsMolloy, Evelyn M. / Tietz, Jonathan I. / Blair, Patricia M. / Mitchell, Douglas A. et al. | 2016
- 6291
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Discovery and development of kibdelomycin, a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomeraseSingh, Sheo B. et al. | 2016
- 6298
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Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureusNgo, Huy X. / Shrestha, Sanjib K. / Green, Keith D. / Garneau-Tsodikova, Sylvie et al. | 2016
- 6307
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Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screeningMatano, Leigh M. / Morris, Heidi G. / Wood, B. McKay / Meredith, Timothy C. / Walker, Suzanne et al. | 2016
- 6315
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A cell-based approach to characterize antimicrobial compounds through kinetic dose responseMacNair, Craig R. / Stokes, Jonathan M. / French, Shawn / Myers, Cullen L. / Iyer, Kali R. / Brown, Eric D. et al. | 2016
- 6320
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Drug discovery strategies to outer membrane targets in Gram-negative pathogensBrown, Dean G. et al. | 2016
- 6332
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Synthesis and antimicrobial activity against Pseudomonas aeruginosa of macrocyclic β-hairpin peptidomimetic antibiotics containing N-methylated amino acidsVetterli, Stefan U. / Moehle, Kerstin / Robinson, John A. et al. | 2016
- 6340
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Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage ϕX174 lysis protein E, and cationic antibacterial peptidesBugg, Timothy D.H. / Rodolis, Maria T. / Mihalyi, Agnes / Jamshidi, Shirin et al. | 2016
- 6348
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Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029Dong, Liao-Bin / Rudolf, Jeffrey D. / Shen, Ben et al. | 2016
- 6354
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Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZHaranahalli, Krupanandan / Tong, Simon / Ojima, Iwao et al. | 2016
- 6370
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Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulenceWalsh, Shawn I. / Craney, Arryn / Romesberg, Floyd E. et al. | 2016
- 6379
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A Gestalt approach to Gram-negative entrySilver, Lynn L. et al. | 2016
- 6390
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Animal models in the pharmacokinetic/pharmacodynamic evaluation of antimicrobial agentsZhao, Miao / Lepak, Alexander J. / Andes, David R. et al. | 2016
- 6401
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From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modelingDrusano, G.L. et al. | 2016
- 6409
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Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibioticTanaka, S. Ken / Steenbergen, Judith / Villano, Stephen et al. | 2016
- 6420
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The solithromycin journey—It is all in the chemistryFernandes, Prabhavathi / Martens, Evan / Bertrand, Daniel / Pereira, David et al. | 2016
- 6429
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Plazomicin is effective in a non-human primate pneumonic plague modelMega, William M. / Doyle-Eisele, Melanie / Cass, Robert T. / Kostrub, Corwin F. / Sherwood, Robert L. / Metz, Matthew A. / Cirz, Ryan T. et al. | 2016
- 6440
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The emergence and evolution of antimicrobial resistance: Impact on a global scaleHwang, Andrew Y. / Gums, John G. et al. | 2016
- 6446
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Regulatory Incentives for Antibiotic Drug Development: A Review of Recent ProposalsSinha, Michael S. / Kesselheim, Aaron S. et al. | 2016
- IFC
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Editorial board| 2016