Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform (Unknown)
Free access
- New search for: Pekar, Lukas
- New search for: Busch, Michael
- New search for: Valldorf, Bernhard
- New search for: Hinz, Steffen C.
- New search for: Toleikis, Lars
- New search for: Krah, Simon
- New search for: Zielonka, Stefan
- New search for: Pekar, Lukas
- New search for: Busch, Michael
- New search for: Valldorf, Bernhard
- New search for: Hinz, Steffen C.
- New search for: Toleikis, Lars
- New search for: Krah, Simon
- New search for: Zielonka, Stefan
In:
mAbs
;
12
, 1
;
2020
- Article (Journal) / Electronic Resource
-
Title:Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform
-
Contributors:Pekar, Lukas ( author ) / Busch, Michael ( author ) / Valldorf, Bernhard ( author ) / Hinz, Steffen C. ( author ) / Toleikis, Lars ( author ) / Krah, Simon ( author ) / Zielonka, Stefan ( author )
-
Published in:mAbs ; 12, 1
-
Publisher:
- New search for: Taylor & Francis
-
Publication date:2020-01-01
-
ISSN:
-
DOI:
-
Type of media:Article (Journal)
-
Type of material:Electronic Resource
-
Language:Unknown
-
Keywords:
-
Source:
Table of contents – Volume 12, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
-
NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodiesLau, Corinna / McAdam, Martin Berner / Bergseth, Grethe / Grevys, Algirdas / Bruun, Jack Ansgar / Ludviksen, Judith Krey / Fure, Hilde / Espevik, Terje / Moen, Anders / Andersen, Jan Terje et al. | 2020
-
Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17AZheng, Songmao / Shen, Fang / Jones, Brian / Fink, Damien / Geist, Brian / Nnane, Ivo / Zhou, Zhao / Hall, Jeff / Malaviya, Ravi / Ort, Tatiana et al. | 2020
-
The Antibody Society’s antibody validation webinar seriesVoskuil, Jan L.A. / Bandrowski, Anita / Begley, C. Glenn / Bradbury, Andrew R.M. / Chalmers, Andrew D. / Gomes, Aldrin V. / Hardcastle, Travis / Lund-Johansen, Fridtjof / Plückthun, Andreas / Roncador, Giovanna et al. | 2020
-
Measuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutionsChaturvedi, Sumit K. / Parupudi, Arun / Juul-Madsen, Kristian / Nguyen, Ai / Vorup-Jensen, Thomas / Dragulin-Otto, Sonia / Zhao, Huaying / Esfandiary, Reza / Schuck, Peter et al. | 2020
-
Biased anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologicsGroßerichter-Wagener, Christina / Kos, Dorien / van Leeuwen, Astrid / Dijk, Lisanne / Jeremiasse, Jorn / Loeff, Floris C. / Rispens, Theo et al. | 2020
-
Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosityCloutier, Theresa K. / Sudrik, Chaitanya / Mody, Neil / Hasige, Sathish A. / Trout, Bernhardt L. et al. | 2020
-
Vaccine-induced CD8 T cells are redirected with peptide-MHC class I-IgG antibody fusion proteins to eliminate tumor cells in vivoFischer, Cornelia / Munks, Michael W. / Hill, Ann B. / Kroczek, Richard A. / Bissinger, Stefan / Brand, Verena / Schmittnaegel, Martina / Imhof-Jung, Sabine / Hoffmann, Eike / Herting, Frank et al. | 2020
-
Hiding in plain sight: structure and sequence analysis reveals the importance of the antibody DE loop for antibody-antigen bindingKelow, Simon P. / Adolf-Bryfogle, Jared / Dunbrack, Roland L. et al. | 2020
-
Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized micevan der Velden, Yme U. / Villaudy, Julien / Siteur - van Rijnstra, Esther / van der Linden, Cynthia A. / Vink, Monique A. / Schermer, Edith E. / Weijer, Kees / Berkhout, Ben / Sanders, Rogier W. / van Gils, Marit J. et al. | 2020
-
Identification and quantitation of hinge cysteinylation on endogenous IgG2 antibodies from human serumAyalew, Luladey / D’Souza, Alicia D. / Chen, Yan / Kim, Michael T. et al. | 2020
-
Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic modelsWang, Feng / Tsai, Jordan C. / Davis, Jonathan H. / Chau, Bryant / Dong, Jia / West, Sean M. / Hogan, Jason M. / Wheeler, Matthew L. / Bee, Christine / Morishige, Winse et al. | 2020
-
Harnessing MerTK agonism for targeted therapeuticsKedage, Vivekananda / Ellerman, Diego / Chen, Yongmei / Liang, Wei-Ching / Borneo, Joven / Wu, Yan / Yan, Minhong et al. | 2020
-
Anti-ErbB2 immunotherapeutics: struggling to make better antibodies for cancer therapyDe Santis, Rita et al. | 2020
-
Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approachHajduk, Joanna / Brunner, Cyrill / Malik, Sebastian / Bangerter, Jana / Schneider, Gisbert / Thomann, Marco / Reusch, Dietmar / Zenobi, Renato et al. | 2020
-
An overview of patents on therapeutic monoclonal antibodies in Europe: are they a hurdle to biosimilar market entry?Moorkens, Evelien / Vulto, Arnold G. / Huys, Isabelle et al. | 2020
-
In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivoStack, Edwina / McMurray, Sheridan / McMurray, Gordon / Wade, Jason / Clark, Melissa / Young, Gareth / Marquette, Kim / Jain, Sadhana / Kelleher, Kerry / Chen, Ting et al. | 2020
-
Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffoldSun, Zehua / Chen, Chuan / Li, Wei / Martinez, David R. / Drelich, Aleksandra / Baek, Du-San / Liu, Xianglei / Mellors, John W. / Tseng, Chien-Te / Baric, Ralph S. et al. | 2020
-
Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectivenessBrücher, Dominik / Franc, Vojtech / Smith, Sheena N. / Heck, Albert J. R. / Plückthun, Andreas et al. | 2020
-
Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of actionAustin, Mark / Burschowsky, Daniel / Chan, Denice T.Y. / Jenkinson, Lesley / Haynes, Stuart / Diamandakis, Agata / Seewooruthun, Chitra / Addyman, Alexandra / Fiedler, Sebastian / Ryman, Stephanie et al. | 2020
-
An accelerated surface-mediated stress assay of antibody instability for developability studiesKopp, Marie R.G. / Wolf Pérez, Adriana-Michelle / Zucca, Marta Virginia / Capasso Palmiero, Umberto / Friedrichsen, Brigitte / Lorenzen, Nikolai / Arosio, Paolo et al. | 2020
-
A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in miceCepeda, Joseph Ray / Sekhar, Nitin S / Han, Junying / Xiong, Wei / Zhang, Ningyan / Yu, Liping / Dai, Shaodong / Davidson, Howard W. / Kappler, John W. / An, Zhiqiang et al. | 2020
-
Monoclonal antibody 2C5 specifically targets neutrophil extracellular trapsMendes, Livia P. / Rostamizadeh, Kobra / Gollomp, Kandace / Myerson, Jacob W. / Marcos-Contreras, Oscar A. / Zamora, Marco / Luther, Ed / Brenner, Jacob S. / Filipczak, Nina / Li, Xiang et al. | 2020
-
Antibodies to watch in 2020Kaplon, Hélène / Muralidharan, Mrinalini / Schneider, Zita / Reichert, Janice M. et al. | 2020
-
Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptorMin, Xiaoshan / Yie, Junming / Wang, Jinghong / Chung, Ben C. / Huang, Ching-Shin / Xu, Haoda / Yang, Jie / Deng, Liying / Lin, Joanne / Chen, Qing et al. | 2020
-
Understanding the human antibody repertoireRees, Anthony R et al. | 2020
-
Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumorsHatterer, Eric / Chauchet, Xavier / Richard, Françoise / Barba, Leticia / Moine, Valéry / Chatel, Laurence / Broyer, Lucile / Pontini, Guillemette / Bautzova, Tereza / Juan, Flora et al. | 2020
-
Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studiesBolisetty, Parimala / Tremml, Gabi / Xu, Sen / Khetan, Anurag et al. | 2020
-
Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge regionHandlogten, Michael W. / Peng, Li / Christian, Elizabeth A. / Xu, Weichen / Lin, Shihua / Venkat, Raghavan / Dall’Acqua, William / Ahuja, Sanjeev et al. | 2020
-
An evaluation of instrument types for mass spectrometry-based multi-attribute analysis of biotherapeuticsZhang, Zhongqi / Chan, Pik K. / Richardson, Jason / Shah, Bhavana et al. | 2020
-
Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregatesKwiatkowski, Allyson / Co, Carl / Kameoka, Sei / Zhang, An / Coughlin, John / Cameron, Tom / Chiao, Eric / Bergelson, Svetlana / Schmid Mason, Cullen et al. | 2020
-
Engineered Fc-glycosylation switch to eliminate antibody effector functionZhou, Qun / Jaworski, Julie / Zhou, Yanfeng / Valente, Delphine / Cotton, Joanne / Honey, Denise / Boudanova, Ekaterina / Beninga, Jochen / Rao, Ercole / Wei, Ronnie et al. | 2020
-
CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulinsJost, Christian / Darowski, Diana / Challier, John / Pulko, Vesna / Hanisch, Lydia J / Xu, Wei / Mössner, Ekkehard / Bujotzek, Alexander / Klostermann, Stefan / Umana, Pablo et al. | 2020
-
Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometryGstöttner, Christoph / Reusch, Dietmar / Haberger, Markus / Dragan, Irina / Van Veelen, Peter / Kilgour, David P. A. / Tsybin, Yury O. / van der Burgt, Yuri E. M. / Wuhrer, Manfred / Nicolardi, Simone et al. | 2020
-
Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studiesLi, Chunze / Zhang, Cindy / Li, Zao / Samineni, Divya / Lu, Dan / Wang, Bei / Chen, Shang-Chiung / Zhang, Rong / Agarwal, Priya / Fine, Bernard M. et al. | 2020
-
Characterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysisShi, Rachel Liuqing / Xiao, Gang / Dillon, Thomas M. / Ricci, Margaret S. / Bondarenko, Pavel V. et al. | 2020
-
Benchmarking biopharmaceutical process development and manufacturing cost contributions to R&DFarid, Suzanne S. / Baron, Max / Stamatis, Christos / Nie, Wenhao / Coffman, Jon et al. | 2020
-
Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignanciesEvers, Mitchell / Ten Broeke, Toine / Jansen, J.H. Marco / Nederend, Maaike / Hamdan, Firas / Reiding, Karli R. / Meyer, Saskia / Moerer, Petra / Brinkman, Iris / Rösner, Thies et al. | 2020
-
A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapyMiao, Xiaoniu / Luo, Yi / Huang, Xi / Lee, Suki M. Y. / Yuan, Zhijun / Tang, Yongzhou / Chen, Liandi / Wang, Chao / Wu, Fan / Xu, Yifeng et al. | 2020
-
Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platformPekar, Lukas / Busch, Michael / Valldorf, Bernhard / Hinz, Steffen C. / Toleikis, Lars / Krah, Simon / Zielonka, Stefan et al. | 2020
-
Native size-exclusion chromatography-mass spectrometry: suitability for antibody–drug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levelsJones, Jay / Pack, Laura / Hunter, Joshua H. / Valliere-Douglass, John F. et al. | 2020
-
Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structuresFernández-Quintero, Monica L. / Heiss, Martin C. / Pomarici, Nancy D. / Math, Barbara A. / Liedl, Klaus R. et al. | 2020
-
Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodiesMa, Fengfei / Raoufi, Fahimeh / Bailly, Marc Andre / Fayadat-Dilman, Laurence / Tomazela, Daniela et al. | 2020
-
COBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumorsPanchal, Anand / Seto, Pui / Wall, Russell / Hillier, Brian J. / Zhu, Ying / Krakow, Jessica / Datt, Aakash / Pongo, Elizabeth / Bagheri, Andisheh / Chen, Tseng-Hui T. et al. | 2020
-
On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodiesTan, Zhijun / Ehamparanathan, Vivekh / Ren, Tingwei / Tang, Peifeng / Hoffman, Laurel / Kuang, June / Liu, Peiran / Huang, Chao / Du, Cheng / Tao, Li et al. | 2020
-
Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodiesScott, Martin J. / Jowett, Amanda / Orecchia, Martin / Ertl, Peter / Ouro-Gnao, Larissa / Ticehurst, Julia / Gower, David / Yates, John / Poulton, Katie / Harris, Carol et al. | 2020
-
In vivo safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat modelWilliams, Iwan P. / Crescioli, Silvia / Sow, Heng Sheng / Bax, Heather J. / Hobbs, Carl / Ilieva, Kristina M. / French, Elise / Pellizzari, Giulia / Cox, Vivienne / Josephs, Debra H. et al. | 2020
-
Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assemblyFarràs, Mercè / Miret, Joan / Camps, Marc / Román, Ramón / Martínez, Óscar / Pujol, Xavier / Erb, Stéphane / Ehkirch, Anthony / Cianferani, Sarah / Casablancas, Antoni et al. | 2020
-
A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasisMurer, Patrizia / Plüss, Louis / Neri, Dario et al. | 2020
-
A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitopeLi, Dong / Li, Jing / Chu, Huanyu / Wang, Zhuozhi et al. | 2020
-
Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formatsMiller, Ami / Carr, Stephen / Rabbitts, Terry / Ali, Hanif et al. | 2020
-
Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chainBauer, Joschka / Mathias, Sven / Kube, Sebastian / Otte, Kerstin / Garidel, Patrick / Gamer, Martin / Blech, Michaela / Fischer, Simon / Karow-Zwick, Anne R et al. | 2020
-
Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCRSimons, Jan Fredrik / Lim, Yoong Wearn / Carter, Kyle P. / Wagner, Ellen K. / Wayham, Nicholas / Adler, Adam S. / Johnson, David S. et al. | 2020
-
Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocessesTang, Peifeng / Tan, Zhijun / Ehamparanathan, Vivekh / Ren, Tingwei / Hoffman, Laurel / Du, Cheng / Song, Yuanli / Tao, Li / Lewandowski, Angela / Ghose, Sanchayita et al. | 2020
-
Selection and verification of antibodies against the cytoplasmic domain of M2 of influenza, a transmembrane proteinVelappan, Nileena / Micheva-Viteva, Sofiya / Adikari, Samantha H. / Waldo, Geoffrey S. / Lillo, Antonietta M. / Bradbury, Andrew R.M. et al. | 2020
-
Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironmentSulea, Traian / Rohani, Nazanin / Baardsnes, Jason / Corbeil, Christopher R. / Deprez, Christophe / Cepero-Donates, Yuneivy / Robert, Alma / Schrag, Joseph D. / Parat, Marie / Duchesne, Mélanie et al. | 2020
-
Rapid two-dimensional Protein-A size exclusion chromatography of monoclonal antibodies for titer and aggregation measurements from harvested cell culture fluid samplesDunn, Zachary D. / Desai, Jayesh / Leme, Gabriel M. / Stoll, Dwight R. / Richardson, Douglas D. et al. | 2020
-
VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosisLow, Sarah / Wu, Haixia / Jerath, Kavita / Tibolla, Annette / Fogal, Birgit / Conrad, Rebecca / Webb, Deborah / MacDougall, Margit / Kerr, Steven / Berger, Valentina et al. | 2020
-
In situ antibody phage display yields optimal inhibitors of integrin α11/β1Gallo, Eugenio / Kelil, Abdellali / Bayliss, Peter E. / Jeganathan, Ajitha / Egorova, Olga / Ploder, Lynda / Adams, Jarrett J. / Giblin, Patricia / Sidhu, Sachdev S. et al. | 2020
-
Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissuesConner, Kip P. / Pastuskovas, Cinthia V. / Soto, Marcus / Thomas, Veena A. / Wagner, Mylo / Rock, Dan A. et al. | 2020
-
Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case studyXu, Jianlin / Xu, Xuankuo / Huang, Chao / Angelo, James / Oliveira, Christopher L. / Xu, Mengmeng / Xu, Xia / Temel, Deniz / Ding, Julia / Ghose, Sanchayita et al. | 2020
-
A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumorsBishop, Michael W. / Hutson, Paul R. / Hank, Jacquelyn A. / Sondel, Paul M. / Furman, Wayne L. / Meagher, Michael M. / Navid, Fariba / Santana, Victor M. et al. | 2020
-
Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemicQian, Kewen / Hu, Shi et al. | 2020
-
Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependentBondza, Sina / ten Broeke, Toine / Nestor, Marika / Leusen, Jeanette H. W. / Buijs, Jos et al. | 2020
-
Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activityCamacho, Raul C. / You, Seohee / D’Aquino, Katharine E. / Li, Wenyu / Wang, Yuanping / Gunnet, Joseph / Littrell, James / Qi, Jian Shen / Kang, Lijuan / Jian, Wenying et al. | 2020
-
Development and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumabSchokker, Sandor / Fusetti, Fabrizia / Bonardi, Francesco / Molenaar, Remco J. / Mathôt, Ron A.A. / van Laarhoven, Hanneke W.M. et al. | 2020
-
CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonismNelke, Johannes / Medler, Juliane / Weisenberger, Daniela / Beilhack, Andreas / Wajant, Harald et al. | 2020
-
Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivoNadal, Lisa / Corbellari, Riccardo / Villa, Alessandra / Weiss, Tobias / Weller, Michael / Neri, Dario / De Luca, Roberto et al. | 2020
-
Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodiesChuang, Gwo-Yu / Asokan, Mangaiarkarasi / Ivleva, Vera B. / Pegu, Amarendra / Yang, Eun Sung / Zhang, Baoshan / Chaudhuri, Rajoshi / Geng, Hui / Lin, Bob C. / Louder, Mark K. et al. | 2020
-
Predicting Antibody Developability Profiles Through Early Stage Discovery ScreeningBailly, Marc / Mieczkowski, Carl / Juan, Veronica / Metwally, Essam / Tomazela, Daniela / Baker, Jeanne / Uchida, Makiko / Kofman, Ester / Raoufi, Fahimeh / Motlagh, Soha et al. | 2020
-
Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosisKraft, Thomas E. / Richter, Wolfgang F. / Emrich, Thomas / Knaupp, Alexander / Schuster, Michaela / Wolfert, Andreas / Kettenberger, Hubert et al. | 2020
-
The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibodyMasiero, Alessandro / Nelly, Lechat / Marianne, Gentric / Christophe, Sourrouille / Florian, Laville / Ronan, Crépin / Claire, Borel / Cornelia, Ziegler / Grégoire, Bisch / Eric, Leclerc et al. | 2020
-
An engineered human IgG1 CH2 domain with decreased aggregation and nonspecific bindingCao, Guangcan / Gao, Xinyu / Zhan, Yancheng / Wang, Qingguang / Zhang, Zhe / Dimitrov, Dimiter S. / Gong, Rui et al. | 2020
-
Exploiting next-generation sequencing in antibody selections – a simple PCR method to recover bindersFerrara, Fortunato / Teixeira, Andre A. / Naranjo, Leslie / Erasmus, M. Frank / D’Angelo, Sara / Bradbury, Andrew R.M. et al. | 2020
-
Discovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologicsMaruthachalam, Bharathikumar Vellalore / Zwolak, Adam / Lin-Schmidt, Xiefan / Keough, Edward / Tamot, Ninkka / Venkataramani, Sathya / Geist, Brian / Singh, Sanjaya / Ganesan, Rajkumar et al. | 2020
-
SPLICELECT™: an adaptable cell surface display technology based on alternative splicing allowing the qualitative and quantitative prediction of secreted product at a single-cell levelAebischer-Gumy, Christel / Moretti, Pierre / Ollier, Romain / Ries Fecourt, Christelle / Rousseau, François / Bertschinger, Martin et al. | 2020
-
10th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticalsTourdot, S. / Abdolzade-Bavil, A. / Bessa, J. / Broët, P. / Fogdell-Hahn, A. / Giorgi, M. / Jawa, V. / Kuranda, K. / Legrand, N. / Pattijn, S. et al. | 2020
-
Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donorsFan, Pengfei / Chi, Xiangyang / Liu, Guodong / Zhang, Guanying / Chen, Zhengshan / Liu, Yujiao / Fang, Ting / Li, Jianmin / Banadyga, Logan / He, Shihua et al. | 2020
-
Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse modelsValente, Delphine / Mauriac, Christine / Schmidt, Thorsten / Focken, Ingo / Beninga, Jochen / Mackness, Brian / Qiu, Huawei / Vicat, Pascale / Kandira, Abdullah / Radošević, Katarina et al. | 2020
-
Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibodyBoyles, Jeffrey S. / Beidler, Catherine B. / Strifler, Beth A. / Girard, Daniel S. / Druzina, Zhanna / Durbin, Jim D. / Swearingen, Michelle L. / Lee, Linda N. / Kikly, Kristine / Chintharlapalli, Sudhakar et al. | 2020
-
Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variantsBurman, Luke / Chong, Yeeting E. / Duncan, Sherie / Klaus, Anders / Rauch, Kaitlyn / Hamel, Kristina / Hervé, Karine / Pfaffen, Stephanie / Collins, David W. / Heyries, Kevin et al. | 2020
-
Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell lineKim, Jun / Luo, Haibin / White, Wendy / Rees, William / Venkat, Raghavan / Albarghouthi, Methal et al. | 2020
-
Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD modelSingh, Aman P. / Zheng, Xirong / Lin-Schmidt, Xiefan / Chen, Wenbo / Carpenter, Thomas J. / Zong, Alice / Wang, Weirong / Heald, Donald L. et al. | 2020
-
Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigenWang, Bo / Yang, Chunning / Jin, Xiaofang / Du, Qun / Wu, Herren / Dall’Acqua, William / Mazor, Yariv et al. | 2020
-
T cell epitope mapping of secukinumab and ixekizumab in healthy donorsSpindeldreher, Sebastian / Karle, Anette / Correia, Evelyne / Tenon, Maxime / Gottlieb, Sascha / Huber, Thomas / Maillere, Bernard / Kolbinger, Frank et al. | 2020
-
A general evidence-based sequence variant control limit for recombinant therapeutic protein developmentZhang, Aming / Chen, Zhengwei / Li, Meinuo / Qiu, Haibo / Lawrence, Shawn / Bak, Hanne / Li, Ning et al. | 2020
-
Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5Molnar, Sebastian / Wieczorek, Lindsay / Zemil, Michelle / Schulte, Bianca / Martinez, Elizabeth / Gift, Syna / Tang, Lan / Streeck, Hendrik / Gramzinski, Robert A. / Michael, Nelson L. et al. | 2020
-
AlbuCORE: an albumin-based molecular scaffold for multivalent biologics designSanches, Mario / D’Angelo, Igor / Jaramillo, Maria / Baardsnes, Jason / Zwaagstra, John / Schrag, Joe / Schoenhofen, Ian / Acchione, Mauro / Lawn, Sam / Wickman, Grant et al. | 2020
-
Targeted IgMs agonize ocular targets with extended vitreal exposureChen, Yvonne / Paluch, Maciej / Zorn, Julie A. / Rajan, Sharmila / Leonard, Brandon / Estevez, Alberto / Brady, John / Chiu, Henry / Phung, Wilson / Famili, Amin et al. | 2020
-
Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humansSepp, Armin / Bergström, Mats / Davies, Marie et al. | 2020
-
Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodiesAlam, Md Jahangir / Xie, Liang / Ang, Caroline / Fahimi, Farnaz / Willingham, Stephen B. / Kueh, Andrew J. / Herold, Marco J. / Mackay, Charles R. / Robert, Remy et al. | 2020
-
Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodiesTilegenova, Cholpon / Izadi, Saeed / Yin, Jianping / Huang, Christine S. / Wu, Jiansheng / Ellerman, Diego / Hymowitz, Sarah G. / Walters, Benjamin / Salisbury, Cleo / Carter, Paul J. et al. | 2020
-
Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoiresHsiao, Yi-Chun / Chen, Ying-Jiun J. / Goldstein, Leonard D. / Wu, Jia / Lin, Zhonghua / Schneider, Kellen / Chaudhuri, Subhra / Antony, Aju / Bajaj Pahuja, Kanika / Modrusan, Zora et al. | 2020
-
Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodiesChen, Serene W. / Tan, Darryl / Yang, Yuan Sheng / Zhang, Wei et al. | 2020
-
Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibodyWang, Yan / Pan, Donghui / Huang, Chenrong / Chen, Bingliang / Li, Mingzhu / Zhou, Shuaixiang / Wang, Lizhen / Wu, Min / Wang, Xinyu / Bian, Yicong et al. | 2020
-
Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAbLan, Wenkui / Valente, Joseph J. / Ilott, Andrew / Chennamsetty, Naresh / Liu, Zhihua / Rizzo, Joseph M. / Yamniuk, Aaron P. / Qiu, Difei / Shackman, Holly M. / Bolgar, Mark S. et al. | 2020
-
Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanismsWalsh, Robin E. / Lannan, Megan / Wen, Yi / Wang, Xiaoli / Moreland, Christopher A. / Willency, Jill / Knierman, Michael D. / Spindler, Laura / Liu, Ling / Zeng, Wei et al. | 2020
-
Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinitySun, Yue / Estevez, Alberto / Schlothauer, Tilman / Wecksler, Aaron T. et al. | 2020
-
A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease modelZheng, Songmao / Niu, Jin / Geist, Brian / Fink, Damien / Xu, Zhenhua / Zhou, Honghui / Wang, Weirong et al. | 2020
-
Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanismSpatola, Bradley N. / Lerner, Alana G. / Wong, Clifford / dela Cruz, Tracy / Welch, Megan / Fung, Wanchi / Kovalenko, Maria / Losenkova, Karolina / Yegutkin, Gennady G. / Beers, Courtney et al. | 2020
-
Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinityRos, Francesca / Offner, Sonja / Klostermann, Stefan / Thorey, Irmgard / Niersbach, Helmut / Breuer, Sebastian / Zarnt, Grit / Lorenz, Stefan / Puels, Juergen / Siewe, Basile et al. | 2020
-
Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding siteHanf, Karl J. M. / Arndt, Joseph W. / Liu, YuTing / Gong, Bang Jian / Rushe, Mia / Sopko, Richelle / Massol, Ramiro / Smith, Benjamin / Gao, Yan / Dalkilic-Liddle, Isin et al. | 2020
-
Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoiresSchmitz, Samuel / Soto, Cinque / Crowe, James E.Jr. / Meiler, Jens et al. | 2020
-
Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometryRouby, G. / Tran, N. T. / Leblanc, Y. / Taverna, M. / Bihoreau, N. et al. | 2020
-
Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristicsChen, Zhiqiang / Qian, Yueming / Song, Yuanli / Xu, Xuankuo / Tao, Li / Mussa, Nesredin / Ghose, Sanchayita / Li, Zheng Jian et al. | 2020
-
Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipelineTuccori, Marco / Ferraro, Sara / Convertino, Irma / Cappello, Emiliano / Valdiserra, Giulia / Blandizzi, Corrado / Maggi, Fabrizio / Focosi, Daniele et al. | 2020
-
Development of a high yielding expression platform for the introduction of non-natural amino acids in protein sequencesRoy, Gargi / Reier, Jason / Garcia, Andrew / Martin, Tom / Rice, Megan / Wang, Jihong / Prophet, Meagan / Christie, Ronald / Dall’Acqua, William / Ahuja, Sanjeev et al. | 2020
-
Defining the right diluent for intravenous infusion of therapeutic antibodiesLuo, Shen / McSweeney, Keisha Melodi / Wang, Tao / Bacot, Silvia M. / Feldman, Gerald M. / Zhang, Baolin et al. | 2020
-
Improved translation of stability for conjugated antibodies using an in vitro whole blood assayFourie-O’Donohue, Aimee / Chu, Phillip Y. / dela Cruz Chuh, Josefa / Tchelepi, Robert / Tsai, Siao Ping / Tran, John C. / Sawyer, William S. / Su, Dian / Ng, Carl / Xu, Keyang et al. | 2020
-
HX008: a humanized PD-1 blocking antibody with potent antitumor activity and superior pharmacologic propertiesZhang, Jibin / Huang, Ying / Xi, Gan / Zhang, Faming et al. | 2020
-
Intein mediated high throughput screening for bispecific antibodiesHofmann, Tim / Schmidt, Johannes / Ciesielski, Elke / Becker, Stefan / Rysiok, Thomas / Schütte, Mark / Toleikis, Lars / Kolmar, Harald / Doerner, Achim et al. | 2020
-
Analytical characterization of coformulated antibodies as combination therapyKim, Jun / Kim, Yoen Joo / Cao, Mingyan / De Mel, Niluka / Miller, Kenneth / Bee, Jared S. / Wang, Jihong / Wang, Xiangyang / Albarghouthi, Methal et al. | 2020
-
A rapid method for relative quantification of N-glycans from a therapeutic monoclonal antibody during trastuzumab biosimilar developmentSegu, Zaneer / Stone, Todd / Berdugo, Claudia / Roberts, Anthony / Doud, Emma / Li, Yunsong et al. | 2020
-
Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodiesDatta-Mannan, Amita / Estwick, Selina / Zhou, Chen / Choi, Hiuwan / Douglass, Nicole E. / Witcher, Derrick R. / Lu, Jirong / Beidler, Catherine / Millican, Rohn et al. | 2020
-
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic miceLow, Benjamin E. / Christianson, Gregory J. / Lowell, Emily / Qin, Wenning / Wiles, Michael V. et al. | 2020
-
Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display librariesDyson, Michael R. / Masters, Edward / Pazeraitis, Deividas / Perera, Rajika L. / Syrjanen, Johanna L. / Surade, Sachin / Thorsteinson, Nels / Parthiban, Kothai / Jones, Philip C. / Sattar, Maheen et al. | 2020