Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions (Unknown)
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mAbs
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13
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2021
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Title:Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions
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Contributors:Lai, Pin-Kuang ( author ) / Ghag, Gaurav ( author ) / Yu, Yao ( author ) / Juan, Veronica ( author ) / Fayadat-Dilman, Laurence ( author ) / Trout, Bernhardt L. ( author )
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Published in:mAbs ; 13, 1
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- New search for: Taylor & Francis
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Publication date:2021-01-01
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Table of contents – Volume 13, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
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Immunogenicity risk assessment for biotherapeutics through in vitro detection of CD134 and CD137 on T helper cellsCohen, Sivan / Myneni, Srividya / Batt, Anna / Guerrero, Joyce / Brumm, Jochen / Chung, Shan et al. | 2021
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Developments and opportunities in continuous biopharmaceutical manufacturingKhanal, Ohnmar / Lenhoff, Abraham M. et al. | 2021
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Protective antibodies against human parainfluenza virus type 3 infectionBoonyaratanakornkit, Jim / Singh, Suruchi / Weidle, Connor / Rodarte, Justas / Bakthavatsalam, Ramasamy / Perkins, Jonathan / Stewart-Jones, Guillaume B.E. / Kwong, Peter D. / McGuire, Andrew T. / Pancera, Marie et al. | 2021
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Animal immunization merges with innovative technologies: A new paradigm shift in antibody discoveryPrabakaran, Ponraj / Rao, Sambasiva P / Wendt, Maria et al. | 2021
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A T cell redirection platform for co-targeting dual antigens on solid tumorsEnderle, Leonie / Shalaby, Karim H. / Gorelik, Maryna / Weiss, Alexander / Blazer, Levi L. / Paduch, Marcin / Cardarelli, Lia / Kossiakoff, Anthony / Adams, Jarrett J. / Sidhu, Sachdev S. et al. | 2021
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A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and preventionKwon, Young D. / Asokan, Mangaiarkarasi / Gorman, Jason / Zhang, Baoshan / Liu, Qingbo / Louder, Mark K. / Lin, Bob C. / McKee, Krisha / Pegu, Amarendra / Verardi, Raffaello et al. | 2021
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Host cell protein detection gap risk mitigation: quantitative IAC-MS for ELISA antibody reagent coverage determinationWaldera-Lupa, Daniel M. / Jasper, Yvonne / Köhne, Pia / Schwichtenhövel, Ronja / Falkenberg, Heiner / Flad, Thomas / Happersberger, Peter / Reisinger, Bernd / Dehghani, Alireza / Moussa, Roland et al. | 2021
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Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein developmentMolden, Rosalynn / Hu, Mengqi / Yen E, Sook / Saggese, Diana / Reilly, James / Mattila, John / Qiu, Haibo / Chen, Gang / Bak, Hanne / Li, Ning et al. | 2021
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Characterizing and understanding the formation of cysteine conjugates and other by-products in a random, lysine-linked antibody drug conjugateQiu, Difei / Huang, Yande / Chennamsetty, Naresh / Miller, Scott A. / Hay, Michael et al. | 2021
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Coming together at the hinges: Therapeutic prospects of IgG3Chu, Thach H. / Patz, Edward F.Jr / Ackerman, Margaret E. et al. | 2021
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Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeysLoberg, Lise I. / Chhaya, Meha / Ibraghimov, Alexander / Tarcsa, Edit / Striebinger, Andreas / Popp, Andreas / Huang, Lili / Oellien, Frank / Barghorn, Stefan et al. | 2021
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Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLLCuesta-Mateos, Carlos / Juárez-Sánchez, Raquel / Mateu-Albero, Tamara / Loscertales, Javier / Mol, Wim / Terrón, Fernando / Muñoz-Calleja, Cecilia et al. | 2021
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Identifying biophysical assays and in silico properties that enrich for slow clearance in clinical-stage therapeutic antibodiesGrinshpun, Boris / Thorsteinson, Nels / Pereira, Joao NS / Rippmann, Friedrich / Nannemann, David / Sood, Vanita D. / Fomekong Nanfack, Yves et al. | 2021
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Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separationBramham, Jack E. / Davies, Stephanie A. / Podmore, Adrian / Golovanov, Alexander P. et al. | 2021
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Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumorsWingert, Susanne / Reusch, Uwe / Knackmuss, Stefan / Kluge, Michael / Damrat, Michael / Pahl, Jens / Schniegler-Mattox, Ute / Mueller, Thomas / Fucek, Ivica / Ellwanger, Kristina et al. | 2021
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Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography–mass spectrometryLippold, Steffen / Knaupp, Alexander / de Ru, Arnoud H. / Tjokrodirijo, Rayman T. N. / van Veelen, Peter A. / van Puijenbroek, Erwin / de Taeye, Steven W. / Reusch, Dietmar / Vidarsson, Gestur / Wuhrer, Manfred et al. | 2021
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Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysisChang, Hsueh-Yuan / Wu, Shengjia / Li, Yingyi / Zhang, Wanying / Burrell, Matthew / Webster, Carl I. / Shah, Dhaval K. et al. | 2021
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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodiesRouet, Romain / Mazigi, Ohan / Walker, Gregory J. / Langley, David B. / Sobti, Meghna / Schofield, Peter / Lenthall, Helen / Jackson, Jennifer / Ubiparipovic, Stephanie / Henry, Jake Y. et al. | 2021
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Correction| 2021
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An integrated approach for characterizing immunogenic responses toward a bispecific antibodyCohen, Sivan / Chung, Shan / Spiess, Christoph / Lundin, Victor / Stefanich, Eric / Laing, Steven T. / Clark, Vanessa / Brumm, Jochen / Zhou, Ying / Huang, Catherine et al. | 2021
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Highly sensitive detection of antibody nonspecific interactions using flow cytometryMakowski, Emily K. / Wu, Lina / Desai, Alec A. / Tessier, Peter M. et al. | 2021
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The therapeutic potential of sialylated Fc domains of human IgGPleass, Richard J. et al. | 2021
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Development of a robust and semi-automated two-step antibody purification processYang, Xiaomin / Yuan, Richard / Garcia, Christopher / Berry, Jessica / Foster, Denisa / He, Dongmei / Zhang, Gui-Feng / Jones, Bryan E. et al. | 2021
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TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHLMalik-Chaudhry, Harbani K. / Prabhakar, Kirthana / Ugamraj, Harshad S. / Boudreau, Andrew A. / Buelow, Benjamin / Dang, Kevin / Davison, Laura M. / Harris, Katherine E. / Jorgensen, Brett / Ogana, Heather et al. | 2021
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The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion proteinSuzuki, Takuo / Hashii, Noritaka / Tada, Minoru / Ishii-Watabe, Akiko et al. | 2021
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Targeting cancer with antibody-drug conjugates: Promises and challengesDean, Alexis Q. / Luo, Shen / Twomey, Julianne D. / Zhang, Baolin et al. | 2021
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Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft modelGupta, Parul / Jiang, Ziyue Karen / Yang, Bing / Manzuk, Lisa / Rosfjord, Edward / Yao, Johnny / Lemon, Luanna / Noorbehesht, Kavon / David, John / Puthenveetil, Sujiet et al. | 2021
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Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reductionPark, Seo-Young / Egan, Susan / Cura, Anthony J. / Aron, Kathryn L. / Xu, Xuankuo / Zheng, Mengyuan / Borys, Michael / Ghose, Sanchayita / Li, Zhengjian / Lee, Kyongbum et al. | 2021
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Ten years in the making: application of CrossMab technology for the development of therapeutic bispecific antibodies and antibody fusion proteinsSurowka, Marlena / Schaefer, Wolfgang / Klein, Christian et al. | 2021
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Preclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancerXiang, Hong / Chan, Abigael G. / Ahene, Ago / Bellovin, David I. / Deng, Rong / Hsu, Amy W. / Jeffry, Ursula / Palencia, Servando / Powers, Janine / Zanghi, James et al. | 2021
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Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common CH2 cleavages in IgGs and IgG-like bispecific antibodiesCao, Mingyan / Jiao, Yang / Parthemore, Conner / Korman, Samuel / Ma, Jiao / Hunter, Alan / Kilby, Greg / Chen, Xiaoyu et al. | 2021
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Nonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinopathiesFjord-Larsen, Lone / Thougaard, Annemette / Wegener, Karen Malene / Christiansen, Joan / Larsen, Frank / Schrøder-Hansen, Lise Maj / Kaarde, Marianne / Ditlevsen, Dorte Kornerup et al. | 2021
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Agonistic nanobodies and antibodies to human VISTAMa, Yu-Heng Vivian / Sparkes, Amanda / Romão, Ema / Saha, Shrayasee / Gariépy, Jean et al. | 2021
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Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecificsChing, Kathryn H. / Berg, Kimberley / Reynolds, Kevin / Pedersen, Darlene / Macias, Alba / Abdiche, Yasmina N. / Harriman, William D. / Leighton, Philip A. et al. | 2021
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Innovative approaches to biologic development on the trail of CT-P13: biosimilars, value-added medicines, and biobettersKim, HoUng / Alten, Rieke / Cummings, Fraser / Danese, Silvio / D’Haens, Geert / Emery, Paul / Ghosh, Subrata / Gilletta de Saint Joseph, Cyrielle / Lee, JongHyuk / Lindsay, James O. et al. | 2021
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A computational method for immune repertoire mining that identifies novel binders from different clonotypes, demonstrated by identifying anti-pertussis toxoid antibodiesRichardson, Eve / Galson, Jacob D. / Kellam, Paul / Kelly, Dominic F. / Smith, Sarah E. / Palser, Anne / Watson, Simon / Deane, Charlotte M. et al. | 2021
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Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibodyCampbell, Sharon M. / DeBartolo, Joseph / Apgar, James R. / Mosyak, Lydia / McManus, Virginie / Beyer, Sonia / Bennett, Eric M. / Lambert, Matthew / Cunningham, Orla et al. | 2021
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Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2Lim, Shion A. / Gramespacher, Josef A. / Pance, Katarina / Rettko, Nicholas J. / Solomon, Paige / Jin, Jing / Lui, Irene / Elledge, Susanna K. / Liu, Jia / Bracken, Colton J. et al. | 2021
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Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivoMester, Simone / Evers, Mitchell / Meyer, Saskia / Nilsen, Jeannette / Greiff, Victor / Sandlie, Inger / Leusen, Jeanette / Andersen, Jan Terje et al. | 2021
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Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapyWaldhauer, Inja / Gonzalez-Nicolini, Valeria / Freimoser-Grundschober, Anne / Nayak, Tapan K / Fahrni, Linda / Hosse, Ralf J. / Gerrits, Danny / Geven, Edwin J. W. / Sam, Johannes / Lang, Sabine et al. | 2021
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N-terminal selective conjugation method widens the therapeutic window of antibody–drug conjugates by improving tolerability and stabilityKo, Min Ji / Song, Daehae / Kim, Juhee / Kim, Jae Yong / Eom, Jaehyun / Sung, Byungje / Son, Yong-Gyu / Kim, Young Min / Lee, Sang Hoon / You, Weon-Kyoo et al. | 2021
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A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351Gu, Chunyin / Cao, Xiaodan / Wang, Zongda / Hu, Xue / Yao, Yanfeng / Zhou, Yiwu / Liu, Peipei / Liu, Xiaowu / Gao, Ge / Hu, Xiao et al. | 2021
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Challenges of non-clinical safety testing for biologics: A Report of the 9th BioSafe European Annual General Membership MeetingKissner, Thomas / Blaich, Guenter / Baumann, Andreas / Kronenberg, Sven / Hey, Adam / Kiessling, Andrea / Schmitt, Petra M. / Driessen, Wouter / Carrez, Chantal / Kramer, Daniel et al. | 2021
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Animal- versus in vitro-derived antibodies: avoiding the extremesBradbury, Andrew R.M. / Dübel, Stefan / Knappik, Achim / Plückthun, Andreas et al. | 2021
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Antibody blockade of CD96 by distinct molecular mechanismsLee, Peter S. / Chau, Bryant / Barman, Ishita / Bee, Christine / Jashnani, Aarti / Hogan, Jason M. / Aguilar, Barbara / Dollinger, Gavin / Rajpal, Arvind / Strop, Pavel et al. | 2021
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Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeuticsKontermann, Roland E. / Ungerechts, Guy / Nettelbeck, Dirk M. et al. | 2021
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Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal modelsKumar, Sujatha / Ghosh, Srimoyee / Sharma, Geeta / Wang, Zebin / Kehry, Marilyn R. / Marino, Margaret H. / Neben, Tamlyn Y. / Lu, Sharon / Luo, Shouqi / Roberts, Simon et al. | 2021
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Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexesBondarenko, Pavel V. / Nichols, Andrew C. / Xiao, Gang / Shi, Rachel Liuqing / Chan, Pik Kay / Dillon, Thomas M / Garces, Fernando / Semin, David J. / Ricci, Margaret S. et al. | 2021
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A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3Rau, Alexander / Kocher, Katharina / Rommel, Mirjam / Kühl, Lennart / Albrecht, Maximilian / Gotthard, Hannes / Aschmoneit, Nadine / Noll, Bettina / Olayioye, Monilola A. / Kontermann, Roland E. et al. | 2021
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A non-clinical comparative study of IL-23 antibodies in psoriasisZhou, Li / Wang, Yibing / Wan, Qi / Wu, Fei / Barbon, Jeffrey / Dunstan, Robert / Gauld, Stephen / Konrad, Mark / Leys, Laura / McCarthy, Richard et al. | 2021
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Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeuticsThorsteinson, Nels / Gunn, John R. / Kelly, Kenneth / Long, Will / Labute, Paul et al. | 2021
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Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody librariesTeixeira, Andre Azevedo Reis / Erasmus, Michael Frank / D’Angelo, Sara / Naranjo, Leslie / Ferrara, Fortunato / Leal-Lopes, Camila / Durrant, Oliver / Galmiche, Cecile / Morelli, Aleardo / Scott-Tucker, Anthony et al. | 2021
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Current strategies for detecting functional convergence across B-cell receptor repertoiresRaybould, Matthew I. J. / Rees, Anthony R. / Deane, Charlotte M. et al. | 2021
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Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibodyFalck, David / Thomann, Marco / Lechmann, Martin / Koeleman, Carolien A. M. / Malik, Sebastian / Jany, Cordula / Wuhrer, Manfred / Reusch, Dietmar et al. | 2021
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Rational selection of building blocks for the assembly of bispecific antibodiesGong, Danyang / Riley, Timothy P. / Bzymek, Krzysztof P. / Correia, Ana R. / Li, Danqing / Spahr, Christopher / Robinson, John H. / Case, Ryan B. / Wang, Zhulun / Garces, Fernando et al. | 2021
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Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoVJiang, Wen / Wang, Junchao / Jiao, Shasha / Gu, Chenjian / Xu, Wei / Chen, Ben / Wang, Rongjuan / Chen, Huilin / Xie, Youhua / Wang, An et al. | 2021
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Sensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studiesValtonen, Salla / Vuorinen, Emmiliisa / Eskonen, Ville / Malakoutikhah, Morteza / Kopra, Kari / Härmä, Harri et al. | 2021
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Impact of IgG subclass on molecular properties of monoclonal antibodiesTang, Yu / Cain, Paul / Anguiano, Victor / Shih, James J. / Chai, Qing / Feng, Yiqing et al. | 2021
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Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIXSheff, Joey G. / Kelly, John F. / Robotham, Anna / Sulea, Traian / Malenfant, Félix / L’Abbé, Denis / Duchesne, Mélanie / Pelletier, Alex / Lefebvre, Jean / Acel, Andrea et al. | 2021
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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumorsRoot, Adam R. / Guntas, Gurkan / Katragadda, Madan / Apgar, James R. / Narula, Jatin / Chang, Chew Shun / Hanscom, Sara / McKenna, Matthew / Wade, Jason / Meade, Caryl et al. | 2021
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Antibodies to watch in 2021Kaplon, Hélène / Reichert, Janice M. et al. | 2021
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Ensembles in solution as a new paradigm for antibody structure prediction and designFernández-Quintero, Monica L. / Georges, Guy / Varga, Janos M. / Liedl, Klaus R. et al. | 2021
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An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tagMurray, Thomas V. / Kozakowska-McDonnell, Kasia / Tibbles, Adam / Taylor, Annabel / Higazi, Daniel / Rossy, Emmanuel / Rossi, Alessandra / Genapathy, Sivaneswary / Tamburrino, Giulia / Rath, Nicola et al. | 2021
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Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodiesLiu, Shufang / Verma, Ashwni / Kettenberger, Hubert / Richter, Wolfgang F. / Shah, Dhaval K. et al. | 2021
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Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IXLenferink, Anne E.G. / McDonald, Paul C. / Cantin, Christiane / Grothé, Suzanne / Gosselin, Mylene / Baardsnes, Jason / Banville, Myriam / Lachance, Paul / Robert, Alma / Cepero-Donates, Yuneivy et al. | 2021
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Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancerSchofield, Darren J. / Percival-Alwyn, Jennifer / Rytelewski, Mateusz / Hood, John / Rothstein, Raymond / Wetzel, Leslie / McGlinchey, Kelly / Adjei, Grace / Watkins, Amanda / Machiesky, LeeAnn et al. | 2021
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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor responseDela Cruz Chuh, Josefa / Go, MaryAnn / Chen, Yvonne / Guo, Jun / Rafidi, Hanine / Mandikian, Danielle / Sun, Yonglian / Lin, Zhonghua / Schneider, Kellen / Zhang, Pamela et al. | 2021
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Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activationWei, Bingchuan / Gao, Xuan / Cadang, Lance / Izadi, Saeed / Liu, Peilu / Zhang, Hui-Min / Hecht, Elizabeth / Shim, Jeongsup / Magill, Gordon / Pabon, Juan Rincon et al. | 2021
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Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parametersLai, Pin-Kuang / Swan, James W. / Trout, Bernhardt L. et al. | 2021
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Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer modelsRabia, Emilia / Garambois, Véronique / Hubert, Julie / Bruciamacchie, Marine / Pirot, Nelly / Delpech, Hélène / Broyon, Morgane / Theillet, Charles / Colombo, Pierre-Emmanuel / Vie, Nadia et al. | 2021
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Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodiesStefan, Maxwell A. / Light, Yooli K. / Schwedler, Jennifer L. / McIlroy, Peter R. / Courtney, Colleen M. / Saada, Edwin A. / Thatcher, Christine E. / Phillips, Ashlee M. / Bourguet, Feliza A. / Mageeney, Catherine M. et al. | 2021
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Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragmentsBan, David / Rice, Cory T. / McCoy, Mark A. et al. | 2021
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Antibody mix-and-read assays based on fluorescence intensity probesPatil, Ujwal / Goyal, Atul / Vu, Binh / Liu, Yanyun / Maranholkar, Vijay / Kourentzi, Katerina / Briggs, James M. / Willson, Richard C. et al. | 2021
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Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumorsMason, Nicola J. / Chester, Nicholas / Xiong, Ailian / Rotolo, Antonia / Wu, Ying / Yoshimoto, Sho / Glassman, Patrick / Gulendran, Gayathri / Siegel, Don L. et al. | 2021
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The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearanceOpolka-Hoffmann, Eugenia / Jordan, Gregor / Otteneder, Michael / Kieferle, Robin / Lechmann, Martin / Winter, Gerhard / Staack, Roland F. et al. | 2021
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Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab librariesBhatta, Pallavi / Whale, Kevin D. / Sawtell, Amy K. / Thompson, Clare L. / Rapecki, Stephen E. / Cook, David A. / Twomey, Breda M. / Mennecozzi, Milena / Starkie, Laura E. / Barry, Emily M. C. et al. | 2021
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In memoriam: Jefferson FooteWard, E. Sally / Jones, Peter / Buss, Tim / Rada, Cristina / Winter, Gregory / Willson, Richard et al. | 2021
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Ab-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitopeWong, Wing Ki / Robinson, Sarah A. / Bujotzek, Alexander / Georges, Guy / Lewis, Alan P. / Shi, Jiye / Snowden, James / Taddese, Bruck / Deane, Charlotte M. et al. | 2021
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One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeuticsChen, Wei / Yang, Fan / Wang, Carole / Narula, Jatin / Pascua, Edward / Ni, Irene / Ding, Sheng / Deng, Xiaodi / Chu, Matthew Ling-Hon / Pham, Amber et al. | 2021
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Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose controlLiu, Qiang / Garg, Pankaj / Hasdemir, Burcu / Wang, Linya / Tuscano, Emily / Sever, Emily / Keane, Erica / Hernandez, Ana G Lujan / Yuan, Tom Z. / Kwan, Eric et al. | 2021
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Collecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusionLe Prieult, Florie / Barini, Erica / Laplanche, Loic / Schlegel, Kerstin / Mezler, Mario et al. | 2021
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An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeuticsFurtmann, Norbert / Schneider, Marion / Spindler, Nadja / Steinmann, Bjoern / Li, Ziyu / Focken, Ingo / Meyer, Joachim / Dimova, Dilyana / Kroll, Katja / Leuschner, Wulf Dirk et al. | 2021
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Accurate determination of epitope for antibodies with unknown 3D structuresTahir, Shifa / Bourquard, Thomas / Musnier, Astrid / Jullian, Yann / Corde, Yannick / Omahdi, Zakaria / Mathias, Laetitia / Reiter, Eric / Crépieux, Pascale / Bruneau, Gilles et al. | 2021
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Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settingsGermovsek, Eva / Cheng, Ming / Giragossian, Craig et al. | 2021
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Selective depletion of radiolabeled HER2-specific antibody for contrast improvement during PETKhare, Priyanka / Sun, Wei / Ramakrishnan, Sreevidhya / Swiercz, Rafal / Hao, Guiyang / Lo, Su-Tang / Nham, Kien / Sun, Xiankai / Ober, Raimund J. / Ward, E. Sally et al. | 2021
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Versatile and rapid microfluidics-assisted antibody discoveryGaa, Ramona / Menang-Ndi, Emmanuel / Pratapa, Shruti / Nguyen, Christine / Kumar, Satyendra / Doerner, Achim et al. | 2021
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Novel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in miceBan, Bhupal / Barrientos, Rodell C. / Oertel, Therese / Komla, Essie / Whalen, Connor / Sopko, Megan / You, Yingjian / Banerjee, Partha / Sulima, Agnieszka / Jacobson, Arthur E. et al. | 2021
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Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactionsLai, Pin-Kuang / Ghag, Gaurav / Yu, Yao / Juan, Veronica / Fayadat-Dilman, Laurence / Trout, Bernhardt L. et al. | 2021
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Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichmentWhite, Ian / Tamot, Ninkka / Doddareddy, Rajitha / Ho, Jason / Jiao, Qun / Harvilla, Paul B. / Yang, Tong-Yuan / Geist, Brian / Borrok, M. Jack / Truppo, Matthew D. et al. | 2021
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Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaignsCunningham, Orla / Scott, Martin / Zhou, Zhaohui Sunny / Finlay, William J.J. et al. | 2021
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Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragmentsNannini, Francesco / Senicar, Lenart / Parekh, Farhaan / Kong, Khai J. / Kinna, Alexander / Bughda, Reyisa / Sillibourne, James / Hu, Xihao / Ma, Biao / Bai, Yuchen et al. | 2021
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Discovery-stage identification of drug-like antibodies using emerging experimental and computational methodsMakowski, Emily K. / Wu, Lina / Gupta, Priyanka / Tessier, Peter M. et al. | 2021
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A platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodiesZhang, Ruijun / Prabakaran, Ponraj / Yu, Xiaocong / Mackness, Brian C. / Boudanova, Ekaterina / Hopke, Joern / Sancho, Jose / Saleh, Jacqueline / Cho, HyunSuk / Zhang, Ningning et al. | 2021
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Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoproteinHarshbarger, Wayne / Abeyrathne, Priyanka D. / Tian, Sai / Huang, Ying / Chandramouli, Sumana / Bottomley, Matthew James / Malito, Enrico et al. | 2021
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Enhancing the multi-attribute method through an automated and high-throughput sample preparationSitasuwan, Pongkwan / Powers, Thomas W. / Medwid, Tiffany / Huang, Yuting / Bare, Bradley / Lee, L. Andrew et al. | 2021
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Antibody-mediated delivery of LIGHT to the tumor boosts natural killer cells and delays tumor progressionStringhini, Marco / Mock, Jacqueline / Fontana, Vanessa / Murer, Patrizia / Neri, Dario et al. | 2021
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Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive bindingShi, Rachel Liuqing / Xiao, Gang / Dillon, Thomas M. / McAuley, Arnold / Ricci, Margaret S. / Bondarenko, Pavel V. et al. | 2021
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Data mining patented antibody sequencesKrawczyk, Konrad / Buchanan, Andrew / Marcatili, Paolo et al. | 2021
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Rigid monoclonal antibodies improve detection of SARS-CoV-2 nucleocapsid proteinHodge, Curtis D. / Rosenberg, Daniel. J. / Grob, Patricia / Wilamowski, Mateusz / Joachimiak, Andrzej / Hura, Greg L. / Hammel, Michal et al. | 2021
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Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1Chen, Weimin / Pandey, Madhu / Sun, Hong / Rolong, Andrea / Cao, Mingyan / Liu, Dengfeng / Wang, Jihong / Zeng, Lingmin / Hunter, Alan / Lin, Shihua et al. | 2021
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501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitroLiu, Haolin / Wei, Pengcheng / Zhang, Qianqian / Chen, Zhongzhou / Aviszus, Katja / Downing, Walter / Peterson, Shelley / Reynoso, Lyndon / Downey, Gregory P. / Frankel, Stephen K. et al. | 2021