Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process (English)
- New search for: Choo, Edna F
- New search for: Alicke, Bruno
- New search for: Boggs, Jason
- New search for: Dinkel, Vikki
- New search for: Gould, Stephen
- New search for: Grina, Jonas
- New search for: West, Kristina
- New search for: Menghrajani, Kapil
- New search for: Ran, Yingqing
- New search for: Rudolph, Joachim
- New search for: Wenglowsky, Steve
- New search for: Choo, Edna F
- New search for: Alicke, Bruno
- New search for: Boggs, Jason
- New search for: Dinkel, Vikki
- New search for: Gould, Stephen
- New search for: Grina, Jonas
- New search for: West, Kristina
- New search for: Menghrajani, Kapil
- New search for: Ran, Yingqing
- New search for: Rudolph, Joachim
- New search for: Wenglowsky, Steve
In:
Xenobiotica
;
41
, 12
;
1076-1087
;
2011
- Article (Journal) / Electronic Resource
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Title:Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process
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Contributors:Choo, Edna F ( author ) / Alicke, Bruno ( author ) / Boggs, Jason ( author ) / Dinkel, Vikki ( author ) / Gould, Stephen ( author ) / Grina, Jonas ( author ) / West, Kristina ( author ) / Menghrajani, Kapil ( author ) / Ran, Yingqing ( author ) / Rudolph, Joachim ( author )
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Published in:Xenobiotica ; 41, 12 ; 1076-1087
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Publisher:
- New search for: Taylor & Francis
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Publication date:2011-12-01
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Size:12 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 41, Issue 12
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1021
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In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4Li, Jinghu / Gödecke, Tanja / Chen, Shao-Nong / Imai, Ayano / Lankin, David C. / Farnsworth, Norman R. / Pauli, Guido F. / van Breemen, Richard B. / Nikolić, Dejan et al. | 2011
- 1031
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Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126Wang, Bingxuan / Robertson, Larry W. / Wang, Kai / Ludewig, Gabriele et al. | 2011
- 1044
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Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cellsFedejko-Kap, Barbara / Niemira, Magdalena / Radominska-Pandya, Anna / Mazerska, Zofia et al. | 2011
- 1056
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Determination of cytochrome P450 enzymes involved in the metabolism of (−)-terpinen-4-ol by human liver microsomesMiyazawa, M. / Haigou, R. et al. | 2011
- 1063
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Disposition, metabolism and mass balance of [14C]apremilast following oral administrationHoffmann, Matthew / Kumar, Gondi / Schafer, Peter / Cedzik, Dorota / Capone, Lori / Fong, Kei-Lai / Gu, Zheming / Heller, Dennis / Feng, Hao / Surapaneni, Sekhar et al. | 2011
- 1076
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Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery processChoo, Edna F / Alicke, Bruno / Boggs, Jason / Dinkel, Vikki / Gould, Stephen / Grina, Jonas / West, Kristina / Menghrajani, Kapil / Ran, Yingqing / Rudolph, Joachim et al. | 2011
- 1088
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Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in humanSalphati, Laurent / Pang, Jodie / Plise, Emile G. / Chou, Bilin / Halladay, Jason S. / Olivero, Alan G. / Rudewicz, Patrick J. / Tian, Qingping / Wong, Susan / Zhang, Xiaolin et al. | 2011
- 1100
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Pharmacokinetics of lurasidone, a novel atypical anti-psychotic drug, in ratsLee, Kyeong-Ryoon / Chae, Yoon-Jee / Koo, Tae-Sung et al. | 2011
- 1108
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The fate of 4-hydroxycarbazole metabolite: metabolism and carcinogenicity assessment of a b-adrenergic receptor modulator containing carbazole structureHe, M. M. / Ji, T. / Barbuch, R. J. / Campanale, K. / Lantz, R. / Hadden, C. / Wilke, A. et al. | 2011
- 1108
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The fate of 4-hydroxycarbazole metabolite: metabolism and carcinogenicity assessment of a β-adrenergic receptor modulator containing carbazole structureHe, Minxia M. / Ji, Tao / Barbuch, Robert J. / Campanale, Kristina / Lantz, Ron / Hadden, Chad / Wilke, August et al. | 2011
- 1122
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Polymorphism in glutathione S-transferases: Susceptibility and treatment outcome for head and neck cancerRuwali, Munindra / Singh, Madhu / Pant, Mohan C. / Parmar, Devendra et al. | 2011
- 1131
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Acknowledgements| 2011