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In order to investigate the effect of the suture density on the mechanical properties of bioprosthetic heart valve, we establish the spherical leaflets models via computer aided design. Finite element analysis is used simulate the mechanical performance of bioprosthetic heart valve when leaflet is closed. The analysis results show that suture density has a significant effect to the stress state of valve, which may lead not only to different stress peak values, but also to different stress distributions. High or low density suture isn’t appropriate for long-term durability of the bioprosthetic heart valve. Suture density tests are needed to perform on the valves to find satisfactory suture density for better mechanical properties of the bioprosthetic heart valve.