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To prevent medical errors or even accidents, our solution is to design the closed-loop application based on Radio Frequency Identification (RFID) technology in the Hospital Information System (HIS). We focus on the information improvement for doctor's order based on RFID. The whole closed-loop process starts from the initial collection of the patient's information, through confirmation of the unique identification of the patient, and to the finishing of the doctor's order at last. The final information is written back into HIS. Medical staff can collect and deal with the patient's information straightly through the system, thereby guarantee maximal medical information correctness. The system design of the closed-loop process of the doctors order includes new workflow and its wireless system architecture based on RFID in the ward environment.