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Laser technology has seen broad applications in the field of ophthalmology. The ability to apply laser procedures safely has resulted in improved treatment. The Q-switch or mode-locked Nd:YAG produce photodisruption, a process wherein the intense light pulse is used to create a shockwave at the point of focus. The localized shockwave has the potential to rupture tissue and cause damage as it traverses the tissue. The shockwave transforms into an acoustic wave as it propagates. The high irradiance produced at the focal point on an ocular lens diverges to such a degree that at posterior segment structures such as the retina and choroid, the irradiance is very low. The acoustic exposure of distant ocular tissues from the shockwave resulting from photodisruption of the crystalline lens causes concern for the safety of Nd:YAG photodisruptor systems. The objective of this paper is to determine a relationship between laser energy and acoustic pressure by measuring acoustic transients generated in human crystalline lens. These results are compared to acoustic transients generated by photodisruption of water.