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The C‑terminal Region of D‑DT Regulates Molecular Recognition for Protein–Ligand Complexes
American Chemical Society | 2024| -
Exploring Subsite Selectivity within Plasmodium vivax N‑Myristoyltransferase Using Pyrazole-Derived Inhibitors
Free accessAmerican Chemical Society | 2024| -
Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated β‑Lactams against Gram-Negative Bacteria
American Chemical Society | 2024| -
Design and Synthesis of Novel Ultralong-Acting Peptides as EDP-EBP Interaction Inhibitors for Pulmonary Fibrosis Treatment
American Chemical Society | 2024| -
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles
American Chemical Society | 2024| -
Development and Initial Characterization of the First 18F‑CXCR2-Targeting Radiotracer for PET Imaging of Neutrophils
American Chemical Society | 2024| -
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases
American Chemical Society | 2024| -
Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression
American Chemical Society | 2024| -
Discovery of New Tricyclic Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcosis and Candidiasis
American Chemical Society | 2024| -
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs
Free accessAmerican Chemical Society | 2024| -
Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
American Chemical Society | 2024| -
Development of Selective Pyrido[2,3‑d]pyrimidin-7(8H)‑one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors
American Chemical Society | 2024| -
Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates
American Chemical Society | 2024| -
A Drug Discovery Perspective on FDA Expedited Development and Incentive Programs
American Chemical Society | 2024| -
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties
American Chemical Society | 2024| -
MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery
American Chemical Society | 2024|
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