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Exosome-mediated delivery and regulation in neurological disease progression
Elsevier | 2024|biological sources, have recently seized the attention of researchers due to their theranostic potential for neurological diseases. Released actively ...Keywords: Drug delivery -
Deuterated active pharmaceutical ingredients: A science‐based proposal for synthesis, analysis, and control. Part 1: Framing the problem
Wiley | 2019|chemistry, analytical chemistry, and drug metabolism and pharmacokinetics have been meeting under the auspices of IQ to define and address these ...Keywords: International Consortium for Innovation & Quality, drug substance -
An Update on Design and Pharmacology of Dendritic Poly(l-lysine)
Online Contents | 2018|in a new drug application category of various regulatory bodies. As dendritic poly(l-lysine) scaffold is biocompatible unlike many other ... -
Taking the individual bias out of examining comparability of biosimilars: A case study on monoclonal antibody therapeutics
Elsevier | 2022|translating to affordable biosimilars. Current practices for regulatory concurrence on analytical similarity data are based on chart visualization and ...Keywords: Electrospray ionization time-of-flight mass spectrometry, International Council for Harmonisationof Technical Requirements for Pharmaceuticals for Human Use, United States Food and Drug Administration -
A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy
Elsevier | 2021|drug resistance through both aerobic glycolysis and non-metabolic pathways. In this review, the functions and regulatory roles of PKM2 are ... -
Phosphatidylinositol-3-kinase as a putative target for anticancer action of clotrimazole
Elsevier | 2015|because of its properties that inhibit glycolytic enzymes and detach them from the cytoskeleton. However, the broad effects of the drug, e.g ... -
Identification and characterization of a flexile G-quadruplex in the distal promoter region of stemness gene REX1
Elsevier | 2023|R1WT to be a promising drug target. The endogenous existence of R1WT was confirmed by BG4 antibody derived chromatin immunoprecipitation ... -
Phosphatidylinositol-3-kinase as a putative target for anticancer action of clotrimazole
Online Contents | 2015|of CTZ because the drug does not affect the interaction of the PI3K regulatory subunit and the insulin receptor substrate (IRS)-1 ... -
Mechanisms Underlying the Health Benefits of Plant Sterol and Stanol Ester Consumption
Online Contents | 2015|addition, they might influence the functioning of our immune system via a changed activity of the regulatory T-cells. This combination of effects ...Keywords: Immune System - drug effects -
Role of Metal-Organic Frameworks (MOFs) in treating and diagnosing microbial infections
Elsevier | 2024|Abstract This review article highlights the innovative role of metal ... -
Trefoil Factor 1 is involved in gastric cell copper homeostasis
Online Contents | 2015|responsive elements present in the regulatory region of the gene. In addition we demonstrate that copper overload causes an accumulation of the ...Keywords: Protein Binding - drug effects, Transcription, Genetic - drug effects, Gene Expression Regulation - drug effects, trans-Golgi Network - drug effects, Protein Multimerization - drug effects, Cytoprotection - drug effects, Homeostasis - drug effects, Cell Survival - drug effects -
The protein–surfactant stoichiometry governs the conformational switching and amyloid nucleation kinetics of tau K18
Online Contents | 2020|of protein amyloid assembly with an emphasis on structural characterization of early, key prefibrillar species is important for targeted drug ...Publisher: Springer International Publishing, Springer, Berlin -
The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives
Elsevier | 2023|. Despite advances in the structure and pharmacology of RNA methylation regulators that have improved drug discovery, regulating these proteins by ... -
Probing the structures of G protein-coupled receptors with mass spectrometry-based techniques
Elsevier | 2022|regulate numerous physiological processes in the human body, and represent one of the largest protein families as targets for drug development for ... -
Preparation methods, structural characteristics, and biological activity of polysaccharides from Platycodon grandiflorus
Elsevier | 2023|, anticancer, antiangiogenic, and immune regulatory properties. Incorporating the principles of traditional Chinese medicine, carrier concepts, and ...Keywords: Drug target -
The role of algal fucoidans in potential anti-allergic therapeutics
Elsevier | 2020|Abstract Allergic diseases are among the commonest causes of chronic ill ...Keywords: regulatory T cells, cluster of differentiation, nuclear factor kappa light chain enhancer of activated B cells -
HILIC–MS Determination of Genotoxic Impurity of 2-Chloro-N-(2-Chloroethyl)Ethanamine in the Vortioxetine Manufacturing Process
Online Contents | 2016|In the last decade, pharmaceutical regulatory agencies are focused on monitoring and evaluation of trace-level genotoxic impurities (GTIs ... -
Modulation of proteins by rare earth elements as a biotechnological tool
Elsevier | 2023|function or regulatory activity of the proteins trigger a variety of applications for these elements in biomedicine and biotechnology. Lanthanide ... -
Elucidation of the anti-colon cancer mechanism of Phellinus baumii polyphenol by an integrative approach of network pharmacology and experimental verification
Elsevier | 2023|constructed a network of “Disease-Drug-Pathways-Targets” and a protein-protein interaction (PPI) network among the targets using Cytoscape 3.9.1 ... -
A Validated Stability-Indicating and Stereoselective HPLC Method for the Determination of Lenalidomide Enantiomers in Bulk Form and Capsules
Online Contents | 2016|International Conference on Harmonization/Food and Drug Administration regulatory requirements, was utilized successfully for the determination of LDM ...
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