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β-1,3-d-glucan particles-based “nest” protected co-loaded Rhein and Emodin regulates microbiota and intestinal immunity for ulcerative colitis treatment
Elsevier | 2023|significantly enhanced the regulatory effects of HA-RH/EMO NYPs on gut microbiota and the Th17/Treg balance. Overall, this research marks the first use ... -
Zosuquidar: An Effective Molecule for Intracellular Ca2+ Measurement in P-gp Positive Cells
Free accessDOAJ | 2024|obstacle since several fluorescent intracellular calcium indicators are substrates of membrane ABC drug transporters. For example, Fluo-3/AM is a ... -
YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1–RPN2–PI3K/AKT/mTOR Axis
Free accessDOAJ | 2023|. However, the regulatory mechanisms of m6A modifications are complex. Whether the m6A reading protein YTHDF1 is involved in the development of ...Keywords: drug sensitivity -
Xyloglucan: A functional biomacromolecule for drug delivery applications
Elsevier | 2017|obtained from Tamarind seeds or kernel.The important properties of xyloglucan include ...Keywords: Drug delivery -
Wnt Signaling in Inner Blood–Retinal Barrier Maintenance
Free accessDOAJ | 2021|the development and maintenance of iBRB in health and disease, with a specific focus on the Wnt signaling pathway and its regulatory role in ... -
WD Repeat and HMG Box DNA Binding Protein 1: An Oncoprotein at the Hub of Tumorigenesis and a Novel Therapeutic Target
Free accessDOAJ | 2023|, pulmonary carcinoma, and breast carcinoma. Additionally, the inhibitor of WDHD1 has been found to enhance radiation sensitivity, improve drug ... -
Upgrading Monocytes Therapy for Critical Limb Ischemia Patient Treatment: Pre-Clinical and GMP-Validation Aspects
Free accessDOAJ | 2022|standard worldwide recognized for drug production is the Good Manufacturing Practices (GMP), widely used in the pharma production of synthesized ... -
Unraveling the Molecular Puzzle: Exploring Gene Networks across Diverse EMT Status of Cell Lines
Free accessDOAJ | 2023|Understanding complex disease mechanisms requires a comprehensive understanding of the gene regulatory networks, as complex diseases are ...Keywords: gene regulatory network -
Universal Stress Proteins: From Gene to Function
Free accessDOAJ | 2023|regulatory role of USPs; and (3) the functions of USPs in species are diverse, and are generally directly related to the stress tolerance. In ...Keywords: molecular mechanism of USPs -
Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells
Free accessDOAJ | 2019|. With a highly regulatory mechanism, called unfolded protein response (UPR), it protects cells from the accumulation of misfolded proteins ... -
Tumor Cell Resistance to the Inhibition of BRAF and MEK1/2
Free accessDOAJ | 2023|BRAF tumors have an intrinsic ability to rapidly adapt to the presence of BRAF and MEK1/2 inhibitors by bypassing drug effects via rewired ...Keywords: drug resistance -
Trends in patterns of antidepressant use in older general population between 2006 and 2012 following publication of practice guidelines
Wiley | 2017|The French regulatory agency published in 2006 practice guidelines related to the management of
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Trehalose Treatment in Zebrafish Model of Lafora Disease
Free accessDOAJ | 2022|drug screening is limited by regulatory restrictions and high breeding costs. To investigate the role of laforin loss of function in early ... -
Trefoil Factor 1 is involved in gastric cell copper homeostasis
Online Contents | 2015|responsive elements present in the regulatory region of the gene. In addition we demonstrate that copper overload causes an accumulation of the ...Keywords: Protein Binding - drug effects, Transcription, Genetic - drug effects, Gene Expression Regulation - drug effects, trans-Golgi Network - drug effects, Protein Multimerization - drug effects, Cytoprotection - drug effects, Homeostasis - drug effects, Cell Survival - drug effects -
Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?
Elsevier | 2022|PCa cells is increased by TGF-β signaling via induction of EMT and MMPs. Furthermore, TGF-β signaling can induce drug resistance of PCa cells ... -
Trans-fatty acids, dangerous bonds for health? A background review paper of their use, consumption, health implications and regulation in France
Online Contents | 2012|existence of an international policy consensus regarding the need for public health action, some industrialized countries, such as France, are still ...Keywords: Regulatory affairs -
Trans-fatty acids, dangerous bonds for health? A background review paper of their use, consumption, health implications and regulation in France
Online Contents | 2012|existence of an international policy consensus regarding the need for public health action, some industrialized countries, such as France, are still ...Keywords: Regulatory affairs -
Trans-fatty acids, dangerous bonds for health? A background review paper of their use, consumption, health implications and regulation in France
Springer Verlag | 2012|With respect to the general precautionary principle and considering the existence of an international policy consensus regarding the need for ...Keywords: Regulatory affairs -
Transcriptome Profiling of Cardiac Glycoside Treatment Reveals EGR1 and Downstream Proteins of MAPK/ERK Signaling Pathway in Human Breast Cancer Cells
Free accessDOAJ | 2023|. In recent times, there has been growing recognition of their potential use as drug leads in cancer treatment. In our prior research, we ...
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