Bioorganic and Medicinal Chemistry Letters
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
Table of contents
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Graphical contents list| 2011
- 39
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Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: Characteristics of broad-spectrum protein binding and its effects on anti-tumor activityZheng, Can-Hui / Yang, Hui / Zhang, Meng et al. | 2011
- 45
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Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogsHaddach, Mustapha / Pierre, Fabrice / Regan, Collin F. et al. | 2011
- 49
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New substituted C-19-andrographolide analogues with potent cytotoxic activitiesSirion, Uthaiwan / Kasemsook, Sakkasem / Suksen, Kanoknetr et al. | 2011
- 53
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The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivativesYang, Na / Wang, Qing-He / Wang, Wen-Qian et al. | 2011
- 57
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Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistrySingh, Pardeep / Singh, Parvesh / Kumar, Malkeet et al. | 2011
- 57
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Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from b-lactams and 7-chloroquinoline using click chemistrySingh, P. / Kumar, M. / Gut, J. et al. | 2012
- 62
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Virtual ligand screening of a-glucosidase: Identification of a novel potent noncarbohydrate mimetic inhibitorHakamata, W. / Ishikawa, R. / Ushijima, Y. et al. | 2012
- 62
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Virtual ligand screening of α-glucosidase: Identification of a novel potent noncarbohydrate mimetic inhibitorHakamata, Wataru / Ishikawa, Ryosuke / Ushijima, Yoriko et al. | 2011
- 65
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A three-step protocol for lead optimization: Quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitorsHuang, Xianhai / Zhu, Xiaohong / Chen, Xiao et al. | 2011
- 71
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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)Semple, Graeme / Santora, Vincent J. / Smith, Jeffrey M. et al. | 2011
- 71
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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4prime-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)Semple, G. / Santora, V. J. / Smith, J. M. et al. | 2012
- 76
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Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathwayTheriault, Jimmy R. / Felts, Andrew S. / Bates, Brittney S. et al. | 2011
- 82
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Combination of two chromophores: Synthesis and PDT application of porphyrin–pentamethinium conjugateBříza, Tomáš / Králová, Jarmila / Cígler, Petr et al. | 2011
- 85
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Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Improvements in clearance of adenosine seriesStokes, Suzanne S. / Gowravaram, Madhusudhan / Huynh, Hoan et al. | 2011
- 90
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Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1)Cadieux, Jay A. / Zhang, Zaihui / Mattice, Maryanne et al. | 2011
- 96
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5-(2-Amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitorsCaruso, Michele / Valsasina, Barbara / Ballinari, Dario et al. | 2011
- 102
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Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-kB pathwaySun, D. d. / Wang, W. z. / Mao, J. w. et al. | 2012
- 102
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Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-κB pathwaySun, Dong-dong / Wang, Wei-zhang / Mao, Jian-wen et al. | 2011
- 106
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Fatty acyl-gramicidin S derivatives with both high antibiotic activity and low hemolytic activityTamaki, Makoto / Fujinuma, Kenta / Harada, Takuji et al. | 2011
- 110
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Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinaseYu, Bing / Tang, Li-da / Li, Yi-liang et al. | 2011
- 115
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Synthesis of [11C]uric acid, using [11C]phosgene, as a possible biomarker in PET imaging for diagnosis of goutYashio, Keiji / Katayama, Yumiko / Takashima, Tadayuki et al. | 2011
- 120
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Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonistsSundar, Babu G. / Bailey, Thomas R. / Dunn, Derek D. et al. | 2011
- 124
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Reassessment of Hammett σ as an effective parameter representing intermolecular interaction energy—links between traditional and modern QSAR approachesYoshida, Tatsusada / Shimizu, Miho / Harada, Masataka et al. | 2011
- 129
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Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probeZhao, Zheng-yun / San, Marie / Duprey, Jean-Louis H.A. et al. | 2011
- 133
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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinasesZificsak, Craig A. / Gingrich, Diane E. / Breslin, Henry J. et al. | 2011
- 138
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Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD)Wu, Yuchuan / Li, Jianchang / Wu, Junjun et al. | 2011
- 144
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Structure–activity relationship studies of S1P agonists with a dihydronaphthalene scaffoldKurata, Haruto / Kusumi, Kensuke / Otsuki, Kazuhiro et al. | 2011
- 149
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Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepinesRajanarendar, E. / Nagi Reddy, M. / Rama Murthy, K. et al. | 2011
- 154
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Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cellsLiu, Li / Ma, Hongyue / Tang, Yuping et al. | 2011
- 154
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Discovery of estrogen receptor a modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cellsLiu, L. / Ma, H. / Tang, Y. et al. | 2012
- 164
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Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimideOta, Eisuke / Takeiri, Masatoshi / Tachibana, Miyuki et al. | 2011
- 168
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Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassayWang, Di / Wang, Fei / Tan, Yexiong et al. | 2011
- 172
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Effect of a second nitroimidazole redox centre on the accumulation of a hypoxia marker: Synthesis and in vitro evaluation of 99mTc-labeled bisnitroimidazole propylene amine oxime complexesHuang, Huafan / Zhou, Hao / Li, Zejun et al. | 2011
- 178
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Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin–ruthenium metalla-cubesSchmitt, Frédéric / Barry, Nicolas P.E. / Juillerat-Jeanneret, Lucienne et al. | 2011
- 181
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Activation of human RNase L by 2′- and 5′-O-methylphosphonate-modified oligoadenylatesPáv, Ondřej / Panova, Natalya / Snášel, Jan et al. | 2011
- 181
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Activation of human RNase L by 2prime- and 5prime-O-methylphosphonate-modified oligoadenylatesPav, O. / Panova, N. / Snasel, J. et al. | 2012
- 186
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Synthesis and evaluation of 4-alkoxy-[1′-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4′-piperidine)] analogues as histamine-3 receptor antagonistsBecknell, Nadine C. / Dandu, Reddeppa Reddy / Lyons, Jacquelyn A. et al. | 2011
- 186
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Synthesis and evaluation of 4-alkoxy-[1prime-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4prime-piperidine)] analogues as histamine-3 receptor antagonistsBecknell, N. C. / Dandu, R. R. / Lyons, J. A. et al. | 2012
- 190
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Novel and selective spiroindoline-based inhibitors of sky kinasePowell, Noel A. / Kohrt, Jeffrey T. / Filipski, Kevin J. et al. | 2011
- 194
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4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonistsHudkins, Robert L. / Aimone, Lisa D. / Dandu, Reddeppa reddy et al. | 2011
- 199
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SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitorsLu, Zhijian / Chen, Yi-heng / Napolitano, Joann B. et al. | 2011
- 204
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Synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as platelet aggregation inhibitorsTian, Xiao / Wang, Li-Ying / Xia, Shuai et al. | 2011
- 207
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Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokinesTamura, Ryuichi / Chen, Yanjie / Shinozaki, Miwako et al. | 2011
- 207
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Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-kB signaling pathway induced by inflammatory cytokinesTamura, R. / Chen, Y. / Shinozaki, M. et al. | 2012
- 212
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Novel bis(indolyl)hydrazide–hydrazones as potent cytotoxic agentsKumar, Dalip / Maruthi Kumar, N. / Ghosh, Soumitra et al. | 2011
- 216
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An expedient synthesis of honokiol and its analogues as potential neuropreventive agentsTripathi, Subhankar / Chan, Ming-Huan / Chen, Chinpiao et al. | 2011
- 222
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Novel poly(ADP-ribose) polymerase-1 inhibitorsDunn, Derek / Husten, Jean / Ator, Mark A. et al. | 2011
- 225
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Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureusMoreira Osório, Thaís / Delle Monache, Franco / Domeneghini Chiaradia, Louise et al. | 2011
- 231
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Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screeningWatanabe, Takumi / Kurata, Ikuko / Umezawa, Yoji et al. | 2011
- 235
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Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophreniaYang, Shu-Wei / Smotryski, Jennifer / McElroy, William T. et al. | 2011
- 240
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Discovery of pyrrolidine-based β-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiencyStachel, Shawn J. / Steele, Thomas G. / Petrocchi, Alessia et al. | 2011
- 240
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Discovery of pyrrolidine-based b-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiencyStachel, S. J. / Steele, T. G. / Petrocchi, A. et al. | 2012
- 245
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Synthesis and evaluation of macrocyclic diarylether heptanoid natural products and their analogsBryant, Vashti C. / Kishore Kumar, G.D. / Nyong, Abijah M. et al. | 2011
- 249
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Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell lineWada, Koji / Ohkoshi, Emika / Morris-Natschke, Susan L. et al. | 2011
- 253
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Fluorescence detection of single nucleotide polymorphisms using nucleic acid probe containing tricyclic base-linked acyclonucleosideHattori, Mayumi / Ohki, Tokimitsu / Yanase, Emiko et al. | 2011
- 258
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Hydroxycoumarins as selective MAO-B inhibitorsSerra, Silvia / Ferino, Giulio / Matos, Maria João et al. | 2011
- 262
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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinasesPlé, Patrick A. / Jung, Frédéric / Ashton, Sue et al. | 2011
- 267
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5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitorsCarta, Fabrizio / Maresca, Alfonso / Scozzafava, Andrea et al. | 2011
- 271
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Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2De Savi, Chris / Morley, Andrew D. / Nash, Ian et al. | 2011
- 278
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Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analoguesJoce, Catherine / White, Rebecca / Stockley, Peter G. et al. | 2011
- 285
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Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitorsShiro, Tomoya / Takahashi, Hirotada / Kakiguchi, Keisuke et al. | 2011
- 289
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Synthesis and biological evaluation of novel derivatives of gambogic acid as anti-hepatocellular carcinoma agentsHe, Liqin / Ling, Yong / Fu, Li et al. | 2011
- 293
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Potent adjuvantic activity of a CCR1-agonistic bis-quinolineUkani, Rehman / Lewis, Tyler C. / Day, Timothy P. et al. | 2011
- 296
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Structural requirements for hybridization at the 5′-position are different in α-l-LNA as compared to β-d-LNASeth, Punit P. / Allerson, Charles R. / Østergaard, Michael E. et al. | 2011
- 296
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Structural requirements for hybridization at the 5prime-position are different in a-l-LNA as compared to b-d-LNASeth, P. P. / Allerson, C. R. / Ostergaard, M. E. et al. | 2012
- 300
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3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymeraseKumar, Dange V. / Rai, Roopa / Brameld, Ken A. et al. | 2011
- 305
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Structure-based design of PDK1 inhibitorsPoulsen, Anders / Blanchard, Stéphanie / Soh, Chang Kai et al. | 2011
- 308
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Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivativesKraljević, Tatjana Gazivoda / Klika, Mateja / Kralj, Marijeta et al. | 2011
- 313
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Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisonsAndré, Sabine / Jarikote, Dilip V. / Yan, Dandan et al. | 2011
- 319
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Synthesis of [18F]-labeled (2-(2-fluoroethoxy)ethyl)triphenylphosphonium cation as a potential agent for myocardial imaging using positron emission tomographyKim, Dong-Yeon / Kim, Hee-Jung / Yu, Kook-Hyun et al. | 2011
- 323
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Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activityHan, Young-Min / Lee, Su-Kyung / Jeong, Dae Gwin et al. | 2011
- 327
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Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivativesEl-Azab, Adel S. / ElTahir, Kamal E.H. et al. | 2011
- 334
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Discovery of cyclic amine-substituted benzoic acids as PPARα agonistsNomura, Masahiro / Yumoto, Kazuhiro / Shinozaki, Takehiro et al. | 2011
- 334
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Discovery of cyclic amine-substituted benzoic acids as PPARa agonistsNomura, M. / Yumoto, K. / Shinozaki, T. et al. | 2012
- 339
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Discovery and bioactivity of 4-(2-arylpyrido[3prime,2prime:3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitorsWang, J. / Wang, X. / Chen, Y. et al. | 2012
- 339
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Discovery and bioactivity of 4-(2-arylpyrido[3′,2′:3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitorsWang, Jia / Wang, Xiang / Chen, Yanhong et al. | 2011
- 343
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Synthesis and spectral studies of 2-[(N-ethyl carbazole)-3-sulfonyl ethylenediamine]-1-N,N-2-(2-methypyridy) as a fluorescence probe for Zn2+Zhang, Jun / Cui, Huiling / Hojo, Masashi et al. | 2011
- 347
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5-HT2C receptor selectivity and structure–activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogsJang, Jae Wan / Baek, Je-sook / Choi, Gil Don et al. | 2011
- 353
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Synthesis and antiviral activity of substituted quercetinsThapa, Mahendra / Kim, Yunjeong / Desper, John et al. | 2011
- 357
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Discovery of potent and specific CXCR3 antagonistsChen, Xiaoqi / Mihalic, Jeff / Deignan, Jeff et al. | 2011
- 363
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Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2Chen, Xiaoqi / Mihalic, Jeff / Fan, Pingchen et al. | 2011
- 367
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Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonismWang, Yingcai / Fu, Zice / Schmitt, Michael et al. | 2011
- 371
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Dirlotapide as a model substrate to refine structure-based drug design strategies on CYP3A4-catalyzed metabolismSun, Hao / Bessire, Andrew J. / Vaz, Alfin et al. | 2011
- 377
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Inhibition of noroviruses by piperazine derivativesDou, Dengfeng / He, Guijia / Mandadapu, Sivakoteswara Rao et al. | 2011
- 380
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3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-b-lactamase inhibitorsHussein, W. M. / Vella, P. / Islam, N. U. et al. | 2012
- 380
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3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitorsFaridoon / Hussein, Waleed M. / Vella, Peter et al. | 2011
- 387
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Ceric ammonium nitrate-promoted oxidative coupling reaction for the synthesis and evaluation of a series of anti-tumor amide anhydrovinblastine analogsSong, Weibin / Lei, Min / Zhao, Kun et al. | 2011
- 391
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Towards a modern definition of vitamin E—evidence for a quinone hypothesisShrader, William D. / Amagata, Akiko / Barnes, Adam et al. | 2011
- 396
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Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivityKambe, Tohru / Maruyama, Toru / Nakano, Masayuki et al. | 2011
- 402
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In vitro inhibition of translation initiation by N,Nprime-diarylureas-potential anti-cancer agentsDenoyelle, S. / Chen, T. / Chen, L. et al. | 2012
- 402
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In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agentsDenoyelle, Séverine / Chen, Ting / Chen, Limo et al. | 2011
- 410
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One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activitiesRao, V. Kameshwara / Chhikara, Bhupender S. / Tiwari, Rakesh et al. | 2011
- 415
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A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicityFilipski, Kevin J. / Bian, Jianwei / Ebner, David C. et al. | 2011
- 421
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Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomniaRavula, Satheesh Babu / Yu, Jinghua / Tran, Joe A. et al. | 2011
- 427
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4-Arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1)Lim, Chae Jo / Kim, Soo Hee / Lee, Byung Ho et al. | 2011
- 431
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Acyl derivatives of boswellic acids as inhibitors of NF-kB and STATsKumar, A. / Shah, B. A. / Singh, S. et al. | 2012
- 431
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Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATsKumar, Ajay / Shah, Bhahwal A. / Singh, Samar et al. | 2011
- 436
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Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moietiesJawale, Dhanaji V. / Pratap, Umesh R. / Rahuja, Neha et al. | 2011
- 440
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Diamine and aminoalcohol derivatives active against Trypanosoma bruceiOlmo, Esther del / Diaz-González, Rosario / Escarcena, Ricardo et al. | 2011
- 444
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Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factorBaeza, José Luis / de la Torre, Beatriz G. / Santiveri, Clara M. et al. | 2011
- 449
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Synthesis of dihydrofuran-fused perhydrophenanthrenes having a phenolic hydroxyl group as a novel anti-Alzheimer’s disease agentSugimoto, Kenji / Tamura, Kosuke / Ohta, Naoki et al. | 2011
- 453
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Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agentsKumbhare, Ravindra M. / Dadmal, Tulshiram / Kosurkar, Umesh et al. | 2011
- 456
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Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinasesSuzuki, Naoyuki / Shiota, Takeshi / Watanabe, Fumihiko et al. | 2011
- 461
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Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kineticsSmits, Rogier A. / Lim, Herman D. / van der Meer, Tiffany et al. | 2011
- 468
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Development of phyllanthin containing microcapsules and their improved biological activity towards skin cells and Staphylococcus aureusLam, Pik-Ling / Gambari, Roberto / Yip, Joanne et al. | 2011
- 472
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Fused thiophene derivatives as MEK inhibitorsLaing, Victoria E. / Brookings, Daniel C. / Carbery, Rachel J. et al. | 2011
- 476
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Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogensKumar, Rajesh / Rathy, Sujata / Hajare, Atul K. et al. | 2011
- 482
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Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanXJia, Chao / Yang, Ke-Wu / Liu, Cheng-Cheng et al. | 2011
- 485
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Synthesis and evaluation of novel prodrugs of caspase inhibitorsCharrier, Jean-Damien / Durrant, Steven J. / Studley, John et al. | 2011
- 489
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Physicochemical properties and inhibition effect on iron deficiency anemia of a novel polysaccharide-iron complex (LPPC)Zhang, Zhong-Shan / Wang, Xiao-Mei / Han, Zhi-Ping et al. | 2011
- 493
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Developing potent backbone cyclic peptides bearing the shared epitope sequence as rheumatoid arthritis drug-leadsNaveh, Shirly / Tal-Gan, Yftah / Ling, Song et al. | 2011
- 497
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Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-dionesRyu, Chung-Kyu / Yoon, Joo Hee / Song, Ae Li et al. | 2011
- 500
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Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-olsRyu, Chung-Kyu / Kim, Yang Hui / Im, Hyun Ah et al. | 2011
- 504
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Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitorsHarada, Koichiro / Kubo, Hideki / Tanaka, Akio et al. | 2011
- 504
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Identification of oxazolidinediones and thiazolidinediones as potent 17b-hydroxysteroid dehydrogenase type 3 inhibitorsHarada, K. / Kubo, H. / Tanaka, A. et al. | 2012
- 508
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AChE inhibitor : A regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3′]-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazoleAshraf Ali, Mohamed / Ismail, Rusli / Choon, Tan Soo et al. | 2011
- 508
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AChE inhibitor : A regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3prime]-oxindole-spiro-[6.3Prime]-2,3-dihydro-1H-inden-1Prime-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazoleAshraf Ali, M. / Ismail, R. / Choon, T. S. et al. | 2012
- 512
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Antiangiogenic activity of 3,4-seco-cycloartane triterpenes from Thai Gardenia spp. and their semi-synthetic analogsPudhom, Khanitha / Nuanyai, Thanesuan / Matsubara, Kiminori et al. | 2011
- 518
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Down-regulation of the human VEGF gene expression by perylene monoimide derivativesTaka, Thanachai / Joonlasak, Khajohn / Huang, Liming et al. | 2011
- 523
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(±)-2-(N-tert-Butylamino)-3′-[125I]-iodo-4′-azidopropiophenone: A dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban)Lapinsky, David J. / Aggarwal, Shaili / Nolan, Tammy L. et al. | 2011
- 523
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(+-)-2-(N-tert-Butylamino)-3prime-[125I]-iodo-4prime-azidopropiophenone: A dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban)Lapinsky, D. J. / Aggarwal, S. / Nolan, T. L. et al. | 2012
- 527
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Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activityPennington, Lewis D. / Croghan, Michael D. / Sham, Kelvin K.C. et al. | 2011
- 532
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Lead optimisation of pyrazoles as novel FPR1 antagonistsMorley, Andrew D. / King, Sarah / Roberts, Bryan et al. | 2011
- 537
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Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonistsGuerrero, Miguel / Urbano, Mariangela / Zhao, Jian et al. | 2011
- 543
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OFF-to-ON type fluorescent probe for the detection of 8-oxo-dG in DNA by the Adap-masked ODN probeTaniguchi, Yosuke / Koga, Yohei / Fukabori, Keitaro et al. | 2011
- 547
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5-Sulfonyl-benzimidazoles as selective CB2 agonists-Part 2Gijsen, Harrie J.M. / De Cleyn, Michel A.J. / Surkyn, Michel et al. | 2011
- 553
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Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffoldHe, Xinhua / Wang, Lili / Zheng, Zhibing et al. | 2011
- 558
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Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteinsBardaweel, Sanaa K. / Ghosh, Brahma / Wagner, Carston R. et al. | 2011
- 561
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Mitochondrial targeting of a cationic amphiphilic polyproline helixKalafut, Deanna / Anderson, Tiffani N. / Chmielewski, Jean et al. | 2011
- 564
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An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseasesLiu, Min / Wang, Shaoru / Zhou, Yi-Dan et al. | 2011
- 571
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Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugatesKamal, Ahmed / Srikanth, Y.V.V. / Ramaiah, M. Janaki et al. | 2011
- 579
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The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathwaysYang, Tingting / Lu, Zhenyu / Meng, Li et al. | 2011
- 586
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LDV peptidomimetics equipped with biotinylated spacer-arms: Synthesis and biological evaluation on CCRF-CEM cell lineGérard, Estelle / Meulle, Aline / Feron, Olivier et al. | 2011
- 591
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Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assemblyIrie, Takayuki / Fujii, Ikuo / Sawa, Masaaki et al. | 2011
- 597
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Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stemsWan, Chunpeng / Yuan, Tao / Li, Liya et al. | 2011
- 597
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Maplexins, new a-glucosidase inhibitors from red maple (Acer rubrum) stemsWan, C. / Yuan, T. / Li, L. et al. | 2012
- 601
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Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolasePecic, Stevan / Deng, Shi-Xian / Morisseau, Christophe et al. | 2011
- 606
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A key cytochrome P450 hydroxylase in pradimicin biosynthesisNapan, Kandy L. / Zeng, Jia / Takemoto, Jon Y. et al. | 2011
- 610
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Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductaseMuhammad, Akhtar / Anis, Itrat / Ali, Zulfiqar et al. | 2011
- 613
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Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the seriesOubrie, Arthur / Kaptein, Allard / de Zwart, Edwin et al. | 2011
- 619
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Chromenones as potent bradykinin B1 antagonistsBryan, Marian C. / Biswas, Kaustav / Peterkin, Tanya A.N. et al. | 2011
- 623
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Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker seriesLachance, Nicolas / Guiral, Sébastien / Huang, Zheng et al. | 2011
- 628
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Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: Potent S1P1 agonists with in vivo lymphocyte-depleting activityFrohn, Mike / Cee, Victor J. / Lanman, Brian A. et al. | 2011
- 634
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Protective effect of ginseng sapogenins against 2,2prime-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damageKang, K. S. / Kim, H. Y. / Yoo, H. H. et al. | 2012
- 634
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Protective effect of ginseng sapogenins against 2,2′-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damageKang, Ki Sung / Kim, Hyun Young / Yoo, Hye Hyun et al. | 2011
- 638
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Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocketDong, Maoqing / Pinon, Delia I. / Miller, Laurence J. et al. | 2011
- 642
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Facile synthesis of 1,2,3-triazole analogs of SGLT2 inhibitors by ‘click chemistry’Li, Lan-Tao / Zhou, Li-Fei / Li, Yan-Jun et al. | 2011
- 645
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aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycleChandrasekhar, Srivari / Pushpavalli, Sreerangam N.C.V.L. / Chatla, Srinivas et al. | 2011
- 649
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Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agentsTelvekar, Vikas N. / Bairwa, Vinod Kumar / Satardekar, Kalpana et al. | 2011
- 653
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Synthesis and evaluation of near-infrared fluorescent sulfonamide derivatives for imaging of hypoxia-induced carbonic anhydrase IX expression in tumorsGroves, Kevin / Bao, Bagna / Zhang, Jun et al. | 2011
- 658
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The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitorsGraham, Thomas H. / Shen, Hong C. / Liu, Wensheng et al. | 2011
- 666
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Synthesis, antitubercular evaluation and 3D-QSAR study of N-phenyl-3-(4-fluorophenyl)-4-substituted pyrazole derivativesKhunt, R.C. / Khedkar, V.M. / Chawda, R.S. et al. | 2011
- 679
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Characterisation of [11C]PR04.MZ in Papio anubis baboon: A selective high-affinity radioligand for quantitative imaging of the dopamine transporterRiss, Patrick J. / Hooker, Jacob M. / Shea, Colleen et al. | 2011
- 683
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Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interactionMalloy, Karla L. / Choi, Hyukjae / Fiorilla, Catherine et al. | 2011
- 689
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From libraries to candidate: The discovery of new ultra long-acting dibasic β2-adrenoceptor agonistsAlcaraz, Lilian / Bailey, Andrew / Cadogan, Elaine et al. | 2011
- 689
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From libraries to candidate: The discovery of new ultra long-acting dibasic b2-adrenoceptor agonistsAlcaraz, L. / Bailey, A. / Cadogan, E. et al. | 2012
- 696
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Conformationally restricted analog and biotin-labeled probe based on beauveriolide IIIDoi, Takayuki / Muraoka, Terushige / Ohshiro, Taichi et al. | 2011
- 700
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4′-Bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-κB signaling pathway in RAW 264.7 macrophagesKim, Dong Han / Yun, Chang Hyeon / Kim, Min Hwan et al. | 2011
- 700
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4prime-Bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-kB signaling pathway in RAW 264.7 macrophagesKim, D. H. / Yun, C. H. / Kim, M. H. et al. | 2012
- 706
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Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophagesHwang, Ji Sang / Lee, Seon A / Hong, Seong Su et al. | 2011
- 709
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Synthesis and activity of folate conjugated didemnin B for potential treatment of inflammatory diseasesHenne, Walter A. / Kularatne, Sumith A. / Ayala-López, Wilfredo et al. | 2011
- 713
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II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamidesAnilkumar, Gopinadhan N. / Selyutin, Oleg / Rosenblum, Stuart B. et al. | 2011
- 718
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Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)McNulty, James / Nair, Jerald J. / Vurgun, Nesrin et al. | 2011
- 723
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Lead diversification. Application to existing drug molecules: Mifepristone 1 and antalarmin 8Abid Masood, M. / Farrant, Elizabeth / Morao, Inaki et al. | 2011
- 729
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A small molecule inhibitor of p53-inducible protein phosphatase PPM1DYagi, Hiroaki / Chuman, Yoshiro / Kozakai, Yuuki et al. | 2011
- 733
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Indole RSK inhibitors. Part 1: Discovery and initial SARBoyer, Stephen J. / Burke, Jennifer / Guo, Xin et al. | 2011
- 738
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Indole RSK inhibitors. Part 2: Optimization of cell potency and kinase selectivityKirrane, Thomas M. / Boyer, Stephen J. / Burke, Jennifer et al. | 2011
- 743
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Design and diversity-oriented synthesis of novel 1,4-thiazepan-3-ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activitiesShi, Feng / Zeng, Xiao-Ning / Cao, Xu-Dong et al. | 2011
- 747
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Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitorsPackard, Garrick K. / Papa, Patrick / Riggs, Jennifer R. et al. | 2011
- 753
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Erratum to “Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres” [Bioorg. Med. Chem. Lett. 20 (2010) 2229–2233]Cohen, Frederick / Koehler, Michael F.T. / Bergeron, Philippe et al. | 2011
- 755
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Corrigendum to “Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors” [Bioorg. Med. Chem. Lett. 21 (2011) 5992–5994]Sleebs, Brad E. / Nikolakopoulos, George / Street, Ian P. et al. | 2011
- IFC
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Editorial board| 2011