3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase (English)
- New search for: Kumar, Dange V.
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- New search for: Kumar, Dange V.
- New search for: Rai, Roopa
- New search for: Brameld, Ken A.
- New search for: Riggs, Jennifer
- New search for: Somoza, John R.
- New search for: Rajagopalan, Ravi
- New search for: Janc, James W.
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In:
Bioorganic and Medicinal Chemistry Letters
;
22
, 1
;
300-304
;
2011
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ISSN:
- Article (Journal) / Electronic Resource
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Title:3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase
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Contributors:Kumar, Dange V. ( author ) / Rai, Roopa ( author ) / Brameld, Ken A. ( author ) / Riggs, Jennifer ( author ) / Somoza, John R. ( author ) / Rajagopalan, Ravi ( author ) / Janc, James W. ( author ) / Xia, Yu M. ( author ) / Ton, Tony L. ( author ) / Hu, Huiyong ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 22, 1 ; 300-304
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2011-11-03
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Size:5 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 22, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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Graphical contents list| 2011
- 39
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Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: Characteristics of broad-spectrum protein binding and its effects on anti-tumor activityZheng, Can-Hui / Yang, Hui / Zhang, Meng / Lu, Shi-Hai / Shi, Duo / Wang, Juan / Chen, Xiu-Hua / Ren, Xiao-Hui / Liu, Jia / Lv, Jia-Guo et al. | 2011
- 45
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Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogsHaddach, Mustapha / Pierre, Fabrice / Regan, Collin F. / Borsan, Cosmin / Michaux, Jerome / Stefan, Eric / Kerdoncuff, Pauline / Schwaebe, Michael K. / Chua, Peter C. / Siddiqui-Jain, Adam et al. | 2011
- 49
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New substituted C-19-andrographolide analogues with potent cytotoxic activitiesSirion, Uthaiwan / Kasemsook, Sakkasem / Suksen, Kanoknetr / Piyachaturawat, Pawinee / Suksamrarn, Apichart / Saeeng, Rungnapha et al. | 2011
- 53
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The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivativesYang, Na / Wang, Qing-He / Wang, Wen-Qian / Wang, Jian / Li, Feng / Tan, Shen-Peng / Cheng, Mao-Sheng et al. | 2011
- 57
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Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistrySingh, Pardeep / Singh, Parvesh / Kumar, Malkeet / Gut, Jiri / Rosenthal, Philip J. / Kumar, Kewal / Kumar, Vipan / Mahajan, Mohinder P. / Bisetty, Krishna et al. | 2011
- 57
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Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from b-lactams and 7-chloroquinoline using click chemistrySingh, P. / Kumar, M. / Gut, J. / Rosenthal, P. J. / Kumar, K. / Kumar, V. / Mahajan, M. P. / Bisetty, K. et al. | 2012
- 62
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Virtual ligand screening of a-glucosidase: Identification of a novel potent noncarbohydrate mimetic inhibitorHakamata, W. / Ishikawa, R. / Ushijima, Y. / Tsukagoshi, T. / Tamura, S. / Hirano, T. / Nishio, T. et al. | 2012
- 62
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Virtual ligand screening of α-glucosidase: Identification of a novel potent noncarbohydrate mimetic inhibitorHakamata, Wataru / Ishikawa, Ryosuke / Ushijima, Yoriko / Tsukagoshi, Takumi / Tamura, Saori / Hirano, Takako / Nishio, Toshiyuki et al. | 2011
- 65
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A three-step protocol for lead optimization: Quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitorsHuang, Xianhai / Zhu, Xiaohong / Chen, Xiao / Zhou, Wei / Xiao, Dong / Degrado, Sylvia / Aslanian, Robert / Fossetta, James / Lundell, Daniel / Tian, Fang et al. | 2011
- 71
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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)Semple, Graeme / Santora, Vincent J. / Smith, Jeffrey M. / Covel, Jonathan A. / Hayashi, Rena / Gallardo, Charlemagne / Ibarra, Jason B. / Schultz, Jeffrey A. / Park, Douglas M. / Estrada, Scott A. et al. | 2011
- 71
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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4prime-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)Semple, G. / Santora, V. J. / Smith, J. M. / Covel, J. A. / Hayashi, R. / Gallardo, C. / Ibarra, J. B. / Schultz, J. A. / Park, D. M. / Estrada, S. A. et al. | 2012
- 76
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Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathwayTheriault, Jimmy R. / Felts, Andrew S. / Bates, Brittney S. / Perez, Jose R. / Palmer, Michelle / Gilbert, Shawn R. / Dawson, Eric S. / Engers, Julie L. / Lindsley, Craig W. / Emmitte, Kyle A. et al. | 2011
- 82
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Combination of two chromophores: Synthesis and PDT application of porphyrin–pentamethinium conjugateBříza, Tomáš / Králová, Jarmila / Cígler, Petr / Kejík, Zdeněk / Poučková, Pavla / Vašek, Petr / Moserová, Irena / Martásek, Pavel / Král, Vladimír et al. | 2011
- 85
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Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Improvements in clearance of adenosine seriesStokes, Suzanne S. / Gowravaram, Madhusudhan / Huynh, Hoan / Lu, Min / Mullen, George B. / Chen, Brendan / Albert, Robert / O’Shea, Thomas J. / Rooney, Michael T. / Hu, Haiqing et al. | 2011
- 90
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Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1)Cadieux, Jay A. / Zhang, Zaihui / Mattice, Maryanne / Brownlie-Cutts, Alison / Fu, Jianmin / Ratkay, Laszlo G. / Kwan, Rainbow / Thompson, Jay / Sanghara, Joseph / Zhong, Jing et al. | 2011
- 96
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5-(2-Amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitorsCaruso, Michele / Valsasina, Barbara / Ballinari, Dario / Bertrand, Jay / Brasca, Maria Gabriella / Caldarelli, Marina / Cappella, Paolo / Fiorentini, Francesco / Gianellini, Laura M. / Scolaro, Alessandra et al. | 2011
- 102
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Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-kB pathwaySun, D. d. / Wang, W. z. / Mao, J. w. / Mei, W. j. / Liu, J. et al. | 2012
- 102
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Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-κB pathwaySun, Dong-dong / Wang, Wei-zhang / Mao, Jian-wen / Mei, Wen-jie / Liu, Jie et al. | 2011
- 106
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Fatty acyl-gramicidin S derivatives with both high antibiotic activity and low hemolytic activityTamaki, Makoto / Fujinuma, Kenta / Harada, Takuji / Takanashi, Kazumasa / Shindo, Mitsuno / Kimura, Masahiro / Uchida, Yoshiki et al. | 2011
- 110
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Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinaseYu, Bing / Tang, Li-da / Li, Yi-liang / Song, Shu-hui / Ji, Xiao-liang / Lin, Mu-sen / Wu, Chun-Fu et al. | 2011
- 115
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Synthesis of [11C]uric acid, using [11C]phosgene, as a possible biomarker in PET imaging for diagnosis of goutYashio, Keiji / Katayama, Yumiko / Takashima, Tadayuki / Ishiguro, Naoki / Doi, Hisashi / Suzuki, Masaaki / Wada, Yasuhiro / Tamai, Ikumi / Watanabe, Yasuyoshi et al. | 2011
- 120
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Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonistsSundar, Babu G. / Bailey, Thomas R. / Dunn, Derek D. / Bacon, Edward R. / Salvino, Joseph M. / Morton, George C. / Aimone, Lisa D. / Zeqi, Huang / Mathiasen, Joanne R. / Dicamillo, Amy et al. | 2011
- 124
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Reassessment of Hammett σ as an effective parameter representing intermolecular interaction energy—links between traditional and modern QSAR approachesYoshida, Tatsusada / Shimizu, Miho / Harada, Masataka / Hitaoka, Seiji / Chuman, Hiroshi et al. | 2011
- 129
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Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probeZhao, Zheng-yun / San, Marie / Duprey, Jean-Louis H.A. / Arrand, John R. / Vyle, Joseph S. / Tucker, James H.R. et al. | 2011
- 133
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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinasesZificsak, Craig A. / Gingrich, Diane E. / Breslin, Henry J. / Dunn, Derek D. / Milkiewicz, Karen L. / Theroff, Jay P. / Thieu, Tho V. / Underiner, Ted L. / Weinberg, Linda R. / Aimone, Lisa D. et al. | 2011
- 138
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Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD)Wu, Yuchuan / Li, Jianchang / Wu, Junjun / Morgan, Paul / Xu, Xin / Rancati, Fabio / Vallese, Stefania / Raveglia, Luca / Hotchandani, Rajeev / Fuller, Nathan et al. | 2011
- 144
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Structure–activity relationship studies of S1P agonists with a dihydronaphthalene scaffoldKurata, Haruto / Kusumi, Kensuke / Otsuki, Kazuhiro / Suzuki, Ryo / Kurono, Masakuni / Tokuda, Natsuko / Takada, Yuka / Shioya, Hiroki / Mizuno, Hirotaka / Komiya, Takaki et al. | 2011
- 149
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Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepinesRajanarendar, E. / Nagi Reddy, M. / Rama Murthy, K. / Surendar, P. / Reddy, R.N. / Reddy, Y.N. et al. | 2011
- 154
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Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cellsLiu, Li / Ma, Hongyue / Tang, Yuping / Chen, Wenxing / Lu, Yin / Guo, Jianming / Duan, Jin-ao et al. | 2011
- 154
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Discovery of estrogen receptor a modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cellsLiu, L. / Ma, H. / Tang, Y. / Chen, W. / Lu, Y. / Guo, J. / Duan, J. a. et al. | 2012
- 164
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Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimideOta, Eisuke / Takeiri, Masatoshi / Tachibana, Miyuki / Ishikawa, Yuichi / Umezawa, Kazuo / Nishiyama, Shigeru et al. | 2011
- 168
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Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassayWang, Di / Wang, Fei / Tan, Yexiong / Dong, Liwei / Chen, Lei / Zhu, Weiliang / Wang, Hongyang et al. | 2011
- 172
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Effect of a second nitroimidazole redox centre on the accumulation of a hypoxia marker: Synthesis and in vitro evaluation of 99mTc-labeled bisnitroimidazole propylene amine oxime complexesHuang, Huafan / Zhou, Hao / Li, Zejun / Wang, Xiangyun / Chu, Taiwei et al. | 2011
- 178
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Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin–ruthenium metalla-cubesSchmitt, Frédéric / Barry, Nicolas P.E. / Juillerat-Jeanneret, Lucienne / Therrien, Bruno et al. | 2011
- 181
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Activation of human RNase L by 2prime- and 5prime-O-methylphosphonate-modified oligoadenylatesPav, O. / Panova, N. / Snasel, J. / Zbornikova, E. / Rosenberg, I. et al. | 2012
- 181
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Activation of human RNase L by 2′- and 5′-O-methylphosphonate-modified oligoadenylatesPáv, Ondřej / Panova, Natalya / Snášel, Jan / Zborníková, Eva / Rosenberg, Ivan et al. | 2011
- 186
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Synthesis and evaluation of 4-alkoxy-[1′-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4′-piperidine)] analogues as histamine-3 receptor antagonistsBecknell, Nadine C. / Dandu, Reddeppa Reddy / Lyons, Jacquelyn A. / Aimone, Lisa D. / Raddatz, Rita / Hudkins, Robert L. et al. | 2011
- 186
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Synthesis and evaluation of 4-alkoxy-[1prime-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4prime-piperidine)] analogues as histamine-3 receptor antagonistsBecknell, N. C. / Dandu, R. R. / Lyons, J. A. / Aimone, L. D. / Raddatz, R. / Hudkins, R. L. et al. | 2012
- 190
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Novel and selective spiroindoline-based inhibitors of sky kinasePowell, Noel A. / Kohrt, Jeffrey T. / Filipski, Kevin J. / Kaufman, Michael / Sheehan, Derek / Edmunds, Jeremy E. / Delaney, Amy / Wang, Yuli / Bourbonais, Francis / Lee, Doh-Yeel et al. | 2011
- 194
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4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonistsHudkins, Robert L. / Aimone, Lisa D. / Dandu, Reddeppa reddy / Dunn, Derek / Gruner, John A. / Huang, Zeqi / Josef, Kurt A. / Lyons, Jacquelyn A. / Mathiasen, Joanne R. / Tao, Ming et al. | 2011
- 199
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SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitorsLu, Zhijian / Chen, Yi-heng / Napolitano, Joann B. / Taylor, Gayle / Ali, Amjad / Hammond, Milton L. / Deng, Qiaolin / Tan, Eugene / Tong, Xinchun / Xu, Suoyu S. et al. | 2011
- 204
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Synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as platelet aggregation inhibitorsTian, Xiao / Wang, Li-Ying / Xia, Shuai / Li, Zhu-Bo / Liu, Xing-Hui / Yuan, Yuan / Fang, Liang / Zuo, Hua et al. | 2011
- 207
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Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokinesTamura, Ryuichi / Chen, Yanjie / Shinozaki, Miwako / Arao, Kei / Wang, Liyan / Tang, Wanxia / Hirano, Seiya / Ogura, Hirotsugu / Mitsui, Tomokazu / Taketani, Shigeru et al. | 2011
- 207
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Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-kB signaling pathway induced by inflammatory cytokinesTamura, R. / Chen, Y. / Shinozaki, M. / Arao, K. / Wang, L. / Tang, W. / Hirano, S. / Ogura, H. / Mitsui, T. / Taketani, S. et al. | 2012
- 212
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Novel bis(indolyl)hydrazide–hydrazones as potent cytotoxic agentsKumar, Dalip / Maruthi Kumar, N. / Ghosh, Soumitra / Shah, Kavita et al. | 2011
- 216
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An expedient synthesis of honokiol and its analogues as potential neuropreventive agentsTripathi, Subhankar / Chan, Ming-Huan / Chen, Chinpiao et al. | 2011
- 222
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Novel poly(ADP-ribose) polymerase-1 inhibitorsDunn, Derek / Husten, Jean / Ator, Mark A. / Chatterjee, Sankar et al. | 2011
- 225
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Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureusMoreira Osório, Thaís / Delle Monache, Franco / Domeneghini Chiaradia, Louise / Mascarello, Alessandra / Regina Stumpf, Taisa / Roberto Zanetti, Carlos / Bardini Silveira, Douglas / Regina Monte Barardi, Célia / de Fatima Albino Smânia, Elza / Viancelli, Aline et al. | 2011
- 231
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Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screeningWatanabe, Takumi / Kurata, Ikuko / Umezawa, Yoji / Takahashi, Yoshikazu / Akamatsu, Yuzuru et al. | 2011
- 235
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Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophreniaYang, Shu-Wei / Smotryski, Jennifer / McElroy, William T. / Tan, Zheng / Ho, Ginny / Tulshian, Deen / Greenlee, William J. / Guzzi, Mario / Zhang, Xiaoping / Mullins, Deborra et al. | 2011
- 240
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Discovery of pyrrolidine-based β-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiencyStachel, Shawn J. / Steele, Thomas G. / Petrocchi, Alessia / Haugabook, Sharie J. / McGaughey, Georgia / Katharine Holloway, M. / Allison, Timothy / Munshi, Sanjeev / Zuck, Paul / Colussi, Dennis et al. | 2011
- 240
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Discovery of pyrrolidine-based b-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiencyStachel, S. J. / Steele, T. G. / Petrocchi, A. / Haugabook, S. J. / McGaughey, G. / Katharine Holloway, M. / Allison, T. / Munshi, S. / Zuck, P. / Colussi, D. et al. | 2012
- 245
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Synthesis and evaluation of macrocyclic diarylether heptanoid natural products and their analogsBryant, Vashti C. / Kishore Kumar, G.D. / Nyong, Abijah M. / Natarajan, Amarnath et al. | 2011
- 249
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Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell lineWada, Koji / Ohkoshi, Emika / Morris-Natschke, Susan L. / Bastow, Kenneth F. / Lee, Kuo-Hsiung et al. | 2011
- 253
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Fluorescence detection of single nucleotide polymorphisms using nucleic acid probe containing tricyclic base-linked acyclonucleosideHattori, Mayumi / Ohki, Tokimitsu / Yanase, Emiko / Ueno, Yoshihito et al. | 2011
- 258
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Hydroxycoumarins as selective MAO-B inhibitorsSerra, Silvia / Ferino, Giulio / Matos, Maria João / Vázquez-Rodríguez, Saleta / Delogu, Giovanna / Viña, Dolores / Cadoni, Enzo / Santana, Lourdes / Uriarte, Eugenio et al. | 2011
- 262
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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinasesPlé, Patrick A. / Jung, Frédéric / Ashton, Sue / Hennequin, Laurent / Laine, Romuald / Morgentin, Rémy / Pasquet, Georges / Taylor, Sian et al. | 2011
- 267
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5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitorsCarta, Fabrizio / Maresca, Alfonso / Scozzafava, Andrea / Supuran, Claudiu T. et al. | 2011
- 271
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Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2De Savi, Chris / Morley, Andrew D. / Nash, Ian / Karoutchi, Galith / Page, Ken / Ting, Attilla / Gerhardt, Stefan et al. | 2011
- 278
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Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analoguesJoce, Catherine / White, Rebecca / Stockley, Peter G. / Warriner, Stuart / Turnbull, W. Bruce / Nelson, Adam et al. | 2011
- 285
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Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitorsShiro, Tomoya / Takahashi, Hirotada / Kakiguchi, Keisuke / Inoue, Yoshifumi / Masuda, Keiki / Nagata, Hidetaka / Tobe, Masanori et al. | 2011
- 289
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Synthesis and biological evaluation of novel derivatives of gambogic acid as anti-hepatocellular carcinoma agentsHe, Liqin / Ling, Yong / Fu, Li / Yin, Dengke / Wang, Xiaoshan / Zhang, Yihua et al. | 2011
- 293
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Potent adjuvantic activity of a CCR1-agonistic bis-quinolineUkani, Rehman / Lewis, Tyler C. / Day, Timothy P. / Wu, Wenyan / Malladi, Subbalakshmi S. / Warshakoon, Hemamali J. / David, Sunil A. et al. | 2011
- 296
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Structural requirements for hybridization at the 5′-position are different in α-l-LNA as compared to β-d-LNASeth, Punit P. / Allerson, Charles R. / Østergaard, Michael E. / Swayze, Eric E. et al. | 2011
- 296
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Structural requirements for hybridization at the 5prime-position are different in a-l-LNA as compared to b-d-LNASeth, P. P. / Allerson, C. R. / Ostergaard, M. E. / Swayze, E. E. et al. | 2012
- 300
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3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymeraseKumar, Dange V. / Rai, Roopa / Brameld, Ken A. / Riggs, Jennifer / Somoza, John R. / Rajagopalan, Ravi / Janc, James W. / Xia, Yu M. / Ton, Tony L. / Hu, Huiyong et al. | 2011
- 305
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Structure-based design of PDK1 inhibitorsPoulsen, Anders / Blanchard, Stéphanie / Soh, Chang Kai / Lee, Chaiping / Williams, Meredith / Wang, Haishan / Dymock, Brian et al. | 2011
- 308
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Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivativesKraljević, Tatjana Gazivoda / Klika, Mateja / Kralj, Marijeta / Martin-Kleiner, Irena / Jurmanović, Stella / Milić, Astrid / Padovan, Jasna / Raić-Malić, Silvana et al. | 2011
- 313
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Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisonsAndré, Sabine / Jarikote, Dilip V. / Yan, Dandan / Vincenz, Lisa / Wang, Guan-Nan / Kaltner, Herbert / Murphy, Paul V. / Gabius, Hans-Joachim et al. | 2011
- 319
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Synthesis of [18F]-labeled (2-(2-fluoroethoxy)ethyl)triphenylphosphonium cation as a potential agent for myocardial imaging using positron emission tomographyKim, Dong-Yeon / Kim, Hee-Jung / Yu, Kook-Hyun / Min, Jung-Joon et al. | 2011
- 323
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Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activityHan, Young-Min / Lee, Su-Kyung / Jeong, Dae Gwin / Ryu, Seong Eon / Han, Dong Cho / Kim, Dae Keun / Kwon, Byoung-Mog et al. | 2011
- 327
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Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivativesEl-Azab, Adel S. / ElTahir, Kamal E.H. et al. | 2011
- 334
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Discovery of cyclic amine-substituted benzoic acids as PPARα agonistsNomura, Masahiro / Yumoto, Kazuhiro / Shinozaki, Takehiro / Isogai, Shigeki / Takano, Yasuo / Murakami, Koji et al. | 2011
- 334
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Discovery of cyclic amine-substituted benzoic acids as PPARa agonistsNomura, M. / Yumoto, K. / Shinozaki, T. / Isogai, S. / Takano, Y. / Murakami, K. et al. | 2012
- 339
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Discovery and bioactivity of 4-(2-arylpyrido[3prime,2prime:3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitorsWang, J. / Wang, X. / Chen, Y. / Chen, S. / Chen, G. / Tong, L. / Meng, L. / Xie, Y. / Ding, J. / Yang, C. et al. | 2012
- 339
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Discovery and bioactivity of 4-(2-arylpyrido[3′,2′:3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitorsWang, Jia / Wang, Xiang / Chen, Yanhong / Chen, Simeng / Chen, Guang / Tong, Linjiang / Meng, Linghua / Xie, Yuyuan / Ding, Jian / Yang, Chunhao et al. | 2011
- 343
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Synthesis and spectral studies of 2-[(N-ethyl carbazole)-3-sulfonyl ethylenediamine]-1-N,N-2-(2-methypyridy) as a fluorescence probe for Zn2+Zhang, Jun / Cui, Huiling / Hojo, Masashi / Shuang, Shaomin / Dong, Chuan et al. | 2011
- 347
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5-HT2C receptor selectivity and structure–activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogsJang, Jae Wan / Baek, Je-sook / Choi, Gil Don / Park, Woo-Kyu / Cho, Yong Seo / Baek, Du-Jong / Pae, Ae Nim et al. | 2011
- 353
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Synthesis and antiviral activity of substituted quercetinsThapa, Mahendra / Kim, Yunjeong / Desper, John / Chang, Kyeong-Ok / Hua, Duy H. et al. | 2011
- 357
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Discovery of potent and specific CXCR3 antagonistsChen, Xiaoqi / Mihalic, Jeff / Deignan, Jeff / Gustin, Darin J. / Duquette, Jason / Du, Xiaohui / Chan, Johann / Fu, Zice / Johnson, Michael / Li, An-Rong et al. | 2011
- 363
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Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2Chen, Xiaoqi / Mihalic, Jeff / Fan, Pingchen / Liang, Lingming / Lindstrom, Michelle / Wong, Sylvia / Ye, Qiuping / Fu, Ying / Jaen, Juan / Chen, Jin-Long et al. | 2011
- 367
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Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonismWang, Yingcai / Fu, Zice / Schmitt, Michael / Wang, Xuemei / Shen, Wang / Rickel, Erika / Martin, Tod / Budelsky, Alison / Marshall, Derek / Collins, Tassie et al. | 2011
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Dirlotapide as a model substrate to refine structure-based drug design strategies on CYP3A4-catalyzed metabolismSun, Hao / Bessire, Andrew J. / Vaz, Alfin et al. | 2011
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Inhibition of noroviruses by piperazine derivativesDou, Dengfeng / He, Guijia / Mandadapu, Sivakoteswara Rao / Aravapalli, Sridhar / Kim, Yunjeong / Chang, Kyeong-Ok / Groutas, William C. et al. | 2011
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3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitorsFaridoon / Hussein, Waleed M. / Vella, Peter / Islam, Nazar Ul / Ollis, David L. / Schenk, Gerhard / McGeary, Ross P. et al. | 2011
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3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-b-lactamase inhibitorsHussein, W. M. / Vella, P. / Islam, N. U. / Ollis, D. L. / Schenk, G. / McGeary, R. P. et al. | 2012
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Ceric ammonium nitrate-promoted oxidative coupling reaction for the synthesis and evaluation of a series of anti-tumor amide anhydrovinblastine analogsSong, Weibin / Lei, Min / Zhao, Kun / Hu, Lingjun / Meng, Yuhui / Guo, Dean / Liu, Xuan / Hu, Lihong et al. | 2011
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Towards a modern definition of vitamin E—evidence for a quinone hypothesisShrader, William D. / Amagata, Akiko / Barnes, Adam / Hinman, Andrew / Jankowski, Orion / Lee, Edgar / Kheifets, Viktoria / Komatsuzaki, Ryo / Mollard, Paul / Murase, Katsuyuki et al. | 2011
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Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivityKambe, Tohru / Maruyama, Toru / Nakano, Masayuki / Nakai, Yoshihiko / Yoshida, Tadahiro / Matsunaga, Naoki / Oida, Hiroji / Konaka, Akira / Maruyama, Takayuki / Nakai, Hisao et al. | 2011
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In vitro inhibition of translation initiation by N,Nprime-diarylureas-potential anti-cancer agentsDenoyelle, S. / Chen, T. / Chen, L. / Wang, Y. / Klosi, E. / Halperin, J. A. / Aktas, B. H. / Chorev, M. et al. | 2012
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In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agentsDenoyelle, Séverine / Chen, Ting / Chen, Limo / Wang, Yibo / Klosi, Edvin / Halperin, José A. / Aktas, Bertal H. / Chorev, Michael et al. | 2011
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One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activitiesRao, V. Kameshwara / Chhikara, Bhupender S. / Tiwari, Rakesh / Shirazi, Amir Nasrolahi / Parang, Keykavous / Kumar, Anil et al. | 2011
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A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicityFilipski, Kevin J. / Bian, Jianwei / Ebner, David C. / Lee, Esther C.Y. / Li, Jian-Cheng / Sammons, Matthew F. / Wright, Stephen W. / Stevens, Benjamin D. / Didiuk, Mary T. / Tu, Meihua et al. | 2011
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Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomniaRavula, Satheesh Babu / Yu, Jinghua / Tran, Joe A. / Arellano, Melissa / Tucci, Fabio C. / Moree, Wilna J. / Li, Bin-Feng / Petroski, Robert E. / Wen, Jianyun / Malany, Siobhan et al. | 2011
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4-Arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1)Lim, Chae Jo / Kim, Soo Hee / Lee, Byung Ho / Oh, Kwang-Seok / Yi, Kyu Yang et al. | 2011
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Acyl derivatives of boswellic acids as inhibitors of NF-kB and STATsKumar, A. / Shah, B. A. / Singh, S. / Hamid, A. / Singh, S. K. / Sethi, V. K. / Saxena, A. K. / Singh, J. / Taneja, S. C. et al. | 2012
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Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATsKumar, Ajay / Shah, Bhahwal A. / Singh, Samar / Hamid, Abid / Singh, Shashank K. / Sethi, Vijay K. / Saxena, Ajit K. / Singh, Jaswant / Taneja, Subhash C. et al. | 2011
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Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moietiesJawale, Dhanaji V. / Pratap, Umesh R. / Rahuja, Neha / Srivastava, Arvind K. / Mane, Ramrao A. et al. | 2011
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Diamine and aminoalcohol derivatives active against Trypanosoma bruceiOlmo, Esther del / Diaz-González, Rosario / Escarcena, Ricardo / Carvalho, Luis / Bustos, Luis A. / Navarro, Miguel / Feliciano, Arturo San et al. | 2011
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Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factorBaeza, José Luis / de la Torre, Beatriz G. / Santiveri, Clara M. / Almeida, Ramiro D. / García-López, M. Teresa / Gerona-Navarro, Guillermo / Jaffrey, Samie R. / Jiménez, M. Ángeles / Andreu, David / González-Muñiz, Rosario et al. | 2011
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Synthesis of dihydrofuran-fused perhydrophenanthrenes having a phenolic hydroxyl group as a novel anti-Alzheimer’s disease agentSugimoto, Kenji / Tamura, Kosuke / Ohta, Naoki / Tohda, Chihiro / Toyooka, Naoki / Nemoto, Hideo / Matsuya, Yuji et al. | 2011
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Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agentsKumbhare, Ravindra M. / Dadmal, Tulshiram / Kosurkar, Umesh / Sridhar, V. / Rao, J. Venkateswara et al. | 2011
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Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinasesSuzuki, Naoyuki / Shiota, Takeshi / Watanabe, Fumihiko / Haga, Norihiro / Murashi, Takami / Ohara, Takafumi / Matsuo, Kenji / Omori, Naoki / Yari, Hiroshi / Dohi, Keiji et al. | 2011
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Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kineticsSmits, Rogier A. / Lim, Herman D. / van der Meer, Tiffany / Kuhne, Sebastiaan / Bessembinder, Karin / Zuiderveld, Obbe P. / Wijtmans, Maikel / de Esch, Iwan J.P. / Leurs, Rob et al. | 2011
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Development of phyllanthin containing microcapsules and their improved biological activity towards skin cells and Staphylococcus aureusLam, Pik-Ling / Gambari, Roberto / Yip, Joanne / Yuen, Marcus Chun-Wah / Lam, Kim-Hung / Wong, Raymond Siu-Ming / Wang, Xiao-Wen / Tang, Johnny Cheuk-On / Kok, Stanton Hon-Lung / Chui, Chung-Hin et al. | 2011
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Fused thiophene derivatives as MEK inhibitorsLaing, Victoria E. / Brookings, Daniel C. / Carbery, Rachel J. / Simorte, Jose Gascon / Hutchings, Martin C. / Langham, Barry J. / Lowe, Martin A. / Allen, Rodger A. / Fetterman, Joanne R. / Turner, James et al. | 2011
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Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogensKumar, Rajesh / Rathy, Sujata / Hajare, Atul K. / Surase, Yogesh B. / Dullu, Jyoti / Jadhav, Jitendra S. / Venkataramanan, R. / Chakrabarti, Anjan / Pandya, Manisha / Bhateja, Pragya et al. | 2011
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Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanXJia, Chao / Yang, Ke-Wu / Liu, Cheng-Cheng / Feng, Lei / Xiao, Jian-Min / Zhou, Li-Sheng / Zhang, Yi-Lin et al. | 2011
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Synthesis and evaluation of novel prodrugs of caspase inhibitorsCharrier, Jean-Damien / Durrant, Steven J. / Studley, John / Lawes, Linda / Weber, Peter et al. | 2011
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Physicochemical properties and inhibition effect on iron deficiency anemia of a novel polysaccharide-iron complex (LPPC)Zhang, Zhong-Shan / Wang, Xiao-Mei / Han, Zhi-Ping / Yin, Li / Zhao, Ming-Xing / Yu, Shu-Chi et al. | 2011
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Developing potent backbone cyclic peptides bearing the shared epitope sequence as rheumatoid arthritis drug-leadsNaveh, Shirly / Tal-Gan, Yftah / Ling, Song / Hoffman, Amnon / Holoshitz, Joseph / Gilon, Chaim et al. | 2011
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Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-dionesRyu, Chung-Kyu / Yoon, Joo Hee / Song, Ae Li / Im, Hyun Ah / Kim, Ji Young / Kim, Aram et al. | 2011
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Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-olsRyu, Chung-Kyu / Kim, Yang Hui / Im, Hyun Ah / Kim, Ji Young / Yoon, Joo Hee / Kim, Aram et al. | 2011
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Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitorsHarada, Koichiro / Kubo, Hideki / Tanaka, Akio / Nishioka, Kazuhiko et al. | 2011
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Identification of oxazolidinediones and thiazolidinediones as potent 17b-hydroxysteroid dehydrogenase type 3 inhibitorsHarada, K. / Kubo, H. / Tanaka, A. / Nishioka, K. et al. | 2012
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AChE inhibitor : A regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3′]-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazoleAshraf Ali, Mohamed / Ismail, Rusli / Choon, Tan Soo / Kumar, Raju Suresh / Osman, Hasnah / Arumugam, Natarajan / Almansour, Abdulrahman I. / Elumalai, Karthikeyan / Singh, Abhimanyu et al. | 2011
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AChE inhibitor : A regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3prime]-oxindole-spiro-[6.3Prime]-2,3-dihydro-1H-inden-1Prime-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazoleAshraf Ali, M. / Ismail, R. / Choon, T. S. / Kumar, R. S. / Osman, H. / Arumugam, N. / Almansour, A. I. / Elumalai, K. / Singh, A. et al. | 2012
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Antiangiogenic activity of 3,4-seco-cycloartane triterpenes from Thai Gardenia spp. and their semi-synthetic analogsPudhom, Khanitha / Nuanyai, Thanesuan / Matsubara, Kiminori / Vilaivan, Tirayut et al. | 2011
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Down-regulation of the human VEGF gene expression by perylene monoimide derivativesTaka, Thanachai / Joonlasak, Khajohn / Huang, Liming / Randall Lee, T. / Chang, Suk-Wah Tam / Tuntiwechapikul, Wirote et al. | 2011
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(±)-2-(N-tert-Butylamino)-3′-[125I]-iodo-4′-azidopropiophenone: A dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban)Lapinsky, David J. / Aggarwal, Shaili / Nolan, Tammy L. / Surratt, Christopher K. / Lever, John R. / Acharya, Rejwi / Vaughan, Roxanne A. / Pandhare, Akash / Blanton, Michael P. et al. | 2011
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(+-)-2-(N-tert-Butylamino)-3prime-[125I]-iodo-4prime-azidopropiophenone: A dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban)Lapinsky, D. J. / Aggarwal, S. / Nolan, T. L. / Surratt, C. K. / Lever, J. R. / Acharya, R. / Vaughan, R. A. / Pandhare, A. / Blanton, M. P. et al. | 2012
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Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activityPennington, Lewis D. / Croghan, Michael D. / Sham, Kelvin K.C. / Pickrell, Alexander J. / Harrington, Paul E. / Frohn, Michael J. / Lanman, Brian A. / Reed, Anthony B. / Lee, Matthew R. / Xu, Han et al. | 2011
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Lead optimisation of pyrazoles as novel FPR1 antagonistsMorley, Andrew D. / King, Sarah / Roberts, Bryan / Lever, Sarah / Teobald, Barry / Fisher, Adrian / Cook, Tony / Parker, Beth / Wenlock, Mark / Phillips, Caroline et al. | 2011
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Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonistsGuerrero, Miguel / Urbano, Mariangela / Zhao, Jian / Crisp, Melissa / Chase, Peter / Hodder, Peter / Schaeffer, Marie-Therese / Brown, Steven / Rosen, Hugh / Roberts, Edward et al. | 2011
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OFF-to-ON type fluorescent probe for the detection of 8-oxo-dG in DNA by the Adap-masked ODN probeTaniguchi, Yosuke / Koga, Yohei / Fukabori, Keitaro / Kawaguchi, Ryota / Sasaki, Shigeki et al. | 2011
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5-Sulfonyl-benzimidazoles as selective CB2 agonists-Part 2Gijsen, Harrie J.M. / De Cleyn, Michel A.J. / Surkyn, Michel / Van Lommen, Guy R.E. / Verbist, Bie M.P. / Nijsen, Marjoleen J.M.A. / Meert, Theo / Wauwe, Jean Van / Aerssens, Jeroen et al. | 2011
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Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffoldHe, Xinhua / Wang, Lili / Zheng, Zhibing / Xiao, Junhai / Zhong, Wu / Li, Song et al. | 2011
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Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteinsBardaweel, Sanaa K. / Ghosh, Brahma / Wagner, Carston R. et al. | 2011
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Mitochondrial targeting of a cationic amphiphilic polyproline helixKalafut, Deanna / Anderson, Tiffani N. / Chmielewski, Jean et al. | 2011
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An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseasesLiu, Min / Wang, Shaoru / Zhou, Yi-Dan / Xiang, Tian / Dong, Huifen / Yang, Kun / Zhang, Xiao-Lian et al. | 2011
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Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugatesKamal, Ahmed / Srikanth, Y.V.V. / Ramaiah, M. Janaki / Khan, M. Naseer Ahmed / Kashi Reddy, M. / Ashraf, Md. / Lavanya, A. / Pushpavalli, S.N.C.V.L. / Pal-Bhadra, Manika et al. | 2011
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The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathwaysYang, Tingting / Lu, Zhenyu / Meng, Li / Wei, Shanjian / Hong, Kui / Zhu, Weiming / Huang, Caiguo et al. | 2011
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LDV peptidomimetics equipped with biotinylated spacer-arms: Synthesis and biological evaluation on CCRF-CEM cell lineGérard, Estelle / Meulle, Aline / Feron, Olivier / Marchand-Brynaert, Jacqueline et al. | 2011
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Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assemblyIrie, Takayuki / Fujii, Ikuo / Sawa, Masaaki et al. | 2011
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Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stemsWan, Chunpeng / Yuan, Tao / Li, Liya / Kandhi, Vamsikrishna / Cech, Nadja B. / Xie, Mingyong / Seeram, Navindra P. et al. | 2011
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Maplexins, new a-glucosidase inhibitors from red maple (Acer rubrum) stemsWan, C. / Yuan, T. / Li, L. / Kandhi, V. / Cech, N. B. / Xie, M. / Seeram, N. P. et al. | 2012
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Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolasePecic, Stevan / Deng, Shi-Xian / Morisseau, Christophe / Hammock, Bruce D. / Landry, Donald W. et al. | 2011
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A key cytochrome P450 hydroxylase in pradimicin biosynthesisNapan, Kandy L. / Zeng, Jia / Takemoto, Jon Y. / Zhan, Jixun et al. | 2011
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Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductaseMuhammad, Akhtar / Anis, Itrat / Ali, Zulfiqar / Awadelkarim, Sufyan / Khan, Ajmal / Khalid, Asaad / Shah, Muhammad Raza / Galal, M. / Khan, Ikhlas A. / Iqbal Choudhary, M. et al. | 2011
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Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the seriesOubrie, Arthur / Kaptein, Allard / de Zwart, Edwin / Hoogenboom, Niels / Goorden, Rianne / van de Kar, Bas / van Hoek, Maaike / de Kimpe, Vera / van der Heijden, Ruud / Borsboom, Judith et al. | 2011
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Chromenones as potent bradykinin B1 antagonistsBryan, Marian C. / Biswas, Kaustav / Peterkin, Tanya A.N. / Rzasa, Robert M. / Arik, Leyla / Lehto, Sonya G. / Sun, Hong / Hsieh, Feng-Yin / Xu, Cen / Fremeau, Robert T. et al. | 2011
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Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker seriesLachance, Nicolas / Guiral, Sébastien / Huang, Zheng / Leclerc, Jean-Philippe / Li, Chun Sing / Oballa, Renata M. / Ramtohul, Yeeman K. / Wang, Hao / Wu, Jin / Zhang, Lei et al. | 2011
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Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: Potent S1P1 agonists with in vivo lymphocyte-depleting activityFrohn, Mike / Cee, Victor J. / Lanman, Brian A. / Pickrell, Alexander J. / Golden, Jennifer / Rivenzon-Segal, Dalia / Middleton, Scot / Fiorino, Mike / Xu, Han / Schrag, Michael et al. | 2011
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Protective effect of ginseng sapogenins against 2,2prime-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damageKang, K. S. / Kim, H. Y. / Yoo, H. H. / Piao, X. L. / Ham, J. / Yang, H. O. / Park, J. H. et al. | 2012
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Protective effect of ginseng sapogenins against 2,2′-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damageKang, Ki Sung / Kim, Hyun Young / Yoo, Hye Hyun / Piao, Xiang Lan / Ham, Jungyeob / Yang, Hyun Ok / Park, Jeong Hill et al. | 2011
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Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocketDong, Maoqing / Pinon, Delia I. / Miller, Laurence J. et al. | 2011
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Facile synthesis of 1,2,3-triazole analogs of SGLT2 inhibitors by ‘click chemistry’Li, Lan-Tao / Zhou, Li-Fei / Li, Yan-Jun / Huang, Juan / Liu, Rui-Hua / Wang, Bin / Wang, Peng et al. | 2011
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aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycleChandrasekhar, Srivari / Pushpavalli, Sreerangam N.C.V.L. / Chatla, Srinivas / Mukhopadhyay, Debasmita / Ganganna, Bogonda / Vijeender, Kandi / Srihari, Pabbaraja / Reddy, Chada Raji / Janaki Ramaiah, M. / Bhadra, Utpal et al. | 2011
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Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agentsTelvekar, Vikas N. / Bairwa, Vinod Kumar / Satardekar, Kalpana / Bellubi, Anirudh et al. | 2011
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Synthesis and evaluation of near-infrared fluorescent sulfonamide derivatives for imaging of hypoxia-induced carbonic anhydrase IX expression in tumorsGroves, Kevin / Bao, Bagna / Zhang, Jun / Handy, Emma / Kennedy, Paul / Cuneo, Garry / Supuran, Claudiu T. / Yared, Wael / Peterson, Jeffrey D. / Rajopadhye, Milind et al. | 2011
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The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitorsGraham, Thomas H. / Shen, Hong C. / Liu, Wensheng / Xiong, Yusheng / Verras, Andreas / Bleasby, Kelly / Bhatt, Urmi R. / Chabin, Renee M. / Chen, Dunlu / Chen, Qing et al. | 2011
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Synthesis, antitubercular evaluation and 3D-QSAR study of N-phenyl-3-(4-fluorophenyl)-4-substituted pyrazole derivativesKhunt, R.C. / Khedkar, V.M. / Chawda, R.S. / Chauhan, N.A. / Parikh, A.R. / Coutinho, E.C. et al. | 2011
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Characterisation of [11C]PR04.MZ in Papio anubis baboon: A selective high-affinity radioligand for quantitative imaging of the dopamine transporterRiss, Patrick J. / Hooker, Jacob M. / Shea, Colleen / Xu, Youwen / Carter, Pauline / Warner, Donald / Ferrari, Valentina / Kim, Sung-Won / Aigbirhio, Franklin I. / Fowler, Joanna S. et al. | 2011
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Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interactionMalloy, Karla L. / Choi, Hyukjae / Fiorilla, Catherine / Valeriote, Fred A. / Matainaho, Teatulohi / Gerwick, William H. et al. | 2011
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From libraries to candidate: The discovery of new ultra long-acting dibasic β2-adrenoceptor agonistsAlcaraz, Lilian / Bailey, Andrew / Cadogan, Elaine / Connolly, Stephen / Jewell, Robert / Jordan, Stephen / Kindon, Nicholas / Lister, Andrew / Lawson, Mandy / Mullen, Alexander et al. | 2011
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From libraries to candidate: The discovery of new ultra long-acting dibasic b2-adrenoceptor agonistsAlcaraz, L. / Bailey, A. / Cadogan, E. / Connolly, S. / Jewell, R. / Jordan, S. / Kindon, N. / Lister, A. / Lawson, M. / Mullen, A. et al. | 2012
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Conformationally restricted analog and biotin-labeled probe based on beauveriolide IIIDoi, Takayuki / Muraoka, Terushige / Ohshiro, Taichi / Matsuda, Daisuke / Yoshida, Masahito / Takahashi, Takashi / Ōmura, Satoshi / Tomoda, Hiroshi et al. | 2011
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4′-Bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-κB signaling pathway in RAW 264.7 macrophagesKim, Dong Han / Yun, Chang Hyeon / Kim, Min Hwan / Naveen Kumar, Ch. / Yun, Bo Hee / Shin, Ji-Sun / An, Hyo Jin / Lee, Young Hun / Yun, Yong Don / Rim, Hong-Kun et al. | 2011
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4prime-Bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-kB signaling pathway in RAW 264.7 macrophagesKim, D. H. / Yun, C. H. / Kim, M. H. / Naveen Kumar, C. / Yun, B. H. / Shin, J. S. / An, H. J. / Lee, Y. H. / Yun, Y. D. / Rim, H. K. et al. | 2012
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Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophagesHwang, Ji Sang / Lee, Seon A / Hong, Seong Su / Han, Xiang Hua / Lee, Chul / Lee, Dongho / Lee, Chong-Kil / Hong, Jin Tae / Kim, Youngsoo / Lee, Mi Kyeong et al. | 2011
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Synthesis and activity of folate conjugated didemnin B for potential treatment of inflammatory diseasesHenne, Walter A. / Kularatne, Sumith A. / Ayala-López, Wilfredo / Doorneweerd, Derek D. / Stinnette, Torian W. / Lu, Yingjuan / Low, Philip S. et al. | 2011
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II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamidesAnilkumar, Gopinadhan N. / Selyutin, Oleg / Rosenblum, Stuart B. / Zeng, Qingbei / Jiang, Yueheng / Chan, Tin-Yau / Pu, Haiyan / Wang, Li / Bennett, Frank / Chen, Kevin X. et al. | 2011
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Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)McNulty, James / Nair, Jerald J. / Vurgun, Nesrin / DiFrancesco, Benjamin R. / Brown, Carla E. / Tsoi, Bernice / Crankshaw, Denis J. / Holloway, Alison C. et al. | 2011
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Lead diversification. Application to existing drug molecules: Mifepristone 1 and antalarmin 8Abid Masood, M. / Farrant, Elizabeth / Morao, Inaki / Bazin, Marc / Perez, Manuel / Bunnage, Mark E. / Fancy, Sally-Ann / Peakman, Torren et al. | 2011
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A small molecule inhibitor of p53-inducible protein phosphatase PPM1DYagi, Hiroaki / Chuman, Yoshiro / Kozakai, Yuuki / Imagawa, Toshiaki / Takahashi, Yu / Yoshimura, Fumihiko / Tanino, Keiji / Sakaguchi, Kazuyasu et al. | 2011
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Indole RSK inhibitors. Part 1: Discovery and initial SARBoyer, Stephen J. / Burke, Jennifer / Guo, Xin / Kirrane, Thomas M. / Snow, Roger J. / Zhang, Yunlong / Sarko, Chris / Soleymanzadeh, Lida / Swinamer, Alan / Westbrook, John et al. | 2011
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Indole RSK inhibitors. Part 2: Optimization of cell potency and kinase selectivityKirrane, Thomas M. / Boyer, Stephen J. / Burke, Jennifer / Guo, Xin / Snow, Roger J. / Soleymanzadeh, Lida / Swinamer, Alan / Zhang, Yunlong / Madwed, Jeffery B. / Kashem, Mohammed et al. | 2011
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Design and diversity-oriented synthesis of novel 1,4-thiazepan-3-ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activitiesShi, Feng / Zeng, Xiao-Ning / Cao, Xu-Dong / Zhang, Shu / Jiang, Bo / Zheng, Wei-Fa / Tu, Shu-Jiang et al. | 2011
- 747
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Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitorsPackard, Garrick K. / Papa, Patrick / Riggs, Jennifer R. / Erdman, Paul / Tehrani, Lida / Robinson, Dale / Harris, Roy / Shevlin, Graziella / Perrin-Ninkovic, Sophie / Hilgraf, Robert et al. | 2011
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Erratum to “Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres” [Bioorg. Med. Chem. Lett. 20 (2010) 2229–2233]Cohen, Frederick / Koehler, Michael F.T. / Bergeron, Philippe / Elliott, Linda O. / Flygare, John A. / Franklin, Matthew C. / Gazzard, Lewis / Keteltas, Stephen F. / Lau, Kevin / Ly, Cuong Q. et al. | 2011
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Corrigendum to “Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors” [Bioorg. Med. Chem. Lett. 21 (2011) 5992–5994]Sleebs, Brad E. / Nikolakopoulos, George / Street, Ian P. / Falk, Hendrik / Baell, Jonathan B. et al. | 2011
- IFC
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Editorial board| 2011