Fragmentation and sequencing of cyclic peptides by MALDI-PSD mass spectrometry (English)
- New search for: Schilling, B.
- New search for: Medzihradszky, K. F.
- New search for: Wang, W.
- New search for: McMurray, J. S.
- New search for: Schilling, B.
- New search for: Medzihradszky, K. F.
- New search for: Wang, W.
- New search for: McMurray, J. S.
- New search for: Fields, G. B.
- New search for: Tam, J. P.
- New search for: Barany, G.
In:
American peptide symposium; Peptides for the new millennium
;
407-408
;
2000
-
ISBN:
- Conference paper / Print
-
Title:Fragmentation and sequencing of cyclic peptides by MALDI-PSD mass spectrometry
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Contributors:Schilling, B. ( author ) / Medzihradszky, K. F. ( author ) / Wang, W. ( author ) / McMurray, J. S. ( author ) / Fields, G. B. / Tam, J. P. / Barany, G.
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Conference:16th, American peptide symposium; Peptides for the new millennium ; 1999 ; Minneapolis, MN
-
Published in:PEPTIDES -AMERICAN SYMPOSIUM- ; 407-408
-
Publisher:
- New search for: Kluwer Academic
-
Place of publication:Dordrecht , London
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Publication date:2000-01-01
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Size:2 pages
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Remarks:Includes bibliographical references and index
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ISBN:
-
Type of media:Conference paper
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Type of material:Print
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Language:English
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Keywords:
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Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents conference proceedings
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 3
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Mimetic peptides, demanding enzymes, and drug discoveryRich, D. H. et al. | 2000
- 19
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Bruce W. Erickson: In memoriamFelix, A. M. et al. | 2000
- 20
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Engineering of a cysteine-containing variant of quadrin, a protein containing the oligomerization site of the hepatitis delta antigenSaderholm, M. J. / Saconn, P. / Shah, N. / Erickson, B. W. et al. | 2000
- 22
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Characterization of betabellins 15D and 16D, designed beta-sandwich proteins that have amyloidogenic propertiesLim, A. / Makhov, A. M. / Connors, L. H. / Bond, J. / Inouye, H. / Griffith, J. D. / Kirschner, D. A. / Costello, C. E. / Erickson, B. W. et al. | 2000
- 24
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Design and synthesis of inhibitors of botulinum neurotoxin A and B metalloproteasesOost, T. K. / Sukonpan, C. / Rich, D. H. et al. | 2000
- 26
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Dimerization inhibitors of HIV-1 protease: Effective inhibition requires the cross-linking of non-identical peptidesShultz, M. D. / Chmielewski, J. A. et al. | 2000
- 28
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Backbone cyclic proteinomimetics derived from the arginine-rich domain of HIV-1 Tat and Rev proteins: One sequence, two conformations, two biological functionsFriedler, A. / Luedtke, N. / Friedler, D. / Loyter, A. / Tor, Y. / Gilon, C. et al. | 2000
- 30
-
Synthesis of several O-glycopeptide analogs of enkephalinMitchell, S. A. / Pratt, M. R. / Hruby, V. J. / Polt, R. et al. | 2000
- 32
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Investigating the role of turns in the folding of a predominantly beta-sheet proteinRotondi, K. S. / Gunasekaran, K. / Gierasch, L. M. et al. | 2000
- 34
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Receptor-bound conformations of integrin alpha~I~I~bbeta~3 antagonists by ^1^5N-edited NMR spectroscopyLocardi, E. / Mattern, R.-H. / Malaney, T. I. / Mullen, D. G. / Minasyan, R. / Pierschbacher, M. D. / Goodman, M. et al. | 2000
- 36
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Design, synthesis, and characterization of two core modules of bovine pancreatic trypsin inhibitorCarulla, N. / Woodward, C. / Barany, G. et al. | 2000
- 38
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The fine tuning of high affinity and selective non-peptide agonists of the delta-opioid receptor via solution and solid-phaseAlfaro-Lopez, J. / Okayama, T. / Hosohata, K. / Davis, P. / Porreca, F. / Yamamura, H. I. / Hruby, V. J. et al. | 2000
- 40
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Cyclic dodecapeptides (LLLD)~3 form ion channels in lipid bilayersWang, D. / Guo, L. / Edwards, P. J. / Jones, L. R. / Roeske, R. W. et al. | 2000
- 42
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Synthesis and evaluation of potential affinity labels for opioid receptorsChoi, H. / Murray, T. F. / Aldrich, J. V. et al. | 2000
- 47
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Polyethyleneglycol-based chains of precise length for chemobodiesRose, K. / Vizzavona, J. et al. | 2000
- 50
-
N^a^l^p^h^a-2-(4-Nitrophenylsulfonyl)ethoxycarbonyl (Nsc) as an amino-protecting group and its application for peptide synthesisKim, H.-J. / Samukov, V. V. et al. | 2000
- 53
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Nsc- and Fmoc-amino acids for automated solid-phase peptide synthesis: Comparative study of the stability in various conditionsLee, Y. S. / Lee, H. J. / Lee, D. / Kim, H.-J. et al. | 2000
- 55
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In situ generation of Fmoc amino acid chlorides for extremely difficult couplings to sterically hindered secondary amines in solid-phase peptide synthesisFalb, E. / Yechezkel, T. / Salitra, Y. / Gellerman, G. / Muller, D. / Gilon, C. et al. | 2000
- 58
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Evaluation of ivDde as a quasi-orthogonal protecting group for Fmoc solid-phase peptide synthesisWilhelm, R. R. / Srinivasan, A. / Schmidt, M. A. et al. | 2000
- 60
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N^i^n-4-Nitrobenzenesulfonyl (Nbs): A new protective group for the indole moiety of tryptophanSabirov, A. N. / Samukov, V. V. / Pozdnyakov, P. I. / Kim, H.-J. et al. | 2000
- 62
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Practical asymmetric synthesis of beta-substituted glutamic acidsSoloshonok, V. A. / Cai, C. / Hruby, V. J. et al. | 2000
- 64
-
Formation of substituted aromatic rings in amino acid systems via ruthenium activated S~NAr reactionsWest, C. W. / Janetka, J. W. / Rich, D. H. et al. | 2000
- 66
-
O-Acetyl-L-homoserine: A versatile synthon for the synthesis of L-homoserine peptides and 3-amino-2-pyrrolidinonesKnaup, G. / Drauz, K. / Schwarm, M. et al. | 2000
- 68
-
Asymmetric synthesis of free unusual beta-amino acid esters via Yb(OTf)~3-catalyzed C-C bond formation and simultaneous deprotection/purificationLi, G. / Kim, S. H. / Wei, H.-X. / Hook, J. D. / Fitzgerald, K. A. et al. | 2000
- 70
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High yield synthesis of heterocyclic beta-substituted alanine derivativesFerreira, P. M. T. / Maia, H. L. S. / Monteiro, L. S. et al. | 2000
- 72
-
Synthesis of (2S,4R) 4-aminoethyl-L-Pro and (2S,4R)-4-carboxymethyl-L-Pro from (2S,4R)-N^a^l^p^h^a-Boc-4-hydroxy-L-Pro methyl esterMcCafferty, D. G. / Schneider, S. L. / Erickson, B. W. et al. | 2000
- 74
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A highly effective method for synthesis of N^o^m^e^g^a-substituted argininesZakhariev, S. / Szekely, Z. / Guarnaccia, C. / Antcheva, N. / Pongor, S. et al. | 2000
- 76
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Diffusion phenomena and reactivity using polymer supports: A principal investigationRapp, W. E. et al. | 2000
- 78
-
Solid-phase peptide synthesis in the N → C directionThieriet, N. / Alsina, J. / Guibe, F. / Albericio, F. et al. | 2000
- 80
-
Diisopropylethylamine salts for protected amino acids: Direct synthesis of peptides on solid-phaseBalse, P. / Han, G. / Hruby, V. J. / Sun, L. et al. | 2000
- 82
-
Synthesis of phosphorylated CRE BP1(19-106) amide using a phosphopeptide thioester prepared directly by an Fmoc solid-phase methodAimoto, S. / Hasegawa, K. / Li, X. / Kawakami, T. et al. | 2000
- 84
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Preparation of phosphohistidyl peptides via oxidative coupling of H-phosphonatesHarding, B. J. / Dodson, W. S. / Bennett, B. D. / Marshall, W. S. / Jarosinski, M. A. et al. | 2000
- 86
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Preparation and incorporation into small peptides and combinatorial libraries of phosphohistidine analogs for study of prokaryotic two-component signal transduction systemsPirrung, M. C. / Drabik, S. J. / Gothelf, K. V. / James, K. D. / Pei, T. et al. | 2000
- 89
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Synthesis of phosphonamides and thiophosphonamides by a one-pot activation-coupling-oxidation protocolRushing, S. D. / Hammer, R. P. et al. | 2000
- 91
-
Synthesis of phosphonopeptide and thiophosphonopeptide analogs as inhibitors of carboxypeptidase AFan, H. / Zhao, Y. / Byers, L. / Hammer, R. P. et al. | 2000
- 94
-
Application of solid-phase Ellman's reagent for preparation of disulfide-paired isomers of alpha-conotoxin SIHargittai, B. / Annis, I. / Barany, G. et al. | 2000
- 96
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Alternative solid-phase reagents for formation of intramolecular sulfur-sulfur bridges in peptides under mild conditionsAnnis, I. / Barany, G. et al. | 2000
- 98
-
An evaluation of a novel safety catch linker for development of cyclic peptide librariesBourne, G. T. / McGeary, R. P. / Golding, S. W. / Meutermans, W. D. F. / Alewood, P. F. / Smythe, M. L. et al. | 2000
- 100
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Solid-phase synthesis of peptide aldehydes by a Backbone Amide Linker (BAL) strategyGuillaumie, F. / Kelly, N. M. / Kappel, J. C. / Barany, G. / Jensen, K. J. et al. | 2000
- 102
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Backbone Amide Linker (BAL) methodology to accommodate C-terminal hindered, unreactive, and/or sensitive modificationsAlsina, J. / Yokum, T. S. / Albericio, F. / Barany, G. et al. | 2000
- 104
-
A new tartaric acid-based linker for the synthesis of C-terminal peptide alpha-oxo-aldehydesFruchart, J.-S. / Grandjean, C. / Bonnet, D. / Rommens, C. / Gras-Masse, H. / Melnyk, O. et al. | 2000
- 107
-
A new approach to the guanidinylation of peptides and peptidomimetics including aminoglycosides and related drugsBaker, T. J. / Goodman, M. et al. | 2000
- 109
-
Photoaffinity-labeled probes for the study of isoprenoid recognition sitesKale, T. A. / Distefano, M. D. et al. | 2000
- 111
-
Orthogonal methods for the synthesis of multiply labeled peptide probes and substratesSongster, M. F. / Biancalana, S. / Cook, R. M. / Dick, D. J. / Hudson, D. et al. | 2000
- 113
-
Strategies for the synthesis of labeled peptidesBibbs, L. / Ambulos, N. P. / Kates, S. A. / Khatri, A. / Medzihradszky, K. F. / Osapay, G. / Weintraub, S. T. et al. | 2000
- 115
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Orthogonal segment ligationMiao, Z. / Yu, Q. / Lu, Y.-A. / Yang, J.-L. / Kaljuste, K. / Wu, C. / Huang, L. / Tam, J. P. et al. | 2000
- 118
-
Use of orthogonal ligation methods for the synthesis of hetero peptide dendrimerLiu, C.-F. / Rao, C. / Tam, J. P. et al. | 2000
- 120
-
Minimization of side reactions during removal of the formyl protecting group from the epsilon-amino group of lysineSemchuk, P. D. / Genest, M. / Kondejewski, L. H. / Hodges, R. S. et al. | 2000
- 122
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Mechanistic studies of an unusual amide bond scissionCreighton, C. J. / Romoff, T. T. / Bu, J. H. / Goodman, M. et al. | 2000
- 124
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Novel methods of making (amidated) peptides: Rapid gram quantities as intein fusions and ton quantities from fusion proteins in the milk of transgenic animalsCottingham, I. R. / Millar, A. / McKee, C. et al. | 2000
- 126
-
Process research toward scale-up and industrial preparation of RPR 109891 (Klerval™)Mencel, J. J. / Vanasse, B. J. / Woodward, R. G. / Sherbine, J. P. / Liu, R. C. / Salazar, D. C. / Shah, H. C. / Powers, M. R. / Sledeski, A. W. / Kubiak, G. C. et al. | 2000
- 129
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Synthesis of cyclic hexapeptide core of antifungal drug candidatesKishore, V. / Wodka, D. / Lundell, E. O. / Funk, K. W. / Li, L. / Klein, L. L. et al. | 2000
- 131
-
Large scale synthesis of a 27-mer: Identification, characterization and suppression of a diastereomer contaminantPowers, S. P. / Keating, K. M. / Jablonski, J.-A. / Franzen, H. M. / Richards, J. et al. | 2000
- 133
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The chemical synthesis of agouti-related protein form CJimenez, C. C. / Quillan, J. M. / Wei, E. T. / Sadee, W. / Chang, J.-K. et al. | 2000
- 136
-
Chemical synthesis and characterization of the hypothalamic form of CART: CART(69-116), a new anorectic neuropeptideDodson, W. S. / Lenz, D. M. / Harding, B. J. / Zamborelli, T. J. / Haniu, M. / Young, Y. / Jarosinski, M. A. et al. | 2000
- 138
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Application of hydrated salt as a source of essential water for enzymatic peptide synthesis in organic mediaTian, G.-l. / Hua, Y.-y. / Xing, G.-w. / He, X.-f. / Ye, Y.-h. et al. | 2000
- 140
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Enzymatic synthesis of N-protected amino acid-steroid derivatives in organic solventYe, Y.-h. / Xing, G.-w. / Yan, A.-x. / Tian, G.-l. / Li, C.-x. et al. | 2000
- 142
-
Peptide amidase-catalyzed C-terminal peptide amidation in a mixture of organic solventsCerovsky, V. / Kula, M.-R. et al. | 2000
- 144
-
Extending the utility of subtilisin-catalyzed peptide synthesis in organic solventsGetun, I. V. / Filippova, I. Y. / Lysogorskaya, E. N. / Bacheva, A. V. / Oksenoit, E. S. et al. | 2000
- 146
-
Backbone amide protection in solid-phase synthesis of peptide isosteres derived from N-terminal gamma-aldehydesGroth, T. / Meldal, M. / Bock, K. et al. | 2000
- 148
-
An efficient preparation of O-succinimidyl carbamate derivatives from N-protected beta-amino acids: Application to the synthesis of urea containing pseudopeptides and oligoureasGuichard, G. / Semetey, V. / Didierjean, C. / Aubry, A. / Rodriguez, M. / Briand, J.-P. et al. | 2000
- 150
-
Mimicry of peptide backbone and side-chain functions: Synthesis of 5- and 7-hydroxymethyl indolizidinone amino acids and indolizidinone amino dicarboxylate, constrained Ser-Pro and Glu-Pro surrogatesPolyak, F. / Lubell, W. D. et al. | 2000
- 153
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A flexible regioselective method for bicyclization of peptidesJohannesson, P. / Lindeberg, G. / Tong, W. / Gogoll, A. / Karlen, A. / Hallberg, A. et al. | 2000
- 155
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Stereoselective synthesis of dipeptidomimetics using chiral allylic aziridinesLarsson, E. / Berts, W. / Luthman, K. et al. | 2000
- 157
-
Partially-modified retro-inverso beta-turn tetrapeptidomimeticHan, Y. / Chorev, M. et al. | 2000
- 161
-
Targeted librariesHuang, L. / Lee, A. / Ellman, J. A. et al. | 2000
- 164
-
New technique for high-throughput synthesis of peptides, peptidomimetics and nonpeptide small organic molecule arraysLebl, M. et al. | 2000
- 167
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Identification of miniproteins using cellulose-bound duotope scansReineke, U. / Sabat, R. / Hoffmuller, U. / Schmidt, M. / Kurzhals, D. / Wenschuh, H. / Volk, H.-D. / Germeroth, L. / Schneider-Mergener, J. et al. | 2000
- 170
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Combinatorial peptide synthesis, NMR-aided screening and testing of low molecular weight RNA-ligandsBaumann, M. / Dietrich, U. / Koenigs, C. / Griesinger, C. et al. | 2000
- 172
-
Synthetic peptide analogs compared with phage displayMartin, L. M. / Messmer, B. / Thaler, D. et al. | 2000
- 174
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Rapid parallel synthesis of 584 betatides, peptides composed largely of beta-amino acids with side-chains not found in natural peptidesLebl, M. / Ma, J. / Pires, J. / Dooley, C. / Houghten, R. et al. | 2000
- 176
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SPOCC resins: Polar and chemically inert resins for organic synthesis and library enzyme assaysMeldal, M. / Rademann, J. / Grotli, M. / Buchardt, J. / Gotfredsen, C. / Halkes, K. / Sams, A. G. / Duus, J. O. / Miranda, L. / StHilaire, P. M. et al. | 2000
- 179
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Preparation and applications of a thioacetal handle for solid-phase synthesisYokum, T. S. / Barany, G. et al. | 2000
- 181
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"Traceless" solid-phase synthesis of benzimidazole librariesHuang, W. / Scarborough, R. M. et al. | 2000
- 183
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Synthesis of small cyclic peptides: An auxiliary approach to address the "difficult cyclization" problemMeutermans, W. D. F. / Golding, S. W. / Bourne, G. T. / Miranda, L. P. / Dooley, M. J. / Alewood, P. F. / Smythe, M. L. et al. | 2000
- 186
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On-resin cyclization of the cyclic depsipeptide callipeltin BBenson, A. G. / Kowalski, J. A. / Lipton, M. A. et al. | 2000
- 189
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Combinatorial chemistry: Solid-phase synthesis of heterocyclic compounds from C^a^l^p^h^a-functionalized amino acidsNefzi, A. / Giulianotti, M. A. / Ong, N. A. / Houghten, R. A. et al. | 2000
- 191
-
Highly efficient and versatile construction of secondary structure peptide mimetic libraries: Application to biology and drug developmentBlaskovich, M. A. / Boatman, P. D. / Cao, B. / Eguchi, M. / Kim, H.-O. / Lee, M. / Little, T. / Mathew, F. / McCann, I. / Mehlin, C. et al. | 2000
- 194
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The usage of a beta-sheet template with diversity points to generate libraries using the Irori methodDattilo, J. / Goodman, B. / Lum, C. / Elliott, C. / Deiparine, M. / Beigel-Orme, S. / Cunningham, D. / Young, J. et al. | 2000
- 196
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Solid-phase syntheses of libraries derived from 2-amino-4-carboxy-thiophenol moietyYokum, T. S. / Alsina, J. / Barany, G. et al. | 2000
- 198
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Solid-phase synthesis of thiol and thioether functions containing peptides and complex organic moleculesBarlos, K. / Gatos, D. / Mourtas, S. / Nikoletou, A. / Karavoltsos, M. / Bali, D. / Shoina, V. et al. | 2000
- 203
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Implant and transdermal innovations for peptide and protein deliveryStevenson, C. L. / Daddona, P. E. et al. | 2000
- 206
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Loligomers: Multi-tasking intracellular peptide shuttlesGariepy, J. / Singh, D. / Kawamura, K. / Bisland, S. et al. | 2000
- 209
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Utilization of cell-adhesion peptides to improve drug deliverySiahaan, T. J. / Makagiansar, I. / Yusuf-Makagiansar, H. / Sinaga, E. / Audus, K. L. et al. | 2000
- 212
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Peptide shuttles for cytoplasmic delivery and nuclear targeting of chemotherapeutic agentsRagin, A. D. / Brickner, M. L. / Chmielewski, J. et al. | 2000
- 214
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Delivering peptides and peptidomimetics across membrane barriers: A prodrug approachWang, W. / Borchardt, R. T. / Sane, D. C. / Wang, B. et al. | 2000
- 217
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Control of apoptosis by using small molecule regulators of Bcl-2 family proteinsWang, J.-L. / Zhang, Z.-J. / Choksi, S. / Shan, S. / Lu, Z. / Croce, C. M. / Alnemri, E. S. / Korngold, R. / Huang, Z. et al. | 2000
- 219
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Bradykinin antagonists: Anti-cancer drugs for the new millennium?Stewart, J. M. / Gera, L. / York, E. J. / Chan, D. C. / Bunn, P. A. / Helfrich, B. et al. | 2000
- 222
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Development of the first CGRP-antagonist with nanomolar affinityBeck-Sickinger, A. G. / Rist, B. / Enzeroth, M. / Lacroix, S. et al. | 2000
- 224
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DP IV-inhibitors: Potential antidiabetic drugsSchlenzig, D. / Kruber, S. / White, H. A. / Pederson, R. A. / Demuth, H.-U. et al. | 2000
- 227
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Synthesis and pharmacological activity of a new antagonist of the OP~4 receptorGuerrini, R. / Salvadori, S. / Tomatis, R. / Calo, G. / Bigoni, R. / Rizzi, A. / Regoli, D. et al. | 2000
- 229
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Opioid dipeptide derivatives with a mixed mu agonist/delta antagonist, partial mu agonist/delta antagonist or mu agonist/partial delta agonist profileSchiller, P. W. / Weltrowska, G. / Nguyen, T. M.-D. / Wilkes, B. C. / Lemieux, C. / Chung, N. N. et al. | 2000
- 231
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Constrained delta opioid peptides: Analogs of DPDPE and deltorphin I containing trimethylphenylalanine instead of phenylalanineSlate, C. A. / Misicka, A. / Hosohata, K. / Davis, P. / Porreca, F. / Yamamura, H. I. / Hruby, V. J. et al. | 2000
- 233
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Inhibition of alpha4beta1 integrin receptor interactions by bicyclic beta-turn mimeticsStasiak, M. / Eguchi, M. / Mehlin, C. / Kahn, M. et al. | 2000
- 235
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Recent progress in the field of alpha~v-integrin antagonistsKessler, H. / Kantlehner, M. / Gibson, C. / Haubner, R. / Finsinger, D. / Dechantsreiter, M. / Planker, E. / Wermuth, J. / Schmitt, J. S. / Meyer, J. et al. | 2000
- 238
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Cytotoxic derivatives of luteinizing hormone-releasing hormone (LHRH): Synthesis and evaluationRahimipour, S. / Gescheidt, G. / Mazur, Y. / Weiner, L. / Koch, Y. / Fridkin, M. et al. | 2000
- 240
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From peptide to non-peptide: The design of LHRH antagonist mimeticsHaviv, F. / Dwight, W. / Crawford, B. / Swenson, R. / Bruncko, M. / Kaminski, M. / Kato, K. / Sugiura, Y. / Frey, L. / Diaz, G. et al. | 2000
- 243
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Identification of melanocortin-1 receptor selective small molecule agonistsHaskell-Luevano, C. / Rosenquist, A. / Souers, A. / Kong, K. / Ellman, J. / Cone, R. D. et al. | 2000
- 245
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Identification and exploitation of structural foci that influence conformational mobility in somatostatin agonists and antagonistsMorgan, B. / Anderson, W. / Coy, D. / Culler, M. / MacArthur, M. / Mierke, D. / Pellegrini, M. / Piserchio, A. / Allee, D. S. / Taylor, J. et al. | 2000
- 248
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Phenyl piperidine-based orally active peptidomimetic agonists for somatostatin receptor subtype-2Nargund, R. / Barakat, K. / Rohrer, S. / Birzin, E. / Mellin, T. / Cashen, D. / Jacks, T. / Schleim, K. / Mosley, R. / Hickey, G. et al. | 2000
- 250
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The design and synthesis of non-peptide somatostatin receptor agonistsYang, L. / Pan, Y. / Guo, L. / Morriello, G. / Pasternak, A. / Rohrer, S. / Schaeffer, J. / Patchett, A. A. et al. | 2000
- 253
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The discovery of orally-active pseudopeptide antagonists of the atrial natriuretic peptide clearance receptorJacobs, R. T. / Aharony, D. / Alford, V. / Bialecki, R. A. / Cook, S. E. / Dantzman, C. L. / Davenport, T. W. / Dock, S. T. / Edwards, P. D. / Hostetler, G. A. et al. | 2000
- 256
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Identification of new blockers of HIV-1 infectivity from synthetic combinatorial librariesReixach, N. / Boggiano, C. / Blondelle, S. E. et al. | 2000
- 258
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Synthetic peptide-based reagents for blocking the entry and inactivation of HIVHossain, M. M. / Nehete, P. N. / Chitta, S. / Sastry, K. J. et al. | 2000
- 260
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Synthesis of model systems of the complement inhibitors, complestatin and chloropeptinElder, A. M. / Rich, D. H. et al. | 2000
- 262
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An intracellular approach for generating stable synthetic peptides and its potential applicationsWalker, J. R. / Warren, J. / Altman, E. et al. | 2000
- 267
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Talking about TOAC: A novel electron spin resonance probe of peptide conformationMillhauser, G. L. / Anderson, D. J. / McNulty, J. / Toniolo, C. / Crisma, M. / Formaggio, F. et al. | 2000
- 270
-
Peptide folding induced by C^a^l^p^h^a-methylated, chiral alpha-amino acids with a long aliphatic side chainCrisma, M. / Peggion, C. / Formaggio, F. / Kaptein, B. / Broxterman, Q. B. / Kamphuis, J. / Toniolo, C. et al. | 2000
- 272
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Constrained amino acid analogs in de novo peptide designHammarstrom, L. G. J. / Gauthier, T. J. / Hammer, R. P. / McLaughlin, M. L. et al. | 2000
- 275
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Peptide folding as a result of the incorporation of large-ring, cycloaliphatic C^a^l^p^h^a^,^a^l^p^h^a-disubstituted glycinesBenedetti, E. / Saviano, M. / Menchise, V. / Iacovino, R. / Crisma, M. / Formaggio, F. / Moretto, A. / Toniolo, C. et al. | 2000
- 277
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Importance of secondary structure specificity determinants in protein folding and stabilityKwok, S. C. / Mant, C. T. / Hodges, R. S. et al. | 2000
- 280
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A calorimetric study of the helix-coil transition using a side-chain bridged peptide that folds and unfolds cooperativelyTaylor, J. W. / Wu, B. / Greenfield, N. J. / Yu, Y. B. / Privalov, P. L. et al. | 2000
- 283
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^1H-NMR structure of a 14-residue peptide incorporating a rigid, helix-stabilizing, (i, i+7)-side-chain bridgeZhang, M. / Yu, C. / Baum, J. / Taylor, J. W. et al. | 2000
- 285
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The design of heterodimeric coiled-coil domains for diagnostic display systemsLitowski, J. R. / Hodges, R. S. et al. | 2000
- 287
-
Structural investigations of designed glycosylated helix-loop-helix polypeptide motifsAndersson, L. / Baltzer, L. et al. | 2000
- 289
-
Effect of D-amino acid substitutions on amphipathic alpha-helical structureLee, D. L. / Chen, J. / Wagschal, K. C. / McKenna, S. / Harland, B. / Mant, C. T. / Hodges, R. S. et al. | 2000
- 291
-
Metal induced assembly and folding of a triple stranded alpha-helical peptideTanaka, T. / Li, X. / Suzuki, K. et al. | 2000
- 293
-
Design of small symmetrical four-helix bundle proteinsGrell, D. / Richardson, J. S. / Richardson, D. C. / Mutter, M. et al. | 2000
- 295
-
Cavitand templated de novo four-helix bundlesWallhorn, D. / Mezo, A. R. / Sherman, J. C. et al. | 2000
- 297
-
Expanding the repertoire of helical bundles: Stabilization of five+ helical bundlesMicklatcher, C. L. / Lutgring, R. / Hart, S. / Issac, R. / Chmielewski, J. et al. | 2000
- 300
-
Induction of alpha-helical protein-like molecular architecture by mono- and dialkyl hydrocarbon chainsForns, P. / Fields, G. B. et al. | 2000
- 302
-
The peptide 3~1~0-helix: Historical background and recent structural studies and applicationsToniolo, C. / Crisma, M. / Formaggio, F. et al. | 2000
- 305
-
The effects of stereochemistry and sequence on 5-t-butylproline type VI beta-turn mimicsHalab, L. / Lubell, W. D. et al. | 2000
- 307
-
Torsion angle based design of a betaI turn adopting dipeptide (Ac-Aib-AzGly-NH~2)Lee, H.-J. / Ro, S. / Ahn, I.-A. / Shin, D.-K. / Lee, K.-B. / Yoon, C.-J. / Choi, Y.-S. et al. | 2000
- 309
-
Conformational analysis of azaproline and other turn inducersBerglund, A. / Marshall, G. R. et al. | 2000
- 311
-
Strain-fred disulfide bridge and stabilization of beta-ribbon structures in short peptidesNambiar, K. P. / Janardhanam, S. / Balachari, D. et al. | 2000
- 313
-
Roles of proline residues in the structure and folding of a beta-clam proteinEyles, S. J. / Habink, J. A. / Gunasekaran, K. / Gierasch, L. M. et al. | 2000
- 316
-
Self-assembly of synthetic peptides: Formation of amphipathic surfaces and head-to-tail self-assemblyGiralt, E. / Dalcol, I. / Millet, O. / Contreras, M. A. / Ferrer, T. / Royo, M. / Pons, M. / Nicolas, E. et al. | 2000
- 318
-
Rotamer number revealed as another parameter to gauge the quality of packing in folded proteinsYu, Y. B. / Levigne, P. / Privalov, P. L. / Hodges, R. S. et al. | 2000
- 320
-
The side-chain classification of loops from high resolution protein crystal structuresTran, T. T. / Bourne, G. T. / Golding, S. W. / Meutermans, W. D. F. / Smythe, M. L. et al. | 2000
- 322
-
Dynamics and stability of partially folded and unfolded BPTI analogsBarbar, E. / Hare, M. / Barany, G. / Woodward, C. et al. | 2000
- 325
-
Conformational studies with optical spectroscopy of peptides taken from hairpin sequences in the human chorionic gonadotropin beta subunitSilva, R. A. G. D. / Sherman, S. A. / Bedows, E. / Keiderling, T. A. et al. | 2000
- 327
-
The mechanism of the propeptide-mediated folding of guanylyl cyclase activating peptidesHidaka, Y. / Ohno, M. / Shimono, C. / Okamura, M. / Schulz, A. / Adermann, K. / Forssmann, W.-G. / Shimonishi, Y. et al. | 2000
- 330
-
The a-factor lipopeptide pheromone of Saccharomyces cerevisiae: Synthesis, bioactivity, and biophysical analyses of position 4, 5 analogsXie, H. / Becker, J. M. / Naider, F. et al. | 2000
- 332
-
Structural implications of a novel peptide dimerizer sequence when anchored to terminal ends of different peptide motifsGururaja, T. L. / Lin, T. / Payan, D. G. / Anderson, D. C. et al. | 2000
- 334
-
Hydrogen-bonded self-assembled peptide nanotubes from cystine-based macrocycles containing bisurea or hydrocarbon segmentsKarle, I. L. / Ranganathan, D. et al. | 2000
- 337
-
Non-Globular Proteins: Folding and Function| 2000
- 339
-
Heterotrimeric collagen peptides as substrates of metalloproteinasesOttl, J. / Gabriel, D. / Bode, W. / Moroder, L. et al. | 2000
- 342
-
Selective hydrolysis of triple-helical peptides by matrix metalloproteinasesLauer-Fields, J. / Nagase, H. / Fields, G. B. et al. | 2000
- 344
-
The stereoelectronic basis of collagen stabilityRaines, R. T. / Bretscher, L. E. / Holmgren, S. K. / Taylor, K. M. et al. | 2000
- 347
-
Contribution of mainchain-mainchain hydrogen bonds to the conformational stability of triple-helical collagenDanielson, M. A. / Raines, R. T. et al. | 2000
- 349
-
Density measurements and differential scanning calorimetry of collagen model peptidesUchiyama, S. / Tomiyama, T. / Kai, T. / Hukada, K. / Kajiyama, K. / Kobayashi, Y. et al. | 2000
- 352
-
Design, synthesis and conformations of novel triple-helical collagen mimetic structuresGoodman, M. / Kwak, J. / Locardi, E. et al. | 2000
- 355
-
Effect of fluoro-substituted proline residues on the conformational stability of triple-helical collagen mimicsBretscher, L. E. / Taylor, K. M. / Raines, R. T. et al. | 2000
- 357
-
Modulating the conformational stability of triple-helical collagen by chemical modificationJenkins, C. L. / Taylor, K. M. / Raines, R. T. et al. | 2000
- 359
-
The assembly and analysis of collagen mimetics on a tris(2-aminoethyl) amine templateKwak, J. / Locardi, E. / Goodman, M. et al. | 2000
- 361
-
Creating functional collagen peptide architectures on solid surfacesDori, Y. / Bianco-Peled, H. / Satja, S. K. / Fields, G. B. / McCarthy, J. B. / Tirrell, M. V. et al. | 2000
- 365
-
Transmembrane Peptides and Proteins| 2000
- 367
-
delta-Regions in proteins: Helices mispredicted as transmembrane segments by the threshold hydrophobicity requirementWang, C. / Liu, L.-P. / Deber, C. M. et al. | 2000
- 370
-
Dimerization of transmembrane helices studied using de novo designed hydrophobic peptidesMelnyk, R. A. / Deber, C. M. et al. | 2000
- 372
-
Transmembrane helix-helix recognition modeled by disulfide trapping in organic-aqueous solutionsXie, L. / Taylor, J. W. et al. | 2000
- 374
-
Determination of the relative positions between TMH V and VI of the mu opioid receptor using site-directed mutagenesisFowler, C. B. / Pogozheva, I. D. / Akil, H. / LeVine, H. / Mosberg, H. I. et al. | 2000
- 376
-
Biophysical studies on a transmembrane peptide of the Saccharomyces cerevisiae alpha-factor receptorNaider, F. R. / Arshava, B. / Xie, H. / Liu, S.-f. / Eng, W. Y. / Wang, S.-H. / Valentine, K. / Veglia, G. / Marassi, F. / Opella, S. J. et al. | 2000
- 379
-
Helix-helix interactions between transmembrane alpha-helices 3 and 4 within the cystic fibrosis transmembrane conductance regulator proteinPartridge, A. W. / Deber, C. M. et al. | 2000
- 381
-
Chemical approach for evaluating role of cysteine residues in pentameric phospholamban structure: Effect on sarcoplasmic reticulum Ca^2^+-ATPaseKarim, C. B. / Reddy, L. G. / Hunter, G. W. / Angell, Y. M. / Barany, G. / Thomas, D. D. et al. | 2000
- 383
-
Synthesis and biophysical characterization of highly hydrophobic transmembrane peptidesPegoraro, S. / Hellstern, S. / Lustig, A. / Frank, S. / Engel, J. / Moroder, L. et al. | 2000
- 385
-
Conformational studies of a detergent-bound transmembrane segment of the rat bradykinin receptorGrijalba, M. T. / Schreier, S. / Oliveira, E. / Nakaie, C. R. / Miranda, A. / Tominaga, M. / Paiva, A. C. M. et al. | 2000
- 387
-
Gramicidin A: Structure and dynamic propertiesDuax, W. L. / Burkhart, B. M. / Pletnev, V. et al. | 2000
- 393
-
The proteome: Analysis and utilityAebersold, R. / Rist, B. / Gygi, S. P. et al. | 2000
- 396
-
NMR analysis tools for the peptide sciencesKeifer, P. A. et al. | 2000
- 399
-
Studying structures attached to solid supports by high resolution magic angle spinning NMR (HR MAS NMR)Warrass, R. / Boutillon, C. / Wieruszeski, J.-M. / Lippens, G. et al. | 2000
- 402
-
Determination of specific peptide-micelle interactions using NMR spectroscopyKallick, D. A. / Watts, C. R. et al. | 2000
- 404
-
Protein dynamics by hydrogen/deuterium exchange coupled to mass spectrometry: Purine nucleoside phosphorylaseWang, F. / Miles, R. / Nieves, E. / Schramm, V. / Angeletti, R. H. et al. | 2000
- 407
-
Fragmentation and sequencing of cyclic peptides by MALDI-PSD mass spectrometrySchilling, B. / Medzihradszky, K. F. / Wang, W. / McMurray, J. S. et al. | 2000
- 409
-
LC/MS reversed-phase columns with excellent polypeptide resolution in low concentrations of TFA and acetic acidLi, M. K. / Kostel, P. J. et al. | 2000
- 411
-
Application of single bead FTIR in the optimization of solid-phase combinatorial and parallel synthesesYan, B. et al. | 2000
- 414
-
Analysis of local conformation within helical peptides via isotope-edited vibrational spectroscopyDecatur, S. M. / Keiderling, T. A. / Silva, R. A. G. D. / Bour, P. et al. | 2000
- 419
-
The role of zymogenicity in caspase activation: How to trigger programmed cell deathSalvesen, G. S. et al. | 2000
- 422
-
Papain has a tolerance for D-stereochemistry at P~1 like caspasesBajusz, S. / Fauszt, I. / Barabas, E. / Nemeth, K. / Juhasz, A. et al. | 2000
- 424
-
Positive and negative selectivity in protease evolution: Investigation of the specificities of plasmin, t-PA, and PSA using substrate phage displayCorey, D. R. / Bergstrom, R. C. / Coombs, G. S. / Madison, E. L. et al. | 2000
- 427
-
Crystal structures of novel insect serine protease inhibitors complexed to bovine alpha-chymotrypsinRoussel, A. / Kellenberger, C. / Mathieu, M. / Luu, B. / Cambillau, C. et al. | 2000
- 429
-
Inhibitors of the bradykinin-degrading enzyme, aminopeptidase PSimmons, W. H. / Orawski, A. T. / Maggiora, L. L. et al. | 2000
- 431
-
Design and synthesis of AHHpA isosteres for potential inhibition of methionine aminopeptidase-1Keding, S. J. / Rich, D. H. et al. | 2000
- 433
-
A first subnanomolar and in vivo active inhibitor of aminopeptidase A (EC 3.4.11.7)David, C. / Bischoff, L. / Reaux, A. / Llorens-Cortes, C. / Fournie-Zaluski, M.-C. / Roques, B. P. et al. | 2000
- 435
-
A novel stable inhibitor of endopeptidases EC 3.4.24.15 and 3.4.24.16 potentiates bradykinin induced hypotensionSmith, I. / Lew, R. A. / Shrimpton, C. N. / Evans, R. G. / Abbenante, G. et al. | 2000
- 438
-
Structural requirements for collagenolytic activity of matrix metalloproteinase 1 (MMP-1)Chung, L. / Shimokawa, K.-i. / Nagase, H. et al. | 2000
- 441
-
The synthesis of matrix metalloprotease inhibitor libraries using a hybrid mix/split parallel approachSanchez, R. M. / Graybill, T. L. / Moore, M. L. / Veber, D. F. et al. | 2000
- 443
-
Combinatorial library of phosphinic peptides for discovery of MMP inhibitors on solid-phaseBuchardt, J. / Schiodt, C. B. / Ferreras, M. / Foged, N. T. / Delaisse, J.-M. / Meldal, M. et al. | 2000
- 445
-
Selectivity in inhibition of proteolytic enzymes from Plasmodium falciparumDunn, B. / Westling, J. / Meze, M. / Nagar, S. / Gootjes, J. / Cipullo, P. / Saft, H. / Mathur, A. / Lee, T. / Lam, M. et al. | 2000
- 448
-
Proteolytic splicing of Hb alpha-chain peptides with internal deletionsSrinivasulu, S. / Acharya, S. A. et al. | 2000
- 450
-
In vivo detection of tumor associated protease activity using long circulating fluorescent labeled peptide substratesTung, C.-H. / Bredow, S. / Mahmood, U. / Weissleder, R. et al. | 2000
- 453
-
Novel inhibitors of the osteoclast specific cysteine protease, cathepsin KVeber, D. F. / Yamashita, D. S. / Oh, H.-J. / Smith, B. R. / Salyers, K. / Levy, M. / Lee, C.-P. / Marzulli, A. / Smith, P. / Tomaszek, T. et al. | 2000
- 456
-
A combinatorial approach to the identification of cysteine protease substrates and inhibitors by application of a solid-phase fluorescence quenching assayHilaire, P. M. S. / Sanderson, S. / Juliano, M. A. / Willert, M. / Mottram, J. / Coombs, G. / Juliano, L. / Meldal, M. et al. | 2000
- 459
-
Pseudopeptide farnesyl-protein transferase inhibitors containing 5,5-dimethylthiazolidine-4-carboxylic acidDong, J. Z. / Le Breton, C. / Morgan, B. A. / Prevost, G. / Viossat, I. / Brezak, M. C. / Lonchampt, M.-O. / Lauer, J. / Carlson, M. / Kasprzyk, P. G. et al. | 2000
- 461
-
Design of peptidomimetic farnesyltransferase inhibitors as anticancer agentsRo, S. / Lee, J. / Baek, S.-G. / Cho, H. Y. / Kim, J. H. / Shin, D.-K. / Jung, W.-H. / Park, C. / Lee, H. / Shin, Y. S. et al. | 2000
- 463
-
Protein farnesyltransferase exhibits pH-dependent activity towards H-Ras peptide substratesSaderholm, M. J. / Hightower, K. E. / Casey, P. J. / Fierke, C. A. et al. | 2000
- 465
-
Biosynthesis and enzymatic characterization of human SKI-1 and the processing of its inhibitory prosegmentToure, B. B. / Basak, A. / Munzer, J. S. / Benjannet, S. / Chretien, M. / Seidah, N. G. et al. | 2000
- 467
-
Structural studies of peptide inhibitors bound to hepatitis C virus protease yield insights into the mechanism of action of the enzymePessi, A. / Orru, S. / Ingallinella, P. / Ingenito, R. / Koch, U. / Pucci, P. / Bianchi, E. et al. | 2000
- 470
-
Optimization of a continuous assay for obtaining sensitive kinetic data on the inhibition of the HCV NS3 proteaseLim-Wilby, M. S. L. / Anderson, S. M. / Gaudette, J. / Levy, O. E. / Nolan, T. / Bergum, P. W. et al. | 2000
- 472
-
Molecular docking of peptide inhibitors to the hepatitis C virus NS3 proteaseShenderovich, M. / Wang, J. / Fisher, C. / Ramnarayan, K. / Abagyan, R. et al. | 2000
- 474
-
Analysis of substrate specificity of HIV protease speciesHradilek, M. / Rinnova, M. / Barinka, C. / Soucek, M. / Konvalinka, J. et al. | 2000
- 476
-
Structure/activity studies of peptide library-based integrase inhibitorsLung, F.-D. T. / Long, Y.-Q. / Neamati, N. / Pommier, Y. / Roller, P. P. et al. | 2000
- 478
-
(Z)-Alkene phospho-Ser-cis-Pro substrate analog for Pin1, a phosphorylation-dependent peptidyl-prolyl isomeraseHart, S. A. / Etzkorn, F. A. et al. | 2000
- 481
-
C-terminal peptides as inhibitors and probes of mammalian ribonucleotide reductaseCooperman, B. S. / Barwis, B. A. / Liehr, S. / Pothion, C. D. / Wu, X. / Kashlan, O. et al. | 2000
- 487
-
Expressed protein ligation: A new tool for studying protein structure and functionCotton, G. J. / Muir, T. W. et al. | 2000
- 490
-
Combinatorial synthesis of de novo metalloproteins with tuned redox potentialRau, H. K. / DeJonge, N. / Haehnel, W. et al. | 2000
- 493
-
Catalysis of pyridoxal phosphate mediated transaminationBaltzer, L. / Allert, M. et al. | 2000
- 496
-
Synthetic steps toward de novo designed catalytic five helix bundle proteinsMicklatcher, C. L. / Lutgring, R. A. / Chmielewski, J. et al. | 2000
- 498
-
HisH^+-His reactive sites in catalytic four-helix bundle catalystsNilsson, J. / Baltzer, L. et al. | 2000
- 500
-
Semisynthetic approaches for the design of proteins with catalytic activity using fatty acid binding protein as a scaffoldDistefano, M. D. / Kuang, H. / Qi, D. / Haring, D. / Ory, J. / Banaszak, L. J. et al. | 2000
- 503
-
A peptide spacer in fullerene (C~6~0)-based donor-acceptor dyadToniolo, C. / Polese, A. / Bianco, A. / Maggini, M. / Scorrano, G. / Guldi, D. M. et al. | 2000
- 505
-
Complexation of metal ions by pseudopeptidesSeyfarth, L. / Greiner, G. / Sternberg, U. / Reissmann, S. et al. | 2000
- 507
-
Photomodulation of conformational states in cyclic peptides by cis/trans isomerization of azobenzeneBehrendt, R. / Renner, C. / Cramer, J. / Schenk, M. / Wachtveitl, J. / Oesterhelt, D. / Moroder, L. et al. | 2000
- 509
-
Design and synthesis of two potent amide linked cyclic analogs of the hormone angiotensin II confirm the importance of ring cluster and relay system in its possible bioactive conformationRoumelioti, P. / Polevaya, L. / Vlahakos, D. V. / Mavromoustakos, T. M. / Kolocouris, A. / Tselios, T. / Matsoukas, J. M. et al. | 2000
- 511
-
Endothelin precursor isoforms: Structural basis for rational drug design of ECE inhibitorsCronin, N. / Peto, H. / Wallace, B. A. et al. | 2000
- 513
-
Rational development of an anti-HIV protein active at low picomolar concentrationsWilken, J. / Thompson, D. / Picard, L. / Kent, S. B. / Hartley, O. / Offord, R. E. et al. | 2000
- 516
-
Rational engineering of a miniprotein inhibitor of HIV-1 infectivityVita, C. / Drakopoulou, E. / Vizzavona, J. / Rochette, S. / Martin, L. / Menez, A. / Roumestand, C. / Yang, Y.-S. / Ylisastigui, L. / Benjouad, A. et al. | 2000
- 519
-
Design and synthesis of a chimeric TASP molecule as potential inhibitor in cell adhesion processesTuchscherer, G. / Grell, D. / Fernandez, J. / Durieux, P. / Giraud, S. / Schapira, M. / Spertini, O. et al. | 2000
- 521
-
Design and synthesis of salt-insensitive cyclic alpha-defensinsYu, Q. / Lehrer, R. I. / Tam, J. P. et al. | 2000
- 523
-
Conformational studies on three synthetic C-terminal fragments of the alpha subunit of a Gs proteinAlbrizio, S. / D Ursi, A. / Greco, G. / Mazzoni, M. R. / Novellino, E. / Rovero, P. et al. | 2000
- 525
-
Insights into glycoproteins: A structural motif for mucins from a glycopeptideLive, D. H. / Kumar, R. A. / Williams, L. / Sames, D. et al. | 2000
- 531
-
Towards artificial antibodies: Protein surface recognition by synthetic receptorsHamilton, A. D. / Park, H. S. / Lin, Q. / Jain, R. et al. | 2000
- 534
-
Synthetic oxytocin receptors prepared by molecular imprintingKempe, M. et al. | 2000
- 536
-
Peptide mimetics of erythropoietin are powerful probes of receptor activation mechanismsJohnson, D. L. / Farrell, F. X. / Middleton, S. A. / Livnah, O. / Barbone, F. P. / McMahon, F. J. / Tullai, J. / Stura, E. A. / Wilson, I. A. / Jolliffee, L. K. et al. | 2000
- 539
-
Recombinant, C-terminally-tagged forms of the human insulin receptor extracellular domain retain insulin binding abilityKubiak, T. M. / Swanson, M. L. / Harris, P. K. W. / Thomsen, D. R. / Bleasdale, J. E. / Adams, L. A. / Drong, R. F. / Tomich, C.-S. C. / Kletzien, R. F. et al. | 2000
- 541
-
New dimensions in the design of potent and receptor selective melanotropin analogsGrieco, P. / Han, G. / Hruby, V. J. et al. | 2000
- 543
-
Design and biological activity of new high-affinity ligands for the urokinase-type plasminogen activator receptor (CD87)Schmiedeberg, N. / Burgle, M. / Wilhelm, O. / Lottspeich, F. / Graeff, H. / Schmitt, M. / Magdolen, V. / Kessler, H. et al. | 2000
- 546
-
Total synthesis of maxadilan and its disulfide isomers, and structural requirements for binding to the PACAP type 1 receptorNokihara, K. / Yasuhara, T. / Nakata, Y. / Wray, V. et al. | 2000
- 548
-
Solid state conformation of serine^3 DPDPEFlippen-Anderson, J. L. / Deschamps, J. R. / George, C. / Hruby, V. J. / Shenderovich, M. / Lipkowski, A. / Misicka, A. et al. | 2000
- 550
-
The cation-pi interaction: From structural biology to neuroreceptor binding sitesDougherty, D. A. et al. | 2000
- 555
-
Chemoenzymatic synthesis of lipidated peptide and protein conjugates: Tools for the study of biological signal transductionWaldmann, H. et al. | 2000
- 558
-
Bone-targeted, nonpeptide inhibitors of the Src SH2 domain: Structure-based design and structure-activity relationshipsBohacek, R. / Weigele, M. / Jacobsen, V. / Macek, K. / Luke, G. / Sundaramoorthi, R. / Metcalf, C. / Shakespeare, W. / Yang, M. / Wang, Y. et al. | 2000
- 561
-
Nonpeptide inhibitors of the pp60^c^-^s^r^c (Src) SH2 domain: Discovery of a novel phosphotyrosine mimeticKawahata, N. / Yang, M. / Luke, G. / Shakespeare, W. / Sundaramoorthi, R. / Wang, Y. / Johnson, D. / Merry, T. / Violette, S. / Guan, W. et al. | 2000
- 563
-
Phosphotyrosyl peptides targeted to the SH2 domain are potent inhibitors of the kinase activity of pp60^c^-^s^r^cRamdas, L. / Wang, W. / Budde, R. J. A. / McMurray, J. S. et al. | 2000
- 566
-
Novel phosphotyrosyl mimetics for the preparation of potent small molecule Grb2 SH2 domain inhibitorsGao, Y. / Yao, Z.-J. / Voigt, J. / Luo, J. H. / Yang, D. / Burke, T. R. et al. | 2000
- 568
-
High affinity nonphosphorylated cyclic peptide inhibitors of Grb2-SH2/growth factor receptor interactionsLong, Y.-Q. / Lung, F.-D. T. / Voigt, J. H. / Yao, Z.-J. / Burke, T. R. / Yang, D. / Luo, J. H. / Guo, R. / King, C. R. / Roller, P. P. et al. | 2000
- 571
-
NMR based solution structure and dynamics of a nonphosphorylated cyclic peptide inhibitor for the Grb2 SH2 domainLung, F.-D. T. / Pai, M.-T. / Lou, Y.-C. / Tzeng, S.-R. / Roller, P. P. / Cheng, J.-W. et al. | 2000
- 573
-
Potent Grb2-SH2 antagonists containing asparagine mimeticsFuret, P. / Gay, B. / Schoepfer, J. / Zeller, M. / Rahuel, J. / Satoh, Y. / Garcia-Echeverria, C. et al. | 2000
- 576
-
Design and synthesis of a new tyrosine analog having chi~1 and chi~2 angles constrained to values observed for an SH2 domain-bound phosphotyrosyl residueYao, Z.-J. / Barchi, J. J. / Burke, T. R. et al. | 2000
- 579
-
Synthesis of more rigid consolidated ligands for the dual Src homology domain SH(32) of Abelson: Strategies to achieve higher affinitiesChen, L. / Xu, Q. / Cowburn, D. / Barany, G. et al. | 2000
- 581
-
A common ligand-binding site in G-protein coupled receptorsOliveira, L. / Vriend, G. / Paiva, A. C. M. et al. | 2000
- 583
-
Bound conformations for ligands of G-protein coupled receptorsMarshall, G. R. / Ragno, R. / Makara, G. M. / Arimoto, R. / Kisselev, O. et al. | 2000
- 585
-
Modeling of secretin-like G-protein coupled receptorsPogozheva, I. D. / Lomize, A. L. / Mosberg, H. I. et al. | 2000
- 587
-
Synthetic peptides of the alpha subunit of G~s protein inhibit receptor mediated adenylyl cyclaseRovero, P. / Galoppini, C. / Taddei, S. / Giusti, L. / Mazzoni, M. R. et al. | 2000
- 589
-
Point mutation in TM6 of the melanocortin-4 receptor results in agonist activity of the MC4R antagonist SHU9119Haskell-Luevano, C. / Wan, Y.-P. / Cone, R. D. et al. | 2000
- 592
-
Modulation of NK-2 receptor associated G-protein signaling by alteration of the aromatic residue at position six in neurokinin A analogsGembitsky, D. S. / Murphy, R. F. / Lovas, S. et al. | 2000
- 594
-
Peptide mimetics of receptor extracellular domains modulate signal transduction by P2Y~2 receptorsBrown, J. / Brown, C. A. / Martin, A. / Langel, U. / Howl, J. et al. | 2000
- 597
-
Molecular characterization of the interaction between parathyroid hormone and its receptorMierke, D. F. / Rolz, C. / Pellegrini, M. et al. | 2000
- 600
-
Glucagon receptor causes glucagon-dependent activation of Erk1/2 in H22 stable cell linesCypess, A. M. / Muse, E. D. / Wu, C.-R. / Unson, C. G. / Sakmar, T. P. et al. | 2000
- 602
-
Peptides for elucidating the signal transduction pathways of CTLA-4 and CD28Singleton, D. H. / Gardner, J. P. / Andrews, G. C. / Fisher, T. S. / Duerr, J. M. / Guarino, B. C. / Nunez, D. / Alegre, M.-L. / Neveu, M. J. et al. | 2000
- 604
-
Design and synthesis of inhibitors of the protein tyrosine phosphatase, SHP-2Wimmers, E. E. / Lehnhoff, J. L. / Ottinger, E. A. et al. | 2000
- 609
-
Efficacy: What is it, and why you should careHruby, V. J. et al. | 2000
- 612
-
Development of a chemical microarray technologyFalsey, J. R. / Li, S. / Lam, K. S. et al. | 2000
- 614
-
Cyclopentapeptides as conformational templates for validating three dimensional models of pharmacophoresNikiforovich, G. V. et al. | 2000
- 616
-
Novel opioid peptides as kappa opioid receptor antagonistsAldrich, J. V. / Wan, Q. / Murray, T. F. et al. | 2000
- 619
-
H-Tyr-Tic-Phe-OH related delta opioid agonists and antagonists have similar receptor-bound conformations but different pharmacophoresWilkes, B. C. / Schiller, P. W. et al. | 2000
- 621
-
Mapping the binding epitopes of IGF-1 and a phage-library derived peptide that inhibits IGFBP-1 binding to insulin-like growth factorLowman, H. B. / Chen, Y. / Jackson, D. / Quan, C. / Baca, M. / Dubaquie, Y. / Skelton, N. et al. | 2000
- 624
-
Stereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1: Biological activity, NMR and conformational analysis of D-amino acid substituted analogsPaterlini, M. G. / Avitabile, F. / Ostrowski, B. G. / Ferguson, D. M. / Portoghese, P. S. et al. | 2000
- 626
-
Stimulation and suppression of the immune response and hemopoiesis by novel natural and synthetic peptidesDeigin, V. I. / Poverenny, A. M. / Semina, O. V. / Semenets, T. N. et al. | 2000
- 628
-
Relating peptide presentation and biological response through supported films of peptide amphiphilesOchsenhirt, S. E. / Dillow, A. K. / Kokkoli, E. / McCarthy, J. B. / Fields, G. B. / Tirrell, M. et al. | 2000
- 630
-
Studying the influence of prolyl amide geometry on bioactivity with 5-t-butylproline oxytocin analogsBelec, L. / Slaninova, J. / Lubell, W. D. et al. | 2000
- 632
-
The effect of disulfide bond replacement by a methylenedithioether bond on the biological activity of oxytocin and deaminooxytocinSlaninova, J. / Machova, A. / Ikeo, T. / Ueki, M. et al. | 2000
- 634
-
Increased serum stability of neurotensin analogs containing arginine mimicsSchmidt, M. A. / Erion, J. L. / Chinen, L. K. / Bugaj, J. E. / Wilhelm, R. R. / Srinivasan, A. et al. | 2000
- 636
-
Synthesis and pharmacological evaluation of a new series of bombesin analogsCristau, M. / Devin, C. / Oiry, C. / Galleyrand, J.-C. / Pannequin, J. / Bernad, N. / Fehrentz, J.-A. / Martinez, J. et al. | 2000
- 639
-
Molecular pharmacology of vasopressin receptorsBarberis, C. / Mouillac, B. / Seyer, R. / Phalipou, S. / Cotte, N. / Balestre, M.-N. / Morin, D. / Durroux, T. / Hibert, M. / Manning, M. et al. | 2000
- 641
-
Discovery of new lead for the design of antagonists of human vasopressin (VP) V~1~b receptorDerick, S. / Barberis, C. / Breton, C. / Guillon, G. / Chan, W. Y. / Stoev, S. / Cheng, L. / Manning, M. et al. | 2000
- 643
-
Biological studies on chimeric dimers of oxytocin and the V~2-antagonist, d(CH~2)~5[D-Ile^2, Ile^4]arginine vasopressinSlaninova, J. / Machova, A. / Golser, R. / Chen, L. / Barany, G. et al. | 2000
- 645
-
Structure and activity of human parathyroid hormone N-terminal fragments in solutionMarx, U. / Adermann, K. / Meyer, M. / Forssmann, W.-G. / Rosch, P. et al. | 2000
- 647
-
Homology-based analysis of thrombin receptorsPolevaya, L. / Matsoukas, J. et al. | 2000
- 649
-
Substitution of cysteic acid for the seven phosphorylated residues in bovine rhodopsin C-terminal peptideArendt, A. / McDowell, J. H. / Miller, R. / Smith, W. C. / Hargrave, P. A. et al. | 2000
- 651
-
The receptor binding domain of apolipoprotein E, linked to a model class A amphipathic helix, enhances internalization and degradation of LDL in fibroblastsChaddha, M. / Datta, G. / Garber, D. W. / Chung, B. H. / Tytler, E. M. / Bradley, W. A. / Gianturco, S. H. / Anantharamaiah, G. M. et al. | 2000
- 653
-
Multimeric forms of lebetin peptide enhance the inhibition of platelet aggregationMabrouk, K. / Gonzalez, M. J. / Regaya, I. / Marrakchi, N. / Giralt, E. / Van Rietschoten, J. / El Ayeb, M. / Rochat, H. et al. | 2000
- 655
-
New LHRH antagonists with enhanced biological activity: Preclinical and clinical resultsKutscher, B. / Bernd, M. / Gunther, E. / Deger, W. / Reissmann, T. / Beckers, T. / Deghenghi, R. / Engel, J. et al. | 2000
- 658
-
Novel, water soluble and long acting GnRH antagonistsJiang, G. / Stalewski, J. / Galyean, R. / Schteingart, C. / Broqua, P. / Aebi, A. / Aubert, M. L. / Semple, G. / Akinsanya, K. / Haigh, R. et al. | 2000
- 660
-
Relaxin and relaxin-related peptides: Synthesis, structure and biological functionTregear, G. W. / Bathgate, R. A. / Claasz, A. A. / Dawson, N. F. / Ferraro, T. / Macris, M. / Mathieu, M. / Summers, R. J. / Tan, Y.-Y. / Zhao, L. et al. | 2000
- 664
-
Towards defining the biologically active site of relaxinWade, J. D. / Tan, Y.-Y. / Otvos, L. / Summers, R. J. / Tregear, G. W. et al. | 2000
- 666
-
Solution structure and RNA-binding activity of the N-terminal leucine-repeat region of hepatitis delta antigenCheng, J.-W. / Lin, I.-J. / Lou, Y.-C. / Pai, M.-T. / Wu, H.-N. et al. | 2000
- 668
-
SAR of the novel neuropeptides orexin-A and BJarosinski, M. A. / Dodson, W. S. / Harding, B. J. / Zamborelli, T. J. / Lenz, D. M. / Cooke, K. / Yan, H. / Baumgartner, J. / Karbon, E. W. et al. | 2000
- 671
-
Glucagon-like peptide-1 and its analogs: A structure/function analysisContillo, L. G. / Andrews, K. M. / Andrews, G. C. / Massefski, W. W. / Parker, J. C. / Singleton, D. H. / Stevenson, R. W. / Withka, J. M. et al. | 2000
- 674
-
Engineering and chemical synthesis of the HCV protease transmembrane protein cofactor NS4ABianchi, E. / Ingenito, R. / Simon, R. J. / Pessi, A. et al. | 2000
- 679
-
Can a discontinuous viral antigenic site be chemically reproduced? A rational approach to a difficult problemBorras, E. / Villen, J. / Giralt, E. / Andreu, D. et al. | 2000
- 681
-
An HLA class II restricted T-cell is able to recognize about a million different peptidesHiemstra, H. S. / van Veelen, P. A. / Willemen, S. J. M. / Benckhuijsen, W. E. / Geluk, A. / Roep, B. O. / Drijfhout, J. W. et al. | 2000
- 683
-
Identification and optimization of antigens for T cell clones of clinical relevance using positional scanning combinatorial librariesPinilla, C. / Houghten, R. / Wilson, D. / Martin, R. et al. | 2000
- 685
-
In situ identification of T helper cell epitopes from a cellulose-bound peptide arrayOtvos, L. / Bokonyi, K. / Pease, A. M. / Giles-Davis, W. / Rogers, M. E. / Hintz, P. A. / Hoffmann, R. / Ertl, H. C. J. et al. | 2000
- 687
-
Cells activation modulates binding of an LFA-1 peptide to the T-cell adhesion receptorsYusuf-Makagiansar, H. / Siahaan, T. J. et al. | 2000
- 689
-
A CD28 CDR3 peptide analog inhibits CD4+ T-cell proliferation in vitroSrinivasan, M. / Wardrop, R. M. / Whitacre, C. C. / Kaumaya, P. T. P. et al. | 2000
- 691
-
Induction of an Ag-specific CTL response by a conformationally biased agonist of human C5a anaphylatoxin as a molecular adjuvantUlrich, J. T. / Cieplak, W. / Paczkowski, N. / Taylor, S. M. / Sanderson, S. D. et al. | 2000
- 693
-
Modulation of proteasomal activity in vitro induces the generation of an HLA-A^*0201 specific CTL-defined epitope derived from the melanoma-associated antigen MAGE-3Servis, C. / Levy, F. / Cerottini, J.-C. / Romero, P. / Valmori, D. et al. | 2000
- 695
-
Evaluation of the immunogenicity of peptide and DNA constructs for HER-2/neu epitopesJiang, H. / Walker, C. / Fowler, J. M. / Copeland, L. J. / Kaumaya, P. T. et al. | 2000
- 697
-
Lipophilic modifications of peptide epitopes: T-cell response and susceptibility to peptidasesPapini, A. M. / Nardi, E. / Mazzucco, S. / Mazzanti, B. / Traggiai, E. / Ballerini, C. / Kalbacher, H. / Beck, H. / Chelli, M. / Ginanneschi, M. et al. | 2000
- 700
-
Peptide vaccine strategy for immunotherapy of HER-2/neu overexpressing cancersDakappagari, N. / Woodbine, D.-B. / Triozzi, P. / Stevens, V. / Kaumaya, P. T. P. et al. | 2000
- 702
-
Rational design of a subtype-specific peptide vaccine against Neisseria meningitisOomen, C. J. / Bonvin, A. M. J. J. / Haseley, S. R. / Hoogerhout, P. / van Alphen, L. / Kroon, J. / Gros, P. et al. | 2000
- 704
-
Immune response to a conformational peptide vaccine for HTLV-1Frangione, M. / Lairmore, M. D. / Kaumaya, P. T. P. et al. | 2000
- 706
-
Synthetic peptide-based HIV vaccine induces protective immunity in SHIV-rhesus modelNehete, P. N. / Chitta, S. / Hossain, M. M. / Hill, L. / Bernacky, B. / Sastry, K. J. et al. | 2000
- 708
-
Recombinant MOG from baculovirus inhibits anti-hMOG(30-50) antibodies detected by the synthetic antigen [Asn^3^1(Glc)]hMOG(30-50)Nardi, E. / Mazzucco, S. / Mata, S. / Chelli, M. / Mazzanti, B. / Traggiai, E. / Ginanneschi, M. / Pinto, F. / Massacesi, L. / Vergelli, M. et al. | 2000
- 713
-
Design and synthesis of prion peptidyl mimetics for the detection and purification of prion proteinsChen, Y. / Kondejewski, L. H. / Kay, C. M. / Irvin, R. T. / Hodges, R. S. et al. | 2000
- 715
-
Synthesis of amyloid beta-peptides: Segment condensation of sparingly soluble protected peptides in chloroform-phenol mixed solventInui, T. / Nishio, H. / Bodi, J. / Nishiuchi, Y. / Kimura, T. et al. | 2000
- 717
-
Conformational changes in native and HCHWA-D (E22Q) mutant forms of beta-amyloidSiligardi, G. / Hussain, R. / Manca, M. F. / Austen, B. et al. | 2000
- 719
-
Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to Alzheimer's beta-amyloid peptideAzizeh, B. Y. / Cribbs, D. H. / Cotman, C. W. / LaFerla, F. M. et al. | 2000
- 721
-
Amyloid fibril formation by partially unfolded islet amyloid polypeptide (IAPP)Kapurniotu, A. / Bernhagen, J. / Kayed, R. / Greenfield, N. / Brunner, H. / Voelter, W. et al. | 2000
- 727
-
Post-translational modification: A two-dimensional strategy for molecular diversity of Conus peptidesHooper, D. / Lirazan, M. B. / Schoenfeld, R. / Cook, B. / Cruz, L. J. / Olivera, B. M. / Bandyopadhyay, P. et al. | 2000
- 730
-
Structural studies on alpha-conotoxin SIJanes, R. W. / Whitford, D. / Benie, A. J. / Hargittai, B. / Barany, G. et al. | 2000
- 733
-
Antiomoebin: A polypeptide ion carrier and channelWallace, B. A. / Snook, C. F. / Duclohier, H. / O Reilly, A. O. et al. | 2000
- 736
-
Development of novel peptide antibiotics for vancomycin resistant infection using the "one-bead, one-compound" combinatorial library methodLiu, G. / Fan, Y. / Zhao, D. / Zhao, Z.-G. / Lam, K. S. et al. | 2000
- 738
-
Can machine learning and combinatorial chemistry coexist? An antimicrobial peptide case studySpatola, A. F. / Page, C. D. / Vogel, D. M. / Crozet, Y. / Blondelle, S. et al. | 2000
- 740
-
Interaction of gramicidin S and its biologically active analogs with phospholipid bilayersJelokhani-Niaraki, M. / Prenner, E. J. / Kondejewski, L. H. / McElhaney, R. N. / Kay, C. M. / Hodges, R. S. et al. | 2000
- 742
-
Biological activities of Polymyxin B nonapeptide analogsTsubery, H. / Cohen, S. / Ofek, I. / Fridkin, M. et al. | 2000
- 744
-
Complexation analysis of the antimicrobial salivary histatin peptidesBrewer, D. / Lajoie, G. et al. | 2000
- 746
-
Design, synthesis, and antibacterial activity of a peptidomimetic libraryHu, B.-H. / Martin, L. M. et al. | 2000
- 748
-
De novo design of small cyclic antimicrobial peptidesMuhle, S. A. / Tam, J. P. et al. | 2000
- 750
-
Cell lysis and its specificity induced by basic peptides are determined by difference of hydrophobicityKiyota, T. / Yanagida, R. / Oka, M. / Miyoshi, M. / Lee, S. / Sugihara, G. et al. | 2000
- 752
-
Modulation of specificity in cyclic antimicrobial peptides by amphipathicityKondejewski, L. H. / McInnes, C. / Jelokhani-Niaraki, M. / Farmer, S. W. / Kay, C. M. / Sykes, B. D. / Hancock, R. E. W. / Hodges, R. S. et al. | 2000
- 754
-
Effect of structural and chemico-physical factors on the biological activity of linear antimicrobial peptidesTossi, A. / Giangaspero, A. / Romeo, D. et al. | 2000
- 756
-
Synthesis of magainin 2 dimer and its interaction with phospholipid bilayerMukai, Y. / Niidome, T. / Hatakeyama, T. / Aoyagi, H. et al. | 2000
- 758
-
SPC3, an HIV-derived multibranched peptide, triggers an ionic conductance in Xenopus oocytesDe Waard, M. / Carlier, E. / Fajloun, Z. / Mabrouk, K. / Sabatier, J.-M. et al. | 2000
- 760
-
Role of disulfide bonds in the structure and activity of ShK toxinPennington, M. W. / Lanigan, M. / Mahnir, V. M. / Kalman, K. / McVaugh, C. T. / Behm, D. / Donaldson, D. / Chandy, K. G. / Kem, W. R. / Norton, R. S. et al. | 2000
- 762
-
Probing SAR of FLRF-NH~2 with its N- and C-terminally modified analogs and retro-inverso peptidesKubiak, T. M. / Larsen, M. J. / Dutton, F. E. / Friedman, A. R. et al. | 2000
- 767
-
Chemical and biological consequences of sugar incorporation into a potential N-glycosylation site in the tubulin-binding repeat of tau proteinOtvos, L. / Craik, D. J. / Bokonyi, K. / Varga, I. / Pease, A. M. / Wade, J. D. / Hoffmann, R. et al. | 2000
- 770
-
Practical glycopeptide analgesics: Blood-brain barrier transport and binding of glycosylated enkephalin analogsPolt, R. L. / Egleton, R. D. / Bilsky, E. J. / Mitchell, S. A. / Kriss, C. T. / Pratt, M. R. / Davis, P. / Jones, H. / Porrecca, F. / Yamamura, H. I. et al. | 2000
- 773
-
Synthesis and application of a glycoprotein derived from the proteoglycan linkage structureBorgia, J. A. / Oegema, T. R. / Fields, G. B. et al. | 2000
- 775
-
Synthesis of glycopeptide modified IgE epitopesJablonkai, I. / Toth, I. et al. | 2000
- 777
-
Lipoamino acid based glycoconjugates for peptide and drug deliveryFalconer, R. A. / Toth, I. et al. | 2000
- 779
-
Novel lipoamino acid and liposaccharide based peptide delivery system for tumor selective somatostatin analogsMalkinson, J. P. / Keri, G. / Artursson, P. / Toth, I. et al. | 2000
- 782
-
Regioselective conjugation of chitosan with a peptide related to an active sequence of lamininNishiyama, Y. / Yoshikawa, T. / Ohara, N. / Mori, T. / Kurita, K. / Hojo, K. / Kamada, H. / Tsutsumi, Y. / Mayumi, T. / Simojoh, M. et al. | 2000
- 784
-
Fully automated synthesis of peptide-oligonucleotide conjugatesRomanelli, A. / De Napoli, L. / Messere, A. / Montesarchio, D. / Piccialli, G. / Zaccaro, L. / Pedone, C. / Rossi, F. / Benedetti, E. et al. | 2000
- 786
-
Chemical synthesis of cyclic peptide nucleic acid-peptide hybridsPlanas, M. / Bardaji, E. / Barany, G. et al. | 2000
- 788
-
Recognition of RNA and DNA targets by peptide nucleic acidsCorey, D. R. / Pitts, A. / Simmons, C. / Mayfield, L. / Hamilton, S. et al. | 2000
- 790
-
Synthesis of PNA-peptide conjugates and their interactions with DNABalasundaram, G. / Takahashi, T. / Ueno, A. / Mihara, H. et al. | 2000
- 792
-
A new Tc(I) radiolabeling method for peptides: Evaluation of neurotensin analogs for tumor targetingTourwe, D. / Iterbeke, K. / Conrath, P. / Schubiger, P. A. / Allemann, L. / Egli, A. / Alberto, R. / Carrell-Remy, N. / Willmann, M. / Blauenstein, P. et al. | 2000
- 797
-
Perspectives for the new peptide millenniumMerrifield, B. / Barany, G. / Deber, C. M. / Goodman, M. / Hodges, R. S. / Hruby, V. J. / Muir, T. W. / Offord, R. / Spatola, A. F. / Veber, D. F. et al. | 2000