Can hERG trafficking be detected in vivo? Effects of sub-acute dosing of arsenic trioxide in telemetered guinea-pigs (English)
- New search for: Cools, F. J.
- New search for: Janssens, S.
- New search for: Vanlommel, A.
- New search for: Verrelst, J.
- New search for: de Hoogt, R.
- New search for: Rohrbacher, J.
- New search for: Lu, H. R.
- New search for: Teisman, A.
- New search for: Gallacher, D. J.
- New search for: Cools, F. J.
- New search for: Janssens, S.
- New search for: Vanlommel, A.
- New search for: Verrelst, J.
- New search for: de Hoogt, R.
- New search for: Rohrbacher, J.
- New search for: Lu, H. R.
- New search for: Teisman, A.
- New search for: Gallacher, D. J.
In:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
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66
, 2
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165
;
2012
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ISSN:
- Article (Journal) / Print
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Title:Can hERG trafficking be detected in vivo? Effects of sub-acute dosing of arsenic trioxide in telemetered guinea-pigs
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Contributors:Cools, F. J. ( author ) / Janssens, S. ( author ) / Vanlommel, A. ( author ) / Verrelst, J. ( author ) / de Hoogt, R. ( author ) / Rohrbacher, J. ( author ) / Lu, H. R. ( author ) / Teisman, A. ( author ) / Gallacher, D. J. ( author )
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Published in:JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS ; 66, 2 ; 165
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2012-01-01
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Size:165 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 615.9
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615.9 -
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© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 66, Issue 2
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 59
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Methodological innovations expand the safety pharmacology horizonPugsley, M. K. / Curtis, M. J. et al. | 2012
- 63
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dP/dtmax - A measure of 'baroinometry'Hamlin, R. L. / del Rio, C. et al. | 2012
- 66
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How do the top 12 pharmaceutical companies operate safety pharmacology?Ewart, L. / Gallacher, D. J. / Gintant, G. / Guillon, J. M. / Leishman, D. / Levesque, P. / McMahon, N. / Mylecraine, L. / Sanders, M. / Suter, W. et al. | 2012
- 71
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Left ventricular pressure, contractility and dP/dtmax in nonclinical drug safety assessment studiesSarazan, R. D. / Kroehle, J. P. / Main, B. W. et al. | 2012
- 79
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Safety immunopharmacology: Evaluation of the adverse potential of pharmaceuticals on the immune systemDescotes, J. et al. | 2012
- 84
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Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6month periodChui, R. W. / Derakhchan, K. / Vargas, H. M. et al. | 2012
- 92
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Quickly finding a needle in a haystack: A new automated cardiac arrhythmia detection software for preclinical studiesKoeppel, F. / Labarre, D. / Zitoun, P. et al. | 2012
- 98
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Evaluation of a method to correct the contractility index LVdP/dtmax for changes in heart rateMarkert, M. / Trautmann, T. / Grosz, M. / Ege, A. / Mayer, K. / Guth, B. et al. | 2012
- 106
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Comparison of non-invasive and implanted telemetric measurement of blood pressure and electrocardiogram in conscious beagle dogsWard, G. / Milliken, P. / Patel, B. / McMahon, N. et al. | 2012
- 114
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Cardiorespiratory safety evaluation in non-human primatesIngram-Ross, J. L. / Curran, A. K. / Miyamoto, M. / Sheehan, J. / Thomas, G. / Verbeeck, J. / de Waal, E. J. / Verstynen, B. / Pugsley, M. K. et al. | 2012
- 125
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Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pigGuns, P. J. / Johnson, D. M. / Weltens, E. / Lissens, J. et al. | 2012
- 135
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Direct effects of arsenic trioxide on action potentials in isolated cardiac tissues: Importance of the choice of species, type of cardiac tissue and perfusion timeLu, H. R. / Vlaminckx, E. / Cools, F. / Gallacher, D. J. et al. | 2012
- 145
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Cardiac tissue slices with prolonged survival for in vitro drug safety screeningBussek, A. / Schmidt, M. / Bauriedl, J. / Ravens, U. / Wettwer, E. / Lohmann, H. et al. | 2012
- 152
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Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: Invasive LVP measurements versus the QA intervalJohnson, D. M. / Geys, R. / Lissens, J. / Guns, P. J. et al. | 2012
- 160
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Effects of hNaV1.5 blockers on the rat QRS intervalEricson, A. C. / Kagstrom, J. / Laumola, E. L. / Martinsson, F. / Eriksson, A. B. et al. | 2012
- 160
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Detection of ECG intervals in anesthetized guinea-pigs: Man versus machineGuns, P. J. / Van Op den bosch, J. / Weltens, E. / Lissens, J. et al. | 2012
- 160
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The electro-mechanical window in anaesthetized guinea-pigs: A new marker for TdP risk screeningGuns, P. J. / Van Op den bosch, J. / Weltens, E. / Lissens, J. et al. | 2012
- 161
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Assessment of respiratory function and duration of action in an anaesthetized dog model with recoveryMontero, J. L. / Doe, C. / Miralpeix, M. / Gavalda, A. et al. | 2012
- 161
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Potential for increased pulmonary vascular pressure due to verapamilVargas-Pinto, P. A. / Pedraza-Toscano, A. M. / Hamlin, R. L. / Del Rio, C. et al. | 2012
- 161
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Use of QA interval to assess cardiac contractility in anesthetized ratSaengklub, N. / Limprasutr, V. / Meedech, P. / Kijtawornrat, A. / del Rio, C. / Hamlin, R. L. et al. | 2012
- 161
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Simultaneous assessment of in vivo ECG liabilities and load-independent myocardial function in guinea pigsUeyama, Y. / del Rio, C. L. / Hamlin, R. L. et al. | 2012
- 162
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Functional observation battery in nonhuman primates with continuous intracerebral infusionAuthier, S. / Bienvenu, J. G. / Tavcar, R. / Fournier, S. / Schneider, A. / Wong, K. et al. | 2012
- 162
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Neurobehavioral assessments of motor activity, startle response, and learning/memory in juvenile ratsToot, J. D. / Herberth, M. T. / Beck, M. J. / Stump, D. G. / Atterson, P. R. / Nemec, M. D. et al. | 2012
- 162
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Modified Irwin Screen parameters in rat inhalation toxicology studiesJonasson, H. / Johansson, L. M. et al. | 2012
- 163
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A harmonized rodent CNS assessment: Reproducibility without boundariesKaiser, R. A. / Barnett, J. / Giuseppina, I. / Wilson, S. / Shearer, J. M. / Diehl, L. M. / Clubb, S. K. / Holzgrefe, H. H. / Meyer, D. J. et al. | 2012
- 163
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Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafishBuck, L. / Winter, M. / Redfern, W. / Whitfield, T. et al. | 2012
- 163
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The RotaRod test for motor coordination: Methodological considerations and potential added value vs. the Irwin testHimmel, H. M. / Sedlak, N. / Stump, V. et al. | 2012
- 163
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Differential effects of cholinesterase inhibitors in the intravenous PTZ infusion seizure test in the Wistar ratParachou, D. / Cayre, E. / Deal, A. / Bertaina-Anglade, V. / la Rochelle, C. D. et al. | 2012
- 164
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Cognitive assays for CNS safety evaluation in the ratQuinn, L. / Hernier, A. M. / Davoust, K. / Coquelin, C. / Castagne, V. / Virley, D. et al. | 2012
- 164
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The development of an Irwin-like test in the nonhuman primate for CNS safety assessmentFroget, G. / Cruz, C. / Hubert, I. / Virley, D. / Lemaire, M. / Duxon, M. S. / Porsolt, R. D. et al. | 2012
- 164
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High-content analysis of signaling networks enables predictive compound profilingde Bruin, L. / Koblizek, T. I. / Dias, J. / Huang, Z. / Bilter, G. / Chan, H. / Siehoff, A. / Pitt, A. / Lamerdin, J. / Westwick, J. et al. | 2012
- 164
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Arousal and spectral analysis: EEG in conscious cynomolgus monkeysAuthier, S. / Schaeffer, E. / Weed, M. / Digavalli, S. / Maghezzi, S. / Gervais, J. / Troncy, E. / Fournier, S. et al. | 2012
- 165
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Mechanistic understanding of drug-induced mitochondrial toxicity using isolated mitochondrial complex assaysLow, E. L. / Burnham, M. / Garside, H. / Valentin, J. P. / Bowes, J. et al. | 2012
- 165
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Development of a hERG trafficking inhibitor screenBurnham, M. P. / Pollard, C. / Valentin, J. P. / Bowes, J. et al. | 2012
- 165
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Can hERG trafficking be detected in vivo? Effects of sub-acute dosing of arsenic trioxide in telemetered guinea-pigsCools, F. J. / Janssens, S. / Vanlommel, A. / Verrelst, J. / de Hoogt, R. / Rohrbacher, J. / Lu, H. R. / Teisman, A. / Gallacher, D. J. et al. | 2012
- 166
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A novel method of selecting human embryonic stem cell derived cardiomyocyte clusters for reliable QT risk assessmentHihara, T. / Yamazaki, K. / Taniguchi, T. / Kohmura, N. / Yoshinaga, T. / Ito, M. / Sawada, K. et al. | 2012
- 166
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In vitro detection of cardiotoxicity using human embryonic stem cell derived cardiomyocytePointon, A. V. / Gerges, N. A. / Sidaway, J. E. et al. | 2012
- 166
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Comparison of electrophysiologic properties of human iPSC and rat embryonic cardiomyocytes using Multi-electrode arraysShi, H. / Kwagh, J. / Lewen, G. / Huang, M. / Flint, O. / Levesque, P. et al. | 2012
- 166
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Development of a comprehensive in vitro system for uncovering cardiac liability using ES derived cardiomyocytesSchwengberg, S. / Kettenhofen, R. / Tressat, K. / Bohlen, H. J. et al. | 2012
- 167
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mGluR5 antagonist MTEP and benzodiazepine chlordiazepoxide psychoactive interaction: A rat drug discrimination analysisSwedberg, M. D. / Velasquez, C. / Stahlberg, M. / Hammar, P. et al. | 2012
- 167
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Evaluation of abuse liability using self-administration, extinction and reinstatement in the monkey using cocaine and fentanylHygate, D. A. / Manguiat, R. / Wong, W. J. / Medakkar, S. / Hutcheson, D. M. et al. | 2012
- 167
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Abuse liability testing of dihydrocodeinone in Sprague-Dawley ratsBaird, T. J. / Gauvin, D. V. / Dalton, J. A. / McComb, M. M. / Code, R. A. et al. | 2012
- 168
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Short and long-term delayed reassessment of drug discrimination testing in adult female SD ratsToot, J. D. / Pershing, M. L. / Hackman, M. L. / Beck, M. J. / Stump, D. G. / Atterson, P. R. / Nemec, M. D. et al. | 2012
- 168
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A large animal model of dependence and withdrawal using male cynomolgus monkeys orally administered ketamine HClSgro, M. / Firman, K. / Poling, J. / Walgren, J. / Carfagna, M. / Kallman, M. J. et al. | 2012
- 168
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Protein binding and disconnects between hERG potency and QT interval prolongationShi, H. / Huang, M. / Sun, L. / Sun, H. / Xing, D. / Levesque, P. et al. | 2012
- 168
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Testing IKr blockers in five screening models of pro-arrhythmia shows insufficient specificity of isolated cardiomyocytesPeschar, M. / Nalos, L. / Varkevisser, R. / van Veen, T. A. / Houtman, M. J. / Beekman, J. D. / van der Nagel, R. / Thomsen, M. B. / Duker, G. / Sartipy, P. et al. | 2012
- 169
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Acute or long term exposure to the drug substance: A potentially different outcome in the hERG channel assayGoineau, S. / Legrand, C. / Maujeul, M. / Hautefeuille, L. / Froget, G. et al. | 2012
- 169
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Mechanisms of hERG channel blockade by methadoneLi, L. / Cui, Y. / Heath, B. / McMahon, N. et al. | 2012
- 169
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Optimization of hERG screening using IonFlux HT automated systemMartinolle, J. P. / Guillemare, E. / Bertrand, J. P. / Verges, P. / Brun, P. et al. | 2012
- 170
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Citalopram metabolites inhibit IKs and IKr differentially: Is this a possible explanation for the sudden deaths in dogs?Rohrbacher, J. / Bex, P. / Gallacher, D. J. et al. | 2012
- 170
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Image-based automatic calcium transient analysis for early cardiotoxicity testing in hiPSC-derived cardiomyocytesMercola, M. / Cerignoli, F. / Whittaker, R. / McDonough, P. / Ingermanson, R. / Towart, R. / Gallacher, D. J. / Price, J. et al. | 2012
- 170
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Can more be done with hERG data? The correlation of hERG block and QT prolongationCrumb, W. J. / Milosavljev, S. / Ekins, S. et al. | 2012
- 170
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Assessing concordance of nonclinical and clinical QT data: The ILSI-HESI cardiovascular safety subcommittee initiative re-visitedSkinner, M. / Valentin, J. P. / Gintant, G. / Koerner, J. / Pettit, S. / Wisialowski, T. et al. | 2012
- 171
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PKPD relationship of hERG blockade and in vivo outcomePehrson, R. / Al-Saffar, A. / Kagstrom, J. / Yan, H. et al. | 2012
- 171
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Dynamics of drug binding to the hERG channel: An in silico cardiac action potential model for early safety assessmentDi Veroli, G. Y. / Davies, M. / Pollard, C. E. / Valentin, J. P. / Zhang, H. / Boyett, M. / Gerges, N. A. et al. | 2012
- 171
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Screening with the CytoPatch(TM) Instrument: Taking the advantage of automated patch clamp without taking the loss in data qualityRascher-Eggstein, G. / Scheel, O. / van Bergen, A. / Knott, T. et al. | 2012
- 172
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Decreased QT variability with DSI ECG pattern recognition: Comparison to algorithm-based analysis in 60 human subjectsMeyer, O. / Holzgrefe, H. H. et al. | 2012
- 172
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Efficacy of ECG pattern recognition analysis in human subjects with variable T-Wave morphology: Impact on study powerMeyer, O. / Holzgrefe, H. H. et al. | 2012
- 172
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Integration into preclinical toxicity studies of functional endpoints captured with telemetry: To implant or not?Guillon, J. m. / Slaoui, M. / Battut, C. / Hamon, B. / Doubovetzky, M. / Palazzi, X. et al. | 2012
- 172
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A new automated arrhythmia detector in preclinical safety studiesMichon, P. / Labarre, D. / Zitoun, P. / Koeppel, F. et al. | 2012
- 173
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Retrospective data-mining as a tool for preclinical to clinical translational scienceLoenders, B. / Van Ammel, K. / Teisman, A. / Gallacher, D. J. et al. | 2012
- 173
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Validation of a novel system for preclinical assessment of ventricular arrhythmiasHamlin, R. L. / Brockway, M. / Brockway, B. / Olson, J. / Martin, R. / Risdal, J. et al. | 2012
- 173
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A literature-based analysis of cardiovascular adverse events impacting on drug developmentValentin, J. P. / Kenna, J. G. / Lainee, P. / Pollard, C. E. / Redfern, W. S. / Roberts, S. / Hammond, T. G. et al. | 2012
- 174
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Impact of LVP catheterization on the statistical power of ECG parameters in Cynomolgus monkeysMiyamoto, M. / Spatzier, B. N. / Kelly, C. M. / Bate, S. / Thomas, G. et al. | 2012
- 174
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Analysis of the QRS complex of the ECGHamlin, R. L. / del Rio, C. / Brown, T. et al. | 2012
- 174
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Cardiac contractility assessment: A case study with clear impact and relevance of preclinical dataLainee, P. / Philp, K. / Harmer, A. / Bridgland-Taylor, M. / Moors, J. / Knight, R. / Valentin, J. P. et al. | 2012
- 174
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Translation of preclinical in vivo canine studies to human Phase 1 studies: An evaluation of some ECG and basic hemodynamic parametersVan Ammel, K. J. / Gallacher, D. / Teisman, A. et al. | 2012
- 175
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Heart rate dependent potentiation of QRS prolongations can be detected in standard dog telemetry studiesCros, C. / Moors, J. / Skinner, M. / Valentin, J. P. / Lainee, P. et al. | 2012
- 175
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Comparisons of Safety Pharmacology and general toxicology ECG's, and cardiovascular functional/pathology dataMilliken, P. H. / Davies, R. C. / Clements, P. J. / Patel, B. A. / McMahon, N. C. et al. | 2012
- 175
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Assessment of left ventricular dP/dtmax in telemetry studies: Essential or excessive?Skinner, M. / Lainee, P. / Valentin, J. P. / Moors, J. et al. | 2012
- 175
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3-Model characterization of the relation between cardiac repolarization and temperature in guinea pigLaursen, M. / Lassen, A. B. / Akerlund, O. / Strange Hansen, R. B. / Christensen, T. / Christiansen, J. / Mow, T. et al. | 2012
- 176
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Pressure-dependent left-ventricular unloading in a chronic model of ischemic heart failure: Evaluation of a novel intra-atrial shuntdel Rio, C. L. / McConnell, P. I. / Nitzan, Y. / Vargas-Pinto, P. / Pedraza-Toscano, A. / Brown, T. / Ueyama, Y. / Abraham, W. T. / Verheye, S. / Hamlin, R. L. et al. | 2012
- 176
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Assessment of DeltaT50, a clinical biomarker of QT variability in preclinical dog telemetry studiesLainee, P. / Philp, K. / Moors, J. / Skinner, M. / Abrahamsson, C. / Ducker, G. / Valentin, J. P. et al. | 2012
- 176
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External telemetry significantly improves ECG assessment in Nonhuman Primates (NHP) over standard methodsSchofield, J. / Grant, C. / Prior, H. / Skinner, M. / Valentin, J. P. / Lainee, P. et al. | 2012
- 177
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Improvements in cardiac injury assessment via combined measurement modalitiesRoche, B. M. / Vinci, T. / Elsass, K. / McCullough, S. / Reed, S. / Behringer, S. et al. | 2012
- 177
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A pharmacovigilance study in chest diseases outpatient clinicUsta, C. / Cilli, A. / Celenk, B. / Uzun, R. et al. | 2012
- 177
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Evaluation of drug-induced cardiac conduction disturbance using conscious ferrets-An alternative small animal telemetry modelVargas, H. M. / Derakhchan, K. et al. | 2012
- 177
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Influence of pharmaceutic promotion and advertisement on prescription habits and medicine intakeRodriguez, L. M. / Martinez, L. M. / de los Angeles Rodriguez, M. / Martinez, G. I. / Cardona, J. / Estrada, M. / Martinez, E. / Grajales, D. C. et al. | 2012
- 178
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Electrophysiological properties of iCell cardiomyocytes obtained by automated patch clamp on QPatchSchroder, R. / Christensen, M. / Anson, B. / Sunesen, M. et al. | 2012
- 178
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Evaluation of a combined model for assessing respiratory and cardiovascular function in the conscious non-restrained monkeyRenninger, J. P. / Murphy, D. J. / Kohrs, L. C. et al. | 2012
- 178
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Simultaneous evaluation of cardiovascular, respiratory and CNS functions in the conscious Cynomolgus monkeyGuillon, J. m. / Dupont, T. / Truphemus, P. / Battut, C. / Hamon, B. / Boixel, C. / Doubovetzky, M. et al. | 2012
- 179
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The development of an in vitro safety assay utilising human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with Multi/micro-electrode array (MEA) technologyNicks, A. M. / Cui, Y. / McMahon, N. / Sridhar, A. et al. | 2012
- 179
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Assessment of the concordance between nonclinical repolarization assays and clinical measure of QT interval prolongationKoerner, J. / Darpo, B. / Skinner, M. / Vargas, H. M. / Willard, J. / Pettit, S. / Valentin, J. P. et al. | 2012
- 179
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A retrospective analysis of gastrointestinal adverse events impacting on drug developmentValentin, J. P. / Al-Saffar, A. / Ewart, L. / Glab, J. / Marks, L. / Redfern, W. S. / Roberts, S. / Hammond, T. G. et al. | 2012
- 179
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Two novel approaches: Shifting the drug development paradigmCoffee, M. S. / Evans, J. R. / Merriman, D. T. / Roche, B. M. et al. | 2012
- 180
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Which possible applications for bioluminescence and fluorescence in preclinical safety studies?Maurin, A. / Martel, E. / Bracq, E. / Brulle, L. / Champeroux, P. / Richard, S. et al. | 2012
- 180
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Does terfenadine-induced VT/VF directly relate to its QT prolongation and Torsades de Pointes?Hermans, A. N. / Lu, H. R. / Gallacher, D. J. et al. | 2012
- 180
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Direct effects of arsenic trioxide on action potentials in isolated cardiac tissues: Importance of the choice of species, type of cardiac tissues and perfusion timeLu, H. R. / Vlaminckx, E. / Rohrbacher, J. / Cools, F. / Gallacher, G. J. et al. | 2012
- 180
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How to address metabolite toxicity and species or organ specific toxicity or in vitro?Otto-Bruc, A. E. / Piwnica, D. / Rein, C. / Sabatier, F. et al. | 2012
- 181
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Detecting QT/APD shortening with rabbit Purkinje fibre action potentials and guinea pig isolated perfused heartDucroq, J. / Didier, H. / Salvetat, C. / Le Grand, M. et al. | 2012
- 181
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Utility of the isolated Langendorff-perfused heart model as part of an early screening strategy in safety pharmacologyRamirez, D. S. / Jenkinson, S. / McHarg, A. D. et al. | 2012
- 181
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Itroconazole decreases left ventricular contractility in the isolated rabbit heart: Mechanism of actionVargas, H. M. / Fang, M. / Lawrence, J. / Gao, B. / Acton, P. / Qu, Y. et al. | 2012
- 181
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Low K^+ alters differentially drugs arrhythmogenic profile in rabbit isolated heartGuillon, J. m. / Ballet, V. / Blanchard, R. h. / Carriot, T. / Barre, C. / Doubovetzky, M. et al. | 2012
- 182
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Effects of hERG openers and the influence of IKS inhibition in an isolated rabbit heart modelGuerard, N. / Traebert, M. / Suter, W. / Dumotier, B. et al. | 2012
- 182
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Pharmacological studies in acute rabbit cardiac slicesSchmidt, M. / Bussek, A. / Himmel, H. / Ravens, U. / Wettwer, E. / Lohmann, H. et al. | 2012
- 182
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Determining the ideal species for ex vivo heart model in predicting cardiac toxicity in drug developmentHenderson, K. A. / Borders, B. R. / Roche, B. M. et al. | 2012
- 183
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Evaluation of Respiratory Inductive Plethysmography using the EMKABelt (Jacket) system in the conscious beagle dogPurbrick, S. / Jordan, S. / Moore, S. / Butler, D. / French, A. / Jones, D. / Peake, E. / Milner, V. / Davies, P. / Meecham, K. et al. | 2012
- 183
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Respiration rate derived from ECG in dogsPehrson, R. / Bulhak, A. et al. | 2012
- 183
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Effects of autonomic interventions on heart rate variability in ambulatory, telemetrized dogsArthur, S. R. / Lehman, B. L. / Cao, J. / Hennan, J. K. et al. | 2012
- 183
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Comparison of cardiac electrophysiological and mechanical effects of torsadogens in the isolated normal and failing rabbit heartsKijtawornrat, A. / Sawangkoon, S. / Del Rio, C. / Hamlin, R. L. et al. | 2012
- 184
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Comparison of surgical techniques for implanted telemetry monitoring of cardiorespiratory parameters in three speciesModdrelle, D. S. / O'Donahue, K. / Denton, T. / Herrmann, E. / Dalton, J. / Gauvin, D. / Baird, T. J. et al. | 2012
- 184
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Assessment of the relationship between core body temperature and QT/QTc in the minipig using DihydrocapsaicinTang, H. M. / Sanders, M. / Baird, T. / Greiter-Wilke, A. et al. | 2012
- 184
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A modified left thoracotomy approach for enhancing ECG P-wave detection in the cynomolgus monkeyModdrelle, D. S. / Ward, J. / O'Donohue, K. / Baird, T. et al. | 2012
- 185
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Comparison of the cardiovascular profile of sotalol in two conscious dog models, the sling and telemetry modelKimpe, A. / Moesen, E. / Geys, H. / Peeters, T. et al. | 2012
- 185
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Evaluation of a CNS compound in two species: Differential pharmacological responses in dogs and minipigsGreiter-Wilke, A. / Baird, T. J. / Mohr, S. / Stewart, L. / Sarmiento, R. M. / Sanders, M. et al. | 2012
- 185
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Meaningful telemetry data can be obtained in the same animal with full TK profiling in toxicological studiesJu, H. / Splain, M. / Carey, C. / Irwin, S. / Suter, W. et al. | 2012
- 185
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Evaluation of a LVdP/dt rate-correction methodTrautmann, T. / Grosz, M. / Ege, A. / Mayer, K. / Markert, M. / Guth, B. et al. | 2012
- 186
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Surgical approach and experimental set-up for high quality cardiovascular signals and accurate analysis of dog telemetry studiesDelpy, E. / Infanti, F. / Garreau, M. / La Rochelle, C. D. et al. | 2012
- 186
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A comprehensive assessment of cardiovascular risk in telemetered cynomolgus monkeysPrior, H. / Purbrick, S. / Lainee, P. / Bowes, J. / Coulson, M. / Meecham, K. / Valentin, J. P. et al. | 2012
- 186
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Differentiation between background and drug-induced arrhythmias in dogs using a pattern based approachRossman, E. I. / Wu, X. / Payseur, J. D. / McAllister, P. R. / Wang, K. F. / Murphy, D. J. et al. | 2012
- 187
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Surgical implantation of the D70-PCTR transmitter: Subcutaneous approach/common carotid artery approachMoesen, E. / Peeters, T. / Kimpe, A. et al. | 2012
- 187
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Hemodynamic, ECG and function telemetry in conscious ferrets administered verapamilHunter, R. L. / Clawson, C. A. / Doyle, J. / Adams, S. T. / Main, B. W. et al. | 2012
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Cardiovascular and video-electroencephalogram (EEG) telemetry collection in freely moving beagle dogs-A qualification studyMetea, M. R. / Gleason, T. R. / Atterson, P. R. et al. | 2012
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Simultaneous assessment of blood pressure and respiratory function in dogs: Validation of a non-invasive telemetry methodBailey, E. L. / Grant, C. / Wang, J. L. / Napoleoni, J. G. / Ewart, L. / Lainee, P. / Valentin, J. P. et al. | 2012
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Collection of cardiovascular data from cynomolgus monkeys using jacketed external telemetry: Effects of thioridazineTichenor, S. D. / Regalia, D. E. / Kaiser, R. A. / Wilson, S. E. / Erwin, R. F. / Holzgrefe, H. H. / Meyer, D. J. et al. | 2012
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Assessment of potential preclinical markers for early detection of myocardial ischemia in the conscious rat and dogMilliken, P. H. / Ward, G. L. / Tennant, A. H. / York, M. J. / McMahon, N. C. / Louttit, J. B. / Patel, B. A. et al. | 2012
- 188
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Functional evaluation of impedance-based telemetric respiratory monitoring in canine, macaque, and miniature swineBaird, T. J. / Gauvin, D. V. / O'Donohue, K. P. / Abernathy, M. M. / Dalton, J. A. et al. | 2012
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A novel IV-diaphragmatic ECG lead implantation approach is well-tolerated in beagle dogs for at least three monthsWalisser, J. A. / Mitchell, A. Z. / Sharma, A. K. / Osinski, M. A. et al. | 2012
- 189
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Comparison of epicardial and jacketed external ECG waveforms for the detection of QT and QTc interval changesWilson, S. E. / Tichenor, S. D. / Norton, K. et al. | 2012
- 189
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Night/day differences in common electrocardiographic indices of arrhythmic liability in telemetered dogsPedraza-Toscano, A. M. / Vargas-Pinto, P. / del Rio, C. / Hamlin, R. L. et al. | 2012
- 189
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A step-wise approach to quantitative arrhythmia assessment: A multi-species and multi-drug validationO'Donohue, K. P. / Holdsworth, D. L. / Tapp, R. L. / Harter, M. L. / May, J. R. / Abernathy, M. M. / Gauvin, D. V. / Dalton, J. A. / Baird, T. J. et al. | 2012
- 189
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Comparative historical cardiorespiratory data collected by telemetry with impedance in swine, canine, and macaquesAbernathy, M. M. / Holdsworth, D. L. / O'Donohue, K. P. / Dalton, J. A. / Gauvin, D. V. / Baird, T. J. et al. | 2012
- 190
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Surgical technique for intravenous ECG lead placement in the dogMitchell, A. Z. / Taschwer, M. / Argue, C. M. / Osinski, M. A. et al. | 2012
- 190
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A novel biomaterial catheter for improved cardiac contractility measurement in freely moving animalsKroehle, J. / Volovsek, B. / Singer, D. / Sarazan, R. D. et al. | 2012
- 190
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Assessment of scopolamine on learning and memory on PND 22-28 juvenile rats using an automated video tracking systemToot, J. D. / Pershing, M. L. / Beck, M. J. / Simons, M. L. / Stump, D. G. / Atterson, P. R. et al. | 2012
- 191
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Electroencephalogram in freely-moving rats to assess proconvulsant risk at preclinical stageGuillon, J. M. / Mathieu-kia, A. M. / Benhamou, J. / Chenede, X. / Hamon, B. / Martinolle, J. P. / Doubovetzky, M. et al. | 2012
- 191
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An optimised methodology for the drug discrimination assessment in ratsMaurin, A. / Maleysson, V. / Bracq, E. / Martel, E. / Champeroux, P. / Richard, S. et al. | 2012
- 191
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Behavioural effects of Compound X and picrotoxin dose-response following ICV administration in the ratFasdelli, N. / Bison, S. / Guidi, A. / Poffe, A. / Giarola, A. et al. | 2012
- 191
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Pica behavior is a useful predictor for evaluation of nausea and vomiting with paroxetine in ratsNozaki, Y. / Yabuuchi, M. / Mino, T. et al. | 2012
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Development of an in vitro screen of neurite outgrowth to predict drug-induced neurotoxicityMcManus, C. L. / Garside, H. / Redfern, W. S. / Valentin, J. P. / Bowes, J. et al. | 2012
- 192
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Non-invasive methods of body temperature measurements in ratsPrior, H. / Motyer, V. / Marks, L. / Cobey, D. / Ewart, L. / Valentin, J. P. et al. | 2012
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Inclusion of microchip transponder body temperature measurements in safety pharmacology and toxicology studiesPrior, H. / Motyer, V. / Cobey, D. / Marks, L. / Ewart, L. / Valentin, J. P. / Redfern, W. et al. | 2012
- 192
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Safe method of propofol infusion for children: Population pharmacokinetic and pharmacodynamic analysis of lipid emulsion propofol in childrenByon, H. J. / Kim, H. S. / Kim, J. T. / Kim, C. S. et al. | 2012
- 193
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A proof of concept study for evaluating antihypertensive compounds in awake, chronically-instrumented, pharmacologically hypertensive monkeysHawk, M. A. / Vinci, T. M. / Hamlin, R. L. / Roche, B. M. / Coffee, M. S. / Gonzalez, E. et al. | 2012
- 193
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A review of convulsion and seizure incidence: Small versus large molecule experienceAmouzadeh, H. R. / Williamson, T. / Vargas, H. M. et al. | 2012
- 193
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Assessing seizure liability in hippocampal slices and neurons using multi-electrode arrays (MEA)Sun, L. / Fan, J. / Kwagh, J. / Chen, S. J. / Burnett, E. / Lewen, G. / Shi, H. / Flint, O. / Levesque, P. et al. | 2012
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Which pathological condition is the most critical for drug-induced torsades de pointes?Chiba, K. / Takasuna, K. / Sanbuissho, A. / Sugiyama, A. et al. | 2012
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Development of a conscious rat model of cardiac output and blood pressure measurement for cardiovascular safety studiesLouttit, J. B. / Gibson, B. K. / Lincoln, R. J. / Patel, B. A. / McMahon, N. C. et al. | 2012
- 194
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Efficacy of novel phosphodiesterase inhibitors in rats with monocrotaline-induced pulmonary hypertensionBruse, K. D. / Pahl, A. et al. | 2012
- 194
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Utilization of telemetry to characterize physiological changes following F. tularensis SCHU S4 aerosol infection in unvaccinated and vaccinated Cynomolgus macaquesBruse, K. D. / Zinter, E. / Brooks, K. / Valderas, M. / Wilder, J. / Hutt, J. / Brasel, T. / Sherwood, R. / Wu, T. / Lyons, R. et al. | 2012
- 195
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A comparison of test article-induced changes in telemetry-based QA interval and left ventricular dP/dt to echocardiography endpoints in the conscious dogKing, L. A. / Turner, S. L. / Zhao, S. Q. / Coatney, R. W. / Murphy, D. J. et al. | 2012
- 195
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Effects of flecainide and dronedarone on atrial and ventricular effective refractory period in the dog with pacing induced atrial remodelingGralinski, M. R. / Senese, P. B. / Huang, J. B. / Wang, H. O. / Buening, J. R. / Janssen, D. L. et al. | 2012
- 195
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Evaluation of effects on cardiac contractility in conscious common marmosets using telemetryKitayama, T. / Saito, T. / Kajihara, M. / Harada, K. et al. | 2012
- 196
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Use of non-human primate models to enable early investigational cardiovascular de-riskingRegan, C. P. / Regan, H. K. / Lynch, J. J. et al. | 2012
- 196
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A model of heart failure via mitral regurgitation and tachypacing: Decreased exercise capacity and functional/neuro humoral remodelingdel Rio, C. L. / Pedraza-Toscano, A. / Vargas-Pinto, P. / Ueyama, Y. / Wallery, J. / Williams, V. / Thibaud, D. / Hamlin, R. L. et al. | 2012
- 196
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Correlation between respiratory minute volumes and blood gas values in artificially-ventilated beagle dogsMetea, M. R. / Gleason, T. R. / Atterson, P. R. et al. | 2012
- 197
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Respiratory assessment in safety pharmacology inhalation studies in telemetered dogsSome, M. et al. | 2012
- 197
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Super-intervals: Application to respiratory safety pharmacology data in ratsAuthier, S. / Some, M. / Fournier, S. / Troncy, E. et al. | 2012
- 197
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Effects of inhalation exposure of methacholine on intra-pleural pressure, airway resistance and compliance in conscious telemetered ratsArmstrong, R. / Donington, S. / Moore, S. / Davies, P. / Jordan, S. / Meecham, K. et al. | 2012
- 198
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Comparison of thoracic impedance pneumography and inductive plethysmography in the assessment of respiratory functionWilson, S. E. / Tichenor, S. D. / Norton, K. et al. | 2012
- 198
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Current scenario leading to renal failureAlaparthi, V. / Vedagiri, S. / Bhojraj, S. / Medabalimi, S. S. et al. | 2012
- 199
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A safety pharmacology strategy for inhaled compoundsLindgren, S. / Some, M. / Bulhak, A. / Ericson, A. C. et al. | 2012
- 199
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Chronic monitoring of brain tissue oxygen in freely moving rats from a fully implanted telemetry systemMalpas, S. / Russell, D. / Gary, E. / Budgett, D. / Taberner, A. et al. | 2012
- 199
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An analysis of safety pharmacology operations across the top 12 pharmaceutical companiesEwart, L. / Gallacher, D. / Gintant, G. / Guillon, J. M. / Leishman, D. / McMahon, N. / Levesque, P. / Mylecraine, L. / Suter, W. / Sanders, M. et al. | 2012
- 199
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Dual recordings of left ventricular and arterial pressure in conscious rats via telemetryMalpas, S. / Stehlin, E. / Guild, S. J. / Budgett, D. / McCormick, D. / Rigel, D. et al. | 2012
- 200
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Simultaneous assessment of proconvulsant and hemodynamic risks in the telemetered ratProvost, D. / Esneault, E. / Peyon, G. / Rompion, S. / Guillaume, P. / Froget, G. et al. | 2012
- 200
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Blood pressure and renal function in mPGES deficient miceStrom, A. C. / Simonsson, E. / Ekstrand, S. / Tallo, K. / Bohlooly, M. / Xu, X. / Ericson, A. C. et al. | 2012
- 200
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Evaluation of postural orthostatic hypotension in normotensive and spontaneously hypertensive telemetered ratsGuillaume, P. / Rompion, S. / Froget, G. et al. | 2012
- 200
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Cardiovascular liabilities of receptor X agonists using selective and non-selective compounds in telemetrized rats and knockout miceLi, J. P. / Thalody, G. / Lehman-McKeeman, L. / Levesque, P. C. / Johnson, V. K. / Hennan, J. K. et al. | 2012
- 201
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QT shift method in guinea pigChamperoux, P. / Jude, S. / Martel, E. / Maurin, A. / Bouard, D. / Contamine, A. / Richard, S. et al. | 2012
- 201
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Assessing methods for the detection of pharmacologically induced myocardial ischemia in the conscious ratMilliken, P. H. / Le Ruez, T. / Tennant, A. H. / Ward, G. L. / York, M. J. / McMahon, N. C. / Louttit, J. B. / Patel, B. A. et al. | 2012
- 201
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Use of jacketed external telemetry in the conscious guinea-pig in early assessment of cardio-respiratory functionEl Amrani, A. I. / Betat, A. M. / Loriot, S. / Forster, R. / Legrand, J. J. et al. | 2012
- 202
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Feasibility of continuous blood pressure and heart rate assessments in juvenile ratsMatheson, R. / Caron, S. / Trudel, Y. / Norton, K. et al. | 2012
- 202
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Advantages and utility of native human cardiac myocytes in compound screeningCrumb, W. J. / Milosavljev, S. / Ekins, S. et al. | 2012
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Simultaneous measurement of contractility and intracellular Ca^2^+ in canine cardiac myocytes: An assay for early assessment of modulators of contractilityPullen, G. F. / Morton, M. J. / Gerges, N. A. / Pollard, C. E. / Valentin, J. P. et al. | 2012
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Functional evaluation of a novel mouse implant for cardiovascular assessmentHarter, M. L. / VanMiddlesworth, J. / O'Donohue, K. / Gauvin, D. / Dalton, J. / Baird, T. et al. | 2012
- 203
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Continuous and simultaneous monitoring of glucose and electrocardiogram in monkeys treated with quinolonesIshizaka, T. / Yoshimatsu, Y. / Ozawa, M. / Sakurai, K. / Kimotsuki, T. / Sanbuissho, A. / Yasuda, M. et al. | 2012
- 203
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Peripherally-restricted dopamine agonist but not norepinephrine uptake inhibitor alters prolactin releaseKinter, L. B. / Venzie, J. / Campbell, P. / Bentley, P. / Andersson, H. / Stewart, J. / Huby, R. / Brott, D. A. et al. | 2012
- 203
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Evaluation of QTc prolongation in animal and human studies: A qualitative assessment of nonclinical and clinical concordance based on the literatureVargas, H. M. / Bass, A. S. / Koerner, J. / Matis-Mitchell, S. / Pugsley, M. K. / Skinner, M. / Burnham, M. / Pettit, S. / Valentin, J. P. et al. | 2012
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Bilateral cannulation of guinea pigs for ototoxicity studies allows multiple assessments and reduction of animalsTapp, R. L. / Abernathy, M. M. / Sweet, J. A. / Yoder, J. D. / Koch, A. A. / Gauvin, D. V. / Baird, T. J. et al. | 2012
- 204
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Evaluation of gastric emptying in the cynomolgus monkeyEl Amrani, A. I. / Michaud, R. / Loriot, S. / Betat, A. M. / Aubert, N. / Forster, R. / Legrand, J. J. et al. | 2012
- 204
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An evaluation of the non-invasive faecal pellet assessment method as an early development screen for gastrointestinal liabilityMarks, L. / Cobey, D. / Motyer, V. / Ewart, L. / Fantham, E. / Moore, N. / Prior, H. / Valentin, J. P. et al. | 2012
- 204
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Gastric secretion in the rat: Influence of analgesicsJaehnige, A. / Hoell, S. / Erni, I. / Schlager-Schaelkle, S. / Guth, B. / Pestel, S. et al. | 2012
- 205
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Concordance of drug-induced changes in renal excretory function between safety pharmacology and toxicology studies in ratsChen, Y. / Brott, D. / Altekar, M. / Caccese, R. / Jonasson, H. / Ericson, A. C. / Pehrson, R. / Pinches, M. / Valentin, J. P. / Kinter, L. et al. | 2012
- 205
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Association networks as a tool to predict drug-induced nausea in manGlab, J. / Muthas, D. / Boyer, S. / Clark, M. / Valentin, J. P. / Ewart, L. et al. | 2012
- 205
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Development of a histopathologic evaluation procedure for preliminary ototoxicity screening in guinea pigsAbernathy, M. M. / Tapp, R. L. / Cole, P. I. / Yoder, J. D. / Hedke, C. A. / Olsen-Urbanek, A. L. / Salinas, J. N. / Koch, A. A. / Gauvin, D. V. / Baird, T. J. et al. | 2012
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Editorial Board| 2012