Optimization of N‑Phenylpropenoyl‑l‑amino Acids as Potent and Selective Inducible Nitric Oxide Synthase Inhibitors for Parkinson’s Disease (English)
- New search for: Hu, Xiao-Long
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- New search for: Wang, Hao
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- New search for: Hu, Xiao-Long
- New search for: Lv, Xian-Yu
- New search for: Wang, Rong
- New search for: Long, Huan
- New search for: Feng, Jia-Hao
- New search for: Wang, Bao-Lin
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- New search for: Zhang, Xiao-Qi
- Further information on Zhang, Xiao-Qi:
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In:
Journal of Medicinal Chemistry
;
64
, 11
;
7760-7777
;
2021
- Article (Journal) / Electronic Resource
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Title:Optimization of N‑Phenylpropenoyl‑l‑amino Acids as Potent and Selective Inducible Nitric Oxide Synthase Inhibitors for Parkinson’s Disease
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Additional title:J. Med. Chem.
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Contributors:Hu, Xiao-Long ( author ) / Lv, Xian-Yu ( author ) / Wang, Rong ( author ) / Long, Huan ( author ) / Feng, Jia-Hao ( author ) / Wang, Bao-Lin ( author ) / Shen, Wei ( author ) / Liu, Hao ( author ) / Xiong, Fei ( author ) / Zhang, Xiao-Qi ( author )
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Published in:Journal of Medicinal Chemistry ; 64, 11 ; 7760-7777
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Publisher:
- New search for: American Chemical Society
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Publication date:2021-06-10
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 64, Issue 11
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 7045
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Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule DrugsZhang, Donglu / Wei, Cong / Hop, Cornelis E. C. A. / Wright, Matthew R. / Hu, Ming / Lai, Yurong / Khojasteh, S. Cyrus / Humphreys, W. Griff et al. | 2021
- 7060
-
Function, Therapeutic Potential, and Inhibition of Hsp70 ChaperonesAmbrose, Andrew J. / Chapman, Eli et al. | 2021
- 7083
-
Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug DiscoverySun, Jiyun / Xiao, Zhiwei / Haider, Ahmed / Gebhard, Catherine / Xu, Hao / Luo, Hai-Bin / Zhang, Han-Ting / Josephson, Lee / Wang, Lu / Liang, Steven H. et al. | 2021
- 7110
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Synthetic RNA Modulators in Drug DiscoveryZamani, Farzad / Suzuki, Takayoshi et al. | 2021
- 7156
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The Medicinal Chemistry of CaffeineFaudone, Giuseppe / Arifi, Silvia / Merk, Daniel et al. | 2021
- 7179
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The Expanding Role of Chemistry in Optimizing Proteins for Human Health ApplicationsRoman, Bart I. et al. | 2021
- 7189
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Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating StrategyWu, Yue / Li, Zhihong / McDonough, Michael A. / Schofield, Christopher J. / Zhang, Xiaojin et al. | 2021
- 7210
-
Target-Based Evaluation of “Drug-Like” Properties and Ligand EfficienciesLeeson, Paul D. / Bento, A. Patricia / Gaulton, Anna / Hersey, Anne / Manners, Emma J. / Radoux, Chris J. / Leach, Andrew R. et al. | 2021
- 7231
-
Focused Libraries for Epigenetic Drug Discovery: The Importance of IsosteresGreen, Adam I. / Burslem, George M. et al. | 2021
- 7241
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Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary DiseaseGrand, Darren Le / Gosling, Martin / Baettig, Urs / Bahra, Parmjit / Bala, Kamlesh / Brocklehurst, Cara / Budd, Emma / Butler, Rebecca / Cheung, Atwood K. / Choudhury, Hedaythul et al. | 2021
- 7261
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Discovery of RRx-001, a Myc and CD47 Downregulating Small Molecule with Tumor Targeted Cytotoxicity and Healthy Tissue Cytoprotective Properties in Clinical DevelopmentOronsky, Bryan / Guo, XiaoNing / Wang, XiaoHui / Cabrales, Pedro / Sher, David / Cannizzo, Lou / Wardle, Bob / Abrouk, Nacer / Lybeck, Michelle / Caroen, Scott et al. | 2021
- 7272
-
Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial BiofilmsNaclerio, George A. / Sintim, Herman O. et al. | 2021
- 7275
-
A Modular Synthetic Route Involving N‑Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3‑Substituted Halogenated Phenazine Antibacterial AgentsYang, Hongfen / Kundra, Shivani / Chojnacki, Michaelle / Liu, Ke / Fuse, Marisa A. / Abouelhassan, Yasmeen / Kallifidas, Dimitris / Zhang, Peilan / Huang, Guangtao / Jin, Shouguang et al. | 2021
- 7296
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Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon ModulatorsNishiguchi, Gisele / Keramatnia, Fatemeh / Min, Jaeki / Chang, Yunchao / Jonchere, Barbara / Das, Sourav / Actis, Marisa / Price, Jeanine / Chepyala, Divyabharathi / Young, Brandon et al. | 2021
- 7312
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Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC OncoproteinsChi, Ya-Hui / Yeh, Teng-Kuang / Ke, Yi-Yu / Lin, Wen-Hsing / Tsai, Chia-Hua / Wang, Wan-Ping / Chen, Yen-Ting / Su, Yu-Chieh / Wang, Pei-Chen / Chen, Yan-Fu et al. | 2021
- 7331
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Design, Synthesis, and Biological Evaluation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer TreatmentZhang, Kehui / Ji, Ming / Lin, Songwen / Peng, Shouguo / Zhang, Zhihui / Zhang, Mingyi / Zhang, Jingbo / Zhang, Yan / Wu, Deyu / Tian, Hua et al. | 2021
- 7341
-
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic LeukemiaZhang, Peng / Min, Zhihui / Gao, Yang / Bian, Jiang / Lin, Xin / He, Jie / Ye, Deyong / Li, Yilin / Peng, Chao / Cheng, Yunfeng et al. | 2021
- 7359
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Selective and Efficient Photoinactivation of Intracellular Staphylococcus aureus and MRSA with Little Accumulation of Drug Resistance: Application of a Ru(II) Complex with Photolabile LigandsSun, Weize / Jian, Yao / Zhou, Mengxue / Yao, Yishan / Tian, Na / Li, Chao / Chen, Jun / Wang, Xuesong / Zhou, Qianxiong et al. | 2021
- 7371
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Design, Synthesis, and Structure–Activity Relationship of N‑Aryl‑N′‑(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer ImmunotherapyChen, Zhipeng / Zhang, Lina / Yang, Junjie / Zheng, Lu / Hu, Fanjie / Duan, Siqin / Nandakumar, Kutty Selva / Liu, Shuwen / Yin, Hang / Cheng, Kui et al. | 2021
- 7390
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Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 InteractionWang, Tianyu / Cai, Shi / Wang, Mingming / Zhang, Wanheng / Zhang, Kuojun / Chen, Dong / Li, Zheng / Jiang, Sheng et al. | 2021
- 7404
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Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular CarcinomaZhou, Zongyuan / Li, Yiming / Ma, Xiaofang / Cao, Biyun / Peng, Ting / Sheng, Yuwen / Peng, Huipan / Li, Runze / Cao, Yu / Xi, Ruiying et al. | 2021
- 7422
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Disulfide-Rich Cyclic Peptides from Clitoria ternatea Protect against β‑Amyloid Toxicity and Oxidative Stress in Transgenic Caenorhabditis elegansKalmankar, Neha V. / Hari, Hrudya / Sowdhamini, Ramanathan / Venkatesan, Radhika et al. | 2021
- 7434
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Discovery of a Candidate Containing an (S)‑3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro‑1H‑inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid LeukemiaZhang, Dongfeng / Li, Peng / Gao, Yongxin / Song, Yaoyao / Zhu, Yaqin / Su, Hong / Yang, Beibei / Li, Li / Li, Gang / Gong, Ningbo et al. | 2021
- 7453
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Discovery of G Protein-Biased Ligands against 5‑HT7RLee, Jieon / Kwag, Rina / Lee, Soyeon / Kim, Doyoung / Woo, Jiwan / Cho, Yakdol / Kim, Hak Joong / Kim, Jeongjin / Jeon, Byungsun / Choo, Hyunah et al. | 2021
- 7468
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Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid CancerRen, Yuhao / Li, Shanshan / Zhu, Ren / Wan, Chengying / Song, Dongmei / Zhu, Jiawen / Cai, Guiping / Long, Sihui / Kong, Lingyi / Yu, Wenying et al. | 2021
- 7483
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Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK‑3 Inhibitors for the Treatment of Alzheimer’s DiseaseYao, Hong / Uras, Giuseppe / Zhang, Pengfei / Xu, Shengtao / Yin, Ying / Liu, Jie / Qin, Shuai / Li, Xinuo / Allen, Stephanie / Bai, Renren et al. | 2021
- 7507
-
Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer ImmunotherapyWang, Zhisong / Gao, Yan / He, Lei / Sun, Shuhao / Xia, Tingting / Hu, Lu / Yao, Licheng / Wang, Liangliang / Li, Dan / Shi, Hui et al. | 2021
- 7533
-
The Good, the Bad, and the Twisted Revisited: An Analysis of Ligand Geometry in Highly Resolved Protein–Ligand X‑ray StructuresLiebeschuetz, John W. et al. | 2021
- 7544
-
Computational Bioactivity Fingerprint Similarities To Navigate the Discovery of Novel ScaffoldsXiong, Guo-Li / Zhao, Yue / Liu, Lu / Ma, Zhong-Ye / Lu, Ai-Ping / Cheng, Yan / Hou, Ting-Jun / Cao, Dong-Sheng et al. | 2021
- 7555
-
Identification of an N‑acylated‑DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced HyperalgesiaQuillet, Raphaëlle / Schneider, Séverine / Utard, Valérie / Drieu la Rochelle, Armand / Elhabazi, Khadija / Henningsen, Jo Beldring / Gizzi, Patrick / Schmitt, Martine / Kugler, Valérie / Simonneaux, Valérie et al. | 2021
- 7565
-
RGD-Peptide Functionalization Affects the In Vivo Diffusion of a Responsive Trimeric MRI Contrast Agent through Interactions with IntegrinsGambino, Giuseppe / Gambino, Tanja / Connah, Liam / La Cava, Francesca / Evrard, Henry / Angelovski, Goran et al. | 2021
- 7575
-
Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast CancerZhang, Xiaomeng / Wang, Yazhou / Li, Xue / Wu, Jie / Zhao, Liwen / Li, Wei / Liu, Jian et al. | 2021
- 7596
-
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)Pimková Polidarová, Markéta / Břehová, Petra / Kaiser, Martin Maxmilian / Smola, Miroslav / Dračínský, Martin / Smith, Joshua / Marek, Aleš / Dejmek, Milan / Šála, Michal / Gutten, Ondrej et al. | 2021
- 7617
-
Synthesis of Methoxy‑, Methylenedioxy‑, Hydroxy‑, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant CancerHu, De-Xuan / Tang, Wen-Lin / Zhang, Yu / Yang, Hao / Wang, Wenjie / Agama, Keli / Pommier, Yves / An, Lin-Kun et al. | 2021
- 7630
-
Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial ConquerorsWang, Jie / Ansari, Mohammad Fawad / Zhou, Cheng-He et al. | 2021
- 7646
-
Design, Synthesis, and Evaluation of o‑(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In VivoOuYang, Yiqiang / Gao, Jian / Zhao, Lei / Lu, Junfeng / Zhong, Haiqing / Tang, Hua / Jin, Shuanglong / Yue, Lu / Li, Yuezhen / Guo, Wenjie et al. | 2021
- 7667
-
Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP–AMP SynthaseTan, Jing / Wu, Bing / Chen, Tingting / Fan, Chen / Zhao, Jiannan / Xiong, Chaodong / Feng, Chunlan / Xiao, Ruoxuan / Ding, Chunyong / Tang, Wei et al. | 2021
- 7691
-
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/NatriureticJiang, Jinlong / Ding, Fa-Xiang / Zhou, Xiaoyan / Bateman, Thomas J. / Dong, Shuzhi / Gu, Xin / Keh deJesus, Reynalda / Pio, Barbara / Tang, Haifeng / Chobanian, Harry R. et al. | 2021
- 7702
-
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV‑1 InfectivityHuang, Boshi / Wang, Huiqun / Zheng, Yi / Li, Mengchu / Kang, Guifeng / Barreto-de-Souza, Victor / Nassehi, Nima / Knapp, Pamela E. / Selley, Dana E. / Hauser, Kurt F. et al. | 2021
- 7724
-
Photocytotoxicity of Thiophene- and Bithiophene-Dipicolinato Luminescent Lanthanide ComplexesRodrigues, Carime V. / Johnson, Katherine R. / Lombardi, Vincent C. / Rodrigues, Marcelo O. / Sobrinho, Josiane A. / de Bettencourt-Dias, Ana et al. | 2021
- 7735
-
Visualizing Tumors in Real Time: A Highly Sensitive PSMA Probe for NIR-II Imaging and Intraoperative Tumor ResectionZhang, Longfei / Shi, Xiaojing / Li, Yuying / Duan, Xiaojiang / Zhang, Zeyu / Fu, Hualong / Yang, Xing / Tian, Jie / Hu, Zhenhua / Cui, Mengchao et al. | 2021
- 7746
-
Discovery of Hyperstable Noncanonical Plant-Derived Epidermal Growth Factor Receptor Agonist and AnalogsLoo, Shining / Kam, Antony / Li, Bin Bin / Feng, Nan / Wang, Xiaoliang / Tam, James P. et al. | 2021
- 7760
-
Optimization of N‑Phenylpropenoyl‑l‑amino Acids as Potent and Selective Inducible Nitric Oxide Synthase Inhibitors for Parkinson’s DiseaseHu, Xiao-Long / Lv, Xian-Yu / Wang, Rong / Long, Huan / Feng, Jia-Hao / Wang, Bao-Lin / Shen, Wei / Liu, Hao / Xiong, Fei / Zhang, Xiao-Qi et al. | 2021
- 7778
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Novel Dual-Target μ‑Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain ManagementBonifazi, Alessandro / Battiti, Francisco O. / Sanchez, Julie / Zaidi, Saheem A. / Bow, Eric / Makarova, Mariia / Cao, Jianjing / Shaik, Anver Basha / Sulima, Agnieszka / Rice, Kenner C. et al. | 2021
- 7809
-
Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant ActivityGuzelj, Samo / Nabergoj, Sanja / Gobec, Martina / Pajk, Stane / Klančič, Veronika / Slütter, Bram / Frkanec, Ruža / Štimac, Adela / Šket, Primož / Plavec, Janez et al. | 2021
- 7839
-
Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARPZheng, Mengzhu / Huo, Junfeng / Gu, Xiaoxia / Wang, Yali / Wu, Canrong / Zhang, Qingzhe / Wang, Wang / Liu, Yang / Liu, Yu / Zhou, Xuechen et al. | 2021
- 7853
-
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code ReprogrammingFord, Daniel J. / Duggan, Nisharnthi M. / Fry, Sarah E. / Ripoll-Rozada, Jorge / Agten, Stijn M. / Liu, Wenyu / Corcilius, Leo / Hackeng, Tilman M. / van Oerle, Rene / Spronk, Henri M. H. et al. | 2021