Improved Synthesis and Impurity Control Strategy of Penehyclidine Hydrochloride (English)
- New search for: Ding, Zezhou
- New search for: Quan, Ruijie
- New search for: Jiang, Bibo
- New search for: Xiang, Jingjing
- New search for: Wang, Qian
- New search for: Yang, Anjiang
- Further information on Yang, Anjiang:
- https://orcid.org/0000-0002-6421-4943
- New search for: Zhang, Tao
- Further information on Zhang, Tao:
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- New search for: Zhang, Fuli
- Further information on Zhang, Fuli:
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- New search for: Ding, Zezhou
- New search for: Quan, Ruijie
- New search for: Jiang, Bibo
- New search for: Xiang, Jingjing
- New search for: Wang, Qian
- New search for: Yang, Anjiang
- Further information on Yang, Anjiang:
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- New search for: Zhang, Tao
- Further information on Zhang, Tao:
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- New search for: Zhang, Fuli
- Further information on Zhang, Fuli:
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In:
Organic Process Research
& Development
;
28
, 1
;
210-224
;
2024
- Article (Journal) / Electronic Resource
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Title:Improved Synthesis and Impurity Control Strategy of Penehyclidine Hydrochloride
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Additional title:Org. Process Res. Dev.
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Contributors:Ding, Zezhou ( author ) / Quan, Ruijie ( author ) / Jiang, Bibo ( author ) / Xiang, Jingjing ( author ) / Wang, Qian ( author ) / Yang, Anjiang ( author ) / Zhang, Tao ( author ) / Zhang, Fuli ( author )
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Published in:Organic Process Research & Development ; 28, 1 ; 210-224
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Publisher:
- New search for: American Chemical Society
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Publication date:2024-01-19
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 28, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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Some Items of Interest to Process R&D Chemists and EngineersSteven, Alan / Mateos, Carlos / Zlota, Andrei A. / Nawrat, Christopher C. / Barthelme, Alexandre / Richardson, Paul F. / Kargbo, Robert B. / Knight, John et al. | 2024
- 11
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[Metal–Diphosphine]-Catalyzed Asymmetric Hydrogenation of β‑Amido β‑Substituted Acrylates: A Practical Literature OverviewStephan, Michel / Jeran, Marko / Mohar, Barbara et al. | 2024
- 26
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Ready to Use Cysteine Thiol Protecting Groups in SPPS, A Practical OverviewChakraborty, Amit / Mthembu, Sinenhlanhla N. / de la Torre, Beatriz G. / Albericio, Fernando et al. | 2024
- 46
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Process Development and Kilogram-Scale Manufacture of Key Intermediates toward Single-Enantiomer CELMoDs: Synthesis of Iberdomide·BSA, Part 1Zacuto, Michael J. / Traverse, John F. / Bostwick, Kirsten F. / Geherty, Maryll E. / Primer, David N. / Zhang, Weihong / Zhang, Chengmin / Janes, Rachel D. / Marton, Christopher et al. | 2024
- 57
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Chirality Control in the Kilogram-Scale Manufacture of Single-Enantiomer CELMoDs: Synthesis of Iberdomide·BSA, Part 2Zacuto, Michael J. / Traverse, John F. / Geherty, Maryll E. / Bostwick, Kirsten F. / Jordan, Christopher / Zhang, Chengmin et al. | 2024
- 67
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Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 1: From Discovery Route to Kilogram-Scale ProductionLeung, Joyce C. / Xu, Yibo / Radomkit, Suttipol / Lee, Jaehee / Kim, Wan Shin / Reeves, Jonathan T. / Dong, Weitong / Jang, Hwanjong / Hou, Xiaowen / Lorenz, Jon C. et al. | 2024
- 78
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Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi EpoxidationTan, Zhulin / Ju, Xuan / Wu, Hao / Dong, Weitong / Leung, Joyce C. / Hou, Xiaowen / Lee, Heewon / Granger, Alice / Paolillo, Joshua M. / DiMeo, Susan V. et al. | 2024
- 92
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Manufacturing Process for 6‑Bromo‑N,N‑bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, a Key Intermediate in the Synthesis of KRAS G12C Inhibitor DivarasibShen, Jeff / White, Nicholas A. / Tian, Qingping / Sirois, Lauren E. / Zhang, Haiming / Gosselin, Francis et al. | 2024
- 102
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Development of a Streamlined Manufacturing Process for the Highly Substituted Quinazoline Core Present in KRAS G12C Inhibitor DivarasibBurkhard, Johannes A. / Herold, Sebastian / Leitner, Christian / Zhang, Haiming / Angelaud, Rémy / Tian, Qingping / Han, Chong / Gosselin, Francis et al. | 2024
- 112
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Continuous Nucleation Process of Lactose and Adipic Acid: Parameter Optimization from Laboratory- to Kilogram Pilot-Scale OperationsRimez, Bart / Debuysschère, Robin / Scheid, Benoit et al. | 2024
- 124
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Process Development for the Manufacture of the Antimalarial Amodiaquine Dihydrochloride DihydrateGohain, Mukut / Malefo, Modibo S. / Kunyane, Phaladi / Scholtz, Chantal / Baruah, Sangeeta / Zitha, Andile / Klashorst, Gerrit van der / Malan, Hannes et al. | 2024
- 132
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Green Solvent Selection for Emulsifiable Concentrate Agrochemical FormulationsPacheco, Ana / Attard, Thomas / Calvert, David / Bullock, James / Clark, James H. / Sherwood, James / McElroy, C. Robert et al. | 2024
- 137
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High-Yielding Process for the Synthesis of Hydroxychloroquine under Concentrated Conditions: Nucleophilic Amination of Chloropyridines Promoted by Dimethyl Sulfoxide or Catalyzed by 3,5-Bis(trifluoromethyl)phenolYalduz, Sümeyye / Eyilcim, Öznur / Kılıç, Nazlıcan / Gülyüz, Sevinç / Denizoğlu, Onuralp / Zorlu, Yunus / Ertürk, Erkan et al. | 2024
- 152
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Thermal Risk Assessment and Optimization of Hazard Ranking for Aromatic Nitro Compounds: Multiparameterization and Quantitative Structure–Property Relationship ModelingQin, Chuanrui / Dang, Mengtao / Meng, Yifei / Zhao, Dongfeng et al. | 2024
- 165
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Practical Synthetic Method for Amino Acid-Derived Diazoketones Shelf-Stable Reagents for Organic SynthesisPendiukh, Viacheslav V. / Yakovleva, Hanna V. / Stadniy, Ivan A. / Pashenko, Alexander E. / Rusanov, Eduard B. / Grabovaya, Natalia V. / Kolotilov, Sergey V. / Rozhenko, Alexander B. / Ryabukhin, Serhiy V. / Volochnyuk, Dmytro M. et al. | 2024
- 177
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Generating Low Cost and High Throughput Candidate Routes for Evaluation in Route Selection for Hybrid Peptide SynthesisA Mathematical Optimization ApproachVaidyaraman, Shankar / Viswanath, Shekhar K. / Kokitkar, Prashant B. et al. | 2024
- 188
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Development of an Optimized Process for the Liver-Targeted Triantennary N‑Acetylgalactosamine LigandKim, Joseph T. / McPherson, Andrew K. / Rodriguez, Andrew A. / Chen, Lijian / Lu, Yee Fung / Moskalev, Nick / Upadhyay, Sunil K. / Green, Caroline / Whetsell, Miranda / Xiang-Rong, Jiang et al. | 2024
- 210
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Improved Synthesis and Impurity Control Strategy of Penehyclidine HydrochlorideDing, Zezhou / Quan, Ruijie / Jiang, Bibo / Xiang, Jingjing / Wang, Qian / Yang, Anjiang / Zhang, Tao / Zhang, Fuli et al. | 2024
- 225
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Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p‑Nitroaniline DiazotizationLiu, Feng / Feng, Wei / Yan, Xing / Hu, Tao / Guo, Zichao / Chen, Wanghua et al. | 2024
- 234
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Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-DibromopyrazoleBrown, Katie / Huang, Yun / Knopf, Kevin / Li, Bryan / Ornelas, Martha A. / Watson, Rebecca B. et al. | 2024
- 238
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Scalable and Cost-Effective Synthetic Process for the Preparation of l‑3,4-DihydroxyphenylalanineLevodopaGoura, Ramesh / Manabolu Surya, Surendra Babu / Katari, Naresh Kumar / Achampeta Kodanda, Ramprasad / Rebelly, Pradeep / Chakilam, Nagaraju et al. | 2024
- 248
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Scale-Up and Development of a One-Step Process for the Synthesis of SuccinylcholineSharma, Brijesh M. / Telang, Nakul / Cook, Daniel W. / Burns, Justina M. / Stringham, Rodger W. / Donsbach, Kai O. / Yue, Tai-Yuen et al. | 2024
- 258
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Process Study on One-Pot Synthesis of DBX‑1 with High Conversion Rate and Intrinsic SafetyHuo, Junda / Xia, Fengyi / Ni, Debin / Hu, Chuan / Han, Jimin / Yang, Li et al. | 2024
- 266
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Development and Kilogram-Scale Implementation of a Flavin-Catalyzed Photoredox FluorodecarboxylationJerkovic, Tatjana / Cruickshank, Harriet / Chen, Yiding / Trindade, Alexandre F. / Dumas, Aaron M. / Edwards, John / Alorati, Anthony / Ho, Hon Eong et al. | 2024
- 273
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Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183Khairnar, Pankaj V. / Aleshire, Sarah L. / Kumar Ongolu, Ravi / Jin, Limei / Laidlaw, Michael G. / Donsbach, Kai O. / Gupton, B. Frank / Nelson, Ryan C. / Shanahan, Charles S. et al. | 2024
- 281
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Points of Interest in the Chemistry of the Levomepromazine Drug Substance: Recycling of Undesired Enantiomer, Identification of New Phenothiazine Dimers, Synthesis of a Pharmacopeial Impurity, and an Unexpected RearrangementPoszávácz, László / Porcs-Makkay, Márta / Halász, Judit / Mórász, Tamás / Nagy, Tamás / Kátai-Fadgyas, Katalin / Simig, Gyula / Volk, Balázs et al. | 2024
- 293
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Formation of N‑Nitrosamines by Reaction of Secondary Dialkylamines with Trace Levels of Nitrite in Aqueous Solution: An Automated Experimental and Kinetic Modeling Study Using Di‑n‑butylamineDiab, Samir / Dominey, Andrew P. / Ferrini, Paola / Hayler, John / Hermitage, Stephen / Urquhart, Michael W. / Whiting, Matthew P. / Wickens, James et al. | 2024
- 305
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Hydrochlorination of Alkenes with Hydrochloric AcidOlivier, Arnaud / Müller, Daniel S. et al. | 2024
- 310
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Evolution of the Synthetic Process to an Advanced GPR40 AgonistHou, Xiaoping / Hernandez, Lucas W. / Jurica, Elizabeth A. / Zhao, Rulin / Wang, Bei / Wong, Michael / Sun, Jung-Hui / Sun, Dawn / Wu, Dauh-Rurng / Yuan, Changxia et al. | 2024
- 325
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Correction to “N‑Nitrosodimethylamine Formation in Metformin Drug Products by the Reaction of Dimethylamine and Atmospheric NO2”Fukuda, Shohei / Kondo, Kanako / Fukumoto, Shoji / Takenaka, Norimichi / Uchikawa, Osamu / Yoshida, Itsuro et al. | 2024
- 326
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Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”Lexa, Katrina W. / Belyk, Kevin M. / Henle, Jeremy / Xiang, Bangping / Sheridan, Robert P. / Denmark, Scott E. / Ruck, Rebecca T. / Sherer, Edward C. et al. | 2024