Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design (Unknown)
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In:
Journal of Medicinal Chemistry
;
51
, 16
;
4986-4999
;
2008
- Article (Journal) / Electronic Resource
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Title:Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design
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Additional title:Identification of AT7519
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Contributors:Wyatt, Paul G. ( author ) / Woodhead, Andrew J. ( author ) / Berdini, Valerio ( author ) / Boulstridge, John A. ( author ) / Carr, Maria G. ( author ) / Cross, David M. ( author ) / Davis, Deborah J. ( author ) / Devine, Lindsay A. ( author ) / Early, Theresa R. ( author ) / Feltell, Ruth E. ( author )
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Published in:Journal of Medicinal Chemistry ; 51, 16 ; 4986-4999
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Publisher:
- New search for: American Chemical Society
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Publication date:2008-08-28
-
ISSN:
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Coden:
-
DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 51, Issue 16
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4581
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Blockade of Glucocorticoid Excess at the Tissue Level: Inhibitors of 11 beta -Hydroxysteroid Dehydrogenase Type 1 as a Therapy for Type 2 DiabetesFotsch, C. / Wang, M. et al. | 2008
- 4851
-
Blockade of Glucocorticoid Excess at the Tissue Level: Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 as a Therapy for Type 2 DiabetesFotsch, Christopher / Wang, Minghan et al. | 2008
- 4858
-
Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal ExposureDegnan, Andrew P. / Chaturvedula, Prasad V. / Conway, Charles M. / Cook, Deborah A. / Davis, Carl D. / Denton, Rex / Han, Xiaojun / Macci, Robert / Mathias, Neil R. / Moench, Paul et al. | 2008
- 4862
-
Exploiting Ordered Waters in Molecular DockingHuang, Niu / Shoichet, Brian K. et al. | 2008
- 4866
-
Discovery of Novel and Long Acting Muscarinic Acetylcholine Receptor AntagonistsJin, Jian / Wang, Yonghui / Shi, Dongchuan / Wang, Feng / Davis, Roderick S. / Jin, Qi / Fu, Wei / Foley, James J. / Webb, Edward F. / Dehaas, Chris J. et al. | 2008
- 4870
-
Enhanced Antimalarial Activity of Novel Synthetic Aculeatin DerivativesPeuchmaur, Marine / Saïdani, Nadia / Botté, Cyrille / Maréchal, Eric / Vial, Henri / Wong, Yung-Sing et al. | 2008
- 4874
-
Synthesis, Stereochemical Identification, and Selective Inhibitory Activity against Human Monoamine Oxidase-B of 2-Methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazonesChimenti, Franco / Maccioni, Elias / Secci, Daniela / Bolasco, Adriana / Chimenti, Paola / Granese, Arianna / Carradori, Simone / Alcaro, Stefano / Ortuso, Francesco / Yáñez, Matilde et al. | 2008
- 4881
-
Toward an Optimal Blood−Brain Barrier Shuttle by Synthesis and Evaluation of Peptide LibrariesMalakoutikhah, Morteza / Teixidó, Meritxell / Giralt, Ernest et al. | 2008
- 4890
-
Redesigning Kinase Inhibitors to Enhance SpecificityCrespo, Alejandro / Zhang, Xi / Fernández, Ariel et al. | 2008
- 4899
-
Novel Amidino-Substituted Thienyl- and Furylvinylbenzimidazole: Derivatives and Their Photochemical Conversion into Corresponding Diazacyclopenta[c]fluorenes. Synthesis, Interactions with DNA and RNA, and Antitumor Evaluation. 4Hranjec, Marijana / Piantanida, Ivo / Kralj, Marijeta / Šuman, Lidija / Pavelić, Krešimir / Karminski-Zamola, Grace et al. | 2008
- 4911
-
Sulindac Derivatives That Activate the Peroxisome Proliferator-activated Receptor γ but Lack Cyclooxygenase InhibitionFelts, Andrew S. / Siegel, Brianna S. / Young, Shiu M. / Moth, Christopher W. / Lybrand, Terry P. / Dannenberg, Andrew J. / Marnett, Lawrence J. / Subbaramaiah, Kotha et al. | 2008
- 4911
-
Sulindac Derivatives That Activate the Peroxisome Proliferator-activated Receptor gamma but Lack Cyclooxygenase InhibitionFelts, A.S. / Siegel, B.S. / Young, S.M. / Moth, C.W. / Lybrand, T.P. / Dannenberg, A.J. / Marnett, L.J. / Subbaramaiah, K. et al. | 2008
- 4920
-
Structure−Activity Relationship of Kahalalide F Synthetic AnaloguesJiménez, José C. / López-Macià, Angel / Gracia, Carol / Varón, Sonia / Carrascal, Marta / Caba, Josep M. / Royo, Miriam / Francesch, Andrés M. / Cuevas, Carmen / Giralt, Ernest et al. | 2008
- 4932
-
Design and Synthesis of a Novel Series of N-Alkyl Isatin Acylhydrazone Derivatives that Act as Selective Cannabinoid Receptor 2 Agonists for the Treatment of Neuropathic PainDiaz, Philippe / Xu, Jijun / Astruc-Diaz, Fanny / Pan, Hao-Min / Brown, David L. / Naguib, Mohamed et al. | 2008
- 4948
-
Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole ScaffoldsLawrence, Harshani R. / Pireddu, Roberta / Chen, Liwei / Luo, Yunting / Sung, Shen-Shu / Szymanski, Ann Marie / Yip, M. L. Richard / Guida, Wayne C. / Sebti, Saïd M. / Wu, Jie et al. | 2008
- 4957
-
A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial RibosomeLolk, Line / Pøhlsgaard, Jacob / Jepsen, Anne Sofie / Hansen, Lykke H. / Nielsen, Henrik / Steffansen, Signe I. / Sparving, Laura / Nielsen, Annette B. / Vester, Birte / Nielsen, Poul et al. | 2008
- 4968
-
Structure Based Development of Phenylimidazole-Derived Inhibitors of Indoleamine 2,3-DioxygenaseKumar, Sanjeev / Jaller, Daniel / Patel, Bhumika / LaLonde, Judith M. / DuHadaway, James B. / Malachowski, William P. / Prendergast, George C. / Muller, Alexander J. et al. | 2008
- 4978
-
Selective Structure-Based Virtual Screening for Full and Partial Agonists of the beta 2 Adrenergic Receptorde Graaf, C. / Rognan, D. et al. | 2008
- 4978
-
Selective Structure-Based Virtual Screening for Full and Partial Agonists of the β2 Adrenergic Receptorde Graaf, Chris / Rognan, Didier et al. | 2008
- 4986
-
Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug DesignWyatt, Paul G. / Woodhead, Andrew J. / Berdini, Valerio / Boulstridge, John A. / Carr, Maria G. / Cross, David M. / Davis, Deborah J. / Devine, Lindsay A. / Early, Theresa R. / Feltell, Ruth E. et al. | 2008
- 5000
-
Structural Basis for the Improved Drug Resistance Profile of New Generation Benzophenone Non-Nucleoside HIV-1 Reverse Transcriptase InhibitorsRen, Jingshan / Chamberlain, Philip P. / Stamp, Anna / Short, Steven A. / Weaver, Kurt L. / Romines, Karen R. / Hazen, Richard / Freeman, Andrew / Ferris, Robert G. / Andrews, C. Webster et al. | 2008
- 5009
-
Synthesis, Biological Evaluation, and Molecular Modeling of Abiraterone Analogues: Novel CYP17 Inhibitors for the Treatment of Prostate CancerPinto-Bazurco Mendieta, Mariano A. E. / Negri, Matthias / Jagusch, Carsten / Müller-Vieira, Ursula / Lauterbach, Thomas / Hartmann, Rolf W. et al. | 2008
- 5019
-
Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) AgonistsCheng, Yuan / Albrecht, Brian K. / Brown, James / Buchanan, John L. / Buckner, William H. / DiMauro, Erin F. / Emkey, Renee / Fremeau, Robert T. / Harmange, Jean-Christophe / Hoffman, Beth J. et al. | 2008
- 5035
-
NMR Screening for Lead Compounds Using Tryptophan-Mutated ProteinsRothweiler, Ulli / Czarna, Anna / Weber, Lutz / Popowicz, Grzegorz M. / Brongel, Kinga / Kowalska, Kaja / Orth, Michael / Stemmann, Olaf / Holak, Tad A. et al. | 2008
- 5043
-
Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 ReplicationYedavalli, Venkat S. R. K. / Zhang, Ning / Cai, Hongyi / Zhang, Peng / Starost, Matthew F. / Hosmane, Ramachandra S. / Jeang, Kuan-Teh et al. | 2008
- 5052
-
Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors with Antitumor ActivityDeng, Yijun / Wang, Yiqiang / Cherian, Christina / Hou, Zhanjun / Buck, Steven A. / Matherly, Larry H. / Gangjee, Aleem et al. | 2008
- 5064
-
Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and SelectivityHeim, Ralf / Lucas, Simon / Grombein, Cornelia M. / Ries, Christina / Schewe, Katarzyna E. / Negri, Matthias / Birk, Barbara / Hartmann, Rolf W. et al. | 2008
- 5075
-
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 2. Synthesis and Structure−Activity Relationship of Potent and Selective Cannabinoid-2 Receptor Agonists Endowed with Analgesic Activity in VivoPasquini, Serena / Botta, Lorenzo / Semeraro, Teresa / Mugnaini, Claudia / Ligresti, Alessia / Palazzo, Enza / Maione, Sabatino / Di Marzo, Vincenzo / Corelli, Federico et al. | 2008
- 5085
-
Novel 1,4-Benzothiazine Derivatives as Large Conductance Ca2+-Activated Potassium Channel OpenersCalderone, Vincenzo / Spogli, Roberto / Martelli, Alma / Manfroni, Giuseppe / Testai, Lara / Sabatini, Stefano / Tabarrini, Oriana / Cecchetti, Violetta et al. | 2008
- 5093
-
Facile Radiosynthesis of Fluorine-18 Labeled β-Blockers. Synthesis, Radiolabeling, and ex Vivo Biodistribution of [18F]-(2S and 2R)-1-(1-Fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-olStephenson, Karin A. / Wilson, Alan A. / Meyer, Jeffrey H. / Houle, Sylvain / Vasdev, Neil et al. | 2008
- 5093
-
Facile Radiosynthesis of Fluorine-18 Labeled beta -Blockers. Synthesis, Radiolabeling, and ex Vivo Biodistribution of [^1^8F]-(2S and 2R)-1-(1-Fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-olStephenson, K.A. / Wilson, A.A. / Meyer, J.H. / Houle, S. / Vasdev, N. et al. | 2008
- 5101
-
3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in MiceSemple, Graeme / Skinner, Philip J. / Gharbaoui, Tawfik / Shin, Young-Jun / Jung, Jae-Kyu / Cherrier, Martin C. / Webb, Peter J. / Tamura, Susan Y. / Boatman, P. Douglas / Sage, Carleton R. et al. | 2008
- 5109
-
Further Studies on Lead Compounds Containing the Opioid Pharmacophore Dmt-TicBalboni, Gianfranco / Fiorini, Stella / Baldisserotto, Anna / Trapella, Claudio / Sasaki, Yusuke / Ambo, Akihiro / Marczak, Ewa D. / Lazarus, Lawrence H. / Salvadori, Severo et al. | 2008
- 5118
-
Reductive Heme-Dependent Activation of the N-Oxide Prodrug AQ4N by Nitric Oxide SynthaseNishida, Clinton R. / Ortiz de Montellano, Paul R. et al. | 2008
- 5121
-
Synthesis of Somatostatin Analogues Containing C-Terminal Adamantane and Their Antiproliferative PropertiesMiyazaki, Anna / Tsuda, Yuko / Fukushima, Shoji / Yokoi, Toshio / Vántus, Tibor / Bökönyi, Gyöngyi / Szabó, Edit / Horváth, Anikó / Kéri, György / Okada, Yoshio et al. | 2008
- 5125
-
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure−Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase InhibitorsPasquini, Serena / Mugnaini, Claudia / Tintori, Cristina / Botta, Maurizio / Trejos, Alejandro / Arvela, Riina K. / Larhed, Mats / Witvrouw, Myriam / Michiels, Martine / Christ, Frauke et al. | 2008
- 5130
-
Novel Ligands Rationally Designed for Characterizing I2−Imidazoline Binding Sites Nature and FunctionsGentili, Francesco / Cardinaletti, Claudia / Vesprini, Cristian / Ghelfi, Francesca / Farande, Aniket / Giannella, Mario / Piergentili, Alessandro / Quaglia, Wilma / Mattioli, Laura / Perfumi, Marina et al. | 2008
- 5135
-
Synthesis and Biological Properties of Benzothiazole, Benzoxazole, and Chromen-4-one Analogues of the Potent Antitumor Agent 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648)Aiello, Stefania / Wells, Geoffrey / Stone, Erica L. / Kadri, Hachemi / Bazzi, Rana / Bell, David R. / Stevens, Malcolm F. G. / Matthews, Charles S. / Bradshaw, Tracey D. / Westwell, Andrew D. et al. | 2008
- 5140
-
Determination of log D via Automated Microfluidic Liquid−Liquid ExtractionAlimuddin, Muhammad / Grant, Daniel / Bulloch, Daryl / Lee, Noelle / Peacock, Martin / Dahl, Russell et al. | 2008
- 5143
-
The Unusual Binding Mode of Cnicin to the Antibacterial Target Enzyme MurA Revealed by X-ray CrystallographySteinbach, Anke / Scheidig, Axel J. / Klein, Christian D. et al. | 2008
- 5148
-
Book Review of Medicinal Chemistry. An Introduction. Second EditionPatrick, Kennerly S. et al. | 2008