Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors (Unknown)
- New search for: Morgan, Cynthia A.
- New search for: Hurley, Thomas D.
- New search for: Morgan, Cynthia A.
- New search for: Hurley, Thomas D.
In:
Journal of Medicinal Chemistry
;
58
, 4
;
1964-1975
;
2015
- Article (Journal) / Electronic Resource
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Title:Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors
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Additional title:J. Med. Chem.
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Contributors:Morgan, Cynthia A. ( author ) / Hurley, Thomas D. ( author )
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Published in:Journal of Medicinal Chemistry ; 58, 4 ; 1964-1975
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Publisher:
- New search for: American Chemical Society
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Publication date:2015-02-26
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 58, Issue 4
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1581
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Inhibiting the Deubiquitinating Enzymes (DUBs)Ndubaku, Chudi / Tsui, Vickie et al. | 2015
- 1596
-
Selective Inhibitors of Protein MethyltransferasesKaniskan, H. Ümit / Konze, Kyle D. / Jin, Jian et al. | 2015
- 1630
-
Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge StudyMackman, Richard L. / Sangi, Michael / Sperandio, David / Parrish, Jay P. / Eisenberg, Eugene / Perron, Michel / Hui, Hon / Zhang, Lijun / Siegel, Dustin / Yang, Hai et al. | 2015
- 1644
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First Evidence That Oligopyridines, α‑Helix Foldamers, Inhibit Mcl‑1 and Sensitize Ovarian Carcinoma Cells to Bcl‑xL‑Targeting StrategiesGloaguen, Céline / Voisin-Chiret, Anne Sophie / Sopkova-de Oliveira Santos, Jana / Fogha, Jade / Gautier, Fabien / De Giorgi, Marcella / Burzicki, Grégory / Perato, Serge / Pétigny-Lechartier, Cécile / Simonin-Le Jeune, Karin et al. | 2015
- 1669
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Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)Takahashi, Hidenori / Riether, Doris / Bartolozzi, Alessandra / Bosanac, Todd / Berger, Valentina / Binetti, Ralph / Broadwater, John / Chen, Zhidong / Crux, Rebecca / De Lombaert, Stéphane et al. | 2015
- 1691
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Synthesis, Characterization, and Optimization for in Vivo Delivery of a Nonselective Isopeptidase Inhibitor as New Antineoplastic AgentCersosimo, Ulma / Sgorbissa, Andrea / Foti, Carmen / Drioli, Sara / Angelica, Rosario / Tomasella, Andrea / Picco, Raffaella / Semrau, Marta Stefania / Storici, Paola / Benedetti, Fabio et al. | 2015
- 1705
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Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor AgentsMa, Li-Ying / Zheng, Yi-Chao / Wang, Sai-Qi / Wang, Bo / Wang, Zhi-Ru / Pang, Lu-Ping / Zhang, Miao / Wang, Jun-Wei / Ding, Lina / Li, Juan et al. | 2015
- 1717
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Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway ScreenMallinger, Aurélie / Crumpler, Simon / Pichowicz, Mark / Waalboer, Dennis / Stubbs, Mark / Adeniji-Popoola, Olajumoke / Wood, Bozena / Smith, Elizabeth / Thai, Ching / Henley, Alan T. et al. | 2015
- 1736
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Far-Red-Absorbing Cationic Phthalocyanine Photosensitizers: Synthesis and Evaluation of the Photodynamic Anticancer Activity and the Mode of Cell Death InductionMachacek, Miloslav / Cidlina, Antonin / Novakova, Veronika / Svec, Jan / Rudolf, Emil / Miletin, Miroslav / Kučera, Radim / Simunek, Tomas / Zimcik, Petr et al. | 2015
- 1750
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Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular InjectionChan, Adriano / Jiang, Jingjing / Fridman, Alla / Guo, Ling T. / Shelton, G. Diane / Liu, Ming-Tao / Green, Carol / Haushalter, Kristofer J. / Patel, Hemal H. / Lee, Jangwoen et al. | 2015
- 1760
-
Discovery of Imidazo[1,2‑b]pyridazine Derivatives: Selective and Orally Available Mps1 (TTK) Kinase Inhibitors Exhibiting Remarkable Antiproliferative ActivityKusakabe, Ken-ichi / Ide, Nobuyuki / Daigo, Yataro / Itoh, Takeshi / Yamamoto, Takahiko / Hashizume, Hiroshi / Nozu, Kohei / Yoshida, Hiroshi / Tadano, Genta / Tagashira, Sachie et al. | 2015
- 1776
-
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain StructuresMonn, James A. / Prieto, Lourdes / Taboada, Lorena / Pedregal, Concepcion / Hao, Junliang / Reinhard, Matt R. / Henry, Steven S. / Goldsmith, Paul J. / Beadle, Christopher D. / Walton, Lesley et al. | 2015
- 1795
-
Synthesis of Xanthohumol Analogues and Discovery of Potent Thioredoxin Reductase Inhibitor as Potential Anticancer AgentZhang, Baoxin / Duan, Dongzhu / Ge, Chunpo / Yao, Juan / Liu, Yaping / Li, Xinming / Fang, Jianguo et al. | 2015
- 1806
-
Development of Cyclic NGR Peptides with Thioether Linkage: Structure and Dynamics Determining Deamidation and BioactivityEnyedi, Kata Nóra / Czajlik, András / Knapp, Krisztina / Láng, András / Majer, Zsuzsa / Lajkó, Eszter / Kőhidai, László / Perczel, András / Mező, Gábor et al. | 2015
- 1818
-
Structural Investigation of B‑Raf Paradox Breaker and Inducer InhibitorsArora, Rohit / Di Michele, Michela / Stes, Elisabeth / Vandermarliere, Elien / Martens, Lennart / Gevaert, Kris / Van Heerde, Erika / Linders, Joannes T. M. / Brehmer, Dirk / Jacoby, Edgar et al. | 2015
- 1832
-
Synthesis of New Steroidal Inhibitors of P‑Glycoprotein-Mediated Multidrug Resistance and Biological Evaluation on K562/R7 Erythroleukemia Cellsde Ravel, Marc Rolland / Alameh, Ghina / Melikian, Maxime / Mahiout, Zahia / Emptoz-Bonneton, Agnès / Matera, Eva-Laure / Lomberget, Thierry / Barret, Roland / Rocheblave, Luc / Walchshofer, Nadia et al. | 2015
- 1846
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Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) InhibitorsYin, Yan / Zheng, Ke / Eid, Nibal / Howard, Shannon / Jeong, Ji-Hak / Yi, Fei / Guo, Jia / Park, Chul Min / Bibian, Mathieu / Wu, Weilin et al. | 2015
- 1862
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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus InfectionWang, Guangyi / Deval, Jerome / Hong, Jin / Dyatkina, Natalia / Prhavc, Marija / Taylor, Joshua / Fung, Amy / Jin, Zhinan / Stevens, Sarah K. / Serebryany, Vladimir et al. | 2015
- 1879
-
Structure−Activity Relationship Studies and in Vivo Activity of Guanidine-Based Sphingosine Kinase Inhibitors: Discovery of SphK1- and SphK2-Selective InhibitorsPatwardhan, Neeraj N. / Morris, Emily A. / Kharel, Yugesh / Raje, Mithun R. / Gao, Ming / Tomsig, Jose L. / Lynch, Kevin R. / Santos, Webster L. et al. | 2015
- 1900
-
Novel C‑4 Heteroaryl 13-cis-Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in MiceMbatia, Hannah W. / Ramalingam, Senthilmurugan / Ramamurthy, Vidya P. / Martin, Marlena S. / Kwegyir-Afful, Andrew K. / Njar, Vincent C. O. et al. | 2015
- 1915
-
Structure–Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV‑1 Integrase and Reverse Transcriptase Ribonuclease H DomainCuzzucoli Crucitti, Giuliana / Métifiot, Mathieu / Pescatori, Luca / Messore, Antonella / Madia, Valentina Noemi / Pupo, Giovanni / Saccoliti, Francesco / Scipione, Luigi / Tortorella, Silvano / Esposito, Francesca et al. | 2015
- 1929
-
Overcoming Mutagenicity and Ion Channel Activity: Optimization of Selective Spleen Tyrosine Kinase InhibitorsEllis, J. Michael / Altman, Michael D. / Bass, Alan / Butcher, John W. / Byford, Alan J. / Donofrio, Anthony / Galloway, Sheila / Haidle, Andrew M. / Jewell, James / Kelly, Nancy et al. | 2015
- 1940
-
Antiprotozoal Activity and DNA Binding of Dicationic AcridonesMontalvo-Quirós, Sandra / Taladriz-Sender, Andrea / Kaiser, Marcel / Dardonville, Christophe et al. | 2015
- 1950
-
Discovery and Profiling of a Selective and Efficacious Syk InhibitorThoma, Gebhard / Smith, Alexander B. / van Eis, Maurice J. / Vangrevelinghe, Eric / Blanz, Joachim / Aichholz, Reiner / Littlewood-Evans, Amanda / Lee, Christian C. / Liu, Hong / Zerwes, Hans-Günter et al. | 2015
- 1964
-
Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 InhibitorsMorgan, Cynthia A. / Hurley, Thomas D. et al. | 2015
- 1976
-
Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2Ren, Li / Grina, Jonas / Moreno, David / Blake, James F. / Gaudino, John J. / Garrey, Rustam / Metcalf, Andrew T. / Burkard, Michael / Martinson, Matthew / Rasor, Kevin et al. | 2015
- 1992
-
Optimization of 2‑Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic AgentsCheng, Jianjun / Giguère, Patrick M. / Onajole, Oluseye K. / Lv, Wei / Gaisin, Arsen / Gunosewoyo, Hendra / Schmerberg, Claire M. / Pogorelov, Vladimir M. / Rodriguiz, Ramona M. / Vistoli, Giulio et al. | 2015
- 2003
-
Folic Acid-Conjugated Europium Complexes as Luminescent Probes for Selective Targeting of Cancer CellsQuici, Silvio / Casoni, Alessandro / Foschi, Francesca / Armelao, Lidia / Bottaro, Gregorio / Seraglia, Roberta / Bolzati, Cristina / Salvarese, Nicola / Carpanese, Debora / Rosato, Antonio et al. | 2015
- 2015
-
Improved Synthesis of N‑Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic ActivityDaum, Steffen / Chekhun, Vasiliy F. / Todor, Igor N. / Lukianova, Natalia Yu. / Shvets, Yulia V. / Sellner, Leopold / Putzker, Kerstin / Lewis, Joe / Zenz, Thorsten / de Graaf, Inge A. M. et al. | 2015
- 2025
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Prodrugs of Reverse Fosmidomycin AnaloguesBrücher, Karin / Gräwert, Tobias / Konzuch, Sarah / Held, Jana / Lienau, Claudia / Behrendt, Christoph / Illarionov, Boris / Maes, Louis / Bacher, Adelbert / Wittlin, Sergio et al. | 2015
- 2036
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Proteasome Inhibitors with Pyrazole Scaffolds from Structure-Based Virtual ScreeningMiller, Zachary / Kim, Keun-Sik / Lee, Do-Min / Kasam, Vinod / Baek, Si Eun / Lee, Kwang Hyun / Zhang, Yan-Yan / Ao, Lin / Carmony, Kimberly / Lee, Na-Ra et al. | 2015
- 2042
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Calbindin D28k and S100B Have a Similar Interaction Site with the Lithium-Inhibitable Enzyme Inositol Monophosphatase-1: A New Drug Target SiteAgam, Galila / Almog, Orna et al. | 2015
- 2045
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Correction to Hunter–Killer Peptide (HKP) for Targeted TherapyEllerby, H. Michael / Bredesen, Dale E. / Fujimura, Satoshi / John, Varghese et al. | 2015