Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes (Unknown)
- New search for: Li, Yao
- Further information on Li, Yao:
- https://orcid.org/0000-0001-5760-9421
- New search for: Shi, Zongjun
- New search for: Chen, Lei
- New search for: Zheng, Suxin
- New search for: Li, Sheng
- New search for: Xu, Bo
- New search for: Liu, Zhenhong
- New search for: Liu, Jianyu
- New search for: Deng, Chongyang
- New search for: Ye, Fei
- New search for: Li, Yao
- Further information on Li, Yao:
- https://orcid.org/0000-0001-5760-9421
- New search for: Shi, Zongjun
- New search for: Chen, Lei
- New search for: Zheng, Suxin
- New search for: Li, Sheng
- New search for: Xu, Bo
- New search for: Liu, Zhenhong
- New search for: Liu, Jianyu
- New search for: Deng, Chongyang
- New search for: Ye, Fei
In:
Journal of Medicinal Chemistry
;
60
, 10
;
4173-4184
;
2017
- Article (Journal) / Electronic Resource
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Title:Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes
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Additional title:J. Med. Chem.
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Contributors:Li, Yao ( author ) / Shi, Zongjun ( author ) / Chen, Lei ( author ) / Zheng, Suxin ( author ) / Li, Sheng ( author ) / Xu, Bo ( author ) / Liu, Zhenhong ( author ) / Liu, Jianyu ( author ) / Deng, Chongyang ( author ) / Ye, Fei ( author )
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Published in:Journal of Medicinal Chemistry ; 60, 10 ; 4173-4184
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Publisher:
- New search for: American Chemical Society
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Publication date:2017-05-25
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 60, Issue 10
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4101
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4‑Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited DiseasesSantucci, Annalisa / Bernardini, Giulia / Braconi, Daniela / Petricci, Elena / Manetti, Fabrizio et al. | 2017
- 4126
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Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal ChemistryFronik, Philipp / Gaiser, Birgit I. / Sejer Pedersen, Daniel et al. | 2017
- 4135
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Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase‑2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking InflammationZhang, Yanmei / Wang, Yican / He, Chuang / Liu, Xiaorong / Lu, Yongzhi / Chen, Tingting / Pan, Qiong / Xiong, Jingfang / She, Miaoqin / Tu, Zhengchao et al. | 2017
- 4147
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Ugi Reaction-Derived α‑Acyl Aminocarboxamides Bind to Phosphatidylinositol 3‑Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma CellsBach, Matthias / Lehmann, Anna / Brünnert, Daniela / Vanselow, Jens T. / Hartung, Andreas / Bargou, Ralf C. / Holzgrabe, Ulrike / Schlosser, Andreas / Chatterjee, Manik et al. | 2017
- 4161
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1‑(4‑[18F]Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine: A Novel Suitable Radioligand with Low Lipophilicity for Imaging σ1 Receptors in the BrainHe, Yingfang / Xie, Fang / Ye, Jiajun / Deuther-Conrad, Winnie / Cui, Bixiao / Wang, Liang / Lu, Jie / Steinbach, Jörg / Brust, Peter / Huang, Yiyun et al. | 2017
- 4173
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Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 DiabetesLi, Yao / Shi, Zongjun / Chen, Lei / Zheng, Suxin / Li, Sheng / Xu, Bo / Liu, Zhenhong / Liu, Jianyu / Deng, Chongyang / Ye, Fei et al. | 2017
- 4185
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Topical Intestinal Aminoimidazole Agonists of G‑Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide‑1 Secretion and Improve Glucose ToleranceLasalle, Manuel / Hoguet, Vanessa / Hennuyer, Nathalie / Leroux, Florence / Piveteau, Catherine / Belloy, Loïc / Lestavel, Sophie / Vallez, Emmanuelle / Dorchies, Emilie / Duplan, Isabelle et al. | 2017
- 4212
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7‑Substituted 2‑Nitro-5,6-dihydroimidazo[2,1‑b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral LeishmaniasisThompson, Andrew M. / O’Connor, Patrick D. / Marshall, Andrew J. / Yardley, Vanessa / Maes, Louis / Gupta, Suman / Launay, Delphine / Braillard, Stephanie / Chatelain, Eric / Franzblau, Scott G. et al. | 2017
- 4234
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1,4,5-Trisubstituted Imidazole-Based p53–MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological CarriersTwarda-Clapa, Aleksandra / Krzanik, Sylwia / Kubica, Katarzyna / Guzik, Katarzyna / Labuzek, Beata / Neochoritis, Constantinos G. / Khoury, Kareem / Kowalska, Kaja / Czub, Miroslawa / Dubin, Grzegorz et al. | 2017
- 4245
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Large-Scale Analysis of Hydrogen Bond Interaction Patterns in Protein–Ligand InterfacesNittinger, Eva / Inhester, Therese / Bietz, Stefan / Meyder, Agnes / Schomburg, Karen T. / Lange, Gudrun / Klein, Robert / Rarey, Matthias et al. | 2017
- 4258
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Development of a Potent Wound Healing Agent Based on the Liver Fluke Granulin Structural FoldBansal, Paramjit S. / Smout, Michael J. / Wilson, David / Cobos Caceres, Claudia / Dastpeyman, Mohadeseh / Sotillo, Javier / Seifert, Julia / Brindley, Paul J. / Loukas, Alex / Daly, Norelle L. et al. | 2017
- 4267
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Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV VariantsGhosh, Arun K. / Rao, Kalapala Venkateswara / Nyalapatla, Prasanth R. / Osswald, Heather L. / Martyr, Cuthbert D. / Aoki, Manabu / Hayashi, Hironori / Agniswamy, Johnson / Wang, Yuan-Fang / Bulut, Haydar et al. | 2017
- 4279
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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 InhibitorsLlona-Minguez, Sabin / Höglund, Andreas / Ghassemian, Artin / Desroses, Matthieu / Calderón-Montaño, José Manuel / Burgos Morón, Estefanía / Valerie, Nicholas C. K. / Wiita, Elisee / Almlöf, Ingrid / Koolmeister, Tobias et al. | 2017
- 4293
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Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor AgonistsEvers, Andreas / Haack, Torsten / Lorenz, Martin / Bossart, Martin / Elvert, Ralf / Henkel, Bernd / Stengelin, Siegfried / Kurz, Michael / Glien, Maike / Dudda, Angela et al. | 2017
- 4304
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Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2‑((6-Amino‑9H‑purin-9-yl)methyl)-5-methyl-3‑(o‑tolyl)quinazolin-4(3H)‑one (IC87114) and Its Conformationally Restricted AnalogsLodola, Alessio / Bertolini, Serena / Biagetti, Matteo / Capacchi, Silvia / Facchinetti, Fabrizio / Gallo, Paola Maria / Pappani, Alice / Mor, Marco / Pala, Daniele / Rivara, Silvia et al. | 2017
- 4316
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Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of BenzenesulfonamidesBruno, Elvira / Buemi, Maria Rosa / Di Fiore, Anna / De Luca, Laura / Ferro, Stefania / Angeli, Andrea / Cirilli, Roberto / Sadutto, Daniele / Alterio, Vincenzo / Monti, Simona Maria et al. | 2017
- 4327
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Exploring the Role of N 6‑Substituents in Potent Dual Acting 5′‑C‑Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in MicePetrelli, Riccardo / Scortichini, Mirko / Kachler, Sonja / Boccella, Serena / Cerchia, Carmen / Torquati, Ilaria / Del Bello, Fabio / Salvemini, Daniela / Novellino, Ettore / Luongo, Livio et al. | 2017
- 4342
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Discovery of Mixed Pharmacology Melanocortin‑3 Agonists and Melanocortin‑4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1‑Arg-(pI)DPhe-Xaa4‑NH2Doering, Skye R. / Freeman, Katie T. / Schnell, Sathya M. / Haslach, Erica M. / Dirain, Marvin / Debevec, Ginamarie / Geer, Phaedra / Santos, Radleigh G. / Giulianotti, Marc A. / Pinilla, Clemencia et al. | 2017
- 4358
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Discovery of a B‑Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based ApproachKamada, Yusuke / Sakai, Nozomu / Sogabe, Satoshi / Ida, Koh / Oki, Hideyuki / Sakamoto, Kotaro / Lane, Weston / Snell, Gyorgy / Iida, Motoo / Imaeda, Yasuhiro et al. | 2017
- 4369
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Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical StudiesYeung, Kap-Sun / Beno, Brett R. / Parcella, Kyle / Bender, John A. / Grant-Young, Katherine A. / Nickel, Andrew / Gunaga, Prashantha / Anjanappa, Prakash / Bora, Rajesh Onkardas / Selvakumar, Kumaravel et al. | 2017
- 4386
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Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic InhibitorsMcCoull, William / Abrams, Roman D. / Anderson, Erica / Blades, Kevin / Barton, Peter / Box, Matthew / Burgess, Jonathan / Byth, Kate / Cao, Qing / Chuaqui, Claudio et al. | 2017
- 4403
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Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)Rowbottom, Martin W. / Bain, Gretchen / Calderon, Imelda / Lasof, Taylor / Lonergan, David / Lai, Andiliy / Huang, Fei / Darlington, Janice / Prodanovich, Patricia / Santini, Angelina M. et al. | 2017
- 4424
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Structure-Based Optimization of Thiophene[3,2‑d]pyrimidine Derivatives as Potent HIV‑1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated VariantsKang, Dongwei / Fang, Zengjun / Huang, Boshi / Lu, Xueyi / Zhang, Heng / Xu, Haoran / Huo, Zhipeng / Zhou, Zhongxia / Yu, Zhao / Meng, Qing et al. | 2017
- 4444
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Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular AtrophyPinard, Emmanuel / Green, Luke / Reutlinger, Michael / Weetall, Marla / Naryshkin, Nikolai A. / Baird, John / Chen, Karen S. / Paushkin, Sergey V. / Metzger, Friedrich / Ratni, Hasane et al. | 2017
- 4458
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Discovery of 5‑Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized BioavailabilityWang, Xiaojing / Kolesnikov, Aleksandr / Tay, Suzanne / Chan, Grace / Chao, Qi / Do, Steven / Drummond, Jason / Ebens, Allen J. / Liu, Ning / Ly, Justin et al. | 2017
- 4474
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4‑Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2)Krapf, Michael K. / Gallus, Jennifer / Wiese, Michael et al. | 2017
- 4496
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Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective ProdrugsJain, Mohit / Harburn, J. Jonathan / Gill, Jason H. / Loadman, Paul M. / Falconer, Robert A. / Mooney, Caitlin A. / Cobb, Steven L. / Berry, David J. et al. | 2017
- 4503
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Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active FormTabata, Hidetsugu / Yoneda, Tetsuya / Oshitari, Tetsuta / Takahashi, Hideyo / Natsugari, Hideaki et al. | 2017
- 4510
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Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood–Brain BarrierMonaco, Ilaria / Camorani, Simona / Colecchia, David / Locatelli, Erica / Calandro, Pierpaolo / Oudin, Anais / Niclou, Simone / Arra, Claudio / Chiariello, Mario / Cerchia, Laura et al. | 2017