Process Development and Pilot Plant Scale Synthesis of Spiro[3.5]nonane-6,8-dione (Unknown)
- New search for: Lehmann, Thomas E.
- New search for: Kuhn, Oliver
- New search for: Krüger, Jochen
- New search for: Lehmann, Thomas E.
- New search for: Kuhn, Oliver
- New search for: Krüger, Jochen
In:
Organic Process Research & Development
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7
, 6
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913-916
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2003
- Article (Journal) / Electronic Resource
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Title:Process Development and Pilot Plant Scale Synthesis of Spiro[3.5]nonane-6,8-dione
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Additional title:Org. Process Res. Dev.
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Contributors:
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Published in:Organic Process Research & Development ; 7, 6 ; 913-916
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Publisher:
- New search for: American Chemical Society
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Publication date:2003-11-21
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 7, Issue 6
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 775
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Easier-To-Read Reaction SchemesLaird, Trevor et al. | 2003
- 776
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Some Items of Interest to Process R&D Chemists and EngineersLaird, Trevor / Hermitage, Stephen A. / Tilstam, Ulf et al. | 2003
- 784
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A Review of U.S. Patents in the Field of Organic Process Development Published during April to July 2003Turner, Keith et al. | 2003
- 794
-
A Convenient Nitroxyl Radical Catalyst for the Selective Oxidation of Primary and Secondary Alcohols to Aldehydes and Ketones by O2 and H2O2 under Mild ConditionsMinisci, Francesco / Recupero, Francesco / Rodinò, Marianna / Sala, Massimiliano / Schneider, Armin et al. | 2003
- 799
-
A Scalable Synthesis of Meso-Substituted DipyrromethanesLaha, Joydev K. / Dhanalekshmi, Savithri / Taniguchi, Masahiko / Ambroise, Arounaguiry / Lindsey, Jonathan S. et al. | 2003
- 813
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Phase-Transfer Catalytic Reaction of 4,4‘-Bis(Chloromethyl)-1,1‘-biphenyl and 1-Butanol in a Two-Phase MediumWang, Maw-Ling / Lee, Ze-Fe et al. | 2003
- 821
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Development of Jacobsen Asymmetric Epoxidation and Sharpless Asymmetric Dihydroxylation Methods for the Large-Scale Preparation of a Chiral Dihydrobenzofuran EpoxidePrasad, J. Siva / Vu, Truc / Totleben, Michael J. / Crispino, Gerard A. / Kacsur, David J. / Swaminathan, Shankar / Thornton, John E. / Fritz, Alan / Singh, Ambarish K. et al. | 2003
- 828
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Enzymatic Hydrocyanation of a Sterically Hindered Aldehyde. Optimization of a Chemoenzymatic Procedure for (R)-2-Chloromandelic Acidvan Langen, Luuk M. / van Rantwijk, Fred / Sheldon, Roger A. et al. | 2003
- 832
-
Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and AvoidanceCapaldi, Daniel C. / Gaus, Hans / Krotz, Achim H. / Arnold, Jim / Carty, Ricaldo L. / Moore, Max N. / Scozzari, Anthony N. / Lowery, Kirsten / Cole, Douglas L. / Ravikumar, Vasulinga T. et al. | 2003
- 839
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The Chemical Development of LB71350Lee, Kyu Woong / Hwang, Sang Yeul / Kim, Chung Ryeol / Nam, Do Hyun / Chang, Jay Hyok / Choi, Sang Chul / Choi, Bo Seung / Choi, Hyeong-wook / Lee, Ki Kon / So, Byungran et al. | 2003
- 846
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Practical Large-Scale Synthesis of Doripenem: A Novel 1β-Methylcarbapenem AntibioticNishino, Yutaka / Kobayashi, Makoto / Shinno, Taneyoshi / Izumi, Kenji / Yonezawa, Hiroshi / Masui, Yoshiyuki / Takahira, Masayuki et al. | 2003
- 846
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Practical Large-Scale Synthesis of Doripenem: A Novel 1b-Methylcarbapenem AntibioticNishino, Y. et al. | 2003
- 851
-
An Efficient and Cost-Effective Synthesis of PagocloneStuk, Timothy L. / Assink, Bryce K. / Bates,, Ronald C. / Erdman, David T. / Fedij, Victor / Jennings, Sandra M. / Lassig, Jennifer A. / Smith, Randy J. / Smith, Traci L. et al. | 2003
- 856
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An Expedient Synthesis of LAF389, a Bengamide B AnalogueXu, David D. / Waykole, Liladhar / Calienni, John V. / Ciszewski, Lech / Lee, George T. / Liu, Wenming / Szewczyk, Joanna / Vargas, Kevin / Prasad, Kapa / Repič, Oljan et al. | 2003
- 866
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A Practical Synthesis of the Platelet Fibrinogen Antagonist, ElarofibanCohen, Judith H. / Bos, Mary Ellen / Cesco-Cancian, Sergio / Harris, Bruce D. / Hortenstine, John T. / Justus, Michael / Maryanoff, Cynthia A. / Mills, John / Muller, Stefan / Roessler, Armin et al. | 2003
- 873
-
Synthesis and Purification of 6-Ethoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic Acid BenzylamideBeaudin, Justin / Bourassa, Dennis E. / Bowles, Paul / Castaldi, Michael J. / Clay, Ronald / Couturier, Michel A. / Karrick, Gregory / Makowski, Teresa W. / McDermott, Ruth E. / Meltz, Clifford N. et al. | 2003
- 879
-
Inhibition of the Cobalt Acetate/Bromide-Catalyzed Hydrogen Peroxide Oxidation of 4-tert-ButyltolueneAmin, Ahmed A. / Beattie, James K. et al. | 2003
- 883
-
Practical Synthesis of N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin- 6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Monohydrochloride: an Arginine Vasopressin AntagonistTsunoda, Takashi / Yamazaki, Atsuki / Iwamoto, Hidenori / Sakamoto, Shuichi et al. | 2003
- 888
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CO2 Offgas as a Mechanistic Probe and Scale-up Tool in N-Acylations Using Mixed Anhydrides from Amino Acids and Isobutyl ChloroformateChaudhary, Apurva / Girgis, Michael J. / Prashad, Mahavir / Hu, Bin / Har, Denis / Repič, Oljan / Blacklock, Thomas J. et al. | 2003
- 896
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Synthesis and Characterisation of Impurities of Manufacture in Support of Certificate of the European Pharmacopoeia Applications Part 1 (Clobetasone Butyrate)McGhie, Stephen / Sewell, Alan / Devlin, John / Wilson, Mark J. / Newton, Lee / McLaren, Kirsty / Thomson, Maranda / Cobb, Steven / Ferguson, Jacqueline / Prudhoe, Kevin et al. | 2003
- 904
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A New Practical Route for the Manufacture of (4aR,10aR)-9-Methoxy-1-methyl-6-trimethylsilanyl- 1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolineBänziger, Markus / Küsters, Ernst / Vecchia, Luigi La / Marterer, Wolfgang / Nozulak, J. et al. | 2003
- 913
-
Process Development and Pilot Plant Scale Synthesis of Spiro[3.5]nonane-6,8-dioneLehmann, Thomas E. / Kuhn, Oliver / Krüger, Jochen et al. | 2003
- 917
-
Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle TimeCheruvallath, Zacharia S. / Carty, Recaldo L. / Andrade, Mark / Moore, Max N. / Song, Quinlai / Rentel, Claus / Cole, Douglas L. / Ravikumar, Vasulinga T. et al. | 2003
- 921
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A Convenient Synthesis of High-Purity 1-Chloro-2,6-difluorobenzeneMoore, Robert M. et al. | 2003
- 925
-
Hydrolysis of Cyclic Phosphites/Phosphoramidites and Its Inhibition-Reversible Cyclization of Acyclic Phosphonate Salts to Cyclic PhosphitesSatish Kumar, N. / Kumaraswamy, Sudha / Said, Musa A. / Kumara Swamy, K. C. et al. | 2003
- 929
-
Chemoselective Removal of Dimeric 1,3-Diol Impurities Generated from Methyl Grignard Addition onto EstersTucker, John L. / Couturier, Michel / Leeman, Kyle R. / Hinderaker, Matthew P. / Andresen, Brian M. et al. | 2003
- 933
-
Process for Developing 3b-(4-(S)-Arylacetylamino-4b-(2-(2-furyl)ethyl)azetidin-2-one: A Carbacephem Key IntermediateKumar, Y. et al. | 2003
- 933
-
Process for Developing 3β-[4-(S)-Arylacetylamino-4β-(2-(2-furyl)ethyl]azetidin-2-one: A Carbacephem Key IntermediateKumar, Yatendra / Tewari, Neera / Nizar, Hashim / Rai, Bishwa Prakash / Singh, Shailendra Kumar et al. | 2003
- 936
-
A Kinetic Study of 2-Ethyl-1-hexanol Oxidation by Dichromate Using Clay-Supported 1-Butyl 4-aza-1-azonia Bicyclo[2.2.2]octane Chloride as the Phase-Transfer CatalystGhiaci, M. / Kalbasi, R. J. / Sedaghat, M. E. et al. | 2003
- 939
-
Synthesis of T2288: From Bench Synthesis to Pilot ProductionGuillaume, Michel / Cuypers, Jef / Vervest, Ivan / De Smaele, Dirk / Leurs, Stef et al. | 2003
- 942
-
Modelling the Kinetics of a Reaction Involving a Sodium Salt of 1,2,4-Triazole and a Complex Substituted Aliphatic HalideGrénman, H. / Salmi, T. / Mäki-Arvela, P. / Wärnå, J. / Eränen, K. / Tirronen, E. / Pehkonen, A. et al. | 2003
- 951
-
Pilot-Scale Lipase-Catalyzed Regioselective Acylation of Ribavirin in Anhydrous Media in the Synthesis of a Novel Prodrug IntermediateTamarez, Maria / Morgan, Brian / Wong, George S. K. / Tong, Weidong / Bennett, Frank / Lovey, Raymond / McCormick, Jinping L. / Zaks, Aleksey et al. | 2003
- 954
-
A Comparison between Kinetic Parameters from the Synthesis of Tris(p-nitrophenyl)phosphite and Tris(p-nitrophenyl)phosphate Using Reaction CalorimetrySeiceira, Rafael C. / Machado e Silva, Carlos F. P. / Estevão, Luciana R. M. / Cajaiba da Silva, João F. et al. | 2003
- 957
-
SPECIAL FEATURE SECTION: POLYMORPHISM AND CRYSTALLIZATIONLaird, Trevor et al. | 2003
- 958
-
An Etoricoxib Phase Diagram: Hemihydrate and AnhydrateCrocker, Louis S. / Ge, Zhihong / Abrahim, Ahmed / Hartman, Robert / Xu, Jing et al. | 2003
- 962
-
Polymorphic Study of l-Arginine Salt of Ragaglitazar (DRF-2725) †Raju, S. / Kumar, P. Rajender / Vyas, K. / Rao, D. Srinivas / Sarma, M. R. / Reddy, S. Vishnuvardhan / Nirmala, M. / Reddy, G. Om et al. | 2003
- 970
-
Structural Characterization of Industrially Relevant Polymorphic Materials from Powder Diffraction DataHarris, Kenneth D. M. / Cheung, Eugene Y. et al. | 2003
- 977
-
In Situ Monitoring of Polymorphic TransitionsO'Sullivan, Brian / Barrett, Paul / Hsiao, Gregor / Carr, Alun / Glennon, Brian et al. | 2003
- 983
-
Phase Transitions in Supersaturated Drug SolutionVeesler, Stéphane / Lafferrère, Laurent / Garcia, Eric / Hoff, Christian et al. | 2003
- 990
-
Salt Selection and Simultaneous Polymorphism Assessment via High-Throughput Crystallization: The Case of SertralineRemenar, Julius F. / MacPhee, J. Michael / Larson, Bridget K. / Tyagi, Viraj A. / Ho, Jason H. / McIlroy, David A. / Hickey, Magali B. / Shaw, Paul B. / Almarsson, Örn et al. | 2003
- 997
-
Crystallization Process Development of an Active Pharmaceutical Ingredient and Particle Engineering via the Use of Ultrasonics and Temperature CyclingKim, Soojin / Wei, Chenkou / Kiang, San et al. | 2003
- 1002
-
Particle Engineering Using Power Ultrasound1Dennehy, Robert Daniel et al. | 2003
- 1007
-
Combined Effect of Polymorphism and Process on Preferential Crystallization: Example with (±)-5(4‘-Methylphenyl)-5-methylhydantoinCourvoisier, L. / Mignot, L. / Petit, M. N. / Coquerel, G. et al. | 2003
- 1007
-
Combined Effect of Polymorphism and Process on Preferential Crystallization: Example with ((plus-minus))-5(4'-Methylphenyl)-5-methylhydantoinCourvoisier, L. et al. | 2003
- 1017
-
Structural and Thermodynamic Explanations of Ostwald's RuleThrelfall, Terry et al. | 2003
- 1028
-
SPECIAL FEATURE SECTION: SAFETY OF CHEMICAL PROCESSESLaird, Trevor et al. | 2003
- 1029
-
Safety Notables: Information from the Literatuream Ende, David J. / Vogt, Paul F. et al. | 2003
- 1034
-
Rapid Scale-Up of the Matrix Metalloproteinase Inhibitor CH5902: Process Safety and Route Development ConsiderationsSmith, Ian H. / Alorati, Anthony / Frampton, Graham / Jones, Steve / O'Rourk, John / Woods, Martin W. et al. | 2003
- 1040
-
Safety Aspects of the Under-Pressure Reaction of Trichloroacetyl Chloride and Acrylonitrile in the Preparation of 3,5,6-Trichloro-2-pyridinolFakhraian, H. / Bazaz, A. / Hadj-Ghanbary, H. et al. | 2003
- 1043
-
Safety vs Efficiency in the Development of a High-Energy CompoundRuggeri, Sally Gut / Bill, David R. / Bourassa, Dennis E. / Castaldi, Michael J. / Houck, Tim L. / Ripin, David H. Brown / Wei, Lulin / Weston, Neil et al. | 2003
- 1048
-
Electrostatic Hazards in Liquids and Relevance to Process ChemistryGiles, Matthew R. et al. | 2003
- 1051
-
Improvement of the Experimental Testing Method for the Determination of the Influence of Air on the Thermal Stability of Chemical CompoundsWiss, Jacques / Fuchs, Jean et al. | 2003
- 1059
-
Online Spectroscopic Investigations (FTIR/Raman) of Industrial Reactions: Synthesis of Tributyltin Azide and Hydrogenation of ChloronitrobenzeneWiss, Jacques / Zilian, Arne et al. | 2003
- 1067
-
Reaction Safety: An Improved Procedure for the Preparation of 1,3,4,12a-Tetrahydro-11H-[1,4]-oxanio[3,4-c][1,4]benzodiazepine-6,12-dione with Iron in Acetic AcidGrimm, Jeffrey / Liu, Fuqiang / Stefanick, Stephen / Sorgi, Kirk L. / Maryanoff, Cynthia A. et al. | 2003
- 1071
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Evaluation and Optimisation of the Reagent Addition Sequence during the Synthesis of Atrazine (6-Chloro-N 2-ethyl-N 4-isopropyl-1,3,5-triazine-2,4-diamine) Using Reaction CalorimetryBarton, Benita / Gouws, Shawn / Schaefer, Melissa C. / Zeelie, Bernard et al. | 2003
- 1077
-
A New Multipurpose Microreactor for Process Safety StudiesBou-Diab, L. / Fierz, H. / Gwerder, C. / Suter, G. et al. | 2003
- 1079
-
Calorimetric Approach and Simulation for Scale-Up of a Friedel−Crafts ReactionGigante, Lucia / Lunghi, Angelo / Martinelli, Simone / Cardillo, Paolo / Picello, Luca / Bortolaso, Roberto / Galvagni, Marco / Rota, Renato et al. | 2003
- 1083
-
Evaluation of Kinetic Parameters from the Synthesis of Triaryl Phosphates Using Reaction Calorimetrye Silva, Carlos F. Pinto Machado / da Silva, Joao F. Cajaiba et al. | 2003
- 1084
-
Cross Coupling Reactions: A Practical Guide Edited by N. Miyaura. Topics in Current Chemistry, Vol. 219. Springer-Verlag: Heidelberg. 2002. 248 pp. 169 ((GBP)104.50, 149 Euros). ISBN 3-540-42175-0.| 2003
- 1084
-
Catalysis in Application Edited by S. D. Jackson, J. S. J. Hargreaves, and D. Lennon. Royal Society of Chemistry: Cambridge. 2003. 318 pp. (GBP)99.95. ISBN 0-8540-4608-9Laird, T. et al. | 2003
- 1084
-
Industrial Organic Chemistry, Completely Revised 4th ed By K. Weissermel and H.-J. Arpe. Wiley-VCH: Weinheim. 2003. 491 pp. £119. ISBN 3-527-30578-5.Spargo, Peter et al. | 2003
- 1084
-
Cross Coupling Reactions: A Practical Guide Edited by N. Miyaura. Topics in Current Chemistry, Vol. 219. Springer-Verlag: Heidelberg. 2002. 248 pp. $169 (£104.50, 149 Euros). ISBN 3-540-42175-0.| 2003
- 1084
-
Catalysis in Application Edited by S. D. Jackson, J. S. J. Hargreaves, and D. Lennon. Royal Society of Chemistry: Cambridge. 2003. 318 pp. £99.95. ISBN 0-8540-4608-9| 2003
- 1084
-
Industrial Organic Chemistry, Completely Revised 4th ed By K. Weissermel and H.-J. Arpe. Wiley-VCH: Weinheim. 2003. 491 pp. (GBP)119. ISBN 3-527-30578-5.Spargo, P. et al. | 2003
- 1085
-
Solvents and Solvent Effects in Organic Chemistry, 3rd updated and enlarged edition C. Reichardt. Wiley-VCH: Weinhem, 2003. 653 pp.129 Euros. ISBN 3-527-30618-8.| 2003
- 1085
-
Handbook of Reagents for Organic Synthesis: Chiral Reagents for Asymmetric Synthesis Edited by L. Paquette. Wiley: Chichester. 2003. 594 pp. £75. ISBN 0-4708-5625-4.| 2003
- 1085
-
Handbook of Reagents for Organic Synthesis: Chiral Reagents for Asymmetric Synthesis Edited by L. Paquette. Wiley: Chichester. 2003. 594 pp. (GBP)75. ISBN 0-4708-5625-4.Laird, T. et al. | 2003